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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FAM19A4-TMF1 (FusionGDB2 ID:28833) |
Fusion Gene Summary for FAM19A4-TMF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM19A4-TMF1 | Fusion gene ID: 28833 | Hgene | Tgene | Gene symbol | FAM19A4 | TMF1 | Gene ID | 151647 | 7110 |
| Gene name | TAFA chemokine like family member 4 | TATA element modulatory factor 1 | |
| Synonyms | FAM19A4|TAFA-4 | ARA160|TMF | |
| Cytomap | 3p14.1 | 3p14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chemokine-like protein TAFA-4family with sequence similarity 19 (chemokine (C-C motif)-like), member A4family with sequence similarity 19 member A4, C-C motif chemokine likeprotein FAM19A4 | TATA element modulatory factorandrogen receptor coactivator 160 kDa proteinandrogen receptor-associated protein of 160 kDa | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000295569, | ENST00000489370, ENST00000398559, ENST00000543976, | |
| Fusion gene scores | * DoF score | 6 X 2 X 4=48 | 5 X 6 X 3=90 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM19A4 [Title/Abstract] AND TMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FAM19A4(68929881)-TMF1(69097713), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FAM19A4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TMF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ACC | TCGA-OR-A5LB-01A | FAM19A4 | chr3 | 68929881 | - | TMF1 | chr3 | 69097713 | - |
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Fusion Gene ORF analysis for FAM19A4-TMF1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000295569 | ENST00000489370 | FAM19A4 | chr3 | 68929881 | - | TMF1 | chr3 | 69097713 | - |
| In-frame | ENST00000295569 | ENST00000398559 | FAM19A4 | chr3 | 68929881 | - | TMF1 | chr3 | 69097713 | - |
| In-frame | ENST00000295569 | ENST00000543976 | FAM19A4 | chr3 | 68929881 | - | TMF1 | chr3 | 69097713 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000295569 | FAM19A4 | chr3 | 68929881 | - | ENST00000398559 | TMF1 | chr3 | 69097713 | - | 7113 | 623 | 493 | 3762 | 1089 |
| ENST00000295569 | FAM19A4 | chr3 | 68929881 | - | ENST00000543976 | TMF1 | chr3 | 69097713 | - | 7120 | 623 | 493 | 3771 | 1092 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000295569 | ENST00000398559 | FAM19A4 | chr3 | 68929881 | - | TMF1 | chr3 | 69097713 | - | 0.000399297 | 0.9996007 |
| ENST00000295569 | ENST00000543976 | FAM19A4 | chr3 | 68929881 | - | TMF1 | chr3 | 69097713 | - | 0.000248383 | 0.9997516 |
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Fusion Genomic Features for FAM19A4-TMF1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FAM19A4-TMF1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:68929881/chr3:69097713) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TMF1 | chr3:68929881 | chr3:69097713 | ENST00000398559 | 0 | 17 | 439_922 | 47 | 1094.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | TMF1 | chr3:68929881 | chr3:69097713 | ENST00000398559 | 0 | 17 | 984_1092 | 47 | 1094.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | TMF1 | chr3:68929881 | chr3:69097713 | ENST00000543976 | 0 | 17 | 439_922 | 47 | 1097.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | TMF1 | chr3:68929881 | chr3:69097713 | ENST00000543976 | 0 | 17 | 984_1092 | 47 | 1097.0 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FAM19A4-TMF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >28833_28833_1_FAM19A4-TMF1_FAM19A4_chr3_68929881_ENST00000295569_TMF1_chr3_69097713_ENST00000398559_length(transcript)=7113nt_BP=623nt AATCAGCGCGTTCCGCGGCGGGCCCGGCCCCTCCTGGTCAGCGCGCTAGCTGGGCTCGGCTCCGCACTGCTAGCTGCGCGCCGCCCTGGA CGGGGCGCACCGACTGCGCGCGCGGCTGCGGGCAAACATCGGGAGTCCTGCCTCAGCTGCCGCTTCTCCAGCAGCAGCTTCAGGCTTCTC CCGCAGGAGCTTCGGGCTTCTCCTGGTAGAGACGTGGGAACTTTTCTTCTCCTGGCGAGGCTGCAGAGGTGATGGGCCGCTCCCGGGGCT CCCGCGGGGAGGCGGCACGGTGAGCGTCCTCGGGCTCCGGTGCGGCGATCAGTACCTAGTTCCGGACGCGCCGGTCCGACTTGGATGCCG GCTCTAGTCGAGTCTTCTGAGCTACGATAATTTTTTGGAACGGCAGAAATGATTGGTTCTAGCAACAGATGGGAATTTGGAGTCACTCTG AAATATATCCTGGAATAAGTGTGTTTGACTAGAACCACATCTTATGAGGTCCCCAAGGATGAGAGTCTGTGCTAAGTCAGTGTTGCTGTC GCACTGGCTCTTTCTAGCCTACGTGTTAATGGTGTGCTGTAAGCTGATGTCCGCCTCAAGCCAGCACCTCCGGGGACATGCAGGAATAAG TTCCCCTGTCAGTGGAGGATGGGATACTTCAACCTGGGGGTTGAAATCAAACACTGAACCTCAGAGTCCACCAATAGCCTCTCCTAAAGC AATCACAAAGCCAGTTCGGAGGACTGTGGTCGATGAATCTGAAAATTTCTTCAGTGCCTTTCTCTCGCCAACTGATGTCCAGACCATTCA GAAGAGTCCAGTGGTATCAAAACCTCCAGCAAAATCACAACGACCAGAAGAAGAAGTGAAAAGCAGCTTACATGAATCCTTGCACATTGG CCAGTCAAGAACTCCTGAAACAACTGAATCACAAGTAAAAGACTCTTCTTTGTGTGTTTCAGGGGAAACTCTGGCAGCAGGTACTTCATC ACCTAAAACTGAAGGCAAGCACGAAGAAACTGTTAATAAAGAATCGGATATGAAGGTGCCAACTGTAAGTTTGAAAGTATCTGAAAGTGT AATTGATGTGAAAACAACTATGGAAAGTATATCTAATACGTCTACGCAGTCTCTCACAGCAGAAACAAAGGACATAGCTTTGGAACCTAA GGAACAAAAACATGAAGACAGGCAGAGCAATACACCTTCTCCTCCTGTTAGTACCTTTTCATCAGGTACTTCTACCACCAGTGATATTGA AGTTTTAGATCATGAAAGTGTAATAAGTGAGAGCTCAGCGAGCTCGAGACAAGAGACTACAGATTCAAAATCAAGTCTTCACTTGATGCA GACATCTTTTCAGCTTCTCTCTGCATCTGCTTGTCCTGAATATAATCGTTTAGATGATTTCCAAAAACTCACTGAGAGTTGCTGTTCATC TGATGCTTTTGAAAGAATAGACTCATTTAGTGTACAGTCATTAGATAGCCGGAGTGTAAGTGAAATCAATTCAGATGATGAATTGTCAGG CAAGGGATATGCTTTAGTGCCTATTATAGTTAATTCTTCAACTCCAAAGTCTAAAACAGTTGAATCTGCTGAAGGAAAATCTGAAGAAGT AAATGAAACATTAGTTATACCCACTGAGGAAGCAGAAATGGAAGAAAGTGGACGAAGTGCAACTCCTGTTAACTGTGAACAGCCTGATAT CTTGGTTTCTTCCACACCAATAAATGAAGGACAGACTGTGTTAGACAAGGTGGCTGAGCAGTGTGAACCTGCTGAAAGTCAGCCAGAAGC ACTTTCTGAGAAGGAAGATGTTTGCAAGACAGTTGAATTTCTGAATGAAAAGCTGGAAAAAAGGGAGGCTCAGTTATTATCTCTTAGTAA GGAAAAAGCACTTCTAGAAGAAGCTTTTGATAACCTGAAAGATGAAATGTTCAGAGTGAAAGAAGAAAGCAGTAGCATTTCTTCCTTGAA AGATGAGTTTACTCAAAGAATTGCAGAAGCAGAAAAGAAAGTTCAACTAGCCTGCAAAGAGAGAGATGCTGCTAAAAAGGAAATCAAAAA CATAAAAGAAGAACTTGCCACTAGATTAAATAGTAGTGAAACTGCAGACCTTTTGAAAGAGAAAGATGAGCAGATCCGAGGGTTAATGGA AGAAGGAGAAAAACTTTCAAAACAGCAGCTGCACAATTCTAACATCATCAAGAAATTAAGAGCTAAAGACAAGGAGAATGAAAATATGGT TGCAAAGCTGAACAAAAAAGTTAAAGAGCTAGAAGAGGAGTTGCAGCATTTGAAACAGGTCCTTGATGGCAAAGAAGAGGTTGAGAAACA ACATAGAGAAAATATTAAAAAACTAAATTCCATGGTAGAACGCCAAGAGAAAGATCTTGGCCGTCTTCAGGTAGACATGGATGAACTTGA AGAAAAGAACCGAAGTATTCAGGCTGCCCTGGATAGTGCATACAAAGAACTTACTGATCTTCACAAAGCCAATGCTGCAAAGGATAGTGA GGCACAGGAAGCTGCTCTGAGCCGTGAAATGAAAGCTAAAGAAGAACTTTCTGCAGCATTAGAGAAGGCCCAAGAAGAAGCCCGTCAGCA GCAAGAAACATTAGCCATTCAAGTGGGGGACCTTAGGCTTGCATTGCAGCGTACAGAACAAGCGGCTGCCAGAAAGGAGGATTATTTACG CCATGAGATCGGTGAACTTCAGCAGAGACTCCAGGAAGCAGAGAATCGAAACCAGGAACTGAGTCAAAGTGTTTCATCAACAACAAGACC ATTGCTTCGACAAATAGAAAATTTGCAAGCAACCCTGGGATCCCAGACATCGTCGTGGGAGAAATTAGAGAAGAATCTTTCTGATAGGCT TGGTGAATCCCAGACCTTGCTGGCAGCAGCAGTTGAGAGAGAACGTGCAGCTACAGAAGAACTCCTTGCTAACAAAATTCAGATGTCTTC CATGGAGTCACAGAATTCTCTTTTAAGACAGGAAAACAGTAGATTTCAAGCCCAGCTAGAATCAGAGAAAAATAGGCTGTGTAAACTGGA GGATGAGAACAATAGGTACCAGGTTGAATTGGAAAACCTAAAAGATGAATATGTAAGAACACTTGAAGAGACGAGGAAAGAAAAGACATT GTTGAATAGTCAGTTAGAAATGGAAAGAATGAAAGTTGAACAAGAAAGGAAGAAAGCCATTTTTACTCAAGAAACAATAAAAGAAAAGGA ACGCAAGCCATTTTCTGTTTCTAGCACTCCCACCATGTCACGCTCAAGTTCAATAAGTGGTGTTGATATGGCAGGACTACAGACATCTTT TCTGTCTCAGGATGAGTCTCATGATCACTCATTTGGACCAATGCCTATATCAGCAAATGGAAGCAATCTTTATGATGCTGTAAGGATGGG AGCAGGATCAAGCATAATTGAAAACCTACAGTCTCAGCTAAAGCTAAGGGAAGGGGAAATCACTCATTTACAGCTAGAAATTGGCAATCT AGAAAAAACTCGATCAATAATGGCTGAAGAACTAGTTAAATTAACAAATCAAAATGATGAACTTGAAGAGAAGGTGAAGGAGATACCCAA ACTTAGAACTCAGCTAAGAGATTTGGATCAAAGGTACAACACTATTCTGCAGATGTATGGAGAAAAAGCAGAAGAGGCAGAAGAACTTCG ATTAGATCTCGAAGATGTAAAAAATATGTACAAAACTCAAATAGATGAACTTTTAAGACAAAGTCTCAGTTAACTTGTGAAAATTGAATT CCCATCAAACTGAATGTAAGCATTTAATATCTAAACATTTAATGTGGACTTCCAATAAATTCTTTTATAGAATTAGAAAGTGGGATTTAC TGTAGAGTGTAAAAATTTTTTTAAAATTGTTTTACACTATGTAGTAATATTTACAGTTAAATTATTTTGTGCAATATTTGAACTTTATTT TTGAAACTATTCTTTAAAGATTTATTTTTTAAAGCATTCATTTTTTTTCCTTGAATAGCACAGAGATTTATTACTTTATCCTCATATAAA TATGGCTAGAGAAGAAGAATGGTGTTCATATATGTATTGTAGATATACAACTAGTTGTATCTATAATTTGTAAGTGTTTATATATATATT AAGAACATTTGAAGAGTAATGTTAACATACTGAAACTTTGAAATCTTTCACATTTAAAATTTCAACATATCTTAATTACTGCTCATGAAA ATGTACATTAAGTGTTAAAGTAAAAAATTATTAAATCTGTGGCTATTAAATTTTAAACTAATTTTTTTCCTTTAAAAGTAAGAGTCACAC TGACACTGTCTGAAATTTAAAGAGTGAATGATTTAAACTTAAAAAAAATTTTGATCTGAAAATTTATTTCACCCAGCTTTCACAATTAAG TCTGTATAAAATGTGGTACCTTTTGGTACCTATCCAGAGAAACCTGTACATATTCAATGTTATCTAGATGTGATTGGATAATGGAGAAAA TTTATTTATAATGATTTTGCAATGGCATCAATAACATTTAAATGATTTTGAAGAAGTATTATTTTACTACCCTATAAAATGAATCGAAAA TAATAAAGTTCTTAACATAATTTACTCTTTAAAAATTACCTGTTCATATTTTGTAAACCCATATTTTTAGCACATTAAAAATGAATGTTT GATATTACAGAATATTCATAACAAAATGGAAGAATTATAGGAATTAACTTGAATTTGGCATTTTTAATTTTGTGATTTATCATTTTATTT TTTCTTGAAATTTCAAACACAAGGAAAGCATAGAATAGCTTTTAAAAGTAGCTATGCCTTCTTCCAAATGTTATTTTATTCAAAAAGGTA ACCAGGTTGTGTTTTAAACCTGTGAAATATTGTGATGCATTTTATTACTGAAAGTTATTTAACTGCCTTTACTTGCACATAAAAACTCTC ATTTACGGCCAGGTGCTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCATATCACCTGATGTCAGGAGTTCAAGA CCAGCATGGCCAGCAGTTTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGTGTGCGCCTGTAATCCTAGCT ACTCGGGAGGCTGAGGCAGGAGCATTGCTTGAACCTGGGAGGTGGAGGTTACAATGAGCCAAGATTGTGCCACTGCACTCCAGCATGGGT GACAGAGAAAGACTCCGTCTCAAAAAAAAAAAAACAAACTCTTATTTAATTTTTAGTTAAAATTAAAACACTAGTACTTCAGAATATAGA TACAAGTACACCATCTTGAAGAATTTGGAGTTTTTCAGGGCAATTCAAATGACCTCATTTTTTGTTCTTTTTGTATTCCAGACAGTGTTT CTGTCATTGGATCTCTGATTGGTAGTGTTAATAAATATTCTTTCAGTGTGAGCCAGATTCATAAAATTAATTTTCTTCATTTTAGTAGTA AAAAGTAGTCTAATAGCTTTTTGTCAGCTTGATTTTTTTGTGTGTGTAATATTCAAGGGCAGAATGACAGGACAGATAAGCAATAAGAAA TGTATAGAATTAGAAAATATAGTAGTTCCCTCTTACCCATGGGACATACGTTCCAAGACCCCCAGTGAACGTCTGAAACCATGGATAGTA TAGACACCTCTATACACTGTTTTTTCCTATACATATATACCTATGATAAAGTTCTATTTATAAATCAGGGACAGCAAGAGATAAACAATA ACTGCAAATAGAACAATTATAACAGTGCACTGTAATAAAAGTGATGTAAATGTGATATGTCTGTCTCTTTCTCTCAAAATATCTTATTGT ACTGTACTCACCTGTAATCAGACTGTGGTTGACCGTGAGTAACCGAAACCACAGAAAGCAAAATCGTGGATAAGGGGAGACTACTCTATA TGAAACTTAAGTTACAAAATTCTCTGAAGCATTTGAAACTAGACGTTTTGGAATTATAAAATAGTCCCTTTAAAATATCCACTAGTAGAA AAAAACTTCATTTGCAGAGAAAAGATTGCAATAAAACTCATTCCTAAACTTTTCAATTTTATAAAATTAAACATTCTTTTTTTATCCGTA TTAACAATTTCTAGTTACATAGTTTCTAGTTACATATTACCATATATTACTCTTTATCTACAAATAAATAGCTGATACTCAAACTGATCA TATTTTGATTGTTAAACACTTGGATCTCTCAATACTTCTGTAAGTTAAAGTGAACTTAAACAGTTTCTTGAAAAACTCCAGTAGGTGGCA GAATACCTATTGAATATTCGTTGCTATACTTTGCTGTTTGTCATTAAAACATCTCTACCCATATTCTTGCAAAATAATATTTATATTTTA ATGGATAGGAAAATGATTTGCAATTAGATGTTTCCATTCTTGAAAGAAAAAAGCTGCAAATAACATTTTCAAGAATATAAAAAAATGAGT AAACAAAGGGAAGGTTGTTTGGTCATTTATAGACAATTAAGCACAGACTGTAGATGTCCTTCCAATTCTTGGGAGGCTAAACTGAGTCTA CCATTTCTTACATTTCTTTTACCTATTTTTTGAGAATTGCCAGTTGTACAGTGTTTAGCATGTGGAATGTACCAAATATATCTATGTTGT GACTTAAGATATTCTAAATGTGGATAACTTCTGACCTAGGAAACATGAAGTTTGTAGTGAAGTAAGTGAAAAGAATGTTCAGGAAATTTT TTTTCTCCATCTCTTCAGTTGGCATTTATTGAGAGTTTTATTTGAATGCTTATTAAAAGTATATGATTTATAATATTTAGAAAATAGAAG AAAAAAGAAAACTGTAGATGTTTTATCTTGTTTTAATACTGTATGTTTAGTACGTATACATTTATGTTCTAGTGTATCAAAATTTTTCAT TTTCATTAAAGTGAATCCAATTTTCCATATTCTAGGTCCATTTTAAACCATGAAAACTTTAATCACATATTTTGTAAAGGGCTGAAAGTA TGATTTAAACTACAGATTGATATATTTTAATTCTAAATGAAAGGTAATGTAAATAAGCATGGATCTGATTGAATAAAGATTTTAAAATAG >28833_28833_1_FAM19A4-TMF1_FAM19A4_chr3_68929881_ENST00000295569_TMF1_chr3_69097713_ENST00000398559_length(amino acids)=1089AA_BP=43 MRSPRMRVCAKSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHAGISSPVSGGWDTSTWGLKSNTEPQSPPIASPKAITKPVRRTVVDESE NFFSAFLSPTDVQTIQKSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKE SDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSAS SRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSST PKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFL NEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNSSET ADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVER QEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLA LQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERE RAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQ ERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLK LREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQI -------------------------------------------------------------- >28833_28833_2_FAM19A4-TMF1_FAM19A4_chr3_68929881_ENST00000295569_TMF1_chr3_69097713_ENST00000543976_length(transcript)=7120nt_BP=623nt AATCAGCGCGTTCCGCGGCGGGCCCGGCCCCTCCTGGTCAGCGCGCTAGCTGGGCTCGGCTCCGCACTGCTAGCTGCGCGCCGCCCTGGA CGGGGCGCACCGACTGCGCGCGCGGCTGCGGGCAAACATCGGGAGTCCTGCCTCAGCTGCCGCTTCTCCAGCAGCAGCTTCAGGCTTCTC CCGCAGGAGCTTCGGGCTTCTCCTGGTAGAGACGTGGGAACTTTTCTTCTCCTGGCGAGGCTGCAGAGGTGATGGGCCGCTCCCGGGGCT CCCGCGGGGAGGCGGCACGGTGAGCGTCCTCGGGCTCCGGTGCGGCGATCAGTACCTAGTTCCGGACGCGCCGGTCCGACTTGGATGCCG GCTCTAGTCGAGTCTTCTGAGCTACGATAATTTTTTGGAACGGCAGAAATGATTGGTTCTAGCAACAGATGGGAATTTGGAGTCACTCTG AAATATATCCTGGAATAAGTGTGTTTGACTAGAACCACATCTTATGAGGTCCCCAAGGATGAGAGTCTGTGCTAAGTCAGTGTTGCTGTC GCACTGGCTCTTTCTAGCCTACGTGTTAATGGTGTGCTGTAAGCTGATGTCCGCCTCAAGCCAGCACCTCCGGGGACATGCAGGAATAAG TTCCCCTGTCAGTGGAGGATGGGATACTTCAACCTGGGGGTTGAAATCAAACACTGAACCTCAGAGTCCACCAATAGCCTCTCCTAAAGC AATCACAAAGCCAGTTCGGAGGACTGTGGTCGATGAATCTGAAAATTTCTTCAGTGCCTTTCTCTCGCCAACTGATGTCCAGACCATTCA GAAGAGTCCAGTGGTATCAAAACCTCCAGCAAAATCACAACGACCAGAAGAAGAAGTGAAAAGCAGCTTACATGAATCCTTGCACATTGG CCAGTCAAGAACTCCTGAAACAACTGAATCACAAGTAAAAGACTCTTCTTTGTGTGTTTCAGGGGAAACTCTGGCAGCAGGTACTTCATC ACCTAAAACTGAAGGCAAGCACGAAGAAACTGTTAATAAAGAATCGGATATGAAGGTGCCAACTGTAAGTTTGAAAGTATCTGAAAGTGT AATTGATGTGAAAACAACTATGGAAAGTATATCTAATACGTCTACGCAGTCTCTCACAGCAGAAACAAAGGACATAGCTTTGGAACCTAA GGAACAAAAACATGAAGACAGGCAGAGCAATACACCTTCTCCTCCTGTTAGTACCTTTTCATCAGGTACTTCTACCACCAGTGATATTGA AGTTTTAGATCATGAAAGTGTAATAAGTGAGAGCTCAGCGAGCTCGAGACAAGAGACTACAGATTCAAAATCAAGTCTTCACTTGATGCA GACATCTTTTCAGCTTCTCTCTGCATCTGCTTGTCCTGAATATAATCGTTTAGATGATTTCCAAAAACTCACTGAGAGTTGCTGTTCATC TGATGCTTTTGAAAGAATAGACTCATTTAGTGTACAGTCATTAGATAGCCGGAGTGTAAGTGAAATCAATTCAGATGATGAATTGTCAGG CAAGGGATATGCTTTAGTGCCTATTATAGTTAATTCTTCAACTCCAAAGTCTAAAACAGTTGAATCTGCTGAAGGAAAATCTGAAGAAGT AAATGAAACATTAGTTATACCCACTGAGGAAGCAGAAATGGAAGAAAGTGGACGAAGTGCAACTCCTGTTAACTGTGAACAGCCTGATAT CTTGGTTTCTTCCACACCAATAAATGAAGGACAGACTGTGTTAGACAAGGTGGCTGAGCAGTGTGAACCTGCTGAAAGTCAGCCAGAAGC ACTTTCTGAGAAGGAAGATGTTTGCAAGGTAACTCTAACAGTTGAATTTCTGAATGAAAAGCTGGAAAAAAGGGAGGCTCAGTTATTATC TCTTAGTAAGGAAAAAGCACTTCTAGAAGAAGCTTTTGATAACCTGAAAGATGAAATGTTCAGAGTGAAAGAAGAAAGCAGTAGCATTTC TTCCTTGAAAGATGAGTTTACTCAAAGAATTGCAGAAGCAGAAAAGAAAGTTCAACTAGCCTGCAAAGAGAGAGATGCTGCTAAAAAGGA AATCAAAAACATAAAAGAAGAACTTGCCACTAGATTAAATAGTAGTGAAACTGCAGACCTTTTGAAAGAGAAAGATGAGCAGATCCGAGG GTTAATGGAAGAAGGAGAAAAACTTTCAAAACAGCAGCTGCACAATTCTAACATCATCAAGAAATTAAGAGCTAAAGACAAGGAGAATGA AAATATGGTTGCAAAGCTGAACAAAAAAGTTAAAGAGCTAGAAGAGGAGTTGCAGCATTTGAAACAGGTCCTTGATGGCAAAGAAGAGGT TGAGAAACAACATAGAGAAAATATTAAAAAACTAAATTCCATGGTAGAACGCCAAGAGAAAGATCTTGGCCGTCTTCAGGTAGACATGGA TGAACTTGAAGAAAAGAACCGAAGTATTCAGGCTGCCCTGGATAGTGCATACAAAGAACTTACTGATCTTCACAAAGCCAATGCTGCAAA GGATAGTGAGGCACAGGAAGCTGCTCTGAGCCGTGAAATGAAAGCTAAAGAAGAACTTTCTGCAGCATTAGAGAAGGCCCAAGAAGAAGC CCGTCAGCAGCAAGAAACATTAGCCATTCAAGTGGGGGACCTTAGGCTTGCATTGCAGCGTACAGAACAAGCGGCTGCCAGAAAGGAGGA TTATTTACGCCATGAGATCGGTGAACTTCAGCAGAGACTCCAGGAAGCAGAGAATCGAAACCAGGAACTGAGTCAAAGTGTTTCATCAAC AACAAGACCATTGCTTCGACAAATAGAAAATTTGCAAGCAACCCTGGGATCCCAGACATCGTCGTGGGAGAAATTAGAGAAGAATCTTTC TGATAGGCTTGGTGAATCCCAGACCTTGCTGGCAGCAGCAGTTGAGAGAGAACGTGCAGCTACAGAAGAACTCCTTGCTAACAAAATTCA GATGTCTTCCATGGAGTCACAGAATTCTCTTTTAAGACAGGAAAACAGTAGATTTCAAGCCCAGCTAGAATCAGAGAAAAATAGGCTGTG TAAACTGGAGGATGAGAACAATAGGTACCAGGTTGAATTGGAAAACCTAAAAGATGAATATGTAAGAACACTTGAAGAGACGAGGAAAGA AAAGACATTGTTGAATAGTCAGTTAGAAATGGAAAGAATGAAAGTTGAACAAGAAAGGAAGAAAGCCATTTTTACTCAAGAAACAATAAA AGAAAAGGAACGCAAGCCATTTTCTGTTTCTAGCACTCCCACCATGTCACGCTCAAGTTCAATAAGTGGTGTTGATATGGCAGGACTACA GACATCTTTTCTGTCTCAGGATGAGTCTCATGATCACTCATTTGGACCAATGCCTATATCAGCAAATGGAAGCAATCTTTATGATGCTGT AAGGATGGGAGCAGGATCAAGCATAATTGAAAACCTACAGTCTCAGCTAAAGCTAAGGGAAGGGGAAATCACTCATTTACAGCTAGAAAT TGGCAATCTAGAAAAAACTCGATCAATAATGGCTGAAGAACTAGTTAAATTAACAAATCAAAATGATGAACTTGAAGAGAAGGTGAAGGA GATACCCAAACTTAGAACTCAGCTAAGAGATTTGGATCAAAGGTACAACACTATTCTGCAGATGTATGGAGAAAAAGCAGAAGAGGCAGA AGAACTTCGATTAGATCTCGAAGATGTAAAAAATATGTACAAAACTCAAATAGATGAACTTTTAAGACAAAGTCTCAGTTAACTTGTGAA AATTGAATTCCCATCAAACTGAATGTAAGCATTTAATATCTAAACATTTAATGTGGACTTCCAATAAATTCTTTTATAGAATTAGAAAGT GGGATTTACTGTAGAGTGTAAAAATTTTTTTAAAATTGTTTTACACTATGTAGTAATATTTACAGTTAAATTATTTTGTGCAATATTTGA ACTTTATTTTTGAAACTATTCTTTAAAGATTTATTTTTTAAAGCATTCATTTTTTTTCCTTGAATAGCACAGAGATTTATTACTTTATCC TCATATAAATATGGCTAGAGAAGAAGAATGGTGTTCATATATGTATTGTAGATATACAACTAGTTGTATCTATAATTTGTAAGTGTTTAT ATATATATTAAGAACATTTGAAGAGTAATGTTAACATACTGAAACTTTGAAATCTTTCACATTTAAAATTTCAACATATCTTAATTACTG CTCATGAAAATGTACATTAAGTGTTAAAGTAAAAAATTATTAAATCTGTGGCTATTAAATTTTAAACTAATTTTTTTCCTTTAAAAGTAA GAGTCACACTGACACTGTCTGAAATTTAAAGAGTGAATGATTTAAACTTAAAAAAAATTTTGATCTGAAAATTTATTTCACCCAGCTTTC ACAATTAAGTCTGTATAAAATGTGGTACCTTTTGGTACCTATCCAGAGAAACCTGTACATATTCAATGTTATCTAGATGTGATTGGATAA TGGAGAAAATTTATTTATAATGATTTTGCAATGGCATCAATAACATTTAAATGATTTTGAAGAAGTATTATTTTACTACCCTATAAAATG AATCGAAAATAATAAAGTTCTTAACATAATTTACTCTTTAAAAATTACCTGTTCATATTTTGTAAACCCATATTTTTAGCACATTAAAAA TGAATGTTTGATATTACAGAATATTCATAACAAAATGGAAGAATTATAGGAATTAACTTGAATTTGGCATTTTTAATTTTGTGATTTATC ATTTTATTTTTTCTTGAAATTTCAAACACAAGGAAAGCATAGAATAGCTTTTAAAAGTAGCTATGCCTTCTTCCAAATGTTATTTTATTC AAAAAGGTAACCAGGTTGTGTTTTAAACCTGTGAAATATTGTGATGCATTTTATTACTGAAAGTTATTTAACTGCCTTTACTTGCACATA AAAACTCTCATTTACGGCCAGGTGCTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCATATCACCTGATGTCAGG AGTTCAAGACCAGCATGGCCAGCAGTTTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCTGGCGTGGTGGTGTGCGCCTGTA ATCCTAGCTACTCGGGAGGCTGAGGCAGGAGCATTGCTTGAACCTGGGAGGTGGAGGTTACAATGAGCCAAGATTGTGCCACTGCACTCC AGCATGGGTGACAGAGAAAGACTCCGTCTCAAAAAAAAAAAAACAAACTCTTATTTAATTTTTAGTTAAAATTAAAACACTAGTACTTCA GAATATAGATACAAGTACACCATCTTGAAGAATTTGGAGTTTTTCAGGGCAATTCAAATGACCTCATTTTTTGTTCTTTTTGTATTCCAG ACAGTGTTTCTGTCATTGGATCTCTGATTGGTAGTGTTAATAAATATTCTTTCAGTGTGAGCCAGATTCATAAAATTAATTTTCTTCATT TTAGTAGTAAAAAGTAGTCTAATAGCTTTTTGTCAGCTTGATTTTTTTGTGTGTGTAATATTCAAGGGCAGAATGACAGGACAGATAAGC AATAAGAAATGTATAGAATTAGAAAATATAGTAGTTCCCTCTTACCCATGGGACATACGTTCCAAGACCCCCAGTGAACGTCTGAAACCA TGGATAGTATAGACACCTCTATACACTGTTTTTTCCTATACATATATACCTATGATAAAGTTCTATTTATAAATCAGGGACAGCAAGAGA TAAACAATAACTGCAAATAGAACAATTATAACAGTGCACTGTAATAAAAGTGATGTAAATGTGATATGTCTGTCTCTTTCTCTCAAAATA TCTTATTGTACTGTACTCACCTGTAATCAGACTGTGGTTGACCGTGAGTAACCGAAACCACAGAAAGCAAAATCGTGGATAAGGGGAGAC TACTCTATATGAAACTTAAGTTACAAAATTCTCTGAAGCATTTGAAACTAGACGTTTTGGAATTATAAAATAGTCCCTTTAAAATATCCA CTAGTAGAAAAAAACTTCATTTGCAGAGAAAAGATTGCAATAAAACTCATTCCTAAACTTTTCAATTTTATAAAATTAAACATTCTTTTT TTATCCGTATTAACAATTTCTAGTTACATAGTTTCTAGTTACATATTACCATATATTACTCTTTATCTACAAATAAATAGCTGATACTCA AACTGATCATATTTTGATTGTTAAACACTTGGATCTCTCAATACTTCTGTAAGTTAAAGTGAACTTAAACAGTTTCTTGAAAAACTCCAG TAGGTGGCAGAATACCTATTGAATATTCGTTGCTATACTTTGCTGTTTGTCATTAAAACATCTCTACCCATATTCTTGCAAAATAATATT TATATTTTAATGGATAGGAAAATGATTTGCAATTAGATGTTTCCATTCTTGAAAGAAAAAAGCTGCAAATAACATTTTCAAGAATATAAA AAAATGAGTAAACAAAGGGAAGGTTGTTTGGTCATTTATAGACAATTAAGCACAGACTGTAGATGTCCTTCCAATTCTTGGGAGGCTAAA CTGAGTCTACCATTTCTTACATTTCTTTTACCTATTTTTTGAGAATTGCCAGTTGTACAGTGTTTAGCATGTGGAATGTACCAAATATAT CTATGTTGTGACTTAAGATATTCTAAATGTGGATAACTTCTGACCTAGGAAACATGAAGTTTGTAGTGAAGTAAGTGAAAAGAATGTTCA GGAAATTTTTTTTCTCCATCTCTTCAGTTGGCATTTATTGAGAGTTTTATTTGAATGCTTATTAAAAGTATATGATTTATAATATTTAGA AAATAGAAGAAAAAAGAAAACTGTAGATGTTTTATCTTGTTTTAATACTGTATGTTTAGTACGTATACATTTATGTTCTAGTGTATCAAA ATTTTTCATTTTCATTAAAGTGAATCCAATTTTCCATATTCTAGGTCCATTTTAAACCATGAAAACTTTAATCACATATTTTGTAAAGGG CTGAAAGTATGATTTAAACTACAGATTGATATATTTTAATTCTAAATGAAAGGTAATGTAAATAAGCATGGATCTGATTGAATAAAGATT >28833_28833_2_FAM19A4-TMF1_FAM19A4_chr3_68929881_ENST00000295569_TMF1_chr3_69097713_ENST00000543976_length(amino acids)=1092AA_BP=43 MRSPRMRVCAKSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHAGISSPVSGGWDTSTWGLKSNTEPQSPPIASPKAITKPVRRTVVDESE NFFSAFLSPTDVQTIQKSPVVSKPPAKSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEETVNKE SDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSNTPSPPVSTFSSGTSTTSDIEVLDHESVISESSAS SRQETTDSKSSLHLMQTSFQLLSASACPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIVNSST PKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKVTLTV EFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLNS SETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSM VERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDL RLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAV ERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMK VEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQS QLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FAM19A4-TMF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TMF1 | chr3:68929881 | chr3:69097713 | ENST00000398559 | 0 | 17 | 333_342 | 47.333333333333336 | 1094.0 | Elongin BC complex | |
| Tgene | TMF1 | chr3:68929881 | chr3:69097713 | ENST00000543976 | 0 | 17 | 333_342 | 47.333333333333336 | 1097.0 | Elongin BC complex |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FAM19A4-TMF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FAM19A4-TMF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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