FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FAM19A5-TBC1D22A (FusionGDB2 ID:28847)

Fusion Gene Summary for FAM19A5-TBC1D22A

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM19A5-TBC1D22A
Fusion gene ID: 28847
HgeneTgene
Gene symbol

FAM19A5

TBC1D22A

Gene ID

25817

25771

Gene nameTAFA chemokine like family member 5TBC1 domain family member 22A
SynonymsFAM19A5|QLLK5208|TAFA-5|UNQ5208C22orf4|HSC79E021
Cytomap

22q13.32

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionchemokine-like protein TAFA-5TAFA protein 5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5family with sequence similarity 19 member A5, C-C motif chemokine likeprotein FAM19A5TBC1 domain family member 22Aputative GTPase activator
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358295, ENST00000402357, 
ENST00000406880, ENST00000473898, 
ENST00000406733, ENST00000472791, 
ENST00000337137, ENST00000355704, 
ENST00000380995, ENST00000407381, 
Fusion gene scores* DoF score13 X 9 X 5=58522 X 24 X 11=5808
# samples 1232
** MAII scorelog2(12/585*10)=-2.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/5808*10)=-4.18189764310839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM19A5 [Title/Abstract] AND TBC1D22A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM19A5(49042558)-TBC1D22A(47274549), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM19A5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBC1D22A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THYMTCGA-5K-AAAP-01AFAM19A5chr22

49042558

-TBC1D22Achr22

47274549

+
ChimerDB4THYMTCGA-5K-AAAPFAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+


Top

Fusion Gene ORF analysis for FAM19A5-TBC1D22A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358295ENST00000406733FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
5CDS-intronENST00000358295ENST00000472791FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
5CDS-intronENST00000402357ENST00000406733FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
5CDS-intronENST00000402357ENST00000472791FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000358295ENST00000337137FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000358295ENST00000355704FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000358295ENST00000380995FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000358295ENST00000407381FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000402357ENST00000337137FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000402357ENST00000355704FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000402357ENST00000380995FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
In-frameENST00000402357ENST00000407381FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000406880ENST00000337137FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000406880ENST00000355704FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000406880ENST00000380995FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000406880ENST00000407381FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000473898ENST00000337137FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000473898ENST00000355704FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000473898ENST00000380995FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-3CDSENST00000473898ENST00000407381FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-intronENST00000406880ENST00000406733FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-intronENST00000406880ENST00000472791FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-intronENST00000473898ENST00000406733FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+
intron-intronENST00000473898ENST00000472791FAM19A5chr22

49042558

+TBC1D22Achr22

47274549

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402357FAM19A5chr2249042558+ENST00000337137TBC1D22Achr2247274549+3379395881311407
ENST00000402357FAM19A5chr2249042558+ENST00000380995TBC1D22Achr2247274549+87439588873262
ENST00000402357FAM19A5chr2249042558+ENST00000407381TBC1D22Achr2247274549+1769395881311407
ENST00000402357FAM19A5chr2249042558+ENST00000355704TBC1D22Achr2247274549+1772395881311407
ENST00000358295FAM19A5chr2249042558+ENST00000337137TBC1D22Achr2247274549+34004161751332385
ENST00000358295FAM19A5chr2249042558+ENST00000380995TBC1D22Achr2247274549+895416175894240
ENST00000358295FAM19A5chr2249042558+ENST00000407381TBC1D22Achr2247274549+17904161751332385
ENST00000358295FAM19A5chr2249042558+ENST00000355704TBC1D22Achr2247274549+17934161751332385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402357ENST00000337137FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0028340520.997166
ENST00000402357ENST00000380995FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0119627840.9880372
ENST00000402357ENST00000407381FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0059490350.9940509
ENST00000402357ENST00000355704FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0059757090.99402434
ENST00000358295ENST00000337137FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0019701450.9980299
ENST00000358295ENST00000380995FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0051887770.9948112
ENST00000358295ENST00000407381FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0040014370.9959986
ENST00000358295ENST00000355704FAM19A5chr2249042558+TBC1D22Achr2247274549+0.0040090060.99599105

Top

Fusion Genomic Features for FAM19A5-TBC1D22A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM19A5chr2249042558+TBC1D22Achr2247274548+2.16E-070.99999976
FAM19A5chr2249042558+TBC1D22Achr2247274548+2.16E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FAM19A5-TBC1D22A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:49042558/chr22:47274549)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTBC1D22Achr22:49042558chr22:47274549ENST00000337137313222_446212518.0DomainRab-GAP TBC
TgeneTBC1D22Achr22:49042558chr22:47274549ENST00000355704111222_446134440.0DomainRab-GAP TBC
TgeneTBC1D22Achr22:49042558chr22:47274549ENST0000038099539222_446165325.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for FAM19A5-TBC1D22A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28847_28847_1_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000337137_length(transcript)=3400nt_BP=416nt
AAAGACACAAATCGCCTCCCGGAGTGGCGCCTCCAGTCGCGGCGGAGCGCGGCGTTGGCGGCGGATGGAGGGCGCGAGCGGGCGGCCGCG
GAGGCTGCACCCGGCGGGGCGCTGATGCGGCGCCTGGACCTTCGCTGCGCGACTTCGGGGGCGTCGGCCGAGTTGGGACTCCGCGATGCA
GCTCCTGAAGGCGCTCTGGGCACTGGCAGGGGCCGCGCTCTGCTGCTTCCTCGTCCTAGTGATCCACGCGCAGTTCCTCAAAGAAGGTCA
GCTGGCCGCCGGCACCTGTGAGATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGC
GTGTAGAAAGGGGCAGATCGCCGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCC
TAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACA
AAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACAT
CCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCC
AGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGA
CACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCAT
TCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCA
CCGGCACCTGGACCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTG
TACCATCCGCCTGTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATG
GAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACAT
CAGCCTGTTGCTGGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCA
GCTGGCCTCACTGTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGT
GAGGTGGCCCCACCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTG
AGATACCAAAGAGAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGC
CAAATGACTGCCTCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAA
CGAGGTAGTGGCCATCTCATACCTACTCTGAAATGCAAAACTTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGA
GACGTTGCGCTGACCCGGGGTCTCTGTGCCGCGAGGTCCCCTCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCC
TGCTTGCTTGGTTTAAACGTGGCTGGGAAGCTGAAGGCTGGAGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAG
GCTGGGAGCAGAGGGAGGCCTCGCCATCGCCTTACTTTCCACCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAG
GGCCAAGTGGCCCCGCCACGCAGGTAGGCGCCGGCCTCAGCCAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCA
GACGGGCAGGGGGTCGCGTCCCTGTCATCAAAGCCCTGAACCACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGA
CTTCCTGGGACTTGCTGTCCTTGTCCAGGTCTGCCAGGTGTAGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGG
TTCCTCCGTGGACCGGTTCCGCCATGGACCGGTTCCGCCATGGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTG
GACTGGTTCCCGCCGTGGACCAGTTCCCGCTGTATACTGGTTCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAG
TGCGGAAGGGCCCAGAGCTGGTCCCTGCCCAGCGCCCTGCTAGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTT
CCCTCGGTGTGTCACAGGCTGCATGACCCCTGGAATGCGGGCAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCA
CGTCCTCAGCGACCCACTGGTGACTGACTTCCCAGACTCTCCTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTG
CCAGAGACTGTGGGACATACAGGCATAAGTGATGTGTGTGTTTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAAT
TAGCACAAAATGCTGTGCAAACGTCAGATGCTCCCAAACCAGCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCT
GCCTTCCGTGTCCCCACCCCAGGGTCAAGGGTTCCTCAGACCAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGA
TTCCGTCACAAGAAGAGCCGCCCCTCGGCCGTGTGCAGGAAGCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCA
GCTCAGATCATGCCGTGTGGCCAGAAGGCTGCGGACACAACTGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGA
GTTCAGCCCTGTGTGCATTTCCTCATGTATGTAAACGCCAAGACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCC

>28847_28847_1_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000337137_length(amino acids)=385AA_BP=80
MQLLKALWALAGAALCCFLVLVIHAQFLKEGQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDEELRRLSWSG
IPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIR
HPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQ
VHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDE

--------------------------------------------------------------
>28847_28847_2_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000355704_length(transcript)=1793nt_BP=416nt
AAAGACACAAATCGCCTCCCGGAGTGGCGCCTCCAGTCGCGGCGGAGCGCGGCGTTGGCGGCGGATGGAGGGCGCGAGCGGGCGGCCGCG
GAGGCTGCACCCGGCGGGGCGCTGATGCGGCGCCTGGACCTTCGCTGCGCGACTTCGGGGGCGTCGGCCGAGTTGGGACTCCGCGATGCA
GCTCCTGAAGGCGCTCTGGGCACTGGCAGGGGCCGCGCTCTGCTGCTTCCTCGTCCTAGTGATCCACGCGCAGTTCCTCAAAGAAGGTCA
GCTGGCCGCCGGCACCTGTGAGATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGC
GTGTAGAAAGGGGCAGATCGCCGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCC
TAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACA
AAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACAT
CCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCC
AGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGA
CACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCAT
TCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCA
CCGGCACCTGGACCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTG
TACCATCCGCCTGTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATG
GAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACAT
CAGCCTGTTGCTGGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCA
GCTGGCCTCACTGTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGT
GAGGTGGCCCCACCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTG
AGATACCAAAGAGAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGC
CAAATGACTGCCTCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAA

>28847_28847_2_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000355704_length(amino acids)=385AA_BP=80
MQLLKALWALAGAALCCFLVLVIHAQFLKEGQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDEELRRLSWSG
IPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIR
HPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQ
VHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDE

--------------------------------------------------------------
>28847_28847_3_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000380995_length(transcript)=895nt_BP=416nt
AAAGACACAAATCGCCTCCCGGAGTGGCGCCTCCAGTCGCGGCGGAGCGCGGCGTTGGCGGCGGATGGAGGGCGCGAGCGGGCGGCCGCG
GAGGCTGCACCCGGCGGGGCGCTGATGCGGCGCCTGGACCTTCGCTGCGCGACTTCGGGGGCGTCGGCCGAGTTGGGACTCCGCGATGCA
GCTCCTGAAGGCGCTCTGGGCACTGGCAGGGGCCGCGCTCTGCTGCTTCCTCGTCCTAGTGATCCACGCGCAGTTCCTCAAAGAAGGTCA
GCTGGCCGCCGGCACCTGTGAGATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGC
GTGTAGAAAGGGGCAGATCGCCGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCC
TAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACA
AAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACAT
CCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCC
AGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGCCTTTCCAGGTTGTGG

>28847_28847_3_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000380995_length(amino acids)=240AA_BP=80
MQLLKALWALAGAALCCFLVLVIHAQFLKEGQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDEELRRLSWSG
IPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIR

--------------------------------------------------------------
>28847_28847_4_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000407381_length(transcript)=1790nt_BP=416nt
AAAGACACAAATCGCCTCCCGGAGTGGCGCCTCCAGTCGCGGCGGAGCGCGGCGTTGGCGGCGGATGGAGGGCGCGAGCGGGCGGCCGCG
GAGGCTGCACCCGGCGGGGCGCTGATGCGGCGCCTGGACCTTCGCTGCGCGACTTCGGGGGCGTCGGCCGAGTTGGGACTCCGCGATGCA
GCTCCTGAAGGCGCTCTGGGCACTGGCAGGGGCCGCGCTCTGCTGCTTCCTCGTCCTAGTGATCCACGCGCAGTTCCTCAAAGAAGGTCA
GCTGGCCGCCGGCACCTGTGAGATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGC
GTGTAGAAAGGGGCAGATCGCCGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCC
TAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACA
AAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACAT
CCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCC
AGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGA
CACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCAT
TCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCA
CCGGCACCTGGACCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTG
TACCATCCGCCTGTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATG
GAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACAT
CAGCCTGTTGCTGGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCA
GCTGGCCTCACTGTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGT
GAGGTGGCCCCACCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTG
AGATACCAAAGAGAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGC
CAAATGACTGCCTCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAA

>28847_28847_4_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000358295_TBC1D22A_chr22_47274549_ENST00000407381_length(amino acids)=385AA_BP=80
MQLLKALWALAGAALCCFLVLVIHAQFLKEGQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDEELRRLSWSG
IPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIR
HPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQ
VHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDE

--------------------------------------------------------------
>28847_28847_5_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000337137_length(transcript)=3379nt_BP=395nt
GGGCCCGGGCGCGGCGGCGGCGGCGGCGGAGGATGGCGCGCGCGGGGCCCGCACGTGGAGGCCGGCGCGGGGGCGCGGGCAGGGCCGGCT
GCTGAGACGCGCTGCTGCCCCCCGCGCGGGCGCCGCGGCTTCAATGGCGCCATCGCCCAGGACCGGCAGCCGGCAAGATGCGACCGCCCT
GCCCAGCATGTCCTCAACTTTCTGGGCGTTCATGATCCTGGCCAGCCTGCTCATCGCCTACTGCAGTCAGCTGGCCGCCGGCACCTGTGA
GATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGCGTGTAGAAAGGGGCAGATCGC
CGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGT
GCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGC
CCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGACCAACACGA
AGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCTGTGGGACAC
CTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGA
AAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGC
CTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACTGTCCCGGGT
GGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCACCCTCCAGG
GGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGAGAGCCAGGG
GAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCCTCGTGCTGC
CCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGCCATCTCATA
CCTACTCTGAAATGCAAAACTTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGAGACGTTGCGCTGACCCGGGGT
CTCTGTGCCGCGAGGTCCCCTCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCCTGCTTGCTTGGTTTAAACGTG
GCTGGGAAGCTGAAGGCTGGAGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAGGCTGGGAGCAGAGGGAGGCCT
CGCCATCGCCTTACTTTCCACCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAGGGCCAAGTGGCCCCGCCACGC
AGGTAGGCGCCGGCCTCAGCCAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCAGACGGGCAGGGGGTCGCGTCC
CTGTCATCAAAGCCCTGAACCACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGACTTCCTGGGACTTGCTGTCCT
TGTCCAGGTCTGCCAGGTGTAGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGGTTCCTCCGTGGACCGGTTCCG
CCATGGACCGGTTCCGCCATGGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTGGACTGGTTCCCGCCGTGGACC
AGTTCCCGCTGTATACTGGTTCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAGTGCGGAAGGGCCCAGAGCTGG
TCCCTGCCCAGCGCCCTGCTAGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTTCCCTCGGTGTGTCACAGGCTG
CATGACCCCTGGAATGCGGGCAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCACGTCCTCAGCGACCCACTGGT
GACTGACTTCCCAGACTCTCCTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTGCCAGAGACTGTGGGACATACA
GGCATAAGTGATGTGTGTGTTTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAATTAGCACAAAATGCTGTGCAAA
CGTCAGATGCTCCCAAACCAGCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCTGCCTTCCGTGTCCCCACCCCA
GGGTCAAGGGTTCCTCAGACCAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGATTCCGTCACAAGAAGAGCCGC
CCCTCGGCCGTGTGCAGGAAGCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCAGCTCAGATCATGCCGTGTGGC
CAGAAGGCTGCGGACACAACTGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGAGTTCAGCCCTGTGTGCATTTC
CTCATGTATGTAAACGCCAAGACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCCATCTGGAATGTTCGGGGTGTG

>28847_28847_5_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000337137_length(amino acids)=407AA_BP=102
MLRRAAAPRAGAAASMAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQI
AGTTRARPACVDEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPE
ALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTF
AQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILE

--------------------------------------------------------------
>28847_28847_6_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000355704_length(transcript)=1772nt_BP=395nt
GGGCCCGGGCGCGGCGGCGGCGGCGGCGGAGGATGGCGCGCGCGGGGCCCGCACGTGGAGGCCGGCGCGGGGGCGCGGGCAGGGCCGGCT
GCTGAGACGCGCTGCTGCCCCCCGCGCGGGCGCCGCGGCTTCAATGGCGCCATCGCCCAGGACCGGCAGCCGGCAAGATGCGACCGCCCT
GCCCAGCATGTCCTCAACTTTCTGGGCGTTCATGATCCTGGCCAGCCTGCTCATCGCCTACTGCAGTCAGCTGGCCGCCGGCACCTGTGA
GATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGCGTGTAGAAAGGGGCAGATCGC
CGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGT
GCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGC
CCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGACCAACACGA
AGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCTGTGGGACAC
CTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGA
AAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGC
CTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACTGTCCCGGGT
GGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCACCCTCCAGG
GGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGAGAGCCAGGG
GAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCCTCGTGCTGC
CCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGCCATCTCATA

>28847_28847_6_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000355704_length(amino acids)=407AA_BP=102
MLRRAAAPRAGAAASMAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQI
AGTTRARPACVDEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPE
ALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTF
AQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILE

--------------------------------------------------------------
>28847_28847_7_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000380995_length(transcript)=874nt_BP=395nt
GGGCCCGGGCGCGGCGGCGGCGGCGGCGGAGGATGGCGCGCGCGGGGCCCGCACGTGGAGGCCGGCGCGGGGGCGCGGGCAGGGCCGGCT
GCTGAGACGCGCTGCTGCCCCCCGCGCGGGCGCCGCGGCTTCAATGGCGCCATCGCCCAGGACCGGCAGCCGGCAAGATGCGACCGCCCT
GCCCAGCATGTCCTCAACTTTCTGGGCGTTCATGATCCTGGCCAGCCTGCTCATCGCCTACTGCAGTCAGCTGGCCGCCGGCACCTGTGA
GATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGCGTGTAGAAAGGGGCAGATCGC
CGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGCCTTTCCAGGTTGTGGTCGGCCTCAGATTCCCATCCT

>28847_28847_7_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000380995_length(amino acids)=262AA_BP=102
MLRRAAAPRAGAAASMAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQI
AGTTRARPACVDEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPE

--------------------------------------------------------------
>28847_28847_8_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000407381_length(transcript)=1769nt_BP=395nt
GGGCCCGGGCGCGGCGGCGGCGGCGGCGGAGGATGGCGCGCGCGGGGCCCGCACGTGGAGGCCGGCGCGGGGGCGCGGGCAGGGCCGGCT
GCTGAGACGCGCTGCTGCCCCCCGCGCGGGCGCCGCGGCTTCAATGGCGCCATCGCCCAGGACCGGCAGCCGGCAAGATGCGACCGCCCT
GCCCAGCATGTCCTCAACTTTCTGGGCGTTCATGATCCTGGCCAGCCTGCTCATCGCCTACTGCAGTCAGCTGGCCGCCGGCACCTGTGA
GATTGTGACCTTGGACCGGGACAGCAGCCAGCCTCGGAGGACGATCGCCCGGCAGACCGCCCGCTGTGCGTGTAGAAAGGGGCAGATCGC
CGGCACCACGAGAGCCCGGCCCGCCTGTGTGGACGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC
GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT
TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC
GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG
TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGT
GCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGC
CCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGACCAACACGA
AGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCTGTGGGACAC
CTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGA
AAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGC
CTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACTGTCCCGGGT
GGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCACCCTCCAGG
GGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGAGAGCCAGGG
GAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCCTCGTGCTGC
CCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGCCATCTCATA

>28847_28847_8_FAM19A5-TBC1D22A_FAM19A5_chr22_49042558_ENST00000402357_TBC1D22A_chr22_47274549_ENST00000407381_length(amino acids)=407AA_BP=102
MLRRAAAPRAGAAASMAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQI
AGTTRARPACVDEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPE
ALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTF
AQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FAM19A5-TBC1D22A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FAM19A5-TBC1D22A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FAM19A5-TBC1D22A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource