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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM168B-HMCES (FusionGDB2 ID:28678)

Fusion Gene Summary for FAM168B-HMCES

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM168B-HMCES
Fusion gene ID: 28678
HgeneTgene
Gene symbol

FAM168B

HMCES

Gene ID

130074

56941

Gene namefamily with sequence similarity 168 member B5-hydroxymethylcytosine binding, ES cell specific
SynonymsMANIC3orf37|DC12|SRAPD1
Cytomap

2q21.1

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionmyelin-associated neurite-outgrowth inhibitorprotein FAM168Babasic site processing protein HMCES5-hydroxymethylcytosine (hmC) binding, ES cell-specificES cell-specific 5hmC-binding proteinSOS response associated peptidase domain containing 1SRAP domain-containing protein 1UPF0361 protein C3orf37embryonic ste
Modification date2020031320200313
UniProtAcc

A1KXE4

Q96FZ2

Ensembl transtripts involved in fusion geneENST00000389915, ENST00000409185, 
ENST00000383463, ENST00000389735, 
ENST00000417226, ENST00000502878, 
Fusion gene scores* DoF score8 X 7 X 5=2806 X 5 X 4=120
# samples 97
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM168B [Title/Abstract] AND HMCES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM168B(131840150)-HMCES(129017197), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHMCES

GO:0006974

cellular response to DNA damage stimulus

30554877


check buttonFusion gene breakpoints across FAM168B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HMCES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AFAM168Bchr2

131840150

-HMCESchr3

129017197

+


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Fusion Gene ORF analysis for FAM168B-HMCES

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389915ENST00000383463FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000389915ENST00000389735FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000389915ENST00000417226FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000389915ENST00000502878FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000409185ENST00000383463FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000409185ENST00000389735FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000409185ENST00000417226FAM168Bchr2

131840150

-HMCESchr3

129017197

+
In-frameENST00000409185ENST00000502878FAM168Bchr2

131840150

-HMCESchr3

129017197

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409185FAM168Bchr2131840150-ENST00000383463HMCESchr3129017197+2151178115789224
ENST00000409185FAM168Bchr2131840150-ENST00000417226HMCESchr3129017197+1258178115789224
ENST00000409185FAM168Bchr2131840150-ENST00000502878HMCESchr3129017197+1406178115789224
ENST00000409185FAM168Bchr2131840150-ENST00000389735HMCESchr3129017197+1227178115789224
ENST00000389915FAM168Bchr2131840150-ENST00000383463HMCESchr3129017197+2301328265939224
ENST00000389915FAM168Bchr2131840150-ENST00000417226HMCESchr3129017197+1408328265939224
ENST00000389915FAM168Bchr2131840150-ENST00000502878HMCESchr3129017197+1556328265939224
ENST00000389915FAM168Bchr2131840150-ENST00000389735HMCESchr3129017197+1377328265939224

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409185ENST00000383463FAM168Bchr2131840150-HMCESchr3129017197+0.0035983530.99640167
ENST00000409185ENST00000417226FAM168Bchr2131840150-HMCESchr3129017197+0.0036911270.99630886
ENST00000409185ENST00000502878FAM168Bchr2131840150-HMCESchr3129017197+0.0033548370.99664515
ENST00000409185ENST00000389735FAM168Bchr2131840150-HMCESchr3129017197+0.0041256170.99587435
ENST00000389915ENST00000383463FAM168Bchr2131840150-HMCESchr3129017197+0.0029719710.99702805
ENST00000389915ENST00000417226FAM168Bchr2131840150-HMCESchr3129017197+0.0035766080.9964234
ENST00000389915ENST00000502878FAM168Bchr2131840150-HMCESchr3129017197+0.0029148150.99708515
ENST00000389915ENST00000389735FAM168Bchr2131840150-HMCESchr3129017197+0.0040241560.9959759

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Fusion Genomic Features for FAM168B-HMCES


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM168Bchr2131840149-HMCESchr3129017196+8.56E-080.9999999
FAM168Bchr2131840149-HMCESchr3129017196+8.56E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM168B-HMCES


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:131840150/chr3:129017197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM168B

A1KXE4

HMCES

Q96FZ2

FUNCTION: Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. {ECO:0000250|UniProtKB:D4AEP3}.FUNCTION: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). {ECO:0000250|UniProtKB:Q8R1M0, ECO:0000269|PubMed:30554877, ECO:0000269|PubMed:31235913, ECO:0000269|PubMed:31235915, ECO:0000269|PubMed:31806351}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000389915-271_1823157.0Topological domainCytoplasmic
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000409185-271_18231704.0Topological domainCytoplasmic
TgeneHMCESchr2:131840150chr3:129017197ENST0000038346337332_338151355.0MotifPIP-box
TgeneHMCESchr2:131840150chr3:129017197ENST0000038973537332_338151355.0MotifPIP-box
TgeneHMCESchr2:131840150chr3:129017197ENST0000050287837332_338151355.0MotifPIP-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000389915-27165_19523157.0Topological domainCytoplasmic
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000389915-2743_14223157.0Topological domainExtracellular
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000409185-27165_195231704.0Topological domainCytoplasmic
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000409185-2743_142231704.0Topological domainExtracellular
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000389915-27143_16423157.0TransmembraneHelical
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000389915-2719_4223157.0TransmembraneHelical
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000409185-27143_164231704.0TransmembraneHelical
HgeneFAM168Bchr2:131840150chr3:129017197ENST00000409185-2719_42231704.0TransmembraneHelical


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Fusion Gene Sequence for FAM168B-HMCES


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28678_28678_1_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000383463_length(transcript)=2301nt_BP=328nt
GTCGGCGGCTCCGGTGGCTGCGCAGCGTCGGCGGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGC
GCGGCGTCCGGGAGGCGGCGGAGACGCGGGGCTCGGAGGGTCAGCCTCTTATCGTAGCAGGTCTCCTCGGCACGCCCCCCTTGTTTCGCC
CCACGGCCAAGCCCGCCGCGGGCCGGCGTGCGCTGGTCACTGAGGCCCAGGTCGCCGCCGCGGCGCGTTTTTGAAATCATGAATCCTGTT
TATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTCAGGTAGCATTGGTGCTGCAGATAGTCCTGA
GAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTGCTGGGAGCCCCCAGAGGGAGGAGATGTCCT
GTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAGGATGCCTGCCATATTAGATGGAGAGGAGGC
AGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCACCCAACAGAGAACATCACCTTCCATGCAGT
CTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTTGGTGGTCAAAAAGGAGCTCAGGGCAAGTGG
CAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAAAACACCTCAAAAGGAAGAGTCAGATGTTCC
CCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGGACTCCTAGAGCAATGGCTGAAGCGGGAGAA
GGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCAAGGCCAGGGTCTGCTGCACTGCTGTTCTGA
TAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTTAGTTGACAGTTGTGGGCTCATGTAGTCTTT
TTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGCTGCTGTTACCAGCCATGTGGGCCCCATAGG
GGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCCTTACCCAGCTGGGAAGTCTCTGCCCTGATC
TGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGTTCTTAAAAATTTATTTTTAAGTTCTAAAAT
AAAATAAAAATAAGTTCTTAAAATTTATTTTTTTCCTGAATAAATTGTATTTGGTAAACTTCTGCCTACATTTTGGAAAGTGATGCTGGT
GGGGAAAGTTCTAGATCTTACTTGGTTTCTTCTAGAATCAGTCTTCAGGAATGGATTTTGTCACAAATGGGGCATGGGGGCTTTCTGAGG
AAATAACTACAAGTCTTGGTGGTGGGCTCCTTATTATGTTTCTTTTTCTTTCATTCTTGATACTTGGAAGTCGTCTGAATCCTTTAGCTT
CAAACCAGCCTGAGTTTGAGTGCTTGCCGTAGCAGAAACTATCCTTACCACAGGTGGGAAGGAAAGGACCAGTTTCTAGCAGTGTCGGGC
CACTCCTCTTTCGAACATCCCTAAGGGAGGCATTCACAAAAGCTGTCCCAAGCAGCTGGAAGAAAACAGCTTCCGAGATGACCAGGAGGA
CTGGGCGGCGCCGAGCCCAGAACGCTCCTGGCGCAGCACCGTTGGCGTTGGCCGATTGCTGCTGGTGGGGGGCGGGGGTGCAGGCCCCAG
TCTCTATGCAAATCAGGGATCAGAAGATCGGAATTTCCACCAATCAGCGGGAAGCCTCGGCCCTGTAACTGCTAATGGGAGACAGCAGCG
CCACGCCACAGGCTTTTCCCCTGGTTTCGGGAGGGGTGGGGAGCCAGGTGGGGCTCCCGCCCAGACCCTTTCCCGAGGTCCGCCCTCTCC
GCCTTTTCTCTAAATTCCTCTTTTGAGTGCCCTCCCTTCCGGTTGAGAGGCGGGGGTTGGCCCGTAGTTGTACACTCAGTCACCCTGCAC
TGTGGAGGCGGGGGCCTCCCTTGTGGACTGATTTGCGTGGGATTTGGTTGTTTTATTAAGAGATTTAAAAAATTCAGATGACTTACTAGT

>28678_28678_1_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000383463_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_2_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000389735_length(transcript)=1377nt_BP=328nt
GTCGGCGGCTCCGGTGGCTGCGCAGCGTCGGCGGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGC
GCGGCGTCCGGGAGGCGGCGGAGACGCGGGGCTCGGAGGGTCAGCCTCTTATCGTAGCAGGTCTCCTCGGCACGCCCCCCTTGTTTCGCC
CCACGGCCAAGCCCGCCGCGGGCCGGCGTGCGCTGGTCACTGAGGCCCAGGTCGCCGCCGCGGCGCGTTTTTGAAATCATGAATCCTGTT
TATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTCAGGTAGCATTGGTGCTGCAGATAGTCCTGA
GAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTGCTGGGAGCCCCCAGAGGGAGGAGATGTCCT
GTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAGGATGCCTGCCATATTAGATGGAGAGGAGGC
AGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCACCCAACAGAGAACATCACCTTCCATGCAGT
CTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTTGGTGGTCAAAAAGGAGCTCAGGGCAAGTGG
CAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAAAACACCTCAAAAGGAAGAGTCAGATGTTCC
CCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGGACTCCTAGAGCAATGGCTGAAGCGGGAGAA
GGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCAAGGCCAGGGTCTGCTGCACTGCTGTTCTGA
TAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTTAGTTGACAGTTGTGGGCTCATGTAGTCTTT
TTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGCTGCTGTTACCAGCCATGTGGGCCCCATAGG
GGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCCTTACCCAGCTGGGAAGTCTCTGCCCTGATC
TGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGTTCTTAAAAATTTATTTTTAAGTTCTAAAAT

>28678_28678_2_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000389735_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_3_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000417226_length(transcript)=1408nt_BP=328nt
GTCGGCGGCTCCGGTGGCTGCGCAGCGTCGGCGGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGC
GCGGCGTCCGGGAGGCGGCGGAGACGCGGGGCTCGGAGGGTCAGCCTCTTATCGTAGCAGGTCTCCTCGGCACGCCCCCCTTGTTTCGCC
CCACGGCCAAGCCCGCCGCGGGCCGGCGTGCGCTGGTCACTGAGGCCCAGGTCGCCGCCGCGGCGCGTTTTTGAAATCATGAATCCTGTT
TATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTCAGGTAGCATTGGTGCTGCAGATAGTCCTGA
GAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTGCTGGGAGCCCCCAGAGGGAGGAGATGTCCT
GTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAGGATGCCTGCCATATTAGATGGAGAGGAGGC
AGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCACCCAACAGAGAACATCACCTTCCATGCAGT
CTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTTGGTGGTCAAAAAGGAGCTCAGGGCAAGTGG
CAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAAAACACCTCAAAAGGAAGAGTCAGATGTTCC
CCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGGACTCCTAGAGCAATGGCTGAAGCGGGAGAA
GGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCAAGGCCAGGGTCTGCTGCACTGCTGTTCTGA
TAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTTAGTTGACAGTTGTGGGCTCATGTAGTCTTT
TTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGCTGCTGTTACCAGCCATGTGGGCCCCATAGG
GGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCCTTACCCAGCTGGGAAGTCTCTGCCCTGATC
TGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGTTCTTAAAAATTTATTTTTAAGTTCTAAAAT

>28678_28678_3_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000417226_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_4_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000502878_length(transcript)=1556nt_BP=328nt
GTCGGCGGCTCCGGTGGCTGCGCAGCGTCGGCGGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGC
GCGGCGTCCGGGAGGCGGCGGAGACGCGGGGCTCGGAGGGTCAGCCTCTTATCGTAGCAGGTCTCCTCGGCACGCCCCCCTTGTTTCGCC
CCACGGCCAAGCCCGCCGCGGGCCGGCGTGCGCTGGTCACTGAGGCCCAGGTCGCCGCCGCGGCGCGTTTTTGAAATCATGAATCCTGTT
TATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTCAGGTAGCATTGGTGCTGCAGATAGTCCTGA
GAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTGCTGGGAGCCCCCAGAGGGAGGAGATGTCCT
GTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAGGATGCCTGCCATATTAGATGGAGAGGAGGC
AGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCACCCAACAGAGAACATCACCTTCCATGCAGT
CTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTTGGTGGTCAAAAAGGAGCTCAGGGCAAGTGG
CAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAAAACACCTCAAAAGGAAGAGTCAGATGTTCC
CCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGGACTCCTAGAGCAATGGCTGAAGCGGGAGAA
GGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCAAGGCCAGGGTCTGCTGCACTGCTGTTCTGA
TAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTTAGTTGACAGTTGTGGGCTCATGTAGTCTTT
TTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGCTGCTGTTACCAGCCATGTGGGCCCCATAGG
GGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCCTTACCCAGCTGGGAAGTCTCTGCCCTGATC
TGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGTTCTTAAAAATTTATTTTTAAGTTCTAAAAT
AAAATAAAAATAAGTTCTTAAAATTTATTTTTTTCCTGAATAAATTGTATTTGGTAAACTTCTGCCTACATTTTGGAAAGTGATGCTGGT
GGGGAAAGTTCTAGATCTTACTTGGTTTCTTCTAGAATCAGTCTTCAGGAATGGATTTTGTCACAAATGGGGCATGGGGGCTTTCTGAGG

>28678_28678_4_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000389915_HMCES_chr3_129017197_ENST00000502878_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_5_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000383463_length(transcript)=2151nt_BP=178nt
GGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGCGCGGCGTCCGGGAGGCGGCGGAGACGCGGGGC
TCGGAGGTTTTTGAAATCATGAATCCTGTTTATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTC
AGGTAGCATTGGTGCTGCAGATAGTCCTGAGAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTG
CTGGGAGCCCCCAGAGGGAGGAGATGTCCTGTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAG
GATGCCTGCCATATTAGATGGAGAGGAGGCAGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCA
CCCAACAGAGAACATCACCTTCCATGCAGTCTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTT
GGTGGTCAAAAAGGAGCTCAGGGCAAGTGGCAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAA
AACACCTCAAAAGGAAGAGTCAGATGTTCCCCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGG
ACTCCTAGAGCAATGGCTGAAGCGGGAGAAGGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCA
AGGCCAGGGTCTGCTGCACTGCTGTTCTGATAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTT
AGTTGACAGTTGTGGGCTCATGTAGTCTTTTTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGC
TGCTGTTACCAGCCATGTGGGCCCCATAGGGGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCC
TTACCCAGCTGGGAAGTCTCTGCCCTGATCTGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGT
TCTTAAAAATTTATTTTTAAGTTCTAAAATAAAATAAAAATAAGTTCTTAAAATTTATTTTTTTCCTGAATAAATTGTATTTGGTAAACT
TCTGCCTACATTTTGGAAAGTGATGCTGGTGGGGAAAGTTCTAGATCTTACTTGGTTTCTTCTAGAATCAGTCTTCAGGAATGGATTTTG
TCACAAATGGGGCATGGGGGCTTTCTGAGGAAATAACTACAAGTCTTGGTGGTGGGCTCCTTATTATGTTTCTTTTTCTTTCATTCTTGA
TACTTGGAAGTCGTCTGAATCCTTTAGCTTCAAACCAGCCTGAGTTTGAGTGCTTGCCGTAGCAGAAACTATCCTTACCACAGGTGGGAA
GGAAAGGACCAGTTTCTAGCAGTGTCGGGCCACTCCTCTTTCGAACATCCCTAAGGGAGGCATTCACAAAAGCTGTCCCAAGCAGCTGGA
AGAAAACAGCTTCCGAGATGACCAGGAGGACTGGGCGGCGCCGAGCCCAGAACGCTCCTGGCGCAGCACCGTTGGCGTTGGCCGATTGCT
GCTGGTGGGGGGCGGGGGTGCAGGCCCCAGTCTCTATGCAAATCAGGGATCAGAAGATCGGAATTTCCACCAATCAGCGGGAAGCCTCGG
CCCTGTAACTGCTAATGGGAGACAGCAGCGCCACGCCACAGGCTTTTCCCCTGGTTTCGGGAGGGGTGGGGAGCCAGGTGGGGCTCCCGC
CCAGACCCTTTCCCGAGGTCCGCCCTCTCCGCCTTTTCTCTAAATTCCTCTTTTGAGTGCCCTCCCTTCCGGTTGAGAGGCGGGGGTTGG
CCCGTAGTTGTACACTCAGTCACCCTGCACTGTGGAGGCGGGGGCCTCCCTTGTGGACTGATTTGCGTGGGATTTGGTTGTTTTATTAAG

>28678_28678_5_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000383463_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_6_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000389735_length(transcript)=1227nt_BP=178nt
GGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGCGCGGCGTCCGGGAGGCGGCGGAGACGCGGGGC
TCGGAGGTTTTTGAAATCATGAATCCTGTTTATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTC
AGGTAGCATTGGTGCTGCAGATAGTCCTGAGAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTG
CTGGGAGCCCCCAGAGGGAGGAGATGTCCTGTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAG
GATGCCTGCCATATTAGATGGAGAGGAGGCAGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCA
CCCAACAGAGAACATCACCTTCCATGCAGTCTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTT
GGTGGTCAAAAAGGAGCTCAGGGCAAGTGGCAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAA
AACACCTCAAAAGGAAGAGTCAGATGTTCCCCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGG
ACTCCTAGAGCAATGGCTGAAGCGGGAGAAGGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCA
AGGCCAGGGTCTGCTGCACTGCTGTTCTGATAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTT
AGTTGACAGTTGTGGGCTCATGTAGTCTTTTTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGC
TGCTGTTACCAGCCATGTGGGCCCCATAGGGGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCC
TTACCCAGCTGGGAAGTCTCTGCCCTGATCTGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGT

>28678_28678_6_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000389735_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_7_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000417226_length(transcript)=1258nt_BP=178nt
GGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGCGCGGCGTCCGGGAGGCGGCGGAGACGCGGGGC
TCGGAGGTTTTTGAAATCATGAATCCTGTTTATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTC
AGGTAGCATTGGTGCTGCAGATAGTCCTGAGAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTG
CTGGGAGCCCCCAGAGGGAGGAGATGTCCTGTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAG
GATGCCTGCCATATTAGATGGAGAGGAGGCAGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCA
CCCAACAGAGAACATCACCTTCCATGCAGTCTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTT
GGTGGTCAAAAAGGAGCTCAGGGCAAGTGGCAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAA
AACACCTCAAAAGGAAGAGTCAGATGTTCCCCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGG
ACTCCTAGAGCAATGGCTGAAGCGGGAGAAGGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCA
AGGCCAGGGTCTGCTGCACTGCTGTTCTGATAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTT
AGTTGACAGTTGTGGGCTCATGTAGTCTTTTTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGC
TGCTGTTACCAGCCATGTGGGCCCCATAGGGGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCC
TTACCCAGCTGGGAAGTCTCTGCCCTGATCTGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGT

>28678_28678_7_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000417226_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------
>28678_28678_8_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000502878_length(transcript)=1406nt_BP=178nt
GGGGAGCGCGGGCTGCGGAGAGGCGGGCCGGGCCAAGCGGAGCCGAGCGAGCGGGAGCGCGGCGTCCGGGAGGCGGCGGAGACGCGGGGC
TCGGAGGTTTTTGAAATCATGAATCCTGTTTATAGTCCTGGATCTTCTGGGGTTCCCTATGCAAATGCCAAAGGAATTGGTTATCCAGTC
AGGTAGCATTGGTGCTGCAGATAGTCCTGAGAACTGGGAGAAAGTCTGGGACAACTGGAGGCTGCTGACAATGGCCGGGATCTTTGACTG
CTGGGAGCCCCCAGAGGGAGGAGATGTCCTGTATTCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAG
GATGCCTGCCATATTAGATGGAGAGGAGGCAGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCAACTCAGGAAGCTCTGAAATTAATCCA
CCCAACAGAGAACATCACCTTCCATGCAGTCTCTTCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTT
GGTGGTCAAAAAGGAGCTCAGGGCAAGTGGCAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACAAAGTCACCCAAAAAGGAAGACTCAAA
AACACCTCAAAAGGAAGAGTCAGATGTTCCCCAGTGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGG
ACTCCTAGAGCAATGGCTGAAGCGGGAGAAGGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCA
AGGCCAGGGTCTGCTGCACTGCTGTTCTGATAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTGTT
AGTTGACAGTTGTGGGCTCATGTAGTCTTTTTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGACAGCTTTGGAAGAGGTGTCCTGC
TGCTGTTACCAGCCATGTGGGCCCCATAGGGGCACTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCC
TTACCCAGCTGGGAAGTCTCTGCCCTGATCTGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGT
TCTTAAAAATTTATTTTTAAGTTCTAAAATAAAATAAAAATAAGTTCTTAAAATTTATTTTTTTCCTGAATAAATTGTATTTGGTAAACT
TCTGCCTACATTTTGGAAAGTGATGCTGGTGGGGAAAGTTCTAGATCTTACTTGGTTTCTTCTAGAATCAGTCTTCAGGAATGGATTTTG

>28678_28678_8_FAM168B-HMCES_FAM168B_chr2_131840150_ENST00000409185_HMCES_chr3_129017197_ENST00000502878_length(amino acids)=224AA_BP=20
MFIVLDLLGFPMQMPKELVIQSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM168B-HMCES


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM168B-HMCES


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM168B-HMCES


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource