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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FAM155B-EDA (FusionGDB2 ID:28590)

Fusion Gene Summary for FAM155B-EDA

Fusion gene summary

Fusion gene information	Fusion gene name: FAM155B-EDA
	Fusion gene ID: 28590
		Hgene	Tgene
	Gene symbol	FAM155B	EDA
	Gene ID	27112	1896
	Gene name	family with sequence similarity 155 member B	ectodysplasin A
	Synonyms	CXorf63\|TED\|TMEM28\|bB57D9.1	ECTD1\|ED1\|ED1-A1\|ED1-A2\|EDA-A1\|EDA-A2\|EDA1\|EDA2\|HED\|HED1\|ODT1\|STHAGX1\|TNLG7C\|XHED\|XLHED
	Cytomap	Xq13.1	Xq13.1
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein FAM155BbB57D9.1 (TED protein)transmembrane protein 28	ectodysplasin-AX-linked anhidroitic ectodermal dysplasia proteinoligodontia 1tumor necrosis factor ligand 7C
	Modification date	20200313	20200313
	UniProtAcc	O75949	Q8WWZ3
	Ensembl transtripts involved in fusion gene	ENST00000252338,	ENST00000502251, ENST00000338901, ENST00000525810, ENST00000527388, ENST00000374552, ENST00000374553, ENST00000524573,
Fusion gene scores	* DoF score	2 X 2 X 2=8	6 X 6 X 5=180
	# samples	2	7
	** MAII score	log2(2/8*10)=1.32192809488736	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM155B [Title/Abstract] AND EDA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM155B(68725986)-EDA(69176877), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EDA	GO:0051092	positive regulation of NF-kappaB transcription factor activity	11039935

Fusion gene breakpoints across FAM155B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EDA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0221-02A	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+

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Fusion Gene ORF analysis for FAM155B-EDA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000252338	ENST00000502251	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+
5CDS-intron	ENST00000252338	ENST00000338901	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+
5CDS-intron	ENST00000252338	ENST00000525810	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+
5CDS-intron	ENST00000252338	ENST00000527388	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+
In-frame	ENST00000252338	ENST00000374552	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+
In-frame	ENST00000252338	ENST00000374553	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+
In-frame	ENST00000252338	ENST00000524573	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000252338

FAM155B

chrX

68725986

ENST00000374553

EDA

chrX

69176877

5537

903

1676

544

ENST00000252338

FAM155B

chrX

68725986

ENST00000374552

EDA

chrX

69176877

5543

903

1682

546

ENST00000252338

FAM155B

chrX

68725986

ENST00000524573

EDA

chrX

69176877

1696

903

1667

541

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000252338	ENST00000374553	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+	0.02609995	0.9739
ENST00000252338	ENST00000374552	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+	0.025298415	0.9747015
ENST00000252338	ENST00000524573	FAM155B	chrX	68725986	+	EDA	chrX	69176877	+	0.07908973	0.9209103

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Fusion Genomic Features for FAM155B-EDA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FAM155B	chrX	68725986	+	EDA	chrX	69176876	+	0.11657933	0.8834207
FAM155B	chrX	68725986	+	EDA	chrX	69176876	+	0.11657933	0.8834207

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM155B-EDA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:68725986/chrX:69176877)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM155B O75949	EDA Q8WWZ3
	FUNCTION: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. {ECO:0000269\|PubMed:11882293}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM155B

chrX:68725986

chrX:69176877

ENST00000252338

80_180

287

473.0

Compositional bias

Pro-rich

Hgene

FAM155B

chrX:68725986

chrX:69176877

ENST00000252338

47_67

287

473.0

Transmembrane

Helical

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000338901

180_229

149.0

Domain

Note=Collagen-like

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374552

180_229

132

392.0

Domain

Note=Collagen-like

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374553

180_229

132

390.0

Domain

Note=Collagen-like

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000524573

180_229

132

387.0

Domain

Note=Collagen-like

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000525810

180_229

136.0

Domain

Note=Collagen-like

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000527388

180_229

4.666666666666667

Domain

Note=Collagen-like

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000338901

1_41

149.0

Topological domain

Cytoplasmic

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000338901

63_391

149.0

Topological domain

Extracellular

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000525810

1_41

136.0

Topological domain

Cytoplasmic

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000525810

63_391

136.0

Topological domain

Extracellular

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000527388

1_41

4.666666666666667

Topological domain

Cytoplasmic

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000527388

63_391

4.666666666666667

Topological domain

Extracellular

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000338901

42_62

149.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000525810

42_62

136.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000527388

42_62

4.666666666666667

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM155B

chrX:68725986

chrX:69176877

ENST00000252338

382_405

287

473.0

Compositional bias

His-rich

Hgene

FAM155B

chrX:68725986

chrX:69176877

ENST00000252338

433_453

287

473.0

Transmembrane

Helical

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374552

1_41

132

392.0

Topological domain

Cytoplasmic

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374552

63_391

132

392.0

Topological domain

Extracellular

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374553

1_41

132

390.0

Topological domain

Cytoplasmic

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374553

63_391

132

390.0

Topological domain

Extracellular

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000524573

1_41

132

387.0

Topological domain

Cytoplasmic

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000524573

63_391

132

387.0

Topological domain

Extracellular

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374552

42_62

132

392.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000374553

42_62

132

390.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

EDA

chrX:68725986

chrX:69176877

ENST00000524573

42_62

132

387.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for FAM155B-EDA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>28590_28590_1_FAM155B-EDA_FAM155B_chrX_68725986_ENST00000252338_EDA_chrX_69176877_ENST00000374552_length(transcript)=5543nt_BP=903nt
CTCGCGCCTGCCTGTTCCCTCCAGCCCGGACCCCCCTGAAATATGTTCAGGGGCGCTTGGATGTGGCCCGGGAAAGACGCCGCCGCGCTG
ACTATCTGCTGCTGCTGCTGCTGCTGGGCTCCCAGGCCGAGCGACAAACCTTGCGCCGACTCCGAGCGGGCGCAGCGATGGCGACTGTCC
CTGGCGTCCCTGCTCTTCTTCACCGTGCTGCTCGCTGACCATCTGTGGCTGTGCGCGGGGGCCCGGCCCCGGGCCAGGGAGCTGAGCAGC
GCCATGCGGCCCCCATGGGGGGCCGGCCGGGAGCGGCAGCCGGTGCCTCCTCGCGCGGTGCTGCCGCTGCCGCCGCCGCCGCCCGGCGAG
CCCAGCGCGCCCCCAGGCACCTGCGGCCCCAGATACAGCAACCTGACCAAAGCCGCCCCCGCCGCCGGCTCTCGGCCGGTCTGCGGCGGC
GTCCCAGAGCCCACGGGGCTGGACGCAGCTTGCACCAAATTGCAATCTTTGCAGAGACTTTTCGAACCGACTACTCCGGCCCCCCCTCTG
CGGCCCCCTGACTCCCTTTCCCGTGCCCCGGCCGAGTTCCCCTCCGCCAAAAAAAACTTGCTCAAAGGCCACTTTCGGAACTTCACTCTC
TCCTTTTGCGACACCTACACGGTCTGGGACTTGCTGCTGGGCATGGACCGCCCCGACAGCCTGGACTGTAGCCTGGACACCCTGATGGGG
GACCTGCTGGCCGTGGTGGCCAGCCCGGGCTCCGGGGCCTGGGAGGCGTGTAGCAACTGTATCGAGGCGTACCAGCGGCTGGACCGACAC
GCTCAGGAAAAATATGACGAGTTCGACCTCGTGCTGCATAAATACTTACAGGCGGAAGAGTACTCAATCCGGTCCTGCACGAAAGGCTGT
AAGATGGCCCTATTGAATTTCTTCTTCCCTGATGAAAAGCCATACTCTGAAGAAGAAAGTAGGCGTGTTCGCCGCAATAAAAGAAGCAAA
AGCAATGAAGGAGCAGATGGCCCAGTTAAAAACAAGAAAAAGGGAAAGAAAGCAGGACCTCCTGGACCCAATGGCCCTCCAGGACCCCCA
GGACCTCCAGGACCCCAGGGACCCCCAGGAATTCCAGGGATTCCTGGAATTCCAGGAACAACTGTTATGGGACCACCTGGTCCTCCAGGT
CCTCCTGGTCCTCAAGGACCCCCTGGCCTCCAGGGACCTTCTGGTGCTGCTGATAAAGCTGGAACTCGAGAAAACCAGCCAGCTGTGGTG
CATCTACAGGGCCAAGGGTCAGCAATTCAAGTCAAGAATGATCTTTCAGGTGGAGTGCTCAATGACTGGTCTCGCATCACTATGAACCCC
AAGGTGTTTAAGCTACATCCCCGCAGCGGGGAGCTGGAGGTACTGGTGGACGGCACCTACTTCATCTATAGTCAGGTAGAAGTATACTAC
ATCAACTTCACTGACTTTGCCAGCTATGAGGTGGTGGTGGATGAGAAGCCCTTCCTGCAGTGCACACGCAGCATCGAGACGGGCAAGACC
AACTACAACACTTGCTATACCGCAGGCGTCTGCCTCCTCAAGGCCCGGCAGAAGATCGCCGTCAAGATGGTGCACGCTGACATCTCCATC
AACATGAGCAAGCACACCACGTTCTTTGGGGCCATCAGGCTGGGTGAAGCCCCTGCATCCTAGATTCCCCCCATTTTGCCTCTGTCCGTG
CCCCTTCCCTGGGTTTGGGAGCCAGGACTCCCAGAACCTCTAAGTGCTGCTGTGGAGTGAGGTGTATTGGTGTTGCAGCCGCAGAGAAAT
GCCCCAGTGTTATTTATTCCCCAGTGACTCCAGGGTGACAAGGCCTGCTTGACTTTCCAGAATGACCTTGAGTTAACAGGACAGTTGATG
GAGCCCCAGGGTTTACATGAAGCAGAACCTTCTTTGGTTCCATGTTGACTGACTTATGGCATGACTCTTCAACCCCGAGGTCCCTGTTGT
CAGATCTATTGTTTGTTGCACTAAAATGAGGATCCAGGGCAGCAGGCCAGAGAAAGCAAAGGTGCACTCCAGACTCTGGGGGTGGACATC
TGACCCCAAGGGGGCTGCTGCTCCTCTCTTGGGTAGGGTAGTGGCTGGGGTGGAGTGGGAAGGGAGCATTGCAGCCTAAGAAGAAGGCCA
GAGAGGGAAAAGGCAGGTGCTTTTGGCAGAGACCATAAGAGAAACCTGCCAAGGAGCATCCTTGGCAGTGGGAATGTTCTTTCTGCTCTA
TACTGTGGCCTGCAGGAGGGTTGGAGTGCTCTTCCCACTCCAGCTGACAGCCACACCGTGGCAGCTTGCTGGGCTTTGGGAAGTTTGCTG
TGCTTTGGAACAATCACAGGGAATGGCCACAAACCTGCCCGCCTAAGACCCTGAATCCGTACTTGGGTCACATGACTCTCATTTTATTTA
CAGCTGTGCTCCACACTCAGAAAATTCCCTGGGGTCACCTTCTAGTTGCCCCCATTCCCAGCCTGACTAGAACTCCTGTCTTCTTTCTCC
ATGGAGCCTACCTCTGTCTGAGACAGGTGCCTAACCTGGGACCTGTGGTCATGTGAGTCTGGGATATTCTTTAGCTTACCTGGGCACAAA
CAGAATTTTCCATTTATTAAGCAGTACAAATGTTTTTCATCCATTCCTAATCAAATTCTGTCTGGGGACGAAGGGTTGGACGGGATGACC
TCCAGAAGTCCCTTCAATTTCTAGTACCTGTGACTCTTAGCCCTCACCACAGCCTTCTAAATTCCCAAATCCTAGACTGCTCCTGGGCAT
TAGCAAGGCAGAGCCTTTTTACCTGGCCTAGAAAGGGCAAGGGGTGAGGATAGGACAGAGGGATTTTGTTCAAGTTTGCTGCAACCCAAG
TGGACGTTAGGCCAGGCCTTATCTGAAAGGCCAGCAGCTGATGCTGTACTAACCCAGTCTTTCTTCACTCTGGCTTCAAAAAGCCACAGC
AGAGCATTGTCACCGCAGGTGCTCATGCTGCTCCCCTAAAGCCAGGCTCAGGAGAAGCCAGTGTCTAGGCACTGAGCAGGGATCTGCCCC
CTAGTTCAGGTCCAAATTCACCTTCCCCTAAACCCCAAGCTTCCCAACAGATCATATGGTAGGACCCTCGAGAGCCTTACTTCAAAGTGC
CTGGGCTCAGCCTGGTTTCTGGGTGCTAGATCCAGCCCAAACCTGGGAAGGCCAGCCTTGTACAGTCTGCTCCTCTTGTTCCTGAAATGT
GTTTCCTTTTCAGGAGATGGGGAATAATTTCCTTCAGGCAGCTGAAATTCACCAAGAACAGCGGGTACTTATTTCTCAGCTGTGCCTTCC
CTTTCTAAGCAACCACACTGCTTGGCCCTTCAAGGGTCAGGGTGAGACGTGATGGGCTAGGCCTCCGTTGTCTGGTTGCTAATGACAGCC
TTGCAACCCAAGGTGAGGTGAACTCCAGGCATGTGTCTGGCCCTAACTCCTATAAAGTGCCTCGGACAGTCCGCAGTTGTAGCAGAAACC
AACAAGAACCACTCCTTCATGTTTGGAAAATAATTTCTCTTGTATTATCTCCTTTGAAGAAGGCAAGGCTGATAATATGACAAACATCAT
TGTTTAGATGAGGCTCAGAGAGGTAGCACTCTCAGAGTGTTTTGACCAGTTTAAGCCGCAGACCTGGAGCTTCAGCCAGGTCTGACTCCA
AAGCTGTTCCATTACACCACAGCATTGTGTGGAATTTGAGGTCTAGAGAGAACCAATAAAAGTGGTAATTGGGAACTGAAATCCTTGAGA
GTTCCGGGGAGAAACCCAGAGATGCCTGATTTCATTCCTCGATGGTAATACCCGTCCTCTCGGCTGCCAGGGGCTCTGTGGCAAAAAGAG
TCAGACATTTCTTTGGAAAACAGCGAACAGCCTTAGAGCTCTTGTGTTCAGAAGAATCTTCCTGGCACAATGTTGGAGCAGCAGGCCTCT
GGGACCCACAGAACTTGTGGCCTTTATGTTCTTTCACCCATCCTAGGAACCAGCCAACCATCATGTGTAGAGCCCCTACTGTGGGCAAAG
TCCTCCTTTCATTACCCTACAGACAGCTTACAGGAGCCAGCCTGCTTCCCACAACTACTAGTGTGACTCCTTATCTCTTTCCACCATACC
TTAGAGACTTTGATACTACCAGGGTCTCTCAGGGATGGAGGGAAGACCTGAAAGAGAGGACTGGTTCTGAGGCCAGAAAGGTGTGAGGAG
AGAGGAGGAAAAGTCTTCCTAATTGTGCCCCTAAAGAGCATCCTGATACCATTCTATTCTCCAGACATGGAGGGGATGATAAAGGAAATA
GGATCTCCACTGGACCCTTGATTCATTCTGAACCCTCCAAAGGAACTCTAGAGGGCGAGGGATGATGAGGGAAGCAATAGGTAGCTGGGG
AGCCCTATTGCTGCTAAGTCATTGGCAAAGTGACAAAGCAATTTACTGATGAGAGAATGTGGAAATAGATGTGCAGTTTGGAATTATGTT
GGTGTGAATTTGCCAGAGGACCAATGCTTGCATGGAGAATGGGACGAGGACATTTGTGGGCAAGCAGATGACAGAGGTTTGAAGGAGAAT
GGCATGGCAGGAGTCTCTGCCAGTTACTTGGGCTTCAACAGCCAAGCTGGCACAAAAGACAGCTGGCGGAGGCTGCTCGGCTACTGGTTA
CCTGGAGAAGTAGTATTTGCCTATTTCCCCCTTCATCCATCCTGAGCCAAATTTCTTTTGCTGAACAGGAAAGAGCTAGGAACCCTGGAG
GTAAACAAAGACTTTGATCCATGTATGAGTGTATGTGTTTATGTAACTTCCTGTGGATGCAAATAGATTCAGAGAAATTTAGAGCTAAAA
AGGCCCTTAGAGGGAATCTAGCCCAACCTACATTCCACCCTGTTACTTATGTAGAAACTGAGGCCCAGAGAGGGAAGATGACCTGCCCCA
AGTGGTGAGCAAGCACCAACCTCCAGACTCAGCAGAGTGAGGGGGTAAAGCAGTTCCTGTCCCACATGGCCATCTTCTTTCTTCCACCCA
CAAACTCCAGGCTGGAAGTACTTGGCCCCCTTCAGGAGCCTGGCCAGGCAGGGAGAGAGTAGCTGCAGCCTTCATCAGAACTCTTCCTCC
TCCCAAGGCATTCTCCCAGCTCTAGCCTCTGGACTGGAAAGCACAAGACTGGCCCAGTGCCAGCAAGTCCTTAGGCTACTGTAATGCTGC
CTCAGGACCCATCCCTGCCTGGAGGCTCCTCTAGGCCCTGTGAGCACAAAGAAGAAAGCTGATTTTTGTCTTTTAATCCATTTCAGGACT
CTCTCCAGGAGGGCTCGGGGTGTGTCATTTCTATATTCCTCCAGCTGGGATTGGGGGGTGGGCTTTGTTGTGAGAATGGCCTGGAGCAGG
CCCAATGCTGCTTTTGGGGGTCAGCATCCAGTGTGAGATACTGTGTATATAAACTATATATAATGTATATAAACTGGGATGTAAGTTTGT

>28590_28590_1_FAM155B-EDA_FAM155B_chrX_68725986_ENST00000252338_EDA_chrX_69176877_ENST00000374552_length(amino acids)=546AA_BP=0
MFRGAWMWPGKDAAALTICCCCCCWAPRPSDKPCADSERAQRWRLSLASLLFFTVLLADHLWLCAGARPRARELSSAMRPPWGAGRERQP
VPPRAVLPLPPPPPGEPSAPPGTCGPRYSNLTKAAPAAGSRPVCGGVPEPTGLDAACTKLQSLQRLFEPTTPAPPLRPPDSLSRAPAEFP
SAKKNLLKGHFRNFTLSFCDTYTVWDLLLGMDRPDSLDCSLDTLMGDLLAVVASPGSGAWEACSNCIEAYQRLDRHAQEKYDEFDLVLHK
YLQAEEYSIRSCTKGCKMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGI
PGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEV
LVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRL

--------------------------------------------------------------
>28590_28590_2_FAM155B-EDA_FAM155B_chrX_68725986_ENST00000252338_EDA_chrX_69176877_ENST00000374553_length(transcript)=5537nt_BP=903nt
CTCGCGCCTGCCTGTTCCCTCCAGCCCGGACCCCCCTGAAATATGTTCAGGGGCGCTTGGATGTGGCCCGGGAAAGACGCCGCCGCGCTG
ACTATCTGCTGCTGCTGCTGCTGCTGGGCTCCCAGGCCGAGCGACAAACCTTGCGCCGACTCCGAGCGGGCGCAGCGATGGCGACTGTCC
CTGGCGTCCCTGCTCTTCTTCACCGTGCTGCTCGCTGACCATCTGTGGCTGTGCGCGGGGGCCCGGCCCCGGGCCAGGGAGCTGAGCAGC
GCCATGCGGCCCCCATGGGGGGCCGGCCGGGAGCGGCAGCCGGTGCCTCCTCGCGCGGTGCTGCCGCTGCCGCCGCCGCCGCCCGGCGAG
CCCAGCGCGCCCCCAGGCACCTGCGGCCCCAGATACAGCAACCTGACCAAAGCCGCCCCCGCCGCCGGCTCTCGGCCGGTCTGCGGCGGC
GTCCCAGAGCCCACGGGGCTGGACGCAGCTTGCACCAAATTGCAATCTTTGCAGAGACTTTTCGAACCGACTACTCCGGCCCCCCCTCTG
CGGCCCCCTGACTCCCTTTCCCGTGCCCCGGCCGAGTTCCCCTCCGCCAAAAAAAACTTGCTCAAAGGCCACTTTCGGAACTTCACTCTC
TCCTTTTGCGACACCTACACGGTCTGGGACTTGCTGCTGGGCATGGACCGCCCCGACAGCCTGGACTGTAGCCTGGACACCCTGATGGGG
GACCTGCTGGCCGTGGTGGCCAGCCCGGGCTCCGGGGCCTGGGAGGCGTGTAGCAACTGTATCGAGGCGTACCAGCGGCTGGACCGACAC
GCTCAGGAAAAATATGACGAGTTCGACCTCGTGCTGCATAAATACTTACAGGCGGAAGAGTACTCAATCCGGTCCTGCACGAAAGGCTGT
AAGATGGCCCTATTGAATTTCTTCTTCCCTGATGAAAAGCCATACTCTGAAGAAGAAAGTAGGCGTGTTCGCCGCAATAAAAGAAGCAAA
AGCAATGAAGGAGCAGATGGCCCAGTTAAAAACAAGAAAAAGGGAAAGAAAGCAGGACCTCCTGGACCCAATGGCCCTCCAGGACCCCCA
GGACCTCCAGGACCCCAGGGACCCCCAGGAATTCCAGGGATTCCTGGAATTCCAGGAACAACTGTTATGGGACCACCTGGTCCTCCAGGT
CCTCCTGGTCCTCAAGGACCCCCTGGCCTCCAGGGACCTTCTGGTGCTGCTGATAAAGCTGGAACTCGAGAAAACCAGCCAGCTGTGGTG
CATCTACAGGGCCAAGGGTCAGCAATTCAAGTCAAGAATGATCTTTCAGGTGGAGTGCTCAATGACTGGTCTCGCATCACTATGAACCCC
AAGGTGTTTAAGCTACATCCCCGCAGCGGGGAGCTGGAGGTACTGGTGGACGGCACCTACTTCATCTATAGTCAGGTATACTACATCAAC
TTCACTGACTTTGCCAGCTATGAGGTGGTGGTGGATGAGAAGCCCTTCCTGCAGTGCACACGCAGCATCGAGACGGGCAAGACCAACTAC
AACACTTGCTATACCGCAGGCGTCTGCCTCCTCAAGGCCCGGCAGAAGATCGCCGTCAAGATGGTGCACGCTGACATCTCCATCAACATG
AGCAAGCACACCACGTTCTTTGGGGCCATCAGGCTGGGTGAAGCCCCTGCATCCTAGATTCCCCCCATTTTGCCTCTGTCCGTGCCCCTT
CCCTGGGTTTGGGAGCCAGGACTCCCAGAACCTCTAAGTGCTGCTGTGGAGTGAGGTGTATTGGTGTTGCAGCCGCAGAGAAATGCCCCA
GTGTTATTTATTCCCCAGTGACTCCAGGGTGACAAGGCCTGCTTGACTTTCCAGAATGACCTTGAGTTAACAGGACAGTTGATGGAGCCC
CAGGGTTTACATGAAGCAGAACCTTCTTTGGTTCCATGTTGACTGACTTATGGCATGACTCTTCAACCCCGAGGTCCCTGTTGTCAGATC
TATTGTTTGTTGCACTAAAATGAGGATCCAGGGCAGCAGGCCAGAGAAAGCAAAGGTGCACTCCAGACTCTGGGGGTGGACATCTGACCC
CAAGGGGGCTGCTGCTCCTCTCTTGGGTAGGGTAGTGGCTGGGGTGGAGTGGGAAGGGAGCATTGCAGCCTAAGAAGAAGGCCAGAGAGG
GAAAAGGCAGGTGCTTTTGGCAGAGACCATAAGAGAAACCTGCCAAGGAGCATCCTTGGCAGTGGGAATGTTCTTTCTGCTCTATACTGT
GGCCTGCAGGAGGGTTGGAGTGCTCTTCCCACTCCAGCTGACAGCCACACCGTGGCAGCTTGCTGGGCTTTGGGAAGTTTGCTGTGCTTT
GGAACAATCACAGGGAATGGCCACAAACCTGCCCGCCTAAGACCCTGAATCCGTACTTGGGTCACATGACTCTCATTTTATTTACAGCTG
TGCTCCACACTCAGAAAATTCCCTGGGGTCACCTTCTAGTTGCCCCCATTCCCAGCCTGACTAGAACTCCTGTCTTCTTTCTCCATGGAG
CCTACCTCTGTCTGAGACAGGTGCCTAACCTGGGACCTGTGGTCATGTGAGTCTGGGATATTCTTTAGCTTACCTGGGCACAAACAGAAT
TTTCCATTTATTAAGCAGTACAAATGTTTTTCATCCATTCCTAATCAAATTCTGTCTGGGGACGAAGGGTTGGACGGGATGACCTCCAGA
AGTCCCTTCAATTTCTAGTACCTGTGACTCTTAGCCCTCACCACAGCCTTCTAAATTCCCAAATCCTAGACTGCTCCTGGGCATTAGCAA
GGCAGAGCCTTTTTACCTGGCCTAGAAAGGGCAAGGGGTGAGGATAGGACAGAGGGATTTTGTTCAAGTTTGCTGCAACCCAAGTGGACG
TTAGGCCAGGCCTTATCTGAAAGGCCAGCAGCTGATGCTGTACTAACCCAGTCTTTCTTCACTCTGGCTTCAAAAAGCCACAGCAGAGCA
TTGTCACCGCAGGTGCTCATGCTGCTCCCCTAAAGCCAGGCTCAGGAGAAGCCAGTGTCTAGGCACTGAGCAGGGATCTGCCCCCTAGTT
CAGGTCCAAATTCACCTTCCCCTAAACCCCAAGCTTCCCAACAGATCATATGGTAGGACCCTCGAGAGCCTTACTTCAAAGTGCCTGGGC
TCAGCCTGGTTTCTGGGTGCTAGATCCAGCCCAAACCTGGGAAGGCCAGCCTTGTACAGTCTGCTCCTCTTGTTCCTGAAATGTGTTTCC
TTTTCAGGAGATGGGGAATAATTTCCTTCAGGCAGCTGAAATTCACCAAGAACAGCGGGTACTTATTTCTCAGCTGTGCCTTCCCTTTCT
AAGCAACCACACTGCTTGGCCCTTCAAGGGTCAGGGTGAGACGTGATGGGCTAGGCCTCCGTTGTCTGGTTGCTAATGACAGCCTTGCAA
CCCAAGGTGAGGTGAACTCCAGGCATGTGTCTGGCCCTAACTCCTATAAAGTGCCTCGGACAGTCCGCAGTTGTAGCAGAAACCAACAAG
AACCACTCCTTCATGTTTGGAAAATAATTTCTCTTGTATTATCTCCTTTGAAGAAGGCAAGGCTGATAATATGACAAACATCATTGTTTA
GATGAGGCTCAGAGAGGTAGCACTCTCAGAGTGTTTTGACCAGTTTAAGCCGCAGACCTGGAGCTTCAGCCAGGTCTGACTCCAAAGCTG
TTCCATTACACCACAGCATTGTGTGGAATTTGAGGTCTAGAGAGAACCAATAAAAGTGGTAATTGGGAACTGAAATCCTTGAGAGTTCCG
GGGAGAAACCCAGAGATGCCTGATTTCATTCCTCGATGGTAATACCCGTCCTCTCGGCTGCCAGGGGCTCTGTGGCAAAAAGAGTCAGAC
ATTTCTTTGGAAAACAGCGAACAGCCTTAGAGCTCTTGTGTTCAGAAGAATCTTCCTGGCACAATGTTGGAGCAGCAGGCCTCTGGGACC
CACAGAACTTGTGGCCTTTATGTTCTTTCACCCATCCTAGGAACCAGCCAACCATCATGTGTAGAGCCCCTACTGTGGGCAAAGTCCTCC
TTTCATTACCCTACAGACAGCTTACAGGAGCCAGCCTGCTTCCCACAACTACTAGTGTGACTCCTTATCTCTTTCCACCATACCTTAGAG
ACTTTGATACTACCAGGGTCTCTCAGGGATGGAGGGAAGACCTGAAAGAGAGGACTGGTTCTGAGGCCAGAAAGGTGTGAGGAGAGAGGA
GGAAAAGTCTTCCTAATTGTGCCCCTAAAGAGCATCCTGATACCATTCTATTCTCCAGACATGGAGGGGATGATAAAGGAAATAGGATCT
CCACTGGACCCTTGATTCATTCTGAACCCTCCAAAGGAACTCTAGAGGGCGAGGGATGATGAGGGAAGCAATAGGTAGCTGGGGAGCCCT
ATTGCTGCTAAGTCATTGGCAAAGTGACAAAGCAATTTACTGATGAGAGAATGTGGAAATAGATGTGCAGTTTGGAATTATGTTGGTGTG
AATTTGCCAGAGGACCAATGCTTGCATGGAGAATGGGACGAGGACATTTGTGGGCAAGCAGATGACAGAGGTTTGAAGGAGAATGGCATG
GCAGGAGTCTCTGCCAGTTACTTGGGCTTCAACAGCCAAGCTGGCACAAAAGACAGCTGGCGGAGGCTGCTCGGCTACTGGTTACCTGGA
GAAGTAGTATTTGCCTATTTCCCCCTTCATCCATCCTGAGCCAAATTTCTTTTGCTGAACAGGAAAGAGCTAGGAACCCTGGAGGTAAAC
AAAGACTTTGATCCATGTATGAGTGTATGTGTTTATGTAACTTCCTGTGGATGCAAATAGATTCAGAGAAATTTAGAGCTAAAAAGGCCC
TTAGAGGGAATCTAGCCCAACCTACATTCCACCCTGTTACTTATGTAGAAACTGAGGCCCAGAGAGGGAAGATGACCTGCCCCAAGTGGT
GAGCAAGCACCAACCTCCAGACTCAGCAGAGTGAGGGGGTAAAGCAGTTCCTGTCCCACATGGCCATCTTCTTTCTTCCACCCACAAACT
CCAGGCTGGAAGTACTTGGCCCCCTTCAGGAGCCTGGCCAGGCAGGGAGAGAGTAGCTGCAGCCTTCATCAGAACTCTTCCTCCTCCCAA
GGCATTCTCCCAGCTCTAGCCTCTGGACTGGAAAGCACAAGACTGGCCCAGTGCCAGCAAGTCCTTAGGCTACTGTAATGCTGCCTCAGG
ACCCATCCCTGCCTGGAGGCTCCTCTAGGCCCTGTGAGCACAAAGAAGAAAGCTGATTTTTGTCTTTTAATCCATTTCAGGACTCTCTCC
AGGAGGGCTCGGGGTGTGTCATTTCTATATTCCTCCAGCTGGGATTGGGGGGTGGGCTTTGTTGTGAGAATGGCCTGGAGCAGGCCCAAT
GCTGCTTTTGGGGGTCAGCATCCAGTGTGAGATACTGTGTATATAAACTATATATAATGTATATAAACTGGGATGTAAGTTTGTGTAAAT

>28590_28590_2_FAM155B-EDA_FAM155B_chrX_68725986_ENST00000252338_EDA_chrX_69176877_ENST00000374553_length(amino acids)=544AA_BP=0
MFRGAWMWPGKDAAALTICCCCCCWAPRPSDKPCADSERAQRWRLSLASLLFFTVLLADHLWLCAGARPRARELSSAMRPPWGAGRERQP
VPPRAVLPLPPPPPGEPSAPPGTCGPRYSNLTKAAPAAGSRPVCGGVPEPTGLDAACTKLQSLQRLFEPTTPAPPLRPPDSLSRAPAEFP
SAKKNLLKGHFRNFTLSFCDTYTVWDLLLGMDRPDSLDCSLDTLMGDLLAVVASPGSGAWEACSNCIEAYQRLDRHAQEKYDEFDLVLHK
YLQAEEYSIRSCTKGCKMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGI
PGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEV
LVDGTYFIYSQVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGE

--------------------------------------------------------------
>28590_28590_3_FAM155B-EDA_FAM155B_chrX_68725986_ENST00000252338_EDA_chrX_69176877_ENST00000524573_length(transcript)=1696nt_BP=903nt
CTCGCGCCTGCCTGTTCCCTCCAGCCCGGACCCCCCTGAAATATGTTCAGGGGCGCTTGGATGTGGCCCGGGAAAGACGCCGCCGCGCTG
ACTATCTGCTGCTGCTGCTGCTGCTGGGCTCCCAGGCCGAGCGACAAACCTTGCGCCGACTCCGAGCGGGCGCAGCGATGGCGACTGTCC
CTGGCGTCCCTGCTCTTCTTCACCGTGCTGCTCGCTGACCATCTGTGGCTGTGCGCGGGGGCCCGGCCCCGGGCCAGGGAGCTGAGCAGC
GCCATGCGGCCCCCATGGGGGGCCGGCCGGGAGCGGCAGCCGGTGCCTCCTCGCGCGGTGCTGCCGCTGCCGCCGCCGCCGCCCGGCGAG
CCCAGCGCGCCCCCAGGCACCTGCGGCCCCAGATACAGCAACCTGACCAAAGCCGCCCCCGCCGCCGGCTCTCGGCCGGTCTGCGGCGGC
GTCCCAGAGCCCACGGGGCTGGACGCAGCTTGCACCAAATTGCAATCTTTGCAGAGACTTTTCGAACCGACTACTCCGGCCCCCCCTCTG
CGGCCCCCTGACTCCCTTTCCCGTGCCCCGGCCGAGTTCCCCTCCGCCAAAAAAAACTTGCTCAAAGGCCACTTTCGGAACTTCACTCTC
TCCTTTTGCGACACCTACACGGTCTGGGACTTGCTGCTGGGCATGGACCGCCCCGACAGCCTGGACTGTAGCCTGGACACCCTGATGGGG
GACCTGCTGGCCGTGGTGGCCAGCCCGGGCTCCGGGGCCTGGGAGGCGTGTAGCAACTGTATCGAGGCGTACCAGCGGCTGGACCGACAC
GCTCAGGAAAAATATGACGAGTTCGACCTCGTGCTGCATAAATACTTACAGGCGGAAGAGTACTCAATCCGGTCCTGCACGAAAGGCTGT
AAGATGGCCCTATTGAATTTCTTCTTCCCTGATGAAAAGCCATACTCTGAAGAAGAAAGTAGGCGTGTTCGCCGCAATAAAAGAAGCAAA
AGCAATGAAGGAGCAGATGGCCCAGTTAAAAACAAGAAAAAGGGAAAGAAAGCAGGACCTCCTGGACCCAATGGCCCTCCAGGACCCCCA
GGACCTCCAGGACCCCAGGGACCCCCAGGAATTCCAGGGATTCCTGGAATTCCAGGAACAACTGTTATGGGACCACCTGGTCCTCCAGGT
CCTCCTGGTCCTCAAGGACCCCCTGGCCTCCAGGGACCTTCTGGTGCTGCTGATAAAGCTGGAACTCGAGAAAACCAGCCAGCTGTGGTG
CATCTACAGGGCCAAGGGTCAGCAATTCAAGTCAAGAATGGTGGAGTGCTCAATGACTGGTCTCGCATCACTATGAACCCCAAGGTGTTT
AAGCTACATCCCCGCAGCGGGGAGCTGGAGGTACTGGTGGACGGCACCTACTTCATCTATAGTCAGGTATACTACATCAACTTCACTGAC
TTTGCCAGCTATGAGGTGGTGGTGGATGAGAAGCCCTTCCTGCAGTGCACACGCAGCATCGAGACGGGCAAGACCAACTACAACACTTGC
TATACCGCAGGCGTCTGCCTCCTCAAGGCCCGGCAGAAGATCGCCGTCAAGATGGTGCACGCTGACATCTCCATCAACATGAGCAAGCAC

>28590_28590_3_FAM155B-EDA_FAM155B_chrX_68725986_ENST00000252338_EDA_chrX_69176877_ENST00000524573_length(amino acids)=541AA_BP=0
MFRGAWMWPGKDAAALTICCCCCCWAPRPSDKPCADSERAQRWRLSLASLLFFTVLLADHLWLCAGARPRARELSSAMRPPWGAGRERQP
VPPRAVLPLPPPPPGEPSAPPGTCGPRYSNLTKAAPAAGSRPVCGGVPEPTGLDAACTKLQSLQRLFEPTTPAPPLRPPDSLSRAPAEFP
SAKKNLLKGHFRNFTLSFCDTYTVWDLLLGMDRPDSLDCSLDTLMGDLLAVVASPGSGAWEACSNCIEAYQRLDRHAQEKYDEFDLVLHK
YLQAEEYSIRSCTKGCKMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGI
PGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNGGVLNDWSRITMNPKVFKLHPRSGELEVLVD
GTYFIYSQVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FAM155B-EDA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FAM155B-EDA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FAM155B-EDA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source