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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM212B-BCAS4 (FusionGDB2 ID:28900)

Fusion Gene Summary for FAM212B-BCAS4

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM212B-BCAS4
Fusion gene ID: 28900
HgeneTgene
Gene symbol

FAM212B

BCAS4

Gene ID

55924

55653

Gene nameinka box actin regulator 2breast carcinoma amplified sequence 4
SynonymsC1orf183|FAM212BCNOL
Cytomap

1p13.2

20q13.13

Type of geneprotein-codingprotein-coding
DescriptionPAK4-inhibitor INKA2HInca-rfamily with sequence similarity 212 member Binduced in neural crest by AP2-alpha protein-related homologprotein FAM212Bbreast carcinoma-amplified sequence 4BCAS4/BCAS3 fusionbreast carcinoma amplified sequence 4/3 fusion protein
Modification date2020031320200313
UniProtAcc.

Q8TDM0

Ensembl transtripts involved in fusion geneENST00000357260, ENST00000534365, 
ENST00000412270, ENST00000444059, 
ENST00000485049, ENST00000262591, 
ENST00000371608, ENST00000609336, 
ENST00000358791, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 8 X 9=792
# samples 311
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/792*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM212B [Title/Abstract] AND BCAS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM212B(112281808)-BCAS4(49493023), # samples:2
Anticipated loss of major functional domain due to fusion event.FAM212B-BCAS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FAM212B-BCAS4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM212B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BCAS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PN-01AFAM212Bchr1

112281807

-BCAS4chr20

49493022

+
ChimerDB4UCSTCGA-N8-A4PN-01AFAM212Bchr1

112281808

-BCAS4chr20

49493023

+
ChimerDB4UCSTCGA-N8-A4PNFAM212Bchr1

112281808

-BCAS4chr20

49493023

+


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Fusion Gene ORF analysis for FAM212B-BCAS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357260ENST00000485049FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
5CDS-intronENST00000357260ENST00000485049FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
5CDS-intronENST00000534365ENST00000485049FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
5CDS-intronENST00000534365ENST00000485049FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
Frame-shiftENST00000357260ENST00000262591FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
Frame-shiftENST00000357260ENST00000262591FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
Frame-shiftENST00000357260ENST00000371608FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
Frame-shiftENST00000357260ENST00000371608FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
Frame-shiftENST00000357260ENST00000609336FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
Frame-shiftENST00000357260ENST00000609336FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
Frame-shiftENST00000534365ENST00000262591FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
Frame-shiftENST00000534365ENST00000262591FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
Frame-shiftENST00000534365ENST00000371608FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
Frame-shiftENST00000534365ENST00000371608FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
Frame-shiftENST00000534365ENST00000609336FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
Frame-shiftENST00000534365ENST00000609336FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
In-frameENST00000357260ENST00000358791FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
In-frameENST00000357260ENST00000358791FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
In-frameENST00000534365ENST00000358791FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
In-frameENST00000534365ENST00000358791FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000412270ENST00000262591FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000412270ENST00000262591FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000412270ENST00000358791FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000412270ENST00000358791FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000412270ENST00000371608FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000412270ENST00000371608FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000412270ENST00000609336FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000412270ENST00000609336FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000444059ENST00000262591FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000444059ENST00000262591FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000444059ENST00000358791FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000444059ENST00000358791FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000444059ENST00000371608FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000444059ENST00000371608FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-3CDSENST00000444059ENST00000609336FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-3CDSENST00000444059ENST00000609336FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-intronENST00000412270ENST00000485049FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-intronENST00000412270ENST00000485049FAM212Bchr1

112281808

-BCAS4chr20

49493023

+
intron-intronENST00000444059ENST00000485049FAM212Bchr1

112281807

-BCAS4chr20

49493022

+
intron-intronENST00000444059ENST00000485049FAM212Bchr1

112281808

-BCAS4chr20

49493023

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357260FAM212Bchr1112281808-ENST00000358791BCAS4chr2049493023+931239365676103
ENST00000534365FAM212Bchr1112281808-ENST00000358791BCAS4chr2049493023+870178304615103
ENST00000357260FAM212Bchr1112281807-ENST00000358791BCAS4chr2049493022+931239365676103
ENST00000534365FAM212Bchr1112281807-ENST00000358791BCAS4chr2049493022+870178304615103

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357260ENST00000358791FAM212Bchr1112281808-BCAS4chr2049493023+0.741843940.2581561
ENST00000534365ENST00000358791FAM212Bchr1112281808-BCAS4chr2049493023+0.65416560.34583437
ENST00000357260ENST00000358791FAM212Bchr1112281807-BCAS4chr2049493022+0.741843940.2581561
ENST00000534365ENST00000358791FAM212Bchr1112281807-BCAS4chr2049493022+0.65416560.34583437

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Fusion Genomic Features for FAM212B-BCAS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM212Bchr1112281807-BCAS4chr2049493022+3.71E-050.9999629
FAM212Bchr1112281807-BCAS4chr2049493022+3.71E-050.9999629
FAM212Bchr1112281807-BCAS4chr2049493022+3.71E-050.9999629
FAM212Bchr1112281807-BCAS4chr2049493022+3.71E-050.9999629

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM212B-BCAS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:112281808/chr20:49493023)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BCAS4

Q8TDM0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM212Bchr1:112281807chr20:49493022ENST00000357260-12137_18019298.0RegionInka box
HgeneFAM212Bchr1:112281807chr20:49493022ENST00000444059-12137_1800283.0RegionInka box
HgeneFAM212Bchr1:112281808chr20:49493023ENST00000357260-12137_18019298.0RegionInka box
HgeneFAM212Bchr1:112281808chr20:49493023ENST00000444059-12137_1800283.0RegionInka box


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Fusion Gene Sequence for FAM212B-BCAS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28900_28900_1_FAM212B-BCAS4_FAM212B_chr1_112281807_ENST00000357260_BCAS4_chr20_49493022_ENST00000358791_length(transcript)=931nt_BP=239nt
GACCGCGCGCGGCTAGCCGCTGGGGAAGCGACTCTGAGTCCCGGGCTCGGAGCGCAGGCTCAGCTCCGCGCTGCGAGCGCTACGGGCGCA
GGGGCGGGGAGCCGGCCCGGAGCGCAGTTTCCAGTGGGGCCGGGGTTTCACCCGGGCCCTCTCTGTTTGAACCGAACCCGACAAATGGGC
GCATGACGATGGAGAGCAGGGAAATGGACTGCTATCTCCGTCGCCTCAAACAGGAGCTGAAGTCACCTGCACCGGTGCCCGTGACGTACG
AGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGT
GAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTGCAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTAT
TTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTCCAGACTGATCTCAAACTCCTGGGCTCAAGTGATCC
ACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAGGCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCAT
GTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCCACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGG
GACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATGGCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGA
TGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTTCTGTTGCCTCCAGACCTCGGTGCCCACAGCCTTGA

>28900_28900_1_FAM212B-BCAS4_FAM212B_chr1_112281807_ENST00000357260_BCAS4_chr20_49493022_ENST00000358791_length(amino acids)=103AA_BP=
MWSSHQERWKVTLCTHCSLGVFSLYCCLFYILKIFKKMSRWGLTMLSRLISNSWAQVIHPPWPSKVVGLWAGASVPRLLPFSNFLPASCE

--------------------------------------------------------------
>28900_28900_2_FAM212B-BCAS4_FAM212B_chr1_112281807_ENST00000534365_BCAS4_chr20_49493022_ENST00000358791_length(transcript)=870nt_BP=178nt
AGCTCCGCGCTGCGAGCGCTACGGGCGCAGGGGCGGGGAGCCGGCCCGGAGCGCAGTTTCCAGTGGGGCCGGGGTTTCACCCGGGCCCTC
TCTGTTTGAACCGAACCCGACAAATGGGCGCATGACGATGGAGAGCAGGGAAATGGACTGCTATCTCCGTCGCCTCAAACAGGAGCTGAA
GTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCA
CCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTGCAGCTT
GGGGGTTTTTTCTTTGTATTGCTGTTTATTTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTCCAGACT
GATCTCAAACTCCTGGGCTCAAGTGATCCACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAGGCTGCT
GCCATTTTCAAATTTCCTCCCTGCCTCATGTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCCACATCG
GCCTGCTTGGGGTTCTACAGGGGTTGAGGGACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATGGCTTTG
CAGGGGCTCCATGGTCCTTCTCTCTGTGATGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTTCTGTTG

>28900_28900_2_FAM212B-BCAS4_FAM212B_chr1_112281807_ENST00000534365_BCAS4_chr20_49493022_ENST00000358791_length(amino acids)=103AA_BP=
MWSSHQERWKVTLCTHCSLGVFSLYCCLFYILKIFKKMSRWGLTMLSRLISNSWAQVIHPPWPSKVVGLWAGASVPRLLPFSNFLPASCE

--------------------------------------------------------------
>28900_28900_3_FAM212B-BCAS4_FAM212B_chr1_112281808_ENST00000357260_BCAS4_chr20_49493023_ENST00000358791_length(transcript)=931nt_BP=239nt
GACCGCGCGCGGCTAGCCGCTGGGGAAGCGACTCTGAGTCCCGGGCTCGGAGCGCAGGCTCAGCTCCGCGCTGCGAGCGCTACGGGCGCA
GGGGCGGGGAGCCGGCCCGGAGCGCAGTTTCCAGTGGGGCCGGGGTTTCACCCGGGCCCTCTCTGTTTGAACCGAACCCGACAAATGGGC
GCATGACGATGGAGAGCAGGGAAATGGACTGCTATCTCCGTCGCCTCAAACAGGAGCTGAAGTCACCTGCACCGGTGCCCGTGACGTACG
AGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGT
GAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTGCAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTAT
TTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTCCAGACTGATCTCAAACTCCTGGGCTCAAGTGATCC
ACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAGGCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCAT
GTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCCACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGG
GACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATGGCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGA
TGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTTCTGTTGCCTCCAGACCTCGGTGCCCACAGCCTTGA

>28900_28900_3_FAM212B-BCAS4_FAM212B_chr1_112281808_ENST00000357260_BCAS4_chr20_49493023_ENST00000358791_length(amino acids)=103AA_BP=
MWSSHQERWKVTLCTHCSLGVFSLYCCLFYILKIFKKMSRWGLTMLSRLISNSWAQVIHPPWPSKVVGLWAGASVPRLLPFSNFLPASCE

--------------------------------------------------------------
>28900_28900_4_FAM212B-BCAS4_FAM212B_chr1_112281808_ENST00000534365_BCAS4_chr20_49493023_ENST00000358791_length(transcript)=870nt_BP=178nt
AGCTCCGCGCTGCGAGCGCTACGGGCGCAGGGGCGGGGAGCCGGCCCGGAGCGCAGTTTCCAGTGGGGCCGGGGTTTCACCCGGGCCCTC
TCTGTTTGAACCGAACCCGACAAATGGGCGCATGACGATGGAGAGCAGGGAAATGGACTGCTATCTCCGTCGCCTCAAACAGGAGCTGAA
GTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCA
CCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTGCAGCTT
GGGGGTTTTTTCTTTGTATTGCTGTTTATTTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTCCAGACT
GATCTCAAACTCCTGGGCTCAAGTGATCCACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAGGCTGCT
GCCATTTTCAAATTTCCTCCCTGCCTCATGTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCCACATCG
GCCTGCTTGGGGTTCTACAGGGGTTGAGGGACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATGGCTTTG
CAGGGGCTCCATGGTCCTTCTCTCTGTGATGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTTCTGTTG

>28900_28900_4_FAM212B-BCAS4_FAM212B_chr1_112281808_ENST00000534365_BCAS4_chr20_49493023_ENST00000358791_length(amino acids)=103AA_BP=
MWSSHQERWKVTLCTHCSLGVFSLYCCLFYILKIFKKMSRWGLTMLSRLISNSWAQVIHPPWPSKVVGLWAGASVPRLLPFSNFLPASCE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM212B-BCAS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM212B-BCAS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM212B-BCAS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource