|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FAM168A-DCAF8 (FusionGDB2 ID:28648) |
Fusion Gene Summary for FAM168A-DCAF8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM168A-DCAF8 | Fusion gene ID: 28648 | Hgene | Tgene | Gene symbol | FAM168A | DCAF8 | Gene ID | 23201 | 50717 |
| Gene name | family with sequence similarity 168 member A | DDB1 and CUL4 associated factor 8 | |
| Synonyms | KIAA0280|TCRP1 | GAN2|H326|WDR42A | |
| Cytomap | 11q13.4 | 1q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM168Atongue cancer chemotherapy resistance-associated protein 1 | DDB1- and CUL4-associated factor 8WD repeat domain 42AWD repeat-containing protein 42A | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q92567 | Q5TAQ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000064778, ENST00000356467, ENST00000450446, | ENST00000326837, ENST00000368073, ENST00000368074, ENST00000475733, ENST00000556710, ENST00000608310, ENST00000610139, | |
| Fusion gene scores | * DoF score | 27 X 14 X 13=4914 | 9 X 11 X 5=495 |
| # samples | 41 | 11 | |
| ** MAII score | log2(41/4914*10)=-3.58320204285672 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM168A [Title/Abstract] AND DCAF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FAM168A(73179450)-DCAF8(160213824), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | FAM168A-DCAF8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FAM168A-DCAF8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FAM168A | GO:1905053 | positive regulation of base-excision repair | 25260657 |
| Fusion gene breakpoints across FAM168A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across DCAF8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| ChimerDB4 | OV | TCGA-57-1582 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
Top |
Fusion Gene ORF analysis for FAM168A-DCAF8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000064778 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000326837 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000368073 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000368074 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000475733 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000556710 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000608310 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000064778 | ENST00000610139 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000326837 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000368073 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000368074 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000475733 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000556710 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000608310 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000356467 | ENST00000610139 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000326837 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000368073 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000368074 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000475733 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000556710 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000608310 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-5UTR | ENST00000450446 | ENST00000610139 | FAM168A | chr11 | 73179449 | - | DCAF8 | chr1 | 160213824 | - |
| 5CDS-intron | ENST00000064778 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000064778 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000064778 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000064778 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000064778 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000064778 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000064778 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000356467 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| 5CDS-intron | ENST00000450446 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160233252 | - |
| Frame-shift | ENST00000064778 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000064778 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000064778 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000064778 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000064778 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000064778 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000356467 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000356467 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000356467 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000356467 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000356467 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000356467 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000450446 | ENST00000326837 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000450446 | ENST00000368073 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000450446 | ENST00000368074 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000450446 | ENST00000556710 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000450446 | ENST00000608310 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| Frame-shift | ENST00000450446 | ENST00000610139 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| In-frame | ENST00000064778 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| In-frame | ENST00000356467 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| In-frame | ENST00000450446 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000064778 | FAM168A | chr11 | 73179450 | - | ENST00000475733 | DCAF8 | chr1 | 160210160 | - | 1504 | 355 | 165 | 1127 | 320 |
| ENST00000450446 | FAM168A | chr11 | 73179450 | - | ENST00000475733 | DCAF8 | chr1 | 160210160 | - | 1413 | 264 | 74 | 1036 | 320 |
| ENST00000356467 | FAM168A | chr11 | 73179450 | - | ENST00000475733 | DCAF8 | chr1 | 160210160 | - | 1498 | 349 | 159 | 1121 | 320 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000064778 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - | 0.004320169 | 0.99567986 |
| ENST00000450446 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - | 0.003419664 | 0.9965803 |
| ENST00000356467 | ENST00000475733 | FAM168A | chr11 | 73179450 | - | DCAF8 | chr1 | 160210160 | - | 0.004221541 | 0.99577844 |
Top |
Fusion Genomic Features for FAM168A-DCAF8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for FAM168A-DCAF8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:73179450/chr1:160213824) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM168A | DCAF8 |
| FUNCTION: In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. {ECO:0000269|PubMed:21334329, ECO:0000269|PubMed:21603883, ECO:0000269|PubMed:23251525, ECO:0000269|PubMed:25260657}. | FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 114_122 | 16 | 598.0 | Motif | Nuclear localization signal | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 114_122 | 16 | 598.0 | Motif | Nuclear localization signal | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 114_122 | 16 | 598.0 | Motif | Nuclear localization signal | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 191_230 | 16 | 598.0 | Repeat | Note=WD 1 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 234_275 | 16 | 598.0 | Repeat | Note=WD 2 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 281_321 | 16 | 598.0 | Repeat | Note=WD 3 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 329_369 | 16 | 598.0 | Repeat | Note=WD 4 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 385_424 | 16 | 598.0 | Repeat | Note=WD 5 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 432_472 | 16 | 598.0 | Repeat | Note=WD 6 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000326837 | 2 | 14 | 476_515 | 16 | 598.0 | Repeat | Note=WD 7 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 191_230 | 16 | 598.0 | Repeat | Note=WD 1 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 234_275 | 16 | 598.0 | Repeat | Note=WD 2 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 281_321 | 16 | 598.0 | Repeat | Note=WD 3 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 329_369 | 16 | 598.0 | Repeat | Note=WD 4 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 385_424 | 16 | 598.0 | Repeat | Note=WD 5 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 432_472 | 16 | 598.0 | Repeat | Note=WD 6 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368073 | 2 | 14 | 476_515 | 16 | 598.0 | Repeat | Note=WD 7 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 191_230 | 16 | 598.0 | Repeat | Note=WD 1 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 234_275 | 16 | 598.0 | Repeat | Note=WD 2 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 281_321 | 16 | 598.0 | Repeat | Note=WD 3 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 329_369 | 16 | 598.0 | Repeat | Note=WD 4 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 385_424 | 16 | 598.0 | Repeat | Note=WD 5 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 432_472 | 16 | 598.0 | Repeat | Note=WD 6 | |
| Tgene | DCAF8 | chr11:73179450 | chr1:160210160 | ENST00000368074 | 2 | 14 | 476_515 | 16 | 598.0 | Repeat | Note=WD 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for FAM168A-DCAF8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >28648_28648_1_FAM168A-DCAF8_FAM168A_chr11_73179450_ENST00000064778_DCAF8_chr1_160210160_ENST00000475733_length(transcript)=1504nt_BP=355nt CCTTCTGAGCGGTCCCCCGCCTCCTCCCTCCGCCTCCTCCTCCCTCGCCCGCAGCCGAGCGTCCCCTCCCCCCACCCGTCGGGCTCCTCG GCGGCTACTGCAGAGGATTCAGAGCCGAGTCGCTGAGGAGGAGGCTCCGGTCCCCGCGCGCCATCCGCCACCCTACTGGACACGGGCGAG AGCGTCGCCGCCGTAGCCTCCGGAGAAGACAAGGGCATCGCCGCCTCAGCCGCCGCCGCCGCCGTTTTCGCCTGCAGCTGCTCACCGGAT CCTCAGTCTTCCACAATGAACCCTGTTTACAGCCCCGTGCAGCCTGGGGCTCCTTATGGCAACCCTAAGAACATGGCCTACACGGGAAGC CTGTCTAGCAGTCCAGAGGAGATGTCTGGAGCTGAAGAGGGGAGGGAGACATCCTCAGGCATTGAAGTGGAGGCCTCAGACCTGAGTTTG AGCTTGACTGGGGATGATGGTGGCCCCAACCGCACCAGCACAGAAAGTCGAGGCACAGACACAGAGAGCTCAGGTGAAGATAAGGACTCT GACAGCATGGAGGACACTGGTCATTACTCCATTAATGATGAAAATCGAGTCCATGACCGCTCAGAGGAAGAGGAAGAGGAGGAAGAAGAG GAGGAAGAAGAGCAGCCTCGGCGCCGTGTACAGCGCAAGCGGGCTAACCGTGACCAGGACTCATCAGATGATGAGCGGGCCCTAGAGGAC TGGGTGTCCTCAGAAACATCAGCTCTACCCCGACCTCGCTGGCAAGCCCTCCCTGCCCTTCGGGAGCGGGAGCTGGGTTCAAGTGCCCGC TTTGTCTATGAGGCCTGTGGGGCAAGAGTCTTTGTGCAGCGTTTCCGCCTGCAGCATGGGCTTGAGGGCCATACTGGTTGTGTCAATACC CTGCACTTTAACCAGCGCGGCACCTGGCTGGCCAGTGGCAGCGATGACCTGAAGGTGGTGGTGTGGGATTGGGTACGGCGGCAGCCAGTA CTGGACTTTGAGAGTGGCCACAAAAGTAATGTGTTCCAGGTGAGGCAAGGGAGCATAATAGCAACTGAGAGAATCAGGCATGAGTTAGAG AAATCTGAACTGCAGCATGGATTGGGAGCTGATAGTGAGTTATTGTAGGAATTACATATCGGGACATGGCCCTACTTTGGCTCCCCTAAT GACCTAAATACACTGAAAGACTCTTGGCAACCCTAGATTCCTTGAGCATGTGGACTGTTGGAAGCCTCATAGGTAGGGTGCATGCAGCTT ATTAAATGTGTGCTGGTAGGAGGCAGTGTAGTATAAGCACAGGCTCTTGAACCAAACTGCCTGAGTTCAAATCCTAGCCCTTCTGCTTAC TAGCTCAGTGATCTTGGCCAAGTTATTTTACCTTTGTCTTCAGTTTATCTGTAAAATGGGACTAATAACACATAGGGTTATGAGGATTAA >28648_28648_1_FAM168A-DCAF8_FAM168A_chr11_73179450_ENST00000064778_DCAF8_chr1_160210160_ENST00000475733_length(amino acids)=320AA_BP=63 MDTGESVAAVASGEDKGIAASAAAAAVFACSCSPDPQSSTMNPVYSPVQPGAPYGNPKNMAYTGSLSSSPEEMSGAEEGRETSSGIEVEA SDLSLSLTGDDGGPNRTSTESRGTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDE RALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWV -------------------------------------------------------------- >28648_28648_2_FAM168A-DCAF8_FAM168A_chr11_73179450_ENST00000356467_DCAF8_chr1_160210160_ENST00000475733_length(transcript)=1498nt_BP=349nt GAGCGGTCCCCCGCCTCCTCCCTCCGCCTCCTCCTCCCTCGCCCGCAGCCGAGCGTCCCCTCCCCCCACCCGTCGGGCTCCTCGGCGGCT ACTGCAGAGGATTCAGAGCCGAGTCGCTGAGGAGGAGGCTCCGGTCCCCGCGCGCCATCCGCCACCCTACTGGACACGGGCGAGAGCGTC GCCGCCGTAGCCTCCGGAGAAGACAAGGGCATCGCCGCCTCAGCCGCCGCCGCCGCCGTTTTCGCCTGCAGCTGCTCACCGGATCCTCAG TCTTCCACAATGAACCCTGTTTACAGCCCCGTGCAGCCTGGGGCTCCTTATGGCAACCCTAAGAACATGGCCTACACGGGAAGCCTGTCT AGCAGTCCAGAGGAGATGTCTGGAGCTGAAGAGGGGAGGGAGACATCCTCAGGCATTGAAGTGGAGGCCTCAGACCTGAGTTTGAGCTTG ACTGGGGATGATGGTGGCCCCAACCGCACCAGCACAGAAAGTCGAGGCACAGACACAGAGAGCTCAGGTGAAGATAAGGACTCTGACAGC ATGGAGGACACTGGTCATTACTCCATTAATGATGAAAATCGAGTCCATGACCGCTCAGAGGAAGAGGAAGAGGAGGAAGAAGAGGAGGAA GAAGAGCAGCCTCGGCGCCGTGTACAGCGCAAGCGGGCTAACCGTGACCAGGACTCATCAGATGATGAGCGGGCCCTAGAGGACTGGGTG TCCTCAGAAACATCAGCTCTACCCCGACCTCGCTGGCAAGCCCTCCCTGCCCTTCGGGAGCGGGAGCTGGGTTCAAGTGCCCGCTTTGTC TATGAGGCCTGTGGGGCAAGAGTCTTTGTGCAGCGTTTCCGCCTGCAGCATGGGCTTGAGGGCCATACTGGTTGTGTCAATACCCTGCAC TTTAACCAGCGCGGCACCTGGCTGGCCAGTGGCAGCGATGACCTGAAGGTGGTGGTGTGGGATTGGGTACGGCGGCAGCCAGTACTGGAC TTTGAGAGTGGCCACAAAAGTAATGTGTTCCAGGTGAGGCAAGGGAGCATAATAGCAACTGAGAGAATCAGGCATGAGTTAGAGAAATCT GAACTGCAGCATGGATTGGGAGCTGATAGTGAGTTATTGTAGGAATTACATATCGGGACATGGCCCTACTTTGGCTCCCCTAATGACCTA AATACACTGAAAGACTCTTGGCAACCCTAGATTCCTTGAGCATGTGGACTGTTGGAAGCCTCATAGGTAGGGTGCATGCAGCTTATTAAA TGTGTGCTGGTAGGAGGCAGTGTAGTATAAGCACAGGCTCTTGAACCAAACTGCCTGAGTTCAAATCCTAGCCCTTCTGCTTACTAGCTC AGTGATCTTGGCCAAGTTATTTTACCTTTGTCTTCAGTTTATCTGTAAAATGGGACTAATAACACATAGGGTTATGAGGATTAAGTAACA >28648_28648_2_FAM168A-DCAF8_FAM168A_chr11_73179450_ENST00000356467_DCAF8_chr1_160210160_ENST00000475733_length(amino acids)=320AA_BP=63 MDTGESVAAVASGEDKGIAASAAAAAVFACSCSPDPQSSTMNPVYSPVQPGAPYGNPKNMAYTGSLSSSPEEMSGAEEGRETSSGIEVEA SDLSLSLTGDDGGPNRTSTESRGTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDE RALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWV -------------------------------------------------------------- >28648_28648_3_FAM168A-DCAF8_FAM168A_chr11_73179450_ENST00000450446_DCAF8_chr1_160210160_ENST00000475733_length(transcript)=1413nt_BP=264nt CGGCTACTGCAGAGGATTCAGAGCCGAGTCGCTGAGGAGGAGGCTCCGGTCCCCGCGCGCCATCCGCCACCCTACTGGACACGGGCGAGA GCGTCGCCGCCGTAGCCTCCGGAGAAGACAAGGGCATCGCCGCCTCAGCCGCCGCCGCCGCCGTTTTCGCCTGCAGCTGCTCACCGGATC CTCAGTCTTCCACAATGAACCCTGTTTACAGCCCCGTGCAGCCTGGGGCTCCTTATGGCAACCCTAAGAACATGGCCTACACGGGAAGCC TGTCTAGCAGTCCAGAGGAGATGTCTGGAGCTGAAGAGGGGAGGGAGACATCCTCAGGCATTGAAGTGGAGGCCTCAGACCTGAGTTTGA GCTTGACTGGGGATGATGGTGGCCCCAACCGCACCAGCACAGAAAGTCGAGGCACAGACACAGAGAGCTCAGGTGAAGATAAGGACTCTG ACAGCATGGAGGACACTGGTCATTACTCCATTAATGATGAAAATCGAGTCCATGACCGCTCAGAGGAAGAGGAAGAGGAGGAAGAAGAGG AGGAAGAAGAGCAGCCTCGGCGCCGTGTACAGCGCAAGCGGGCTAACCGTGACCAGGACTCATCAGATGATGAGCGGGCCCTAGAGGACT GGGTGTCCTCAGAAACATCAGCTCTACCCCGACCTCGCTGGCAAGCCCTCCCTGCCCTTCGGGAGCGGGAGCTGGGTTCAAGTGCCCGCT TTGTCTATGAGGCCTGTGGGGCAAGAGTCTTTGTGCAGCGTTTCCGCCTGCAGCATGGGCTTGAGGGCCATACTGGTTGTGTCAATACCC TGCACTTTAACCAGCGCGGCACCTGGCTGGCCAGTGGCAGCGATGACCTGAAGGTGGTGGTGTGGGATTGGGTACGGCGGCAGCCAGTAC TGGACTTTGAGAGTGGCCACAAAAGTAATGTGTTCCAGGTGAGGCAAGGGAGCATAATAGCAACTGAGAGAATCAGGCATGAGTTAGAGA AATCTGAACTGCAGCATGGATTGGGAGCTGATAGTGAGTTATTGTAGGAATTACATATCGGGACATGGCCCTACTTTGGCTCCCCTAATG ACCTAAATACACTGAAAGACTCTTGGCAACCCTAGATTCCTTGAGCATGTGGACTGTTGGAAGCCTCATAGGTAGGGTGCATGCAGCTTA TTAAATGTGTGCTGGTAGGAGGCAGTGTAGTATAAGCACAGGCTCTTGAACCAAACTGCCTGAGTTCAAATCCTAGCCCTTCTGCTTACT AGCTCAGTGATCTTGGCCAAGTTATTTTACCTTTGTCTTCAGTTTATCTGTAAAATGGGACTAATAACACATAGGGTTATGAGGATTAAG >28648_28648_3_FAM168A-DCAF8_FAM168A_chr11_73179450_ENST00000450446_DCAF8_chr1_160210160_ENST00000475733_length(amino acids)=320AA_BP=63 MDTGESVAAVASGEDKGIAASAAAAAVFACSCSPDPQSSTMNPVYSPVQPGAPYGNPKNMAYTGSLSSSPEEMSGAEEGRETSSGIEVEA SDLSLSLTGDDGGPNRTSTESRGTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDE RALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWV -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for FAM168A-DCAF8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FAM168A-DCAF8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FAM168A-DCAF8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies