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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AGGF1-RAF1 (FusionGDB2 ID:2882) |
Fusion Gene Summary for AGGF1-RAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGGF1-RAF1 | Fusion gene ID: 2882 | Hgene | Tgene | Gene symbol | AGGF1 | RAF1 | Gene ID | 55109 | 6037 |
| Gene name | angiogenic factor with G-patch and FHA domains 1 | ribonuclease A family member 3 | |
| Synonyms | GPATC7|GPATCH7|HSU84971|HUS84971|VG5Q | ECP|RAF1|RNS3 | |
| Cytomap | 5q13.3 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | angiogenic factor with G patch and FHA domains 1G patch domain-containing protein 7angiogenic factor VG5Qvasculogenesis gene on 5q protein | eosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8N302 | P04049 | |
| Ensembl transtripts involved in fusion gene | ENST00000312916, ENST00000503538, ENST00000506806, | ENST00000251849, ENST00000442415, ENST00000534997, ENST00000542177, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 19 X 16 X 7=2128 |
| # samples | 3 | 18 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/2128*10)=-3.56342933917152 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGGF1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AGGF1(76335544)-RAF1(12641914), # samples:5 RAF1(12645635)-AGGF1(76342172), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AGGF1 | GO:0001938 | positive regulation of endothelial cell proliferation | 14961121 |
| Hgene | AGGF1 | GO:0007155 | cell adhesion | 14961121 |
| Hgene | AGGF1 | GO:0045766 | positive regulation of angiogenesis | 14961121 |
| Tgene | RAF1 | GO:0002227 | innate immune response in mucosa | 12860195 |
| Tgene | RAF1 | GO:0019731 | antibacterial humoral response | 12860195 |
| Tgene | RAF1 | GO:0043152 | induction of bacterial agglutination | 23992292 |
| Tgene | RAF1 | GO:0045087 | innate immune response | 23992292 |
| Tgene | RAF1 | GO:0050829 | defense response to Gram-negative bacterium | 23992292 |
| Tgene | RAF1 | GO:0050830 | defense response to Gram-positive bacterium | 12860195|23992292 |
| Tgene | RAF1 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12860195 |
| Fusion gene breakpoints across AGGF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RAF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-CH-5737-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ChimerDB4 | THCA | TCGA-BJ-A2N7-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ChimerDB4 | THCA | TCGA-DJ-A2Q4-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ChimerDB4 | THCA | TCGA-EM-A1CS-01A | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
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Fusion Gene ORF analysis for AGGF1-RAF1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000312916 | ENST00000251849 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000312916 | ENST00000442415 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000312916 | ENST00000534997 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000312916 | ENST00000542177 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000503538 | ENST00000251849 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000503538 | ENST00000442415 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000503538 | ENST00000534997 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000503538 | ENST00000542177 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000506806 | ENST00000251849 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000506806 | ENST00000442415 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000506806 | ENST00000534997 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000506806 | ENST00000542177 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000251849 | RAF1 | chr3 | 12641914 | - | 3278 | 1252 | 286 | 2364 | 692 |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000442415 | RAF1 | chr3 | 12641914 | - | 3081 | 1252 | 286 | 2364 | 692 |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000534997 | RAF1 | chr3 | 12641914 | - | 2612 | 1252 | 286 | 2364 | 692 |
| ENST00000312916 | AGGF1 | chr5 | 76335544 | + | ENST00000542177 | RAF1 | chr3 | 12641914 | - | 2546 | 1252 | 286 | 2364 | 692 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000312916 | ENST00000251849 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.003556621 | 0.99644333 |
| ENST00000312916 | ENST00000442415 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.005202861 | 0.99479717 |
| ENST00000312916 | ENST00000534997 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.00489195 | 0.99510807 |
| ENST00000312916 | ENST00000542177 | AGGF1 | chr5 | 76335544 | + | RAF1 | chr3 | 12641914 | - | 0.005396192 | 0.9946038 |
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Fusion Genomic Features for AGGF1-RAF1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AGGF1-RAF1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:76335544/chr3:12641914) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGGF1 | RAF1 |
| FUNCTION: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. | FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 18_88 | 290 | 715.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 12_15 | 290 | 715.0 | Compositional bias | Note=Poly-Pro |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 349_609 | 278 | 649.0 | Domain | Protein kinase | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 349_609 | 298 | 669.0 | Domain | Protein kinase | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 355_363 | 278 | 649.0 | Nucleotide binding | ATP | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 355_363 | 298 | 669.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 18_88 | 0 | 177.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 12_15 | 0 | 177.0 | Compositional bias | Note=Poly-Pro |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 434_487 | 290 | 715.0 | Domain | FHA |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000312916 | + | 5 | 14 | 619_665 | 290 | 715.0 | Domain | G-patch |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 434_487 | 0 | 177.0 | Domain | FHA |
| Hgene | AGGF1 | chr5:76335544 | chr3:12641914 | ENST00000506806 | + | 1 | 3 | 619_665 | 0 | 177.0 | Domain | G-patch |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 56_131 | 278 | 649.0 | Domain | RBD | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 56_131 | 298 | 669.0 | Domain | RBD | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 138_184 | 278 | 649.0 | Zinc finger | Phorbol-ester/DAG-type | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 138_184 | 298 | 669.0 | Zinc finger | Phorbol-ester/DAG-type |
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Fusion Gene Sequence for AGGF1-RAF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >2882_2882_1_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000251849_length(transcript)=3278nt_BP=1252nt GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT GGGGCGGGGCCGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCACATCATGTGTATACAAGGA AGCCAGGAATACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGTTATCTGATGGTCCCTCAAT >2882_2882_1_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000251849_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- >2882_2882_2_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000442415_length(transcript)=3081nt_BP=1252nt GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT >2882_2882_2_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000442415_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- >2882_2882_3_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000534997_length(transcript)=2612nt_BP=1252nt GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA >2882_2882_3_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000534997_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- >2882_2882_4_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000542177_length(transcript)=2546nt_BP=1252nt GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG >2882_2882_4_AGGF1-RAF1_AGGF1_chr5_76335544_ENST00000312916_RAF1_chr3_12641914_ENST00000542177_length(amino acids)=692AA_BP=322 MPARSSGLWVRRRPFRPERSPSAATSSLAPELMASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQ NAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVEND AYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTG IYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQR ERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AGGF1-RAF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000251849 | 6 | 17 | 331_349 | 278.0 | 649.0 | PEBP1/RKIP | |
| Tgene | RAF1 | chr5:76335544 | chr3:12641914 | ENST00000442415 | 7 | 18 | 331_349 | 298.0 | 669.0 | PEBP1/RKIP |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AGGF1-RAF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AGGF1-RAF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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