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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM172A-NFIA (FusionGDB2 ID:28709)

Fusion Gene Summary for FAM172A-NFIA

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM172A-NFIA
Fusion gene ID: 28709
HgeneTgene
Gene symbol

FAM172A

NFIA

Gene ID

83989

4774

Gene namefamily with sequence similarity 172 member Anuclear factor I A
SynonymsC5orf21|ToupeeBRMUTD|CTF|NF-I/A|NF1-A|NFI-A|NFI-L
Cytomap

5q15

1p31.3

Type of geneprotein-codingprotein-coding
Descriptioncotranscriptional regulator FAM172Aprotein FAM172Anuclear factor 1 A-typeCCAAT-box-binding transcription factorTGGCA-binding protein
Modification date2020031320200313
UniProtAcc

Q8WUF8

Q12857

Ensembl transtripts involved in fusion geneENST00000395965, ENST00000505869, 
ENST00000509163, ENST00000504768, 
ENST00000509739, 		ENST00000357977, 
ENST00000371184, ENST00000371185, 
ENST00000371187, ENST00000371189, 
ENST00000403491, ENST00000479364, 
ENST00000485903, ENST00000371191, 
ENST00000407417, 
Fusion gene scores* DoF score18 X 17 X 8=244821 X 24 X 8=4032
# samples 2328
** MAII scorelog2(23/2448*10)=-3.41189779174828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4032*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM172A [Title/Abstract] AND NFIA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM172A(93386435)-NFIA(61553820), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM172A-NFIA seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FAM172A-NFIA seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFIA

GO:0045944

positive regulation of transcription by RNA polymerase II

17010934


check buttonFusion gene breakpoints across FAM172A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NFIA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4G6FAM172Achr5

93386435

-NFIAchr1

61553820

+


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Fusion Gene ORF analysis for FAM172A-NFIA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000395965ENST00000357977FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000371184FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000371185FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000371187FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000371189FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000403491FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000479364FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000395965ENST00000485903FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000357977FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000371184FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000371185FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000371187FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000371189FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000403491FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000479364FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000505869ENST00000485903FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000357977FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000371184FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000371185FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000371187FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000371189FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000403491FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000479364FAM172Achr5

93386435

-NFIAchr1

61553820

+
5CDS-intronENST00000509163ENST00000485903FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-3CDSENST00000504768ENST00000371191FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-3CDSENST00000504768ENST00000407417FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000357977FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000371184FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000371185FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000371187FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000371189FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000403491FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000479364FAM172Achr5

93386435

-NFIAchr1

61553820

+
5UTR-intronENST00000504768ENST00000485903FAM172Achr5

93386435

-NFIAchr1

61553820

+
Frame-shiftENST00000505869ENST00000371191FAM172Achr5

93386435

-NFIAchr1

61553820

+
Frame-shiftENST00000505869ENST00000407417FAM172Achr5

93386435

-NFIAchr1

61553820

+
Frame-shiftENST00000509163ENST00000371191FAM172Achr5

93386435

-NFIAchr1

61553820

+
Frame-shiftENST00000509163ENST00000407417FAM172Achr5

93386435

-NFIAchr1

61553820

+
In-frameENST00000395965ENST00000371191FAM172Achr5

93386435

-NFIAchr1

61553820

+
In-frameENST00000395965ENST00000407417FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-3CDSENST00000509739ENST00000371191FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-3CDSENST00000509739ENST00000407417FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000357977FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000371184FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000371185FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000371187FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000371189FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000403491FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000479364FAM172Achr5

93386435

-NFIAchr1

61553820

+
intron-intronENST00000509739ENST00000485903FAM172Achr5

93386435

-NFIAchr1

61553820

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395965FAM172Achr593386435-ENST00000371191NFIAchr161553820+21604521401954604
ENST00000395965FAM172Achr593386435-ENST00000407417NFIAchr161553820+22204521401954604

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395965ENST00000371191FAM172Achr593386435-NFIAchr161553820+0.0030645560.9969355
ENST00000395965ENST00000407417FAM172Achr593386435-NFIAchr161553820+0.0022749810.99772507

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Fusion Genomic Features for FAM172A-NFIA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM172Achr593386435-NFIAchr161553820+0.0005124070.9994875
FAM172Achr593386435-NFIAchr161553820+0.0005124070.9994875

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM172A-NFIA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:93386435/chr1:61553820)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM172A

Q8WUF8

NFIA

Q12857

FUNCTION: Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}.FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFIAchr5:93386435chr1:61553820ENST000004074170111_1941502.0DNA bindingCTF/NF-I
TgeneNFIAchr5:93386435chr1:61553820ENST00000371187010394_4029499.0Motif9aaTAD
TgeneNFIAchr5:93386435chr1:61553820ENST00000371189112394_40254555.0Motif9aaTAD
TgeneNFIAchr5:93386435chr1:61553820ENST00000403491011394_4029510.0Motif9aaTAD
TgeneNFIAchr5:93386435chr1:61553820ENST00000407417011394_4021502.0Motif9aaTAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM172Achr5:93386435chr1:61553820ENST00000395965-411413_416103417.0MotifPrevents secretion from ER
HgeneFAM172Achr5:93386435chr1:61553820ENST00000505869-39413_41657307.0MotifPrevents secretion from ER
HgeneFAM172Achr5:93386435chr1:61553820ENST00000509163-310413_41657371.0MotifPrevents secretion from ER
TgeneNFIAchr5:93386435chr1:61553820ENST000003711870101_1949499.0DNA bindingCTF/NF-I
TgeneNFIAchr5:93386435chr1:61553820ENST000003711891121_19454555.0DNA bindingCTF/NF-I
TgeneNFIAchr5:93386435chr1:61553820ENST000004034910111_1949510.0DNA bindingCTF/NF-I


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Fusion Gene Sequence for FAM172A-NFIA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28709_28709_1_FAM172A-NFIA_FAM172A_chr5_93386435_ENST00000395965_NFIA_chr1_61553820_ENST00000371191_length(transcript)=2160nt_BP=452nt
GGTCGGGGCGCGGATCCCGAGAGGGAAAGTCATAACAACCGCACGAGGGAGTTCGACTGGCGAACTGGAAGGCCACGCCTCCTCCCGCCT
GCCCCCTCAGCCCTGTGGCTGGGGGCAGAGCTCAGACTGTCTTCTGAAGATTGATGTCTATTTCCTTGAGCTCTTTAATTTTGTTGCCAA
TTTGGATAAACATGGCACAAATCCAGCAGGGAGGTCCAGATGAAAAAGAAAAGACTACCGCACTGAAAGATTTATTATCTAGGATAGATT
TGGATGAACTAATGAAAAAAGATGAACCGCCTCTTGATTTTCCTGATACCCTGGAAGGATTTGAATATGCTTTTAATGAAAAGGGACAGT
TAAGACACATAAAAACTGGGGAACCATTTGTTTTTAACTACCGGGAAGATTTACACAGATGGAACCAGAAAAGATACGAGGCTCTAGGAG
AGGATGAATTTCATCCTTTCATCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAA
AATACTTCAAAAAACATGAAAAGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGC
AGAAGTGGGCATCTCGACTTCTGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAA
AACCTCCATGTTGTGTTCTTTCCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGT
TGGACCTTGTTATGGTGATTTTGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATC
CAGGGCTCTGTGTCCAACCCCATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGATTCAA
GTCAATCTGAAAGTCCCAGCCAGCCAAGTGACGCTGACATTAAGGACCAGCCAGAAAATGGACATTTGGGCTTCCAGGACAGTTTTGTCA
CATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCTCTCTCAGATT
TGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACAAAGCGCCTCA
AGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGTCAGTCAAGTG
GATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCCCCTTCACAGA
CCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCATCGACTCTTC
ATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACGCTGAAAGAAT
TTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGCAAGGTGCACA
ACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGACACAAAGCCTC
CAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGATTCGTCAGTG
TTGGACCACGGGATCCAAGCTTTGTAAATATCCCTCAACAGACACAGTCCTGGTACCTGGGATAAAAGTTGCAGCGTCCCACCATCCACC
AGACAGACCACCTGACCCCTTCTCAACTCTGTAACATGGACGCAACCTCAACCCAGCGCAGTTACAACTTCACTATCAGCGGAAGGGGAG
AAAAACCGATTCAAATCAACTTGTACATGGAAACAGCAAGCATTATGGTCAAACAGCAAAGGCCATAACCTTTTGGGATTTTTTTTTTTT

>28709_28709_1_FAM172A-NFIA_FAM172A_chr5_93386435_ENST00000395965_NFIA_chr1_61553820_ENST00000371191_length(amino acids)=604AA_BP=104
MMSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYRED
LHRWNQKRYEALGEDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRP
EYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKEL
DLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRS
LPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVIT
GPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPM

--------------------------------------------------------------
>28709_28709_2_FAM172A-NFIA_FAM172A_chr5_93386435_ENST00000395965_NFIA_chr1_61553820_ENST00000407417_length(transcript)=2220nt_BP=452nt
GGTCGGGGCGCGGATCCCGAGAGGGAAAGTCATAACAACCGCACGAGGGAGTTCGACTGGCGAACTGGAAGGCCACGCCTCCTCCCGCCT
GCCCCCTCAGCCCTGTGGCTGGGGGCAGAGCTCAGACTGTCTTCTGAAGATTGATGTCTATTTCCTTGAGCTCTTTAATTTTGTTGCCAA
TTTGGATAAACATGGCACAAATCCAGCAGGGAGGTCCAGATGAAAAAGAAAAGACTACCGCACTGAAAGATTTATTATCTAGGATAGATT
TGGATGAACTAATGAAAAAAGATGAACCGCCTCTTGATTTTCCTGATACCCTGGAAGGATTTGAATATGCTTTTAATGAAAAGGGACAGT
TAAGACACATAAAAACTGGGGAACCATTTGTTTTTAACTACCGGGAAGATTTACACAGATGGAACCAGAAAAGATACGAGGCTCTAGGAG
AGGATGAATTTCATCCTTTCATCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAA
AATACTTCAAAAAACATGAAAAGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGC
AGAAGTGGGCATCTCGACTTCTGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAA
AACCTCCATGTTGTGTTCTTTCCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGT
TGGACCTTGTTATGGTGATTTTGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATC
CAGGGCTCTGTGTCCAACCCCATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGATTCAA
GTCAATCTGAAAGTCCCAGCCAGCCAAGTGACGCTGACATTAAGGACCAGCCAGAAAATGGACATTTGGGCTTCCAGGACAGTTTTGTCA
CATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCTCTCTCAGATT
TGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACAAAGCGCCTCA
AGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGTCAGTCAAGTG
GATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCCCCTTCACAGA
CCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCATCGACTCTTC
ATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACGCTGAAAGAAT
TTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGCAAGGTGCACA
ACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGACACAAAGCCTC
CAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGATTCGTCAGTG
TTGGACCACGGGATCCAAGCTTTGTAAATATCCCTCAACAGACACAGTCCTGGTACCTGGGATAAAAGTTGCAGCGTCCCACCATCCACC
AGACAGACCACCTGACCCCTTCTCAACTCTGTAACATGGACGCAACCTCAACCCAGCGCAGTTACAACTTCACTATCAGCGGAAGGGGAG
AAAAACCGATTCAAATCAACTTGTACATGGAAACAGCAAGCATTATGGTCAAACAGCAAAGGCCATAACCTTTTGGGATTTTTTTTTTTT

>28709_28709_2_FAM172A-NFIA_FAM172A_chr5_93386435_ENST00000395965_NFIA_chr1_61553820_ENST00000407417_length(amino acids)=604AA_BP=104
MMSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYRED
LHRWNQKRYEALGEDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRP
EYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKEL
DLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRS
LPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVIT
GPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPM

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Fusion Gene PPI Analysis for FAM172A-NFIA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM172A-NFIA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM172A-NFIA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource