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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM192A-CES2 (FusionGDB2 ID:28783)

Fusion Gene Summary for FAM192A-CES2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM192A-CES2
Fusion gene ID: 28783
HgeneTgene
Gene symbol

FAM192A

CES2

Gene ID

80011

8824

Gene nameproteasome activator subunit 3 interacting protein 1carboxylesterase 2
SynonymsC16orf94|CDA018|CDA10|FAM192A|NIP30|PIP30CE-2|CES2A1|PCE-2|iCE
Cytomap

16q13

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionPSME3-interacting proteinNEFA-interacting nuclear protein NIP30PA28G interacting protein 30kDaPA28G-interacting proteinPSME3 interacting protein 30kDafamily with sequence similarity 192 member Aprotein FAM192Acocaine esterasecarboxylesterase 2 (intestine, liver)intestinal carboxylesterase; liver carboxylesterase-2methylumbelliferyl-acetate deacetylase 2
Modification date2020031320200313
UniProtAcc.

O00748

Ensembl transtripts involved in fusion geneENST00000566077, ENST00000309137, 
ENST00000389447, ENST00000564108, 
ENST00000567439, ENST00000569266, 
ENST00000562400, 		ENST00000317091, 
ENST00000417689, 
Fusion gene scores* DoF score5 X 6 X 4=1205 X 5 X 2=50
# samples 76
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM192A [Title/Abstract] AND CES2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM192A(57207640)-CES2(66971940), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM192A-CES2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FAM192A-CES2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCES2

GO:0006693

prostaglandin metabolic process

21049984


check buttonFusion gene breakpoints across FAM192A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CES2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2MM-06AFAM192Achr16

57207640

-CES2chr16

66971940

+


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Fusion Gene ORF analysis for FAM192A-CES2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000566077ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
5UTR-3CDSENST00000566077ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+
Frame-shiftENST00000309137ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
Frame-shiftENST00000309137ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+
Frame-shiftENST00000389447ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
Frame-shiftENST00000389447ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+
Frame-shiftENST00000564108ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
Frame-shiftENST00000564108ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+
In-frameENST00000567439ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
In-frameENST00000567439ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+
In-frameENST00000569266ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
In-frameENST00000569266ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+
intron-3CDSENST00000562400ENST00000317091FAM192Achr16

57207640

-CES2chr16

66971940

+
intron-3CDSENST00000562400ENST00000417689FAM192Achr16

57207640

-CES2chr16

66971940

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000569266FAM192Achr1657207640-ENST00000417689CES2chr1666971940+2798198171753578
ENST00000569266FAM192Achr1657207640-ENST00000317091CES2chr1666971940+2873198171801594
ENST00000567439FAM192Achr1657207640-ENST00000417689CES2chr1666971940+29583582311913560
ENST00000567439FAM192Achr1657207640-ENST00000317091CES2chr1666971940+30333582311961576

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569266ENST00000417689FAM192Achr1657207640-CES2chr1666971940+0.0034813740.9965186
ENST00000569266ENST00000317091FAM192Achr1657207640-CES2chr1666971940+0.0028151020.99718493
ENST00000567439ENST00000417689FAM192Achr1657207640-CES2chr1666971940+0.0032756980.9967243
ENST00000567439ENST00000317091FAM192Achr1657207640-CES2chr1666971940+0.002619420.99738055

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Fusion Genomic Features for FAM192A-CES2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM192Achr1657207639-CES2chr1666971939+2.64E-060.9999974
FAM192Achr1657207639-CES2chr1666971939+2.64E-060.9999974

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM192A-CES2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:57207640/chr16:66971940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CES2

O00748

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). {ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:9169443, ECO:0000303|PubMed:28677105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCES2chr16:57207640chr16:66971940ENST00000317091012556_55989624.0MotifPrevents secretion from ER
TgeneCES2chr16:57207640chr16:66971940ENST00000417689012556_55989608.0MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM192A-CES2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28783_28783_1_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000567439_CES2_chr16_66971940_ENST00000317091_length(transcript)=3033nt_BP=358nt
TATTGTGGCGGTGAGGAACAGGAAGCCCTGAAGGGTCAAAAGAAATACAAAAGCAAAGGCTATTTTCTTTTTTTTTTTCTTTCTTTCATT
CATTCCTTCCTCTGTTTCTTTCTTTCTTCCTTTCATTTTTTTTTCTTTTTTAAGAGCGAGCGGCTCTGCGGTGGCGGTTTGGGGTGGGCG
CCGCCGAGGTGAGGTCGTCTCGCCTCCCGCGCGCCGATTGGTTGTTTCATTATGGATGGAGGGGATGATGGTAACCTTATTATCAAAAAG
AGGTTTGTGTCTGAGGCAGAACTAGATGAACGGCGCAAAAGGAGGCAAGAAGAATGGGAGAAAGTTCGAAAACCTGAAGATCCAGAAGGC
CAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA
ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAATCTTGGAGTGGTGTGAGG
GATGGAACCACCCATCCGGCCATGTGTCTACAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCC
GACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAAGGCTCTAACCTGCCGGTGATGGTGTGGATC
CACGGTGGTGCGCTTGTTTTTGGCATGGCTTCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAG
TACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGGGGCTACCTGGACCAAGTGGCTGCACTACGC
TGGGTCCAGCAGAATATCGCCCACTTTGGAGGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCG
CTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTGGCCCTCCTGCCCGGCCTCATTGCCAGCTCA
GCTGATGTCATCTCCACGGTGGTGGCCAACCTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGT
AAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGGGTCTTCCTGCCCAGGCACCCCCAGGAGCTG
CTGGCCTCTGCCGACTTTCAGCCTGTCCCTAGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATC
TATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTAACGCTGCTGATGTTGCCTCCTACATTTGGT
GACCTGCTGAGGGAGGAGTACATTGGGGACAATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTT
GTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTACGAGTTCCAGCATCAGCCCAGCTGGCTCAAG
AACATCAGGCCACCGCACATGAAGGCAGACCATGGTGATGAGCTTCCTTTTGTTTTCAGAAGTTTCTTTGGGGGCAACTACATTAAATTC
ACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGAAATGGGAACCCCAATGGCGAGGGTCTGCCA
CACTGGCCGCTGTTCGACCAGGAGGAGCAATACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAG
TTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACACACAGAGCTGTAGCTCCCTGTGCCGGGGAGG
AGGGGGTGGGTTCGCTGACAGGCGAGGGTCAGCCTGCTGTGCCCACACACACCCACTAAGGAGAAAGAAGTTGATTCCTTCATTCACTTC
GCCATTCATTCATACTTCCGTCCATCCATTCAGAAAGCATTTATTAAGAATTTACTCAGGCATGATGGCCCATACTTGTAATCCCAGCTA
TTGGGAAGGATGAGATGGGAGGATGGCTTGAGGCCAGAGGTTTGAGACCGACCAGCCAGGGCAACACAGTGAGACCCCTTCTCAAAAAAA
AAAAAAAAAAAGAGAGAGTGTGTGATTAGAAGCTAAATAGGAAAGTTTTGAGCTTCAAGTCAGTGAGGAGTAAAAAAGATTTTTAAAAAG
CAAAGAAAACAAAATATAAGGGAAAAATATGAGAAAAATAAAAATAAAAAGAGAATAATAGGCCAGGCACTGTGGCTCATGCCCCTAATC
CCAGCACTTTTGGGAGGTCAAGGTGAGCAGAACACCTGAGGACAGGAGTTTGAGACCAGCCTGCCCAACGTGGTGAAACCCCATCTCTAT
GAAAAATACAAAAATCAGACGGGCACAGTGGTGGTGCCCACCTGTGATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTACTTGAACC
TGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGTACTCCAGCCTGGGCAACAAGAGCGAGACTCCGTTTCCAAAAAAATAAGA
GAGAATAGAAGAAGCTACTGCATGATGTTAGTTACCAAGCCTGCCATGGGTCCTCTCTTGCTAGACACACTCCATAGATCCCCCCACTGA
GCTGTGGATGGGCAAACCCCGGTGGAATCCCACCCTCCCCAACACCCCACTGAGCCCTGGGCCCCCTCCTCCCTTCCTCACCTCCACCTT
CTCCCTGCCTTCTCTCTTCTCTCGTCTGAGCCCCCAGGCCTTTTCCACTTTGAGGGAGGTGCTTCGAAGAATGTTGCCCACACCTAAGTG

>28783_28783_1_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000567439_CES2_chr16_66971940_ENST00000317091_length(amino acids)=576AA_BP=40
MDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRF
APPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSM
LAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIME
SGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNN
NEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPV
YFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQ

--------------------------------------------------------------
>28783_28783_2_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000567439_CES2_chr16_66971940_ENST00000417689_length(transcript)=2958nt_BP=358nt
TATTGTGGCGGTGAGGAACAGGAAGCCCTGAAGGGTCAAAAGAAATACAAAAGCAAAGGCTATTTTCTTTTTTTTTTTCTTTCTTTCATT
CATTCCTTCCTCTGTTTCTTTCTTTCTTCCTTTCATTTTTTTTTCTTTTTTAAGAGCGAGCGGCTCTGCGGTGGCGGTTTGGGGTGGGCG
CCGCCGAGGTGAGGTCGTCTCGCCTCCCGCGCGCCGATTGGTTGTTTCATTATGGATGGAGGGGATGATGGTAACCTTATTATCAAAAAG
AGGTTTGTGTCTGAGGCAGAACTAGATGAACGGCGCAAAAGGAGGCAAGAAGAATGGGAGAAAGTTCGAAAACCTGAAGATCCAGAAGGC
CAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA
ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAATCTTGGAGTGGTGTGAGG
GATGGAACCACCCATCCGGCCATGTGTCTACAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCC
GACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAAGGCTCTAACCTGCCGGTGATGGTGTGGATC
CACGGTGGTGCGCTTGTTTTTGGCATGGCTTCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAG
TACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGGGGCTACCTGGACCAAGTGGCTGCACTACGC
TGGGTCCAGCAGAATATCGCCCACTTTGGAGGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCG
CTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTGGCCCTCCTGCCCGGCCTCATTGCCAGCTCA
GCTGATGTCATCTCCACGGTGGTGGCCAACCTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGT
AAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGGGTCTTCCTGCCCAGGCACCCCCAGGAGCTG
CTGGCCTCTGCCGACTTTCAGCCTGTCCCTAGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATC
TATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTAACGCTGCTGATGTTGCCTCCTACATTTGGT
GACCTGCTGAGGGAGGAGTACATTGGGGACAATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTT
GTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTACGAGTTCCAGCATCAGCCCAGCTGGCTCAAG
AACATCAGGCCACCGCACATGAAGGCAGACCATGTTAAATTCACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCC
AACTTTGCGAGAAATGGGAACCCCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAATACCTGCAGCTGAACCTA
CAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAGTTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCT
GAAGAGAGACACACAGAGCTGTAGCTCCCTGTGCCGGGGAGGAGGGGGTGGGTTCGCTGACAGGCGAGGGTCAGCCTGCTGTGCCCACAC
ACACCCACTAAGGAGAAAGAAGTTGATTCCTTCATTCACTTCGCCATTCATTCATACTTCCGTCCATCCATTCAGAAAGCATTTATTAAG
AATTTACTCAGGCATGATGGCCCATACTTGTAATCCCAGCTATTGGGAAGGATGAGATGGGAGGATGGCTTGAGGCCAGAGGTTTGAGAC
CGACCAGCCAGGGCAACACAGTGAGACCCCTTCTCAAAAAAAAAAAAAAAAAAGAGAGAGTGTGTGATTAGAAGCTAAATAGGAAAGTTT
TGAGCTTCAAGTCAGTGAGGAGTAAAAAAGATTTTTAAAAAGCAAAGAAAACAAAATATAAGGGAAAAATATGAGAAAAATAAAAATAAA
AAGAGAATAATAGGCCAGGCACTGTGGCTCATGCCCCTAATCCCAGCACTTTTGGGAGGTCAAGGTGAGCAGAACACCTGAGGACAGGAG
TTTGAGACCAGCCTGCCCAACGTGGTGAAACCCCATCTCTATGAAAAATACAAAAATCAGACGGGCACAGTGGTGGTGCCCACCTGTGAT
CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGTACTCCAG
CCTGGGCAACAAGAGCGAGACTCCGTTTCCAAAAAAATAAGAGAGAATAGAAGAAGCTACTGCATGATGTTAGTTACCAAGCCTGCCATG
GGTCCTCTCTTGCTAGACACACTCCATAGATCCCCCCACTGAGCTGTGGATGGGCAAACCCCGGTGGAATCCCACCCTCCCCAACACCCC
ACTGAGCCCTGGGCCCCCTCCTCCCTTCCTCACCTCCACCTTCTCCCTGCCTTCTCTCTTCTCTCGTCTGAGCCCCCAGGCCTTTTCCAC

>28783_28783_2_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000567439_CES2_chr16_66971940_ENST00000417689_length(amino acids)=560AA_BP=40
MDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRF
APPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSM
LAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIME
SGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNN
NEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPV
YFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWK

--------------------------------------------------------------
>28783_28783_3_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000569266_CES2_chr16_66971940_ENST00000317091_length(transcript)=2873nt_BP=198nt
TGTGAGTTCATTCCTCCCTGCTCAGATTCTTCAGCTCCTCGTGGTTGGTTTATTCAATTGGTTGTTTCATTATGGATGGAGGGGATGATG
GTAACCTTATTATCAAAAAGAGGTTTGTGTCTGAGGCAGAACTAGATGAACGGCGCAAAAGGAGGCAAGAAGAATGGGAGAAAGTTCGAA
AACCTGAAGATCCAGAAGGCCAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGG
GCGCCAATGCCGGGGTCCAAACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTG
AATCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTACAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGT
TCAACATGACCTTCCCTTCCGACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAAGGCTCTAACC
TGCCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCTTCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACG
TGGTGGTGGTCATCATCCAGTACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGGGGCTACCTGG
ACCAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGAGGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGG
GTGGCACGAGTGTGTCTTCGCTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTGGCCCTCCTGC
CCGGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAACCTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGG
GCTGCCTGCGGGGCAAGAGTAAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGGGTCTTCCTGC
CCAGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCTAGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCA
TCCCCAAGGTCATGAGGATCTATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTAACGCTGCTGA
TGTTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGACAATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGA
TGATGGCGGACTCCATGTTTGTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTACGAGTTCCAGC
ATCAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGACCATGGTGATGAGCTTCCTTTTGTTTTCAGAAGTTTCTTTG
GGGGCAACTACATTAAATTCACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGAAATGGGAACC
CCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAATACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTC
TGAAGGCCCACAGGCTCCAGTTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACACACAGAGCTGT
AGCTCCCTGTGCCGGGGAGGAGGGGGTGGGTTCGCTGACAGGCGAGGGTCAGCCTGCTGTGCCCACACACACCCACTAAGGAGAAAGAAG
TTGATTCCTTCATTCACTTCGCCATTCATTCATACTTCCGTCCATCCATTCAGAAAGCATTTATTAAGAATTTACTCAGGCATGATGGCC
CATACTTGTAATCCCAGCTATTGGGAAGGATGAGATGGGAGGATGGCTTGAGGCCAGAGGTTTGAGACCGACCAGCCAGGGCAACACAGT
GAGACCCCTTCTCAAAAAAAAAAAAAAAAAAGAGAGAGTGTGTGATTAGAAGCTAAATAGGAAAGTTTTGAGCTTCAAGTCAGTGAGGAG
TAAAAAAGATTTTTAAAAAGCAAAGAAAACAAAATATAAGGGAAAAATATGAGAAAAATAAAAATAAAAAGAGAATAATAGGCCAGGCAC
TGTGGCTCATGCCCCTAATCCCAGCACTTTTGGGAGGTCAAGGTGAGCAGAACACCTGAGGACAGGAGTTTGAGACCAGCCTGCCCAACG
TGGTGAAACCCCATCTCTATGAAAAATACAAAAATCAGACGGGCACAGTGGTGGTGCCCACCTGTGATCCCAGCTACTCAGGAGGCTGAG
GCAGGAGAATTACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGTACTCCAGCCTGGGCAACAAGAGCGAGACT
CCGTTTCCAAAAAAATAAGAGAGAATAGAAGAAGCTACTGCATGATGTTAGTTACCAAGCCTGCCATGGGTCCTCTCTTGCTAGACACAC
TCCATAGATCCCCCCACTGAGCTGTGGATGGGCAAACCCCGGTGGAATCCCACCCTCCCCAACACCCCACTGAGCCCTGGGCCCCCTCCT
CCCTTCCTCACCTCCACCTTCTCCCTGCCTTCTCTCTTCTCTCGTCTGAGCCCCCAGGCCTTTTCCACTTTGAGGGAGGTGCTTCGAAGA

>28783_28783_3_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000569266_CES2_chr16_66971940_ENST00000317091_length(amino acids)=594AA_BP=58
MLRFFSSSWLVYSIGCFIMDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEGQDSASPIRTTHTGQVLGSLVHVKGANAGV
QTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVW
IHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVS
SLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQE
LLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSM
FVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGL

--------------------------------------------------------------
>28783_28783_4_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000569266_CES2_chr16_66971940_ENST00000417689_length(transcript)=2798nt_BP=198nt
TGTGAGTTCATTCCTCCCTGCTCAGATTCTTCAGCTCCTCGTGGTTGGTTTATTCAATTGGTTGTTTCATTATGGATGGAGGGGATGATG
GTAACCTTATTATCAAAAAGAGGTTTGTGTCTGAGGCAGAACTAGATGAACGGCGCAAAAGGAGGCAAGAAGAATGGGAGAAAGTTCGAA
AACCTGAAGATCCAGAAGGCCAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGG
GCGCCAATGCCGGGGTCCAAACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTG
AATCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTACAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGT
TCAACATGACCTTCCCTTCCGACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAAGGCTCTAACC
TGCCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCTTCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACG
TGGTGGTGGTCATCATCCAGTACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGGGGCTACCTGG
ACCAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGAGGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGG
GTGGCACGAGTGTGTCTTCGCTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTGGCCCTCCTGC
CCGGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAACCTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGG
GCTGCCTGCGGGGCAAGAGTAAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGGGTCTTCCTGC
CCAGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCTAGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCA
TCCCCAAGGTCATGAGGATCTATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTAACGCTGCTGA
TGTTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGACAATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGA
TGATGGCGGACTCCATGTTTGTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTACGAGTTCCAGC
ATCAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGACCATGTTAAATTCACTGAGGAAGAGGAGCAGCTAAGCAGGA
AGATGATGAAGTACTGGGCCAACTTTGCGAGAAATGGGAACCCCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGC
AATACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAGTTCTGGAAGAAGGCGCTGCCCCAAAAGA
TCCAGGAGCTCGAGGAGCCTGAAGAGAGACACACAGAGCTGTAGCTCCCTGTGCCGGGGAGGAGGGGGTGGGTTCGCTGACAGGCGAGGG
TCAGCCTGCTGTGCCCACACACACCCACTAAGGAGAAAGAAGTTGATTCCTTCATTCACTTCGCCATTCATTCATACTTCCGTCCATCCA
TTCAGAAAGCATTTATTAAGAATTTACTCAGGCATGATGGCCCATACTTGTAATCCCAGCTATTGGGAAGGATGAGATGGGAGGATGGCT
TGAGGCCAGAGGTTTGAGACCGACCAGCCAGGGCAACACAGTGAGACCCCTTCTCAAAAAAAAAAAAAAAAAAGAGAGAGTGTGTGATTA
GAAGCTAAATAGGAAAGTTTTGAGCTTCAAGTCAGTGAGGAGTAAAAAAGATTTTTAAAAAGCAAAGAAAACAAAATATAAGGGAAAAAT
ATGAGAAAAATAAAAATAAAAAGAGAATAATAGGCCAGGCACTGTGGCTCATGCCCCTAATCCCAGCACTTTTGGGAGGTCAAGGTGAGC
AGAACACCTGAGGACAGGAGTTTGAGACCAGCCTGCCCAACGTGGTGAAACCCCATCTCTATGAAAAATACAAAAATCAGACGGGCACAG
TGGTGGTGCCCACCTGTGATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAG
ATTGTGCCACTGTACTCCAGCCTGGGCAACAAGAGCGAGACTCCGTTTCCAAAAAAATAAGAGAGAATAGAAGAAGCTACTGCATGATGT
TAGTTACCAAGCCTGCCATGGGTCCTCTCTTGCTAGACACACTCCATAGATCCCCCCACTGAGCTGTGGATGGGCAAACCCCGGTGGAAT
CCCACCCTCCCCAACACCCCACTGAGCCCTGGGCCCCCTCCTCCCTTCCTCACCTCCACCTTCTCCCTGCCTTCTCTCTTCTCTCGTCTG
AGCCCCCAGGCCTTTTCCACTTTGAGGGAGGTGCTTCGAAGAATGTTGCCCACACCTAAGTGTTAGAAGCCTATGTCCGTTCATCCCTGA

>28783_28783_4_FAM192A-CES2_FAM192A_chr16_57207640_ENST00000569266_CES2_chr16_66971940_ENST00000417689_length(amino acids)=578AA_BP=58
MLRFFSSSWLVYSIGCFIMDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEGQDSASPIRTTHTGQVLGSLVHVKGANAGV
QTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVW
IHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVS
SLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQE
LLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSM
FVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM192A-CES2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFAM192Achr16:57207640chr16:66971940ENST00000309137-27201_25442.333333333333336255.0PSME3
HgeneFAM192Achr16:57207640chr16:66971940ENST00000389447-17201_25442.333333333333336318.3333333333333PSME3
HgeneFAM192Achr16:57207640chr16:66971940ENST00000564108-38201_25442.333333333333336255.0PSME3
HgeneFAM192Achr16:57207640chr16:66971940ENST00000567439-27201_25442.333333333333336255.0PSME3
HgeneFAM192Achr16:57207640chr16:66971940ENST00000569266-27201_25442.333333333333336255.0PSME3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM192A-CES2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM192A-CES2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource