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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM162A-GSK3B (FusionGDB2 ID:28633)

Fusion Gene Summary for FAM162A-GSK3B

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM162A-GSK3B
Fusion gene ID: 28633
HgeneTgene
Gene symbol

FAM162A

GSK3B

Gene ID

26355

2932

Gene namefamily with sequence similarity 162 member Aglycogen synthase kinase 3 beta
SynonymsC3orf28|E2IG5|HGTD-P-
Cytomap

3q21.1

3q13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM162AE2-induced gene 5 proteinHIF-1 alpha-responsive proapoptotic moleculegrowth and transformation-dependent proteinglycogen synthase kinase-3 betaGSK-3 betaGSK3beta isoformserine/threonine-protein kinase GSK3B
Modification date2020031320200315
UniProtAcc

Q96A26

C14orf129

Ensembl transtripts involved in fusion geneENST00000469967, ENST00000477892, 
ENST00000232125, 		ENST00000473886, 
ENST00000264235, ENST00000316626, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 3 X 3=27
# samples 103
** MAII scorelog2(10/150*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM162A [Title/Abstract] AND GSK3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM162A(122103146)-GSK3B(119624699), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM162A

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

15082785

HgeneFAM162A

GO:0043065

positive regulation of apoptotic process

15082785

HgeneFAM162A

GO:0071456

cellular response to hypoxia

15082785

HgeneFAM162A

GO:0090200

positive regulation of release of cytochrome c from mitochondria

15082785

TgeneGSK3B

GO:0005977

glycogen metabolic process

8638126

TgeneGSK3B

GO:0006468

protein phosphorylation

11035810|16315267|20937854

TgeneGSK3B

GO:0006983

ER overload response

14744935

TgeneGSK3B

GO:0018105

peptidyl-serine phosphorylation

8638126|11104755|11955436|14744935|17139249

TgeneGSK3B

GO:0018107

peptidyl-threonine phosphorylation

11955436|17139249|25897075

TgeneGSK3B

GO:0031175

neuron projection development

19830702

TgeneGSK3B

GO:0031334

positive regulation of protein complex assembly

8638126

TgeneGSK3B

GO:0032091

negative regulation of protein binding

16890161

TgeneGSK3B

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19364825

TgeneGSK3B

GO:0035556

intracellular signal transduction

14749367

TgeneGSK3B

GO:0043066

negative regulation of apoptotic process

14744935

TgeneGSK3B

GO:0046777

protein autophosphorylation

23184662

TgeneGSK3B

GO:0046827

positive regulation of protein export from nucleus

14744935

TgeneGSK3B

GO:1901215

negative regulation of neuron death

19830702

TgeneGSK3B

GO:1901216

positive regulation of neuron death

18508033

TgeneGSK3B

GO:2000300

regulation of synaptic vesicle exocytosis

17989287


check buttonFusion gene breakpoints across FAM162A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GSK3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5798-01AFAM162Achr3

122103146

+GSK3Bchr3

119624699

-


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Fusion Gene ORF analysis for FAM162A-GSK3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000469967ENST00000473886FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
5CDS-intronENST00000477892ENST00000473886FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
5UTR-3CDSENST00000232125ENST00000264235FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
5UTR-3CDSENST00000232125ENST00000316626FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
5UTR-intronENST00000232125ENST00000473886FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
In-frameENST00000469967ENST00000264235FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
In-frameENST00000469967ENST00000316626FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
In-frameENST00000477892ENST00000264235FAM162Achr3

122103146

+GSK3Bchr3

119624699

-
In-frameENST00000477892ENST00000316626FAM162Achr3

122103146

+GSK3Bchr3

119624699

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000477892FAM162Achr3122103146+ENST00000264235GSK3Bchr3119624699-613111884665193
ENST00000477892FAM162Achr3122103146+ENST00000316626GSK3Bchr3119624699-80711884704206
ENST00000469967FAM162Achr3122103146+ENST00000264235GSK3Bchr3119624699-611510268649193
ENST00000469967FAM162Achr3122103146+ENST00000316626GSK3Bchr3119624699-79110268688206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000477892ENST00000264235FAM162Achr3122103146+GSK3Bchr3119624699-0.0051969110.994803
ENST00000477892ENST00000316626FAM162Achr3122103146+GSK3Bchr3119624699-0.0253078170.97469217
ENST00000469967ENST00000264235FAM162Achr3122103146+GSK3Bchr3119624699-0.0051454120.99485457
ENST00000469967ENST00000316626FAM162Achr3122103146+GSK3Bchr3119624699-0.0241958870.9758041

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Fusion Genomic Features for FAM162A-GSK3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM162A-GSK3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:122103146/chr3:119624699)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM162A

Q96A26

GSK3B

C14orf129

FUNCTION: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). {ECO:0000250|UniProtKB:Q9D6U8, ECO:0000269|PubMed:15082785}.139

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM162Achr3:122103146chr3:119624699ENST00000477892+1576_10211155.0RegionRequired for proapoptotic activity
HgeneFAM162Achr3:122103146chr3:119624699ENST00000477892+15103_12011155.0TransmembraneHelical
TgeneGSK3Bchr3:122103146chr3:119624699ENST0000026423551156_340238421.0DomainProtein kinase
TgeneGSK3Bchr3:122103146chr3:119624699ENST0000031662651256_340238434.0DomainProtein kinase
TgeneGSK3Bchr3:122103146chr3:119624699ENST0000026423551162_70238421.0Nucleotide bindingATP
TgeneGSK3Bchr3:122103146chr3:119624699ENST0000031662651262_70238434.0Nucleotide bindingATP


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Fusion Gene Sequence for FAM162A-GSK3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28633_28633_1_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000469967_GSK3B_chr3_119624699_ENST00000264235_length(transcript)=6115nt_BP=102nt
ACATTGAGCTCACCAGCGCCACCGTCCCCGGCGAAGTTCTGCGCTGGTCGGCGGAGTAGCAAGTGGCCATGGGGAGCCTCAGCGGTCTGC
GCCTGGCAGCAGATGTATGGTCTGCTGGCTGTGTGTTGGCTGAGCTGTTACTAGGACAACCAATATTTCCAGGGGATAGTGGTGTGGATC
AGTTGGTAGAAATAATCAAGGTCCTGGGAACTCCAACAAGGGAGCAAATCAGAGAAATGAACCCAAACTACACAGAATTTAAATTCCCTC
AAATTAAGGCACATCCTTGGACTAAGGTCTTCCGACCCCGAACTCCACCGGAGGCAATTGCACTGTGTAGCCGTCTGCTGGAGTATACAC
CAACTGCCCGACTAACACCACTGGAAGCTTGTGCACATTCATTTTTTGATGAATTACGGGACCCAAATGTCAAACTACCAAATGGGCGAG
ACACACCTGCACTCTTCAACTTCACCACTCAAGAACTGTCAAGTAATCCACCTCTGGCTACCATCCTTATTCCTCCTCATGCTCGGATTC
AAGCAGCTGCTTCAACCCCCACAAATGCCACAGCAGCGTCAGATGCTAATACTGGAGACCGTGGACAGACCAATAATGCTGCTTCTGCAT
CAGCTTCCAACTCCACCTGAACAGTCCCGAGCAGCCAGCTGCACAGGAAAAACCACCAGTTACTTGAGTGTCACTCAGCAACACTGGTCA
CGTTTGGAAAGAATATTAAAAAGAGAAAAAAATCCTGTTCATTTTAGTGTTCAATTTTTTTATTATTATTGTTGTTCTTATTTAACCTTG
TAAAATATCTATAAATACAAACCAATTTCATTGTATTCTCACTTTGAGGGAGATCCAGGGGGTGGGAGGGGTTGTGGGGAGGGGGAAAGC
GGAGCACTAGAACATACAATCTCTCTCCCACGACAATCTTTTTTTATTAAAAGTCTGCTGTTGTATACTTTAAAAACAGGACTCCTGCCT
CATGCCCCTTCCACAAAAGAAGAAAACCTTTTTCTGTGCTGATGGGTTTTTTTGAACTTTGTTTTCTTTTAAAGTCTAGTGTGAGACTTT
GGTATAGTGCACAGCTTGAAATTGGTTGGGAGCTTAGCAGGTATAACTCAACGGGGACTTAAATGTCACTTGTAAAATTAATCCATATCT
TCGGGTATTTATAGACTTGCCTTTGGCATGTTGGTGGCAGGTGTGGCAGACAAAGAAATGTGTATCATTCGTAACCCAGGGAGGTCAATA
AAGTTTGGAACTCTACAGGGAAGATTCTTAGTAGATTTGTTAAGGTTTTGTTTTGCTCTCAGTTAGTGCTAGTGATGTAGAGGCTTGTAC
AGGAGGCTGCCAGAGGGGAAGCAGCAAGCAAGACTCAGGCACACATGCTCTACAGGTGGCTCTTTGTTTGCCTGACCAAAGTTCTTTGCA
AATCTTAGCACAGTTTCAAACTAGTGACCTGGGAGGAGATGGAAGGGGTGTTGAGCAGGCTGAGCTAGCTGCTGAGGTCAAAGGCTGATG
AGCCCAGAGGAAGGGGACAGGTCAGGGATACATCTCACCACTGTGAATAAGTTTGTCCAGATTTTTTTCTAAAGTTACTTCCCTTGGAAA
GATACACTTGAGAGGACATTGTAGTTAAATAATGTGAACTGTAACAGTCATCTACTGGTTTATTTTTCATATTTTTTAATTGAAAATTGA
GCTTGCAGAAATAGCCACATTCTACACATAGTTCTAATTTTAAATCCAAATCTAGAATCTGTATTTAATTTGTTTTTTAACCTCATGCTT
TTTACATTTATTTATTGATGCATGTCAGATGGTAGAAATATTAAAAACTACACATCAGAATGATACAGTCACTTATACCTGCTGACTTTA
TAGGAAAGCTGATGATATAAATGTGTGTATATATGTTATATATACATATATTCAATACTGCCTTTTTTTTTGTCTACAGTATCAAAATTG
ACTGGTTGAAGCATGAGAAGAATGTTTCCCCCACACCCAGTTAAGAGTTTTTGTGTCTGTTTTCTTTGTGTATCAGTGAACGATGTTAAG
AATCAGTCTCTCTTTTTGAAGAAAAAGCAATATTCCTTGGAAAGCAAGGAGAATTGAAGGACTATGTTTGCCGTGAGGAAATAGATTTTC
ATGACTAGTTTGTTTTATACTTTTAAGGTTGGCATCTATGTGGGCCTTATATACTCTAAAATGAACTTTAGTCACCTTGGTGCTTATGGG
CCATTACTTGACCTATGAATCTTTAAGGCACAATCAGTTGTACTTTACATTTAAAGATCACTTGAGTGATGGCCGCCTTTCCCTCCTACC
CGCTCCTTCCCCACATGCCTTCCAAGGTTAGCTGGTAACTGTAGGGCTGCAGAGCTGAGCCCATGGTTGTGTGTAACTTGCCCTCACCCT
CCTCATTGCCACCTTAGGTCACTTTATGGGTCTCGTCCTCCAGAGGGTTCGGAAGTGGAGTCTGTTGGCAGCCCTCCTGCAGGCCCTAGC
ACCCTGTCCTGCTCCTTAACTGTGTGTGTGACTCTCCAAGAGAGTTGTCCTGCCTGCTGAAGTGAACCAGTACCCAGAAAGACAACTGTG
AGCCATCTTGGTTTTCACTCGCTGTTTAGCTGAGGTCTTGGGCCACAAAAGGGGTTTCACAAACCTCTGGATATATCAGAGTTTATGAGA
AAGGAAACATGCTCAGTCAAACCAAATCAAACAAATTGAATTTTATGTTTTATAAAGTGCTTCTGAAAGCTAAGATTTGAAAGAAGTCTG
AAATCAAAGTATTTGGCAGCATAACTCCTTAAAGGTAGTGGCGTTGATAGACCATTTTCAGACAGAATTTATAAAGAATCTGAAAAGGCA
GGTCTGTGATAGAGAAATGGACCTGCATTCAGATCCAACTGCCCAGCAAGCGTTTGGATGCAGACACTGCTCTGGACGTGGTATACTCCC
CAGAGTCCATAAAAATCAGTGCTTATTTTAGGAAACAGGTTGCCCCCCACAACTGGGGTAAAAGAAGAGAGAAAAGTCACGCTTTTCTCT
CATTTCATTGTGTGTGCATGTGTGCGTGTGTGTGTGTGTGTGTGTGTGCTGAGATGTGTGATTTTTCTTTCTCAAGGATCATGGTGGGAT
CACAGAACTCTTTTATACAAGTGAGATCCAGGTCTCTGAATATCTTTTTGTATATAATAATAATAAAAAGCTCCTCACCAAATTCAAGCT
TGTACATTATATTTTCTTTCTGTGTTTTTAAATTTAAGTTTTATTGTTTTGTATGTAAATATGTGGACCCAGGAACTGTTATTAATGAGC
AAAAAGTTACTGTTCAGGGCAGTGATTCTGTTTAATAATCAGACAAAATGTAGACGAGCTTTTTAAAGCCATATAGTTTTAACTCTGTAC
AGTAGGTACCGGCCTGTATTATTGTAACAATAACTCTAGCAATGTATAGTGTATCTATATAGTTTGGAGTGCCTTCGCTTCCATGTGTTT
TTTTTTTTAATTTGTTCTTTTTTAAATTTTAATTGGTTTCCTTTATCCATGTCTCCCTGTCCACCCCCTTTCCCTTTGAAATAATAACTC
ACTCATAACAGTATCTTTGCCCCTTCCACAGTTAAGTTTCAGTGATACCATACTCAGGAGTGGGAAGAGGAAATCATATTCGTAATTTCA
TTTCGTTGAAGCCCTGCCTTTGTTTTGGTTCTGAATGTCTTTCCTCCTCGGTAGCAGTGAGACCGGTTTCATTTCATACTTAGTCCATTC
AGGGACTTAGTGTAGCACCAGGGAGCCCTAGAGCTGGAGGATATCGAATAGATTAAATTTTGCTCGTCTCTTCCACAAGCCCTAACCATG
GGTCTTAAAAACAGCAGATTCTGGGAGCCTTCCATGCTCTCTCTCTCTCCTCTTTTATCTACTTCCCTCCCAAATGAGAGAGTGACAGAG
AATTGTTTTTTTATAAATCGAAGTTTCTTAATAGTATCAGGTTTTGATACGTCAGTGGTCTAAAATGCTATAGTGCAATTACTAGCAGTT
ACTGCACGGAGTGCCACCGTGCCAATAGAGGACTGTTGTTTTAACAAGGGAACTCTTAGCCCATTTCCTCCCTCCCGCCATCTCTACCCT
TGCTCAATGAAATATCATTTTAATTTCTTTTAAAAAAAATCAGTTTAATTCTTACTGTGTGCCCAACACGAAGGCCTTTTTTGAAAGAAA
AATAGAATGTTTTGCCTCAAAGTAGTCCATATAAAATGTCTTGAATAGAAGAAAAAACTACCAAACCAAAGGTTACTATTTTTGAAACAT
CGTGTGTTCATTCCAGCAAGGCAGAAGACTGCACCTTCTTTCCAGTGACATGCTGTGTCATTTTTTTTAAGTCCTCTTAATTTTTAGACA
CATTTTTGGTTTATGTTTTAACAATGTATGCCTAACCAGTCATCTTGTCTGCACCAATGCAAAGGTTTCTGAGAGGAGTATTCTCTATCC
CTGTGGATATGAAGACACTGGCATTTCATCTATTTTTCCCTTTCCTTTTTAAAGGATTTAACTTTGGAATCTTCCAAAGGAAGTTTGGCC
AATGCCAGATCCCCAGGAATTTGGGGGGTTTTCTTTCTTTTCAACTGAAATTGTATCTGATTCCTACTGTTCATGTTAGTGATCATCTAA
TCACAGAGCCAAACACTTTTCTCCCCTGTGTGGAAAAGTAGGTATGCTTTACAATAAAATCTGTCTTTTCTGGTAGAAACCTGAGCCACT
GAAAATAAAAGAGACAACTAGAAGCACAGTAGAGTCCCAGACTGAGATCTACCTTTGAGAGGCTTTGAAAGTAATCCCTGGGGTTTGGAT
TATTTTCACAAGGGTTATGCCGTTTTATTCAAGTTTGTTGCTCCGTTTTGCACCTCTGCAATAAAAGCAAAATGACAACCAGTACATAAG
GGGTTAGCTTGACAAAGTAGACTTCCTTGTGTTAATTTTTAAGTTTTTTTTTCCTTAACTATATCTGTCTACAGGCAGATACAGATAGTT
GTATGAAAATCTGCTTGCCTGTAAAATTTGCATTTATAAATGTGTTGCCGATGGATCACTTGGGCCTGTACACATACCAATTAGCGTGAC
CACTTCCATCTTAAAAACAAACCTAAAAAACAAAATTTATTATATATATATATATATATATATAAAGGACTGTGGGTTGTATACAAACTA
TTGCAAACACTTGTGCAAATCTGTCTTGATATAAAGGAAAAGCAAAATCTGTATAACATTATTACTACTTGAATGCCTCTGTGACTGATT
TTTTTTTCATTTTAAATATAAACTTTTTTGTGAAAAGTATGCTCAATGTTTTTTTTCCCTTTCCCCATTCCCTTGTAAATACATTTTGTT
CTATGTGACTTGGTTTGGAAATAGTTAACTGGTACTGTAATTTGCATTAAATAAAAAGTAGGTTAGCCTGGAAATGAAATTAAAATTCAC
AAGTGTGTGGTCTTTATTTCAGTACCCAACCCTCTTCCTTCACCCTACTATTTTGCCGCTGCAATATGTAGTCACATCACCATTTCCATT
CCTCTAATTAGGGAAACATTAATCTTTGTTATACAGAACAAGATATCAATACCACTTCTTGTTCTTTCCAATGATTTTATTCCATTGTGT
AGCCCCAAGAGGTGCAGCTTCCACCTTGGAAACCTTTGGATTTGATGTAGAGGAAGCTTTGCAGACACTGCTTAGAAAAGAAAGAAAACA
ACTCTGAAAGGGACAGTTTTTAAATGTGTATAAGCTGCTGTCTTTGATTACTGTGTTCATGATTTGGTGTGGCTGTATTTTCTTTTAACT
TTCATCCTATTAGTAATGGTCTTTGGGGGTCTCTGTAAAATATATGGACACCACGAACAGTGGGGCTGTACCTCCCAGGTAACCAACACA
TGTTGTGTTTGAGTCTGCTCATTTCCAATACTGGATGATGTATGTAAACATGTTATGTCTCTTAGTGCAAAAAGAAACATCATTTTTTTA

>28633_28633_1_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000469967_GSK3B_chr3_119624699_ENST00000264235_length(amino acids)=193AA_BP=11
MGSLSGLRLAADVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC
SRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ

--------------------------------------------------------------
>28633_28633_2_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000469967_GSK3B_chr3_119624699_ENST00000316626_length(transcript)=791nt_BP=102nt
ACATTGAGCTCACCAGCGCCACCGTCCCCGGCGAAGTTCTGCGCTGGTCGGCGGAGTAGCAAGTGGCCATGGGGAGCCTCAGCGGTCTGC
GCCTGGCAGCAGATGTATGGTCTGCTGGCTGTGTGTTGGCTGAGCTGTTACTAGGACAACCAATATTTCCAGGGGATAGTGGTGTGGATC
AGTTGGTAGAAATAATCAAGGTCCTGGGAACTCCAACAAGGGAGCAAATCAGAGAAATGAACCCAAACTACACAGAATTTAAATTCCCTC
AAATTAAGGCACATCCTTGGACTAAGGATTCGTCAGGAACAGGACATTTCACCTCAGGAGTGCGGGTCTTCCGACCCCGAACTCCACCGG
AGGCAATTGCACTGTGTAGCCGTCTGCTGGAGTATACACCAACTGCCCGACTAACACCACTGGAAGCTTGTGCACATTCATTTTTTGATG
AATTACGGGACCCAAATGTCAAACTACCAAATGGGCGAGACACACCTGCACTCTTCAACTTCACCACTCAAGAACTGTCAAGTAATCCAC
CTCTGGCTACCATCCTTATTCCTCCTCATGCTCGGATTCAAGCAGCTGCTTCAACCCCCACAAATGCCACAGCAGCGTCAGATGCTAATA
CTGGAGACCGTGGACAGACCAATAATGCTGCTTCTGCATCAGCTTCCAACTCCACCTGAACAGTCCCGAGCAGCCAGCTGCACAGGAAAA

>28633_28633_2_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000469967_GSK3B_chr3_119624699_ENST00000316626_length(amino acids)=206AA_BP=11
MGSLSGLRLAADVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRV
FRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNA

--------------------------------------------------------------
>28633_28633_3_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000477892_GSK3B_chr3_119624699_ENST00000264235_length(transcript)=6131nt_BP=118nt
ACTCCAACGCTGGGTGACATTGAGCTCACCAGCGCCACCGTCCCCGGCGAAGTTCTGCGCTGGTCGGCGGAGTAGCAAGTGGCCATGGGG
AGCCTCAGCGGTCTGCGCCTGGCAGCAGATGTATGGTCTGCTGGCTGTGTGTTGGCTGAGCTGTTACTAGGACAACCAATATTTCCAGGG
GATAGTGGTGTGGATCAGTTGGTAGAAATAATCAAGGTCCTGGGAACTCCAACAAGGGAGCAAATCAGAGAAATGAACCCAAACTACACA
GAATTTAAATTCCCTCAAATTAAGGCACATCCTTGGACTAAGGTCTTCCGACCCCGAACTCCACCGGAGGCAATTGCACTGTGTAGCCGT
CTGCTGGAGTATACACCAACTGCCCGACTAACACCACTGGAAGCTTGTGCACATTCATTTTTTGATGAATTACGGGACCCAAATGTCAAA
CTACCAAATGGGCGAGACACACCTGCACTCTTCAACTTCACCACTCAAGAACTGTCAAGTAATCCACCTCTGGCTACCATCCTTATTCCT
CCTCATGCTCGGATTCAAGCAGCTGCTTCAACCCCCACAAATGCCACAGCAGCGTCAGATGCTAATACTGGAGACCGTGGACAGACCAAT
AATGCTGCTTCTGCATCAGCTTCCAACTCCACCTGAACAGTCCCGAGCAGCCAGCTGCACAGGAAAAACCACCAGTTACTTGAGTGTCAC
TCAGCAACACTGGTCACGTTTGGAAAGAATATTAAAAAGAGAAAAAAATCCTGTTCATTTTAGTGTTCAATTTTTTTATTATTATTGTTG
TTCTTATTTAACCTTGTAAAATATCTATAAATACAAACCAATTTCATTGTATTCTCACTTTGAGGGAGATCCAGGGGGTGGGAGGGGTTG
TGGGGAGGGGGAAAGCGGAGCACTAGAACATACAATCTCTCTCCCACGACAATCTTTTTTTATTAAAAGTCTGCTGTTGTATACTTTAAA
AACAGGACTCCTGCCTCATGCCCCTTCCACAAAAGAAGAAAACCTTTTTCTGTGCTGATGGGTTTTTTTGAACTTTGTTTTCTTTTAAAG
TCTAGTGTGAGACTTTGGTATAGTGCACAGCTTGAAATTGGTTGGGAGCTTAGCAGGTATAACTCAACGGGGACTTAAATGTCACTTGTA
AAATTAATCCATATCTTCGGGTATTTATAGACTTGCCTTTGGCATGTTGGTGGCAGGTGTGGCAGACAAAGAAATGTGTATCATTCGTAA
CCCAGGGAGGTCAATAAAGTTTGGAACTCTACAGGGAAGATTCTTAGTAGATTTGTTAAGGTTTTGTTTTGCTCTCAGTTAGTGCTAGTG
ATGTAGAGGCTTGTACAGGAGGCTGCCAGAGGGGAAGCAGCAAGCAAGACTCAGGCACACATGCTCTACAGGTGGCTCTTTGTTTGCCTG
ACCAAAGTTCTTTGCAAATCTTAGCACAGTTTCAAACTAGTGACCTGGGAGGAGATGGAAGGGGTGTTGAGCAGGCTGAGCTAGCTGCTG
AGGTCAAAGGCTGATGAGCCCAGAGGAAGGGGACAGGTCAGGGATACATCTCACCACTGTGAATAAGTTTGTCCAGATTTTTTTCTAAAG
TTACTTCCCTTGGAAAGATACACTTGAGAGGACATTGTAGTTAAATAATGTGAACTGTAACAGTCATCTACTGGTTTATTTTTCATATTT
TTTAATTGAAAATTGAGCTTGCAGAAATAGCCACATTCTACACATAGTTCTAATTTTAAATCCAAATCTAGAATCTGTATTTAATTTGTT
TTTTAACCTCATGCTTTTTACATTTATTTATTGATGCATGTCAGATGGTAGAAATATTAAAAACTACACATCAGAATGATACAGTCACTT
ATACCTGCTGACTTTATAGGAAAGCTGATGATATAAATGTGTGTATATATGTTATATATACATATATTCAATACTGCCTTTTTTTTTGTC
TACAGTATCAAAATTGACTGGTTGAAGCATGAGAAGAATGTTTCCCCCACACCCAGTTAAGAGTTTTTGTGTCTGTTTTCTTTGTGTATC
AGTGAACGATGTTAAGAATCAGTCTCTCTTTTTGAAGAAAAAGCAATATTCCTTGGAAAGCAAGGAGAATTGAAGGACTATGTTTGCCGT
GAGGAAATAGATTTTCATGACTAGTTTGTTTTATACTTTTAAGGTTGGCATCTATGTGGGCCTTATATACTCTAAAATGAACTTTAGTCA
CCTTGGTGCTTATGGGCCATTACTTGACCTATGAATCTTTAAGGCACAATCAGTTGTACTTTACATTTAAAGATCACTTGAGTGATGGCC
GCCTTTCCCTCCTACCCGCTCCTTCCCCACATGCCTTCCAAGGTTAGCTGGTAACTGTAGGGCTGCAGAGCTGAGCCCATGGTTGTGTGT
AACTTGCCCTCACCCTCCTCATTGCCACCTTAGGTCACTTTATGGGTCTCGTCCTCCAGAGGGTTCGGAAGTGGAGTCTGTTGGCAGCCC
TCCTGCAGGCCCTAGCACCCTGTCCTGCTCCTTAACTGTGTGTGTGACTCTCCAAGAGAGTTGTCCTGCCTGCTGAAGTGAACCAGTACC
CAGAAAGACAACTGTGAGCCATCTTGGTTTTCACTCGCTGTTTAGCTGAGGTCTTGGGCCACAAAAGGGGTTTCACAAACCTCTGGATAT
ATCAGAGTTTATGAGAAAGGAAACATGCTCAGTCAAACCAAATCAAACAAATTGAATTTTATGTTTTATAAAGTGCTTCTGAAAGCTAAG
ATTTGAAAGAAGTCTGAAATCAAAGTATTTGGCAGCATAACTCCTTAAAGGTAGTGGCGTTGATAGACCATTTTCAGACAGAATTTATAA
AGAATCTGAAAAGGCAGGTCTGTGATAGAGAAATGGACCTGCATTCAGATCCAACTGCCCAGCAAGCGTTTGGATGCAGACACTGCTCTG
GACGTGGTATACTCCCCAGAGTCCATAAAAATCAGTGCTTATTTTAGGAAACAGGTTGCCCCCCACAACTGGGGTAAAAGAAGAGAGAAA
AGTCACGCTTTTCTCTCATTTCATTGTGTGTGCATGTGTGCGTGTGTGTGTGTGTGTGTGTGTGCTGAGATGTGTGATTTTTCTTTCTCA
AGGATCATGGTGGGATCACAGAACTCTTTTATACAAGTGAGATCCAGGTCTCTGAATATCTTTTTGTATATAATAATAATAAAAAGCTCC
TCACCAAATTCAAGCTTGTACATTATATTTTCTTTCTGTGTTTTTAAATTTAAGTTTTATTGTTTTGTATGTAAATATGTGGACCCAGGA
ACTGTTATTAATGAGCAAAAAGTTACTGTTCAGGGCAGTGATTCTGTTTAATAATCAGACAAAATGTAGACGAGCTTTTTAAAGCCATAT
AGTTTTAACTCTGTACAGTAGGTACCGGCCTGTATTATTGTAACAATAACTCTAGCAATGTATAGTGTATCTATATAGTTTGGAGTGCCT
TCGCTTCCATGTGTTTTTTTTTTTAATTTGTTCTTTTTTAAATTTTAATTGGTTTCCTTTATCCATGTCTCCCTGTCCACCCCCTTTCCC
TTTGAAATAATAACTCACTCATAACAGTATCTTTGCCCCTTCCACAGTTAAGTTTCAGTGATACCATACTCAGGAGTGGGAAGAGGAAAT
CATATTCGTAATTTCATTTCGTTGAAGCCCTGCCTTTGTTTTGGTTCTGAATGTCTTTCCTCCTCGGTAGCAGTGAGACCGGTTTCATTT
CATACTTAGTCCATTCAGGGACTTAGTGTAGCACCAGGGAGCCCTAGAGCTGGAGGATATCGAATAGATTAAATTTTGCTCGTCTCTTCC
ACAAGCCCTAACCATGGGTCTTAAAAACAGCAGATTCTGGGAGCCTTCCATGCTCTCTCTCTCTCCTCTTTTATCTACTTCCCTCCCAAA
TGAGAGAGTGACAGAGAATTGTTTTTTTATAAATCGAAGTTTCTTAATAGTATCAGGTTTTGATACGTCAGTGGTCTAAAATGCTATAGT
GCAATTACTAGCAGTTACTGCACGGAGTGCCACCGTGCCAATAGAGGACTGTTGTTTTAACAAGGGAACTCTTAGCCCATTTCCTCCCTC
CCGCCATCTCTACCCTTGCTCAATGAAATATCATTTTAATTTCTTTTAAAAAAAATCAGTTTAATTCTTACTGTGTGCCCAACACGAAGG
CCTTTTTTGAAAGAAAAATAGAATGTTTTGCCTCAAAGTAGTCCATATAAAATGTCTTGAATAGAAGAAAAAACTACCAAACCAAAGGTT
ACTATTTTTGAAACATCGTGTGTTCATTCCAGCAAGGCAGAAGACTGCACCTTCTTTCCAGTGACATGCTGTGTCATTTTTTTTAAGTCC
TCTTAATTTTTAGACACATTTTTGGTTTATGTTTTAACAATGTATGCCTAACCAGTCATCTTGTCTGCACCAATGCAAAGGTTTCTGAGA
GGAGTATTCTCTATCCCTGTGGATATGAAGACACTGGCATTTCATCTATTTTTCCCTTTCCTTTTTAAAGGATTTAACTTTGGAATCTTC
CAAAGGAAGTTTGGCCAATGCCAGATCCCCAGGAATTTGGGGGGTTTTCTTTCTTTTCAACTGAAATTGTATCTGATTCCTACTGTTCAT
GTTAGTGATCATCTAATCACAGAGCCAAACACTTTTCTCCCCTGTGTGGAAAAGTAGGTATGCTTTACAATAAAATCTGTCTTTTCTGGT
AGAAACCTGAGCCACTGAAAATAAAAGAGACAACTAGAAGCACAGTAGAGTCCCAGACTGAGATCTACCTTTGAGAGGCTTTGAAAGTAA
TCCCTGGGGTTTGGATTATTTTCACAAGGGTTATGCCGTTTTATTCAAGTTTGTTGCTCCGTTTTGCACCTCTGCAATAAAAGCAAAATG
ACAACCAGTACATAAGGGGTTAGCTTGACAAAGTAGACTTCCTTGTGTTAATTTTTAAGTTTTTTTTTCCTTAACTATATCTGTCTACAG
GCAGATACAGATAGTTGTATGAAAATCTGCTTGCCTGTAAAATTTGCATTTATAAATGTGTTGCCGATGGATCACTTGGGCCTGTACACA
TACCAATTAGCGTGACCACTTCCATCTTAAAAACAAACCTAAAAAACAAAATTTATTATATATATATATATATATATATAAAGGACTGTG
GGTTGTATACAAACTATTGCAAACACTTGTGCAAATCTGTCTTGATATAAAGGAAAAGCAAAATCTGTATAACATTATTACTACTTGAAT
GCCTCTGTGACTGATTTTTTTTTCATTTTAAATATAAACTTTTTTGTGAAAAGTATGCTCAATGTTTTTTTTCCCTTTCCCCATTCCCTT
GTAAATACATTTTGTTCTATGTGACTTGGTTTGGAAATAGTTAACTGGTACTGTAATTTGCATTAAATAAAAAGTAGGTTAGCCTGGAAA
TGAAATTAAAATTCACAAGTGTGTGGTCTTTATTTCAGTACCCAACCCTCTTCCTTCACCCTACTATTTTGCCGCTGCAATATGTAGTCA
CATCACCATTTCCATTCCTCTAATTAGGGAAACATTAATCTTTGTTATACAGAACAAGATATCAATACCACTTCTTGTTCTTTCCAATGA
TTTTATTCCATTGTGTAGCCCCAAGAGGTGCAGCTTCCACCTTGGAAACCTTTGGATTTGATGTAGAGGAAGCTTTGCAGACACTGCTTA
GAAAAGAAAGAAAACAACTCTGAAAGGGACAGTTTTTAAATGTGTATAAGCTGCTGTCTTTGATTACTGTGTTCATGATTTGGTGTGGCT
GTATTTTCTTTTAACTTTCATCCTATTAGTAATGGTCTTTGGGGGTCTCTGTAAAATATATGGACACCACGAACAGTGGGGCTGTACCTC
CCAGGTAACCAACACATGTTGTGTTTGAGTCTGCTCATTTCCAATACTGGATGATGTATGTAAACATGTTATGTCTCTTAGTGCAAAAAG
AAACATCATTTTTTTAGGGCTGGCTCACTCTGTCAGGCCTAATCTAAAGGCTAGATATAAGGTCATGTGACTGCTGCTTCAATAAAAACA

>28633_28633_3_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000477892_GSK3B_chr3_119624699_ENST00000264235_length(amino acids)=193AA_BP=11
MGSLSGLRLAADVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC
SRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ

--------------------------------------------------------------
>28633_28633_4_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000477892_GSK3B_chr3_119624699_ENST00000316626_length(transcript)=807nt_BP=118nt
ACTCCAACGCTGGGTGACATTGAGCTCACCAGCGCCACCGTCCCCGGCGAAGTTCTGCGCTGGTCGGCGGAGTAGCAAGTGGCCATGGGG
AGCCTCAGCGGTCTGCGCCTGGCAGCAGATGTATGGTCTGCTGGCTGTGTGTTGGCTGAGCTGTTACTAGGACAACCAATATTTCCAGGG
GATAGTGGTGTGGATCAGTTGGTAGAAATAATCAAGGTCCTGGGAACTCCAACAAGGGAGCAAATCAGAGAAATGAACCCAAACTACACA
GAATTTAAATTCCCTCAAATTAAGGCACATCCTTGGACTAAGGATTCGTCAGGAACAGGACATTTCACCTCAGGAGTGCGGGTCTTCCGA
CCCCGAACTCCACCGGAGGCAATTGCACTGTGTAGCCGTCTGCTGGAGTATACACCAACTGCCCGACTAACACCACTGGAAGCTTGTGCA
CATTCATTTTTTGATGAATTACGGGACCCAAATGTCAAACTACCAAATGGGCGAGACACACCTGCACTCTTCAACTTCACCACTCAAGAA
CTGTCAAGTAATCCACCTCTGGCTACCATCCTTATTCCTCCTCATGCTCGGATTCAAGCAGCTGCTTCAACCCCCACAAATGCCACAGCA
GCGTCAGATGCTAATACTGGAGACCGTGGACAGACCAATAATGCTGCTTCTGCATCAGCTTCCAACTCCACCTGAACAGTCCCGAGCAGC

>28633_28633_4_FAM162A-GSK3B_FAM162A_chr3_122103146_ENST00000477892_GSK3B_chr3_119624699_ENST00000316626_length(amino acids)=206AA_BP=11
MGSLSGLRLAADVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRV
FRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM162A-GSK3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM162A-GSK3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM162A-GSK3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource