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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FAM208B-NET1 (FusionGDB2 ID:28873)

Fusion Gene Summary for FAM208B-NET1

Fusion gene summary

Fusion gene information	Fusion gene name: FAM208B-NET1
	Fusion gene ID: 28873
		Hgene	Tgene
	Gene symbol	FAM208B	NET1
	Gene ID	54906	55119
	Gene name	transcription activation suppressor family member 2	pre-mRNA processing factor 38B
	Synonyms	C10orf18\|FAM208B\|bA318E3.2	NET1
	Cytomap	10p15.1	1p13.3
	Type of gene	protein-coding	protein-coding
	Description	protein TASOR 2family with sequence similarity 208 member Bprotein FAM208B	pre-mRNA-splicing factor 38BPRP38 pre-mRNA processing factor 38 domain containing Bsarcoma antigen NY-SAR-27
	Modification date	20200313	20200313
	UniProtAcc	.	Q7Z628
	Ensembl transtripts involved in fusion gene	ENST00000328090, ENST00000463468,	ENST00000380359, ENST00000542715, ENST00000484741, ENST00000355029,
Fusion gene scores	* DoF score	18 X 9 X 8=1296	5 X 6 X 6=180
	# samples	23	9
	** MAII score	log2(23/1296*10)=-2.49435995194025 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/180*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM208B [Title/Abstract] AND NET1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM208B(5727138)-NET1(5468618), # samples:1 FAM208B(5803434)-NET1(5498551), # samples:1 FAM208B(5803434)-NET1(5471133), # samples:1 FAM208B(5773166)-NET1(5493793), # samples:1
Anticipated loss of major functional domain due to fusion event.	FAM208B-NET1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FAM208B-NET1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FAM208B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NET1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1F6-01A	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
ChimerDB4	BRCA	TCGA-C8-A12K-01A	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
ChimerDB4	BRCA	TCGA-E9-A248-01A	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
ChimerDB4	STAD	TCGA-CD-A4MH-01A	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+

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Fusion Gene ORF analysis for FAM208B-NET1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000328090	ENST00000380359	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
5CDS-5UTR	ENST00000328090	ENST00000542715	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
5CDS-5UTR	ENST00000328090	ENST00000542715	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
5CDS-intron	ENST00000328090	ENST00000380359	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
5CDS-intron	ENST00000328090	ENST00000484741	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
5CDS-intron	ENST00000328090	ENST00000484741	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
5CDS-intron	ENST00000328090	ENST00000484741	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
5UTR-3CDS	ENST00000328090	ENST00000355029	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
5UTR-5UTR	ENST00000328090	ENST00000542715	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
5UTR-intron	ENST00000328090	ENST00000380359	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
5UTR-intron	ENST00000328090	ENST00000484741	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
Frame-shift	ENST00000328090	ENST00000355029	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
Frame-shift	ENST00000328090	ENST00000355029	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
Frame-shift	ENST00000328090	ENST00000542715	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
In-frame	ENST00000328090	ENST00000355029	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
In-frame	ENST00000328090	ENST00000380359	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
intron-3CDS	ENST00000463468	ENST00000355029	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
intron-3CDS	ENST00000463468	ENST00000355029	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
intron-3CDS	ENST00000463468	ENST00000355029	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
intron-3CDS	ENST00000463468	ENST00000355029	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
intron-3CDS	ENST00000463468	ENST00000380359	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
intron-3CDS	ENST00000463468	ENST00000542715	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
intron-5UTR	ENST00000463468	ENST00000380359	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
intron-5UTR	ENST00000463468	ENST00000542715	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
intron-5UTR	ENST00000463468	ENST00000542715	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
intron-5UTR	ENST00000463468	ENST00000542715	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+
intron-intron	ENST00000463468	ENST00000380359	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
intron-intron	ENST00000463468	ENST00000380359	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
intron-intron	ENST00000463468	ENST00000484741	FAM208B	chr10	5727138	+	NET1	chr10	5468618	+
intron-intron	ENST00000463468	ENST00000484741	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+
intron-intron	ENST00000463468	ENST00000484741	FAM208B	chr10	5803434	+	NET1	chr10	5471133	+
intron-intron	ENST00000463468	ENST00000484741	FAM208B	chr10	5773166	+	NET1	chr10	5493793	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000328090

FAM208B

chr10

5803434

ENST00000355029

NET1

chr10

5498551

9675

7799

625

8205

2526

ENST00000328090

FAM208B

chr10

5803434

ENST00000380359

NET1

chr10

5498551

9675

7799

625

8205

2526

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000328090	ENST00000355029	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+	0.000255493	0.9997445
ENST00000328090	ENST00000380359	FAM208B	chr10	5803434	+	NET1	chr10	5498551	+	0.000255493	0.9997445

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Fusion Genomic Features for FAM208B-NET1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FAM208B	chr10	5803434	+	NET1	chr10	5498550	+	0.07846942	0.92153054
FAM208B	chr10	5773166	+	NET1	chr10	5493792	+	0.04721244	0.9527875
FAM208B	chr10	5803434	+	NET1	chr10	5471132	+	0.003134989	0.996865
FAM208B	chr10	5727138	+	NET1	chr10	5468617	+	1.48E-06	0.99999857
FAM208B	chr10	5803434	+	NET1	chr10	5498550	+	0.07846942	0.92153054
FAM208B	chr10	5773166	+	NET1	chr10	5493792	+	0.04721244	0.9527875
FAM208B	chr10	5803434	+	NET1	chr10	5471132	+	0.003134989	0.996865
FAM208B	chr10	5727138	+	NET1	chr10	5468617	+	1.48E-06	0.99999857

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM208B-NET1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:5727138/chr10:5468618)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NET1 Q7Z628
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269\|PubMed:21373644}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000355029

174_356

461

597.0

Domain

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000355029

386_501

461

597.0

Domain

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000380359

174_356

407

543.0

Domain

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000380359

386_501

407

543.0

Domain

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000355029

12_19

461

597.0

Motif

Nuclear localization signal

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000355029

66_72

461

597.0

Motif

Nuclear localization signal

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000380359

12_19

407

543.0

Motif

Nuclear localization signal

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000380359

66_72

407

543.0

Motif

Nuclear localization signal

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000355029

1_74

461

597.0

Region

Necessary for nuclear localization

Tgene

NET1

chr10:5803434

chr10:5498551

ENST00000380359

1_74

407

543.0

Region

Necessary for nuclear localization

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Fusion Gene Sequence for FAM208B-NET1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>28873_28873_1_FAM208B-NET1_FAM208B_chr10_5803434_ENST00000328090_NET1_chr10_5498551_ENST00000355029_length(transcript)=9675nt_BP=7799nt
GCTTCCGGTTGCTAGCGCCGGTCAGAGAGAAAGTCGGCATGTTCTCGCAGGCTGCCGGGCGTCCCGGGGTTGCCTCTTGCCCGTGACCCT
GACGGGAGACAGAGCGCGGGCGGCCGCGGCGTCCCTGTCAGCGCCCGCGGCGAGGACCCCGGGGCTGGGGCGGACGGCGTGCCCCTGAGG
GGGGTCCCCGCGGGAGCGCGGAGCCGGCGACTGGTGCTTCCCACGTGCGCCGGTGTCGCGAGGGCCCGGGAGGACGCAGAGCACGGCCGG
GAGAAGCATGGGAAGGAGGCCGAGCCGGGATCTCAGGTCCTCGGGGGCGGCGGCCACGCCAAGGACGGTACAAAACTTTTTACCAACAAA
AAAAAGCAAGTAGTTATACTCAGGAAGAACTTCAAGACACTTACGGGTTTCTTCTGTTTGATACTGAAAAGCAGGTGTATACATTTCCAA
ATACTCCGACTGTCTTCATTCAAGACCATGGTATCATGGGAAATCTGGTTATGTTGTAATTTTTAATATAATTAAGTATTACTTTTACGA
ACTTTCAGGCAACACCGTTATTGAACGACCCAGACAGATCTGTCCTTATGTAATTGTAGCTTTTCGATACAGGGAATCTAAAACTATGGC
ACCACCAGCTCATAAAAGCATACTTGAACGCAGTGAAAATGTTCTCATGTCTCCATGGAAAGGGAAATTAATTGTTCAAGACCGTATGCT
ATGTGATATAGCTCTTTGGTCCACTTACGGTGCAATGATTCCAACACAGCTACCGCAGGAACTAGATTTTAAATATGTAATGAAAGTGTC
TTCCTTGAAAAAAAGACTACCAGAGGCTGCCTTCAGAAAACAGAATTACTTGGAGGAGAAAGTCTGTTTTCAAGATTTGTGCTTCAATTT
GTATGAGGTAGAACTGTCAAACAGACAAGGGGAAAATATAGATAAATTAACAGAATGTATTAAAAACAAGCAATTGGCAATCATCAAATG
CTTAGAAGATCGAGGGTTTTTCATTTTACTTACATCATCAGCCTTACTATCAGAACCAGATTTTGGAGGCAAGCAGATGGGTCTGCATGG
GTTACATTTATTTCGTTCACCCCTGTCAACAGGGGTGAAAGATTTGAAAGTTGAAGATGACATCTCAATGAAGGTGATACCTATTTTATC
TACCCTTAATTGTGCCCTGCTAGAAACAAAGAAATCACTTCCTGAAGAAAGAATCCATCCAAACACATTAGTAAAGCGTCATTTCCAAGA
ATTGTACAAGGCGGACAGAAGCCCTTCATTGAGTGTTGCTCCTCAGGATAGAATGAAAGACCCTACATTCTTGGGGAAACTGCCCAGTGG
TTTTGACTTGATTCCTCCAGCTGAAAAGTGCCCTTCAGAGTCTTTAACTCAGTTGAACTCTTATTTTTCAGACCCTAGTGCTTACATTTT
GGAAGTGTCTACTGCTTTGGACTTGCTAGCAGAGCATCCTCAGTCTCCTTGTGTTTCAGACGGAATTTGTGATGCTGGATTTTCCTTAGT
TATGACTCCAGATCCTGAATTTCTTGTCTCAGAGGCAGAAGTGAGAAAAGAAACTGAAACAAAAAAGGATTCTGAAGAAATGTTGAAAGC
AAAGAAGAGAGTTTTTCCATTGAGTCCAGCGTCAAATCTGAGAGTGCAGCCTAAGAGGAAGGCCAGCATGCCCCACATGGTGCAGAGTAA
AAAGGTGAACTTGTGCCGCCCCTTTCCCAAAAGAACTGCTTCCAGAGCAGACAACAGCTCGGACTCTCCAACAACTCTTAAGTTAGTTAA
AGGACAGTTTCCTCAGAAAAGAAAAAGAGGTGCGGAAGTGCTGACTGCACAGTTTGTACAGAAAACCAAATTGGATAGGAAAAACCAAGA
AGCTCCTATTTCTAAAGATGTTCCAGTGCCAACAAATGCTAAAAGGGCAAGGAAACAAGAGAAATCTCCAGTCAAAACTGTTCCAAGGGC
TAAGCCACCTGTGAAGAAATCTCCACAAAAACAGAGAGTAAATATAGTAAAAGGCAATGAGAACCCCAGAAACAGAAAGCAGCTACAACC
TGTCAAAGGAGAAACTGCTTCAAAGCTTCAATCAGAAATTTCAAGAGGTTGTCAAGAAGATGGGATTAGCATAAATAGTGTTCAACCAGA
AAATACCACAGCGGCTCACAATGATCTTCCTGAAAACTCCATCGTCAACTATGACTCCCAGGCCCTAAATATGTTAGCCGATCTAGCATT
AAGCTCTGCTACTTCTTCCACACCAGTATCTGAGGCTAGAAATCTTCACTGTTCCTCTGAATTGCCACAAAATGATGTTTTGCTCTCTAA
AGAAAATTCTTTGCGAGGTACATCTGACCATGAATATCATAGAGGAGTTAAAACTCAAAAAGGTGAATTACTACCTAACCCATCTTCTGA
TAGGAAGAGTAATTCTGGATCAGACTTAACAGTTAGCCAAGATGAAGAAAGCTTGGTTCCTTGTAGTCAGGCCCCTGCTAAAGCCCAGTC
AGCACTTACTGAGGAAATGCTAGAATCTTCAGATGCAAGCCAAAGCTCTTCTGTTTCTGTGGAACATTCATATGCCCTGCTCCTTACAGA
ACATTCAAAGAAACATCTACAGGAGAGAGAGATACTAAGCCCTCTGTTTCCCAGGAATGGGACAAAAAGCCCTGAAGCAGCAACCCCAGT
GGGGAAAGTCATGCCATTTCGGCATCAGCCCGGCCTTTTGCTTCAGCAAAAGCCTCCTGACGACCCCGTGGTGAAGCCCAAGGATCGACC
ACCGTCTGCCCGTGTGAAAAAATCTTCTTGCTCTCGTATAGTGCTTAGCTGTGATGACTCCGTTAAGATCACTTTCAAATGTGAAACAGA
ATATGCATTCAGTTTAGACAGCAAATATACCAACAACCCACTGGAGAAAACTGTAGTAAGAGCATTACATGGGCCCTGGAATACTGATTT
GCCTGATAATGTGGAAGAAGTGAAGCTTTTACTTCATATGTGGGTAGCTCTGTTTTACAGCAATCAGAACAAAATCATACGATCTTCCCG
AAAGGTTGTAGAACACAGCAACCCAGCAAAATATGTGTCTATAAATAGCACGTTAGAATCTTGTGAGCTCCGTGAAATTGAGGAGTCCCT
TGGTTTGGAAAAATGTTCTGCAGACTCTCTGTTGGAGACTAACGAAATTTCCAGGGCTCATGCTGCTGAAGTATCCTTCCGTGATCCTAA
CTGCTTGCTTCCTTTCATTAAAACACCACTTACCCAAGGCTTGGAACTCTGTGTACAAAATGAACAGAAAAAAACTTTTGCAAGAGAGTG
TGATCCAGACACCCAAGAAGACCAGAATTTCATCTGTTCTTACAATAATGAGGTAACTGGGGAAGAAGCTAAACAAGAATCATTGGAGAC
TTCTAATCTTGTGCTTTCGGGTATTGGAAGTACACAAACTAATGGACCTTCTGTTCCTAGTGAAGAAGAAATTGTTCAGCCACTGGATAG
CACAAGAGTGGCTTCTTACAGTGGCACTGTTACTCAAGCCACATTCACCAGGACTTACGATGGGCCTGGCAGTCAGCCAGTGATATGTCA
GAGCTCTGTGTACGGCACCCTTGAAAACAAAGTGGATATTCTTGATGCAGCAGTGCAAACAAAAACAGGTACTTTACAGGACCTTATCCA
ACATGGCAGCCCCATAAACAATGAATGTCACCCTTCCTTGGAAAGAAAGGATGATAATATGGGGTGTGCAGTGATTAACCCGGAACCAAT
TACTCTCACCTTTGAAAAAAATGCACATGTACCAATACAGACAGAAGGTGTAAATACTGCTGATGAACGTACAACCTTTAAGAAGGAGTT
GATTAAGCAAGTATCACCTGCTGCAAGCCTTAGACATCCTGTATCCACCTCGGAAAATGCACGAACACAAGGCCTGAGGGACATTCCCTC
TCTAGTAGTTGCAGGACAGAAGGGCACTAAGTACCTTTGTGCCTCGTCAGTAGGTGGAGAGACACTTGATAAAGCAGTGTGTTCATTACA
GAAGGAGACGCCCCTTCCAGTCTCTCTACCATCTGATAAAACAATGGTCATGGAGGCACTATCATTAGCTAAAAGTTCTAGTCATCTATC
ACCCAGTGAAGAAGTGAGATGCACTCAGGATTTCCTTTCACAGACTCAGAGTCTCCTCGGCCTATCTTCAGAAGGGCTTCTAGAACTGAC
ACAGGTTGAAGTGGACTCATCATCAGCCTCTACCACCTTGGGAAGGCAGTGTTCACTTAACTGCATTTCGTCAGGATGCCACACATCAGG
TGACTCTTTAGAACTAAGGAAGAATCACAAGAATGGTCCAAACACTGAAAATATGAATTTGGAAGCGTTTGATTCAGTATTTATCAAACA
AACAAGCCTGTCTGTGAGTAGAGAGGTCAGCCTAGAGTTATCAGAGGAAGATTCTGACATTGACTTAGCTCTAACAATATCACCACCTAC
AAGTCCCAGAGAAGAAATGCCAGCTGGTGAAATAGAGCAATTTGAGGAGGCCCCATTCTCAAATTTAGAACTTCAGGATGTAGCTGAGGA
AATAGGTGAACCGGAAGAGGTGGCTCTCACAGAAAGCAGAGAAGTGAGTTCTGCTGACAATGTGTCAGTATATCCCTCAGTGTCAGAAGA
ACCAGTAGAAAATAAGGAGAGAAAGGGGGATAATTTACAACCAGTTACTTTAATACTTTCTAAAGAAAATTGCACCCTTGAGATTGCAGA
GGAAATTAATGTGACCTCTGATTTTCCCTTTGATTCTGTAATTGAAGAAGTATCACCAGCGTCTAGTCCTGAACCTCCAGTACCAGTTAA
AGAGACACGACCATATCAGGCTGTGACTCCATGCATTTTAAAACTTCATGGTACACAGTGTGAGAAGAGCAACCAAATCTCCCAATGTGA
GTCAGAAGACTTAGGCATAACAGAAAAAGAAAATGTTTTTGTTGGTCCTACCCATCCAGTGGGGCAAGATAACTTTACCCAGGTACAACA
AATGCAGGTCTCTGCCGAAATGCCTCTAATATTAACTGATCATCCAGGAAGAACAGGTAGACCAACCCTTCCTGGTAAAGTAACTGAGGA
AATTGTCTCAAGTGAGCATGATGAGGGTTTATCTTTCTCAGGAAAGGTGCAGTGCTATGGTAGGGAGTTAAACCAGCCTGCCTCAGCTGC
CAAATGCACAGGTGACTTCAGTCCTTCTCCTGAAAAACTGGTAAAATCAGGAAATCCATTGCAGCCAGTTAGTATAGAGAATAGAAATTT
GGACTTAAAACATCTTGTCTTGGAGTCCAGTGAACCTCCATTTGGTCCTAGAAATGTTATTGAAAATAAGTCTTTGTCTGACACATTGGT
TTCCACAACTGCACCAAGTGGTATAGTGAATGTGTCAGTAAAACAGCAGACTAGCCCTAAAAGCAGTCAGAACCATCTCTTTCCCGGTGA
TTTGAAAACAGATGAAGGCATTTATCTGCAGGTGAAGTCCTTGACAGCTGCCTCGGTTGATGGAGCTTATTCTACACAGGGATGCATGTG
CTCAGTGGTCCCCACGCTTTGTTCTTCCTCAGACAATGCTACATTAACCCATTATGTAAGACCAATAAATGCAGAGCCAGTGTTTCAAGC
ACAGGAAATACCAGCAGGCAGAATGGCCAGTTTGCTTAAGAATGGTGAGCCTGAAGCTGAGTTACATAAAGAAACCACAGGTCCAGGCAC
TGCTGGCCCTCAGTCCAACACCACATCTTCTCTAAAAGGTGAACGCAAAGCCATCCACACGCTGCAAGATGTGTCAACATGTGAAACAAA
GGAGCTATTGAATGTCGGGGTTTCCTCCCTTTGTGCTGGTCCCTACCAAAATACAGCAGACACCAAGGAAAACCTCAGTAAAGAGCCTTT
GGCCTCCTTTGTTTCAGAATCCTTTGATACTTCTGTTTGTGGAATAGCCACAGAGCACGTAGAAATTGAGAACAGTGGGGAGGGGCTCAG
GGCTGAGGCTGGTTCTGAAACCCTAGGCAGAGATGGAGAGGTCGGTGTGAATTCCGACATGCACTATGAACTCTCTGGAGATTCTGATCT
AGACCTGCTTGGTGATTGTAGAAATCCCAGACTGGATTTGGAGGATTCTTATACTTTAAGAGGTAGTTACACCAGGAAAAAAGATGTTCC
CACAGATGGCTATGAGTCGTCGTTGAACTTCCACAACAACAACCAAGAGGACTGGGGCTGCTCTAGCTGGGTTCCAGGCATGGAGACGAG
CCTCCCTCCCGGGCACTGGACTGCTGCGGTAAAGAAAGAAGAGAAGTGTGTGCCGCCTTACGTCCAAATCCGAGATCTCCACGGGATCCT
CAGGACTTACGCCAACTTCTCTATAACAAAAGAACTCAAAGATACCATGAGAACTTCACACGGCCTGAGGAGGCACCCGAGTTTCAGTGC
AAACTGTGGCCTGCCCAGCTCCTGGACAAGCACTTGGCAGGTGGCAGACGACCTCACCCAGAACACTTTAGACCTGGAGTATCTGCGTTT
TGCACATAAACTAAAACAGACCATAAAGAATGGGGATTCTCAGCATTCTGCCTCCTCTGCCAATGTCTTTCCAAAGGAGTCACCAACCCA
GATCTCCATTGGTGCTTTCCCTTCGACAAAAATCTCTGAGGCCCCATTTCTGCATCCTGCACCTAGGAGCAGAAGCCCCCTTCTGGTAAC
AGTTGTGGAGTCAGATCCCAGACCACAGGGGCAGCCCAGGAGAGGCTACACAGCCAGCAGTCTGGACAGCTCTTCCTCTTGGAGAGAGAG
ATGTAGTCATAATAGAGATCTTAGAAATTCTCAAAGAAATCACACTGTTTCATTCCACCTCAACAAACTGAAATACAACAGTACTGTGAA
GGAATCTCGGAATGATATTTCACTTATTCTCAATGAGTATGCTGAATTCAACAAGGTGATGAAGAATAGCAACCAATTCATTTTCCAAGA
CAAAGAGCTAAATGATGTTTCTGGAGAAGCCACTGCTCAAGAGATGTATCTGCCTTTCCCAGGACGGTCAGCCTCCTATGAAGACATAAT
CATAGACGTGTGCACCAATTTGCACGTCAAACTAAGAAGTGTTGTGAAAGAGGCTTGTAAAAGTACCTTCCTGTTCTACCTTGTCGAAAC
AGAAGACAAATCATTCTTTGTAAGAACAAAGAACCTTCTGAGGAAAGGAGGCCATACAGAAATTGAACCTCAGCACTTCTGTCAAGCTTT
CCACAGAGAGAATGATACACTAATCATCATCATCAGAAATGAAGATATATCATCACATTTGCATCAGATTCCTTCTTTGCTGAAGCTGAA
GCATTTCCCCAGTGTCATCTTTGCTGGAGTAGACAGCCCTGGAGATGTTCTTGATCACACCTACCAAGAACTGTTTCGTGCAGGAGGCTT
TGTGATATCAGATGACAAGATACTAGAAGCTGTAACATTAGTTCAACTGAAGGAAATTATCAAAATCCTGGAAAAACTAAATGGAAATGG
AAGATGGAAGTGGTTGCTTCACTACAGGGAAAATAAAAAGCTAAAAGAAGATGAAAGAGTGGATTCAACTGCACATAAGAAGAACATAAT
GTTGAAGTCATTTCAGAGTGCAAATATCATTGAATTGCTTCATTATCACCAGTGTGACTCTCGATCATCAACAAAAGCAGAAATTCTGAA
ATGTTTGCTAAACCTGCAAATTCAGCATATTGATGCCAGGTTTGCTGTCCTCCTAACAGCTAAAAATATCTTTAGAATTCGCTTCCATGA
CCCCTCTCCAGCCCAGTCTCACACTCTGCAAGCCAATGACGTGTTCCACAAGCAGCAGTGGTTCAACTGTATTCGAGCGGCCATTGCCCC
CTTCCAGTCGGCAGGCAGTCCACCTGAGCTGCAGGGCCTGCCGGAGCTGCACGAAGAGTGTGAGGGGAACCACCCCTCTGCGAGGAAACT
CACAGCCCAGAGGAGGGCATCCACAGTTTCCAGTGTTACTCAGGTAGAAGTTGATGAAAACGCTTACAGATGTGGCTCTGGCATGCAGAT
GGCAGAGGACAGCAAGAGCTTAAAGACACACCAGACACAGCCCGGCATCCGAAGAGCGAGGGACAAAGCCCTTTCTGGTGGCAAACGGAA
AGAGACTTTGGTGTAGAGAAGGCTCTGTGTGTTAACTGATGGGAGAGACTGTTTGTTTATAAATGTGTACAGTTTTGTTTTCTCGTAAGG
GGAGCATCATAGGGTTACTTTATACCAGTTGTAACATTTTCATTGTTTTTGGTTGTTCTTTTTTCTTTTTTTAATGGCAGCTAAAGATAT
ACAGATTACTGTTAAATTGCAGTCCTTTTTTTTTTAAAGATATTTTCTTGAATTATTTAGAACATGGTAAGCCTGGTATTTTTTAATCAA
ACAAAATATTTATGAAATGGGTTTTCTCTTAATTCTGGATTCATCATGGCTTTCTAATACCAATTGTAATATTTACAATATTCACCAAAA
CTTAGAATTTTGCAAATGCTGGAATTCTGCCAGTGTTTCTTTGCTAAGCCTTGCATGCAAAATTTGAAATTTTAACATTGGCACCCAAAA
CCTACATGGAATGTATGTCTGGAGTATTTCAAACTTTACATTGAAACATAATTTCCTTGGAAAACAAACCATAAGCCTGAGGAGGTTTTT
ATCAACTGGAATGCTTTATATTAGTTTGTTTTTCACTGTACATTCCTCATTTTACATTCATTTAACCTGCCGATTATTTAATTTTTTTAT
TGTAAAGTAGTTTTTAGCATTTGCTTTTATTTTTTTACTTTGATGCCTTTTCAAATTGGCATGTCTTTAAAGTATTTTTCTTCCTGATTA
AAAATGTGTGTGTATGTGTGTGTGTGTGTGTATATATATATATATTTTTAAATCACATTAATTTTACCAAGTGAAACCAAGCCATACTGT
TTTTGAGCCAATTAAGAAAATTGCCATTTTTAAAGTGTAGCATTTCAGGGTAAAGACCCATGAAATGGCTTGATGTATTCTAGACTACTG
AAAGAAAACCACTTCAAAGATTTTGTTGAAAGTTTTAGTGTTGTCTGAAATGCAAGAGGGAAGGTGATTGGTAGTGAGTTAAAAGAAAAA
GAGAGGAAAAGAGAGTAGTTTTGTCTTCAAGTAAAATGTCTGGTTGTGCCAGACATTTCACAAGTGTGAAAGGAGATAGGAGAAGCTCAA
CTTGAGGGCGTGTAGTAAGTTGTAGAAGGCTCGAGGGGACGTGGACTTATTTGCCTTGGTTTGCAATACCTGCAAATAATGAGTTTGAAA
AGAAACAATGAAATGTGTTAAAAATTTGACCATATTAGATAAATTTTCGTGGATTTAGTCATAAGATGGAAAAAGACTGGTGAATCTTTT
ATTACAAAATGTTTCTGTTAAAATGGGATCATCATCTTTGAAAGGGGGGAGGAGGAGTAAAAGCCCGATTATAATGGTGATCAATTCAAG
TCAGTGTTGACTATTCTGTGAAATATATTTGGCCAGTGGAAATGATAATCAGAAAAGACTGTAAATAGATCCATCCAAATGATTTCTCTG

>28873_28873_1_FAM208B-NET1_FAM208B_chr10_5803434_ENST00000328090_NET1_chr10_5498551_ENST00000355029_length(amino acids)=2526AA_BP=2391
MAPPAHKSILERSENVLMSPWKGKLIVQDRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEEKVCFQDLCF
NLYEVELSNRQGENIDKLTECIKNKQLAIIKCLEDRGFFILLTSSALLSEPDFGGKQMGLHGLHLFRSPLSTGVKDLKVEDDISMKVIPI
LSTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLSVAPQDRMKDPTFLGKLPSGFDLIPPAEKCPSESLTQLNSYFSDPSAY
ILEVSTALDLLAEHPQSPCVSDGICDAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKRVFPLSPASNLRVQPKRKASMPHMVQ
SKKVNLCRPFPKRTASRADNSSDSPTTLKLVKGQFPQKRKRGAEVLTAQFVQKTKLDRKNQEAPISKDVPVPTNAKRARKQEKSPVKTVP
RAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRGCQEDGISINSVQPENTTAAHNDLPENSIVNYDSQALNMLADL
ALSSATSSTPVSEARNLHCSSELPQNDVLLSKENSLRGTSDHEYHRGVKTQKGELLPNPSSDRKSNSGSDLTVSQDEESLVPCSQAPAKA
QSALTEEMLESSDASQSSSVSVEHSYALLLTEHSKKHLQEREILSPLFPRNGTKSPEAATPVGKVMPFRHQPGLLLQQKPPDDPVVKPKD
RPPSARVKKSSCSRIVLSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALHGPWNTDLPDNVEEVKLLLHMWVALFYSNQNKIIRS
SRKVVEHSNPAKYVSINSTLESCELREIEESLGLEKCSADSLLETNEISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCVQNEQKKTFAR
ECDPDTQEDQNFICSYNNEVTGEEAKQESLETSNLVLSGIGSTQTNGPSVPSEEEIVQPLDSTRVASYSGTVTQATFTRTYDGPGSQPVI
CQSSVYGTLENKVDILDAAVQTKTGTLQDLIQHGSPINNECHPSLERKDDNMGCAVINPEPITLTFEKNAHVPIQTEGVNTADERTTFKK
ELIKQVSPAASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLDKAVCSLQKETPLPVSLPSDKTMVMEALSLAKSSSH
LSPSEEVRCTQDFLSQTQSLLGLSSEGLLELTQVEVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLEAFDSVFI
KQTSLSVSREVSLELSEEDSDIDLALTISPPTSPREEMPAGEIEQFEEAPFSNLELQDVAEEIGEPEEVALTESREVSSADNVSVYPSVS
EEPVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPFDSVIEEVSPASSPEPPVPVKETRPYQAVTPCILKLHGTQCEKSNQISQ
CESEDLGITEKENVFVGPTHPVGQDNFTQVQQMQVSAEMPLILTDHPGRTGRPTLPGKVTEEIVSSEHDEGLSFSGKVQCYGRELNQPAS
AAKCTGDFSPSPEKLVKSGNPLQPVSIENRNLDLKHLVLESSEPPFGPRNVIENKSLSDTLVSTTAPSGIVNVSVKQQTSPKSSQNHLFP
GDLKTDEGIYLQVKSLTAASVDGAYSTQGCMCSVVPTLCSSSDNATLTHYVRPINAEPVFQAQEIPAGRMASLLKNGEPEAELHKETTGP
GTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELLNVGVSSLCAGPYQNTADTKENLSKEPLASFVSESFDTSVCGIATEHVEIENSGEG
LRAEAGSETLGRDGEVGVNSDMHYELSGDSDLDLLGDCRNPRLDLEDSYTLRGSYTRKKDVPTDGYESSLNFHNNNQEDWGCSSWVPGME
TSLPPGHWTAAVKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTSHGLRRHPSFSANCGLPSSWTSTWQVADDLTQNTLDLEYL
RFAHKLKQTIKNGDSQHSASSANVFPKESPTQISIGAFPSTKISEAPFLHPAPRSRSPLLVTVVESDPRPQGQPRRGYTASSLDSSSSWR
ERCSHNRDLRNSQRNHTVSFHLNKLKYNSTVKESRNDISLILNEYAEFNKVMKNSNQFIFQDKELNDVSGEATAQEMYLPFPGRSASYED
IIIDVCTNLHVKLRSVVKEACKSTFLFYLVETEDKSFFVRTKNLLRKGGHTEIEPQHFCQAFHRENDTLIIIIRNEDISSHLHQIPSLLK
LKHFPSVIFAGVDSPGDVLDHTYQELFRAGGFVISDDKILEAVTLVQLKEIIKILEKLNGNGRWKWLLHYRENKKLKEDERVDSTAHKKN
IMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAI
APFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGK

--------------------------------------------------------------
>28873_28873_2_FAM208B-NET1_FAM208B_chr10_5803434_ENST00000328090_NET1_chr10_5498551_ENST00000380359_length(transcript)=9675nt_BP=7799nt
GCTTCCGGTTGCTAGCGCCGGTCAGAGAGAAAGTCGGCATGTTCTCGCAGGCTGCCGGGCGTCCCGGGGTTGCCTCTTGCCCGTGACCCT
GACGGGAGACAGAGCGCGGGCGGCCGCGGCGTCCCTGTCAGCGCCCGCGGCGAGGACCCCGGGGCTGGGGCGGACGGCGTGCCCCTGAGG
GGGGTCCCCGCGGGAGCGCGGAGCCGGCGACTGGTGCTTCCCACGTGCGCCGGTGTCGCGAGGGCCCGGGAGGACGCAGAGCACGGCCGG
GAGAAGCATGGGAAGGAGGCCGAGCCGGGATCTCAGGTCCTCGGGGGCGGCGGCCACGCCAAGGACGGTACAAAACTTTTTACCAACAAA
AAAAAGCAAGTAGTTATACTCAGGAAGAACTTCAAGACACTTACGGGTTTCTTCTGTTTGATACTGAAAAGCAGGTGTATACATTTCCAA
ATACTCCGACTGTCTTCATTCAAGACCATGGTATCATGGGAAATCTGGTTATGTTGTAATTTTTAATATAATTAAGTATTACTTTTACGA
ACTTTCAGGCAACACCGTTATTGAACGACCCAGACAGATCTGTCCTTATGTAATTGTAGCTTTTCGATACAGGGAATCTAAAACTATGGC
ACCACCAGCTCATAAAAGCATACTTGAACGCAGTGAAAATGTTCTCATGTCTCCATGGAAAGGGAAATTAATTGTTCAAGACCGTATGCT
ATGTGATATAGCTCTTTGGTCCACTTACGGTGCAATGATTCCAACACAGCTACCGCAGGAACTAGATTTTAAATATGTAATGAAAGTGTC
TTCCTTGAAAAAAAGACTACCAGAGGCTGCCTTCAGAAAACAGAATTACTTGGAGGAGAAAGTCTGTTTTCAAGATTTGTGCTTCAATTT
GTATGAGGTAGAACTGTCAAACAGACAAGGGGAAAATATAGATAAATTAACAGAATGTATTAAAAACAAGCAATTGGCAATCATCAAATG
CTTAGAAGATCGAGGGTTTTTCATTTTACTTACATCATCAGCCTTACTATCAGAACCAGATTTTGGAGGCAAGCAGATGGGTCTGCATGG
GTTACATTTATTTCGTTCACCCCTGTCAACAGGGGTGAAAGATTTGAAAGTTGAAGATGACATCTCAATGAAGGTGATACCTATTTTATC
TACCCTTAATTGTGCCCTGCTAGAAACAAAGAAATCACTTCCTGAAGAAAGAATCCATCCAAACACATTAGTAAAGCGTCATTTCCAAGA
ATTGTACAAGGCGGACAGAAGCCCTTCATTGAGTGTTGCTCCTCAGGATAGAATGAAAGACCCTACATTCTTGGGGAAACTGCCCAGTGG
TTTTGACTTGATTCCTCCAGCTGAAAAGTGCCCTTCAGAGTCTTTAACTCAGTTGAACTCTTATTTTTCAGACCCTAGTGCTTACATTTT
GGAAGTGTCTACTGCTTTGGACTTGCTAGCAGAGCATCCTCAGTCTCCTTGTGTTTCAGACGGAATTTGTGATGCTGGATTTTCCTTAGT
TATGACTCCAGATCCTGAATTTCTTGTCTCAGAGGCAGAAGTGAGAAAAGAAACTGAAACAAAAAAGGATTCTGAAGAAATGTTGAAAGC
AAAGAAGAGAGTTTTTCCATTGAGTCCAGCGTCAAATCTGAGAGTGCAGCCTAAGAGGAAGGCCAGCATGCCCCACATGGTGCAGAGTAA
AAAGGTGAACTTGTGCCGCCCCTTTCCCAAAAGAACTGCTTCCAGAGCAGACAACAGCTCGGACTCTCCAACAACTCTTAAGTTAGTTAA
AGGACAGTTTCCTCAGAAAAGAAAAAGAGGTGCGGAAGTGCTGACTGCACAGTTTGTACAGAAAACCAAATTGGATAGGAAAAACCAAGA
AGCTCCTATTTCTAAAGATGTTCCAGTGCCAACAAATGCTAAAAGGGCAAGGAAACAAGAGAAATCTCCAGTCAAAACTGTTCCAAGGGC
TAAGCCACCTGTGAAGAAATCTCCACAAAAACAGAGAGTAAATATAGTAAAAGGCAATGAGAACCCCAGAAACAGAAAGCAGCTACAACC
TGTCAAAGGAGAAACTGCTTCAAAGCTTCAATCAGAAATTTCAAGAGGTTGTCAAGAAGATGGGATTAGCATAAATAGTGTTCAACCAGA
AAATACCACAGCGGCTCACAATGATCTTCCTGAAAACTCCATCGTCAACTATGACTCCCAGGCCCTAAATATGTTAGCCGATCTAGCATT
AAGCTCTGCTACTTCTTCCACACCAGTATCTGAGGCTAGAAATCTTCACTGTTCCTCTGAATTGCCACAAAATGATGTTTTGCTCTCTAA
AGAAAATTCTTTGCGAGGTACATCTGACCATGAATATCATAGAGGAGTTAAAACTCAAAAAGGTGAATTACTACCTAACCCATCTTCTGA
TAGGAAGAGTAATTCTGGATCAGACTTAACAGTTAGCCAAGATGAAGAAAGCTTGGTTCCTTGTAGTCAGGCCCCTGCTAAAGCCCAGTC
AGCACTTACTGAGGAAATGCTAGAATCTTCAGATGCAAGCCAAAGCTCTTCTGTTTCTGTGGAACATTCATATGCCCTGCTCCTTACAGA
ACATTCAAAGAAACATCTACAGGAGAGAGAGATACTAAGCCCTCTGTTTCCCAGGAATGGGACAAAAAGCCCTGAAGCAGCAACCCCAGT
GGGGAAAGTCATGCCATTTCGGCATCAGCCCGGCCTTTTGCTTCAGCAAAAGCCTCCTGACGACCCCGTGGTGAAGCCCAAGGATCGACC
ACCGTCTGCCCGTGTGAAAAAATCTTCTTGCTCTCGTATAGTGCTTAGCTGTGATGACTCCGTTAAGATCACTTTCAAATGTGAAACAGA
ATATGCATTCAGTTTAGACAGCAAATATACCAACAACCCACTGGAGAAAACTGTAGTAAGAGCATTACATGGGCCCTGGAATACTGATTT
GCCTGATAATGTGGAAGAAGTGAAGCTTTTACTTCATATGTGGGTAGCTCTGTTTTACAGCAATCAGAACAAAATCATACGATCTTCCCG
AAAGGTTGTAGAACACAGCAACCCAGCAAAATATGTGTCTATAAATAGCACGTTAGAATCTTGTGAGCTCCGTGAAATTGAGGAGTCCCT
TGGTTTGGAAAAATGTTCTGCAGACTCTCTGTTGGAGACTAACGAAATTTCCAGGGCTCATGCTGCTGAAGTATCCTTCCGTGATCCTAA
CTGCTTGCTTCCTTTCATTAAAACACCACTTACCCAAGGCTTGGAACTCTGTGTACAAAATGAACAGAAAAAAACTTTTGCAAGAGAGTG
TGATCCAGACACCCAAGAAGACCAGAATTTCATCTGTTCTTACAATAATGAGGTAACTGGGGAAGAAGCTAAACAAGAATCATTGGAGAC
TTCTAATCTTGTGCTTTCGGGTATTGGAAGTACACAAACTAATGGACCTTCTGTTCCTAGTGAAGAAGAAATTGTTCAGCCACTGGATAG
CACAAGAGTGGCTTCTTACAGTGGCACTGTTACTCAAGCCACATTCACCAGGACTTACGATGGGCCTGGCAGTCAGCCAGTGATATGTCA
GAGCTCTGTGTACGGCACCCTTGAAAACAAAGTGGATATTCTTGATGCAGCAGTGCAAACAAAAACAGGTACTTTACAGGACCTTATCCA
ACATGGCAGCCCCATAAACAATGAATGTCACCCTTCCTTGGAAAGAAAGGATGATAATATGGGGTGTGCAGTGATTAACCCGGAACCAAT
TACTCTCACCTTTGAAAAAAATGCACATGTACCAATACAGACAGAAGGTGTAAATACTGCTGATGAACGTACAACCTTTAAGAAGGAGTT
GATTAAGCAAGTATCACCTGCTGCAAGCCTTAGACATCCTGTATCCACCTCGGAAAATGCACGAACACAAGGCCTGAGGGACATTCCCTC
TCTAGTAGTTGCAGGACAGAAGGGCACTAAGTACCTTTGTGCCTCGTCAGTAGGTGGAGAGACACTTGATAAAGCAGTGTGTTCATTACA
GAAGGAGACGCCCCTTCCAGTCTCTCTACCATCTGATAAAACAATGGTCATGGAGGCACTATCATTAGCTAAAAGTTCTAGTCATCTATC
ACCCAGTGAAGAAGTGAGATGCACTCAGGATTTCCTTTCACAGACTCAGAGTCTCCTCGGCCTATCTTCAGAAGGGCTTCTAGAACTGAC
ACAGGTTGAAGTGGACTCATCATCAGCCTCTACCACCTTGGGAAGGCAGTGTTCACTTAACTGCATTTCGTCAGGATGCCACACATCAGG
TGACTCTTTAGAACTAAGGAAGAATCACAAGAATGGTCCAAACACTGAAAATATGAATTTGGAAGCGTTTGATTCAGTATTTATCAAACA
AACAAGCCTGTCTGTGAGTAGAGAGGTCAGCCTAGAGTTATCAGAGGAAGATTCTGACATTGACTTAGCTCTAACAATATCACCACCTAC
AAGTCCCAGAGAAGAAATGCCAGCTGGTGAAATAGAGCAATTTGAGGAGGCCCCATTCTCAAATTTAGAACTTCAGGATGTAGCTGAGGA
AATAGGTGAACCGGAAGAGGTGGCTCTCACAGAAAGCAGAGAAGTGAGTTCTGCTGACAATGTGTCAGTATATCCCTCAGTGTCAGAAGA
ACCAGTAGAAAATAAGGAGAGAAAGGGGGATAATTTACAACCAGTTACTTTAATACTTTCTAAAGAAAATTGCACCCTTGAGATTGCAGA
GGAAATTAATGTGACCTCTGATTTTCCCTTTGATTCTGTAATTGAAGAAGTATCACCAGCGTCTAGTCCTGAACCTCCAGTACCAGTTAA
AGAGACACGACCATATCAGGCTGTGACTCCATGCATTTTAAAACTTCATGGTACACAGTGTGAGAAGAGCAACCAAATCTCCCAATGTGA
GTCAGAAGACTTAGGCATAACAGAAAAAGAAAATGTTTTTGTTGGTCCTACCCATCCAGTGGGGCAAGATAACTTTACCCAGGTACAACA
AATGCAGGTCTCTGCCGAAATGCCTCTAATATTAACTGATCATCCAGGAAGAACAGGTAGACCAACCCTTCCTGGTAAAGTAACTGAGGA
AATTGTCTCAAGTGAGCATGATGAGGGTTTATCTTTCTCAGGAAAGGTGCAGTGCTATGGTAGGGAGTTAAACCAGCCTGCCTCAGCTGC
CAAATGCACAGGTGACTTCAGTCCTTCTCCTGAAAAACTGGTAAAATCAGGAAATCCATTGCAGCCAGTTAGTATAGAGAATAGAAATTT
GGACTTAAAACATCTTGTCTTGGAGTCCAGTGAACCTCCATTTGGTCCTAGAAATGTTATTGAAAATAAGTCTTTGTCTGACACATTGGT
TTCCACAACTGCACCAAGTGGTATAGTGAATGTGTCAGTAAAACAGCAGACTAGCCCTAAAAGCAGTCAGAACCATCTCTTTCCCGGTGA
TTTGAAAACAGATGAAGGCATTTATCTGCAGGTGAAGTCCTTGACAGCTGCCTCGGTTGATGGAGCTTATTCTACACAGGGATGCATGTG
CTCAGTGGTCCCCACGCTTTGTTCTTCCTCAGACAATGCTACATTAACCCATTATGTAAGACCAATAAATGCAGAGCCAGTGTTTCAAGC
ACAGGAAATACCAGCAGGCAGAATGGCCAGTTTGCTTAAGAATGGTGAGCCTGAAGCTGAGTTACATAAAGAAACCACAGGTCCAGGCAC
TGCTGGCCCTCAGTCCAACACCACATCTTCTCTAAAAGGTGAACGCAAAGCCATCCACACGCTGCAAGATGTGTCAACATGTGAAACAAA
GGAGCTATTGAATGTCGGGGTTTCCTCCCTTTGTGCTGGTCCCTACCAAAATACAGCAGACACCAAGGAAAACCTCAGTAAAGAGCCTTT
GGCCTCCTTTGTTTCAGAATCCTTTGATACTTCTGTTTGTGGAATAGCCACAGAGCACGTAGAAATTGAGAACAGTGGGGAGGGGCTCAG
GGCTGAGGCTGGTTCTGAAACCCTAGGCAGAGATGGAGAGGTCGGTGTGAATTCCGACATGCACTATGAACTCTCTGGAGATTCTGATCT
AGACCTGCTTGGTGATTGTAGAAATCCCAGACTGGATTTGGAGGATTCTTATACTTTAAGAGGTAGTTACACCAGGAAAAAAGATGTTCC
CACAGATGGCTATGAGTCGTCGTTGAACTTCCACAACAACAACCAAGAGGACTGGGGCTGCTCTAGCTGGGTTCCAGGCATGGAGACGAG
CCTCCCTCCCGGGCACTGGACTGCTGCGGTAAAGAAAGAAGAGAAGTGTGTGCCGCCTTACGTCCAAATCCGAGATCTCCACGGGATCCT
CAGGACTTACGCCAACTTCTCTATAACAAAAGAACTCAAAGATACCATGAGAACTTCACACGGCCTGAGGAGGCACCCGAGTTTCAGTGC
AAACTGTGGCCTGCCCAGCTCCTGGACAAGCACTTGGCAGGTGGCAGACGACCTCACCCAGAACACTTTAGACCTGGAGTATCTGCGTTT
TGCACATAAACTAAAACAGACCATAAAGAATGGGGATTCTCAGCATTCTGCCTCCTCTGCCAATGTCTTTCCAAAGGAGTCACCAACCCA
GATCTCCATTGGTGCTTTCCCTTCGACAAAAATCTCTGAGGCCCCATTTCTGCATCCTGCACCTAGGAGCAGAAGCCCCCTTCTGGTAAC
AGTTGTGGAGTCAGATCCCAGACCACAGGGGCAGCCCAGGAGAGGCTACACAGCCAGCAGTCTGGACAGCTCTTCCTCTTGGAGAGAGAG
ATGTAGTCATAATAGAGATCTTAGAAATTCTCAAAGAAATCACACTGTTTCATTCCACCTCAACAAACTGAAATACAACAGTACTGTGAA
GGAATCTCGGAATGATATTTCACTTATTCTCAATGAGTATGCTGAATTCAACAAGGTGATGAAGAATAGCAACCAATTCATTTTCCAAGA
CAAAGAGCTAAATGATGTTTCTGGAGAAGCCACTGCTCAAGAGATGTATCTGCCTTTCCCAGGACGGTCAGCCTCCTATGAAGACATAAT
CATAGACGTGTGCACCAATTTGCACGTCAAACTAAGAAGTGTTGTGAAAGAGGCTTGTAAAAGTACCTTCCTGTTCTACCTTGTCGAAAC
AGAAGACAAATCATTCTTTGTAAGAACAAAGAACCTTCTGAGGAAAGGAGGCCATACAGAAATTGAACCTCAGCACTTCTGTCAAGCTTT
CCACAGAGAGAATGATACACTAATCATCATCATCAGAAATGAAGATATATCATCACATTTGCATCAGATTCCTTCTTTGCTGAAGCTGAA
GCATTTCCCCAGTGTCATCTTTGCTGGAGTAGACAGCCCTGGAGATGTTCTTGATCACACCTACCAAGAACTGTTTCGTGCAGGAGGCTT
TGTGATATCAGATGACAAGATACTAGAAGCTGTAACATTAGTTCAACTGAAGGAAATTATCAAAATCCTGGAAAAACTAAATGGAAATGG
AAGATGGAAGTGGTTGCTTCACTACAGGGAAAATAAAAAGCTAAAAGAAGATGAAAGAGTGGATTCAACTGCACATAAGAAGAACATAAT
GTTGAAGTCATTTCAGAGTGCAAATATCATTGAATTGCTTCATTATCACCAGTGTGACTCTCGATCATCAACAAAAGCAGAAATTCTGAA
ATGTTTGCTAAACCTGCAAATTCAGCATATTGATGCCAGGTTTGCTGTCCTCCTAACAGCTAAAAATATCTTTAGAATTCGCTTCCATGA
CCCCTCTCCAGCCCAGTCTCACACTCTGCAAGCCAATGACGTGTTCCACAAGCAGCAGTGGTTCAACTGTATTCGAGCGGCCATTGCCCC
CTTCCAGTCGGCAGGCAGTCCACCTGAGCTGCAGGGCCTGCCGGAGCTGCACGAAGAGTGTGAGGGGAACCACCCCTCTGCGAGGAAACT
CACAGCCCAGAGGAGGGCATCCACAGTTTCCAGTGTTACTCAGGTAGAAGTTGATGAAAACGCTTACAGATGTGGCTCTGGCATGCAGAT
GGCAGAGGACAGCAAGAGCTTAAAGACACACCAGACACAGCCCGGCATCCGAAGAGCGAGGGACAAAGCCCTTTCTGGTGGCAAACGGAA
AGAGACTTTGGTGTAGAGAAGGCTCTGTGTGTTAACTGATGGGAGAGACTGTTTGTTTATAAATGTGTACAGTTTTGTTTTCTCGTAAGG
GGAGCATCATAGGGTTACTTTATACCAGTTGTAACATTTTCATTGTTTTTGGTTGTTCTTTTTTCTTTTTTTAATGGCAGCTAAAGATAT
ACAGATTACTGTTAAATTGCAGTCCTTTTTTTTTTAAAGATATTTTCTTGAATTATTTAGAACATGGTAAGCCTGGTATTTTTTAATCAA
ACAAAATATTTATGAAATGGGTTTTCTCTTAATTCTGGATTCATCATGGCTTTCTAATACCAATTGTAATATTTACAATATTCACCAAAA
CTTAGAATTTTGCAAATGCTGGAATTCTGCCAGTGTTTCTTTGCTAAGCCTTGCATGCAAAATTTGAAATTTTAACATTGGCACCCAAAA
CCTACATGGAATGTATGTCTGGAGTATTTCAAACTTTACATTGAAACATAATTTCCTTGGAAAACAAACCATAAGCCTGAGGAGGTTTTT
ATCAACTGGAATGCTTTATATTAGTTTGTTTTTCACTGTACATTCCTCATTTTACATTCATTTAACCTGCCGATTATTTAATTTTTTTAT
TGTAAAGTAGTTTTTAGCATTTGCTTTTATTTTTTTACTTTGATGCCTTTTCAAATTGGCATGTCTTTAAAGTATTTTTCTTCCTGATTA
AAAATGTGTGTGTATGTGTGTGTGTGTGTGTATATATATATATATTTTTAAATCACATTAATTTTACCAAGTGAAACCAAGCCATACTGT
TTTTGAGCCAATTAAGAAAATTGCCATTTTTAAAGTGTAGCATTTCAGGGTAAAGACCCATGAAATGGCTTGATGTATTCTAGACTACTG
AAAGAAAACCACTTCAAAGATTTTGTTGAAAGTTTTAGTGTTGTCTGAAATGCAAGAGGGAAGGTGATTGGTAGTGAGTTAAAAGAAAAA
GAGAGGAAAAGAGAGTAGTTTTGTCTTCAAGTAAAATGTCTGGTTGTGCCAGACATTTCACAAGTGTGAAAGGAGATAGGAGAAGCTCAA
CTTGAGGGCGTGTAGTAAGTTGTAGAAGGCTCGAGGGGACGTGGACTTATTTGCCTTGGTTTGCAATACCTGCAAATAATGAGTTTGAAA
AGAAACAATGAAATGTGTTAAAAATTTGACCATATTAGATAAATTTTCGTGGATTTAGTCATAAGATGGAAAAAGACTGGTGAATCTTTT
ATTACAAAATGTTTCTGTTAAAATGGGATCATCATCTTTGAAAGGGGGGAGGAGGAGTAAAAGCCCGATTATAATGGTGATCAATTCAAG
TCAGTGTTGACTATTCTGTGAAATATATTTGGCCAGTGGAAATGATAATCAGAAAAGACTGTAAATAGATCCATCCAAATGATTTCTCTG

>28873_28873_2_FAM208B-NET1_FAM208B_chr10_5803434_ENST00000328090_NET1_chr10_5498551_ENST00000380359_length(amino acids)=2526AA_BP=2391
MAPPAHKSILERSENVLMSPWKGKLIVQDRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEEKVCFQDLCF
NLYEVELSNRQGENIDKLTECIKNKQLAIIKCLEDRGFFILLTSSALLSEPDFGGKQMGLHGLHLFRSPLSTGVKDLKVEDDISMKVIPI
LSTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLSVAPQDRMKDPTFLGKLPSGFDLIPPAEKCPSESLTQLNSYFSDPSAY
ILEVSTALDLLAEHPQSPCVSDGICDAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKRVFPLSPASNLRVQPKRKASMPHMVQ
SKKVNLCRPFPKRTASRADNSSDSPTTLKLVKGQFPQKRKRGAEVLTAQFVQKTKLDRKNQEAPISKDVPVPTNAKRARKQEKSPVKTVP
RAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRGCQEDGISINSVQPENTTAAHNDLPENSIVNYDSQALNMLADL
ALSSATSSTPVSEARNLHCSSELPQNDVLLSKENSLRGTSDHEYHRGVKTQKGELLPNPSSDRKSNSGSDLTVSQDEESLVPCSQAPAKA
QSALTEEMLESSDASQSSSVSVEHSYALLLTEHSKKHLQEREILSPLFPRNGTKSPEAATPVGKVMPFRHQPGLLLQQKPPDDPVVKPKD
RPPSARVKKSSCSRIVLSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALHGPWNTDLPDNVEEVKLLLHMWVALFYSNQNKIIRS
SRKVVEHSNPAKYVSINSTLESCELREIEESLGLEKCSADSLLETNEISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCVQNEQKKTFAR
ECDPDTQEDQNFICSYNNEVTGEEAKQESLETSNLVLSGIGSTQTNGPSVPSEEEIVQPLDSTRVASYSGTVTQATFTRTYDGPGSQPVI
CQSSVYGTLENKVDILDAAVQTKTGTLQDLIQHGSPINNECHPSLERKDDNMGCAVINPEPITLTFEKNAHVPIQTEGVNTADERTTFKK
ELIKQVSPAASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLDKAVCSLQKETPLPVSLPSDKTMVMEALSLAKSSSH
LSPSEEVRCTQDFLSQTQSLLGLSSEGLLELTQVEVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLEAFDSVFI
KQTSLSVSREVSLELSEEDSDIDLALTISPPTSPREEMPAGEIEQFEEAPFSNLELQDVAEEIGEPEEVALTESREVSSADNVSVYPSVS
EEPVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPFDSVIEEVSPASSPEPPVPVKETRPYQAVTPCILKLHGTQCEKSNQISQ
CESEDLGITEKENVFVGPTHPVGQDNFTQVQQMQVSAEMPLILTDHPGRTGRPTLPGKVTEEIVSSEHDEGLSFSGKVQCYGRELNQPAS
AAKCTGDFSPSPEKLVKSGNPLQPVSIENRNLDLKHLVLESSEPPFGPRNVIENKSLSDTLVSTTAPSGIVNVSVKQQTSPKSSQNHLFP
GDLKTDEGIYLQVKSLTAASVDGAYSTQGCMCSVVPTLCSSSDNATLTHYVRPINAEPVFQAQEIPAGRMASLLKNGEPEAELHKETTGP
GTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELLNVGVSSLCAGPYQNTADTKENLSKEPLASFVSESFDTSVCGIATEHVEIENSGEG
LRAEAGSETLGRDGEVGVNSDMHYELSGDSDLDLLGDCRNPRLDLEDSYTLRGSYTRKKDVPTDGYESSLNFHNNNQEDWGCSSWVPGME
TSLPPGHWTAAVKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTSHGLRRHPSFSANCGLPSSWTSTWQVADDLTQNTLDLEYL
RFAHKLKQTIKNGDSQHSASSANVFPKESPTQISIGAFPSTKISEAPFLHPAPRSRSPLLVTVVESDPRPQGQPRRGYTASSLDSSSSWR
ERCSHNRDLRNSQRNHTVSFHLNKLKYNSTVKESRNDISLILNEYAEFNKVMKNSNQFIFQDKELNDVSGEATAQEMYLPFPGRSASYED
IIIDVCTNLHVKLRSVVKEACKSTFLFYLVETEDKSFFVRTKNLLRKGGHTEIEPQHFCQAFHRENDTLIIIIRNEDISSHLHQIPSLLK
LKHFPSVIFAGVDSPGDVLDHTYQELFRAGGFVISDDKILEAVTLVQLKEIIKILEKLNGNGRWKWLLHYRENKKLKEDERVDSTAHKKN
IMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAI
APFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGK

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Fusion Gene PPI Analysis for FAM208B-NET1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FAM208B-NET1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FAM208B-NET1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source