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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FAM213A-IGJ (FusionGDB2 ID:28906)

Fusion Gene Summary for FAM213A-IGJ

Fusion gene summary

Fusion gene information	Fusion gene name: FAM213A-IGJ
	Fusion gene ID: 28906
		Hgene	Tgene
	Gene symbol	FAM213A	IGJ
	Gene ID	84293	3512
	Gene name	peroxiredoxin like 2A	joining chain of multimeric IgA and IgM
	Synonyms	Adrx\|C10orf58\|FAM213A\|PAMM	IGCJ\|IGJ\|JCH
	Cytomap	10q23.1	4q13.3
	Type of gene	protein-coding	protein-coding
	Description	peroxiredoxin-like 2AAdiporedoxinUPF0765 protein C10orf58family with sequence similarity 213 member Aperoxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytesperoxiredoxin-like 2 activated in M-CSF stimulated monocytesredox-regulatory prote	immunoglobulin J chainIgJ chainJ chainimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000372181, ENST00000372185, ENST00000372187, ENST00000372188,	ENST00000254801, ENST00000543780,
Fusion gene scores	* DoF score	8 X 9 X 5=360	5 X 4 X 3=60
	# samples	9	5
	** MAII score	log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM213A [Title/Abstract] AND IGJ [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM213A(82180401)-IGJ(71527932), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FAM213A	GO:0045670	regulation of osteoclast differentiation	19951071
Hgene	FAM213A	GO:0055114	oxidation-reduction process	19951071
Tgene	IGJ	GO:0002250	adaptive immune response	21786026
Tgene	IGJ	GO:0019731	antibacterial humoral response	23250751
Tgene	IGJ	GO:0045087	innate immune response	21786026
Tgene	IGJ	GO:0060267	positive regulation of respiratory burst	24145934

Fusion gene breakpoints across FAM213A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IGJ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AQ-A04L-01B	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-

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Fusion Gene ORF analysis for FAM213A-IGJ

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000372181	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372181	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372185	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372185	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372187	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372187	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372188	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-
In-frame	ENST00000372188	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372188	FAM213A	chr10	82180401	+	ENST00000254801	IGJ	chr4	71527932	-	1512	308	130	723	197
ENST00000372188	FAM213A	chr10	82180401	+	ENST00000543780	IGJ	chr4	71527932	-	724	308	130	723	198
ENST00000372187	FAM213A	chr10	82180401	+	ENST00000254801	IGJ	chr4	71527932	-	1535	331	153	746	197
ENST00000372187	FAM213A	chr10	82180401	+	ENST00000543780	IGJ	chr4	71527932	-	747	331	153	746	197
ENST00000372185	FAM213A	chr10	82180401	+	ENST00000254801	IGJ	chr4	71527932	-	1517	313	168	728	186
ENST00000372185	FAM213A	chr10	82180401	+	ENST00000543780	IGJ	chr4	71527932	-	729	313	168	728	186
ENST00000372181	FAM213A	chr10	82180401	+	ENST00000254801	IGJ	chr4	71527932	-	1852	648	470	1063	197
ENST00000372181	FAM213A	chr10	82180401	+	ENST00000543780	IGJ	chr4	71527932	-	1064	648	470	1063	198

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372188	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.000861665	0.99913836
ENST00000372188	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.005033897	0.9949661
ENST00000372187	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.000716047	0.99928397
ENST00000372187	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.001935993	0.998064
ENST00000372185	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.000779421	0.9992206
ENST00000372185	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.002100121	0.9978999
ENST00000372181	ENST00000254801	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.001223955	0.998776
ENST00000372181	ENST00000543780	FAM213A	chr10	82180401	+	IGJ	chr4	71527932	-	0.004238473	0.9957616

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Fusion Genomic Features for FAM213A-IGJ

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM213A-IGJ

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:82180401/chr4:71527932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM213A

chr10:82180401

chr4:71527932

ENST00000372181

14_112

230.0

Region

Thioredoxin fold

Hgene

FAM213A

chr10:82180401

chr4:71527932

ENST00000372185

14_112

219.0

Region

Thioredoxin fold

Hgene

FAM213A

chr10:82180401

chr4:71527932

ENST00000372187

14_112

230.0

Region

Thioredoxin fold

Hgene

FAM213A

chr10:82180401

chr4:71527932

ENST00000372188

14_112

230.0

Region

Thioredoxin fold

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Fusion Gene Sequence for FAM213A-IGJ

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>28906_28906_1_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1852nt_BP=648nt
AGTATCCTCTGATCACAGAAGAGAAAGCTGCCCCTACCCAGGGACATGATCCTGAGCCACCTGGATTGTGAGGGAGAATCAGGCATTGAT
GAGGAGGGGAATGAGGAAGTAGTCTGCCTACAGGGGACATAGCTCGGCACAGCTCCACAGAGCTAGGGGCTGCAACTTGGGGCATGAGAA
GAGAGAGCAGCAAGAGAACCATTTGAGAAGGCTGTCCTTTCTCTGTCATCACTCCTGATGCCCTGGTGAGCTCCACGGTGCAGGAACCTC
CATGTGTGTGCTGCATCCCCAAGTTCTGGTGGCAGCAGGTGCTTAGCAGCCCTTGTCCAGTCTCGCCTGTGACACTGCTGCTCCCTTCCC
CTGTCCTGACCTCCTGGTTGGCTGTCCTGCCAGAGCCTTGCCTGGAAGATGAAATTCCAGCTACCCTGTGGGAGCAGTAACGCCTTCTTC
CTTCTTCTCAATCTCCAGAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGG
CTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACC
TGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCC
GTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCA
CCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAG
TTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGG
TCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGACTAATTTAAGTCATTGCTGA
CTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAGTTAGCATATTTATTACCAATGAATTTGAAACCAGGGCTTTTTT
TTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTAAAATAGTCACATTGTTATCTTTATTAGGTAATCACTTCTTAAT
TATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCACCTGAAAGAGGTATGCTCTCTTAGGAATACAGTTTCTAGCATT
AAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCAGGAGGTGTAATAAAATGTTCCTCGCATTCCCCCCCGCTTTTTT
TTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCTTTACTATTCTTTTTAAAAAAAGTTTCACTGTGTAGAGAACATA
TATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATAATTGGAAAACATGTTCTAGAACTAGTTACAAAAATAATTTAAG
GTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTAAAATATATTTGGACATAACAGACTTGGAAGCAGATGATACAGA
CTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAACAATCCATTTTGTAACTGAACCTTATGAAATATATGTATTTCA

>28906_28906_1_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_2_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000543780_length(transcript)=1064nt_BP=648nt
AGTATCCTCTGATCACAGAAGAGAAAGCTGCCCCTACCCAGGGACATGATCCTGAGCCACCTGGATTGTGAGGGAGAATCAGGCATTGAT
GAGGAGGGGAATGAGGAAGTAGTCTGCCTACAGGGGACATAGCTCGGCACAGCTCCACAGAGCTAGGGGCTGCAACTTGGGGCATGAGAA
GAGAGAGCAGCAAGAGAACCATTTGAGAAGGCTGTCCTTTCTCTGTCATCACTCCTGATGCCCTGGTGAGCTCCACGGTGCAGGAACCTC
CATGTGTGTGCTGCATCCCCAAGTTCTGGTGGCAGCAGGTGCTTAGCAGCCCTTGTCCAGTCTCGCCTGTGACACTGCTGCTCCCTTCCC
CTGTCCTGACCTCCTGGTTGGCTGTCCTGCCAGAGCCTTGCCTGGAAGATGAAATTCCAGCTACCCTGTGGGAGCAGTAACGCCTTCTTC
CTTCTTCTCAATCTCCAGAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGG
CTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACC
TGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCC
GTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCA
CCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAG
TTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGG

>28906_28906_2_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=198AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_3_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1517nt_BP=313nt
TGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGTT
TGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGGACCCAAGTTTCTTCACCATGGGGATGTGG
TCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCC
CTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGT
GCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAAC
AACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACA
GAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGAC
AGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTAT
CCTGACTAATTTAAGTCATTGCTGACTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAGTTAGCATATTTATTACCA
ATGAATTTGAAACCAGGGCTTTTTTTTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTAAAATAGTCACATTGTTAT
CTTTATTAGGTAATCACTTCTTAATTATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCACCTGAAAGAGGTATGCTC
TCTTAGGAATACAGTTTCTAGCATTAAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCAGGAGGTGTAATAAAATGT
TCCTCGCATTCCCCCCCGCTTTTTTTTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCTTTACTATTCTTTTTAAAA
AAAGTTTCACTGTGTAGAGAACATATATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATAATTGGAAAACATGTTCTA
GAACTAGTTACAAAAATAATTTAAGGTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTAAAATATATTTGGACATAA
CAGACTTGGAAGCAGATGATACAGACTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAACAATCCATTTTGTAACTG

>28906_28906_3_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=186AA_BP=48
MGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRII
VPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTP

--------------------------------------------------------------
>28906_28906_4_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000543780_length(transcript)=729nt_BP=313nt
TGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGTT
TGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGGACCCAAGTTTCTTCACCATGGGGATGTGG
TCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCC
CTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGT
GCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAAC
AACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACA
GAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGAC
AGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTAT

>28906_28906_4_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=186AA_BP=48
MGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRII
VPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTP

--------------------------------------------------------------
>28906_28906_5_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1535nt_BP=331nt
ATGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGT
TTGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGAAATGTCTTTCCTCCAGGACCCAAGTTTC
TTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCC
AAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTT
GACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGA
ATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGT
AAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAG
ACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTA
ACCCCAGATGCCTGCTATCCTGACTAATTTAAGTCATTGCTGACTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAG
TTAGCATATTTATTACCAATGAATTTGAAACCAGGGCTTTTTTTTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTA
AAATAGTCACATTGTTATCTTTATTAGGTAATCACTTCTTAATTATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCA
CCTGAAAGAGGTATGCTCTCTTAGGAATACAGTTTCTAGCATTAAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCA
GGAGGTGTAATAAAATGTTCCTCGCATTCCCCCCCGCTTTTTTTTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCT
TTACTATTCTTTTTAAAAAAAGTTTCACTGTGTAGAGAACATATATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATA
ATTGGAAAACATGTTCTAGAACTAGTTACAAAAATAATTTAAGGTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTA
AAATATATTTGGACATAACAGACTTGGAAGCAGATGATACAGACTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAA
CAATCCATTTTGTAACTGAACCTTATGAAATATATGTATTTCATGGTACGTATTCTCTAGCACAGTCTGAGCAATTAAATAGATTCATAA

>28906_28906_5_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_6_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000543780_length(transcript)=747nt_BP=331nt
ATGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGT
TTGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGAAATGTCTTTCCTCCAGGACCCAAGTTTC
TTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCC
AAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTT
GACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGA
ATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGT
AAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAG
ACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTA

>28906_28906_6_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_7_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1512nt_BP=308nt
TGCCCAGACTGGTCTTGAACTCCTGGGCTCAAGCGATCCTCCCAAAGCCCTGAGATTACAGGCGTGAGCCAGCGCGCCGGACACAACCTC
CTACTTTCATGAAAGAGTGGGCACTTCCAACAGGAGGAAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCAT
TGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGA
GTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCG
GATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAG
GGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGT
GGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAA
CAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGA
CTAATTTAAGTCATTGCTGACTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAGTTAGCATATTTATTACCAATGAA
TTTGAAACCAGGGCTTTTTTTTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTAAAATAGTCACATTGTTATCTTTA
TTAGGTAATCACTTCTTAATTATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCACCTGAAAGAGGTATGCTCTCTTA
GGAATACAGTTTCTAGCATTAAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCAGGAGGTGTAATAAAATGTTCCTC
GCATTCCCCCCCGCTTTTTTTTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCTTTACTATTCTTTTTAAAAAAAGT
TTCACTGTGTAGAGAACATATATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATAATTGGAAAACATGTTCTAGAACT
AGTTACAAAAATAATTTAAGGTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTAAAATATATTTGGACATAACAGAC
TTGGAAGCAGATGATACAGACTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAACAATCCATTTTGTAACTGAACCT

>28906_28906_7_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_8_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000543780_length(transcript)=724nt_BP=308nt
TGCCCAGACTGGTCTTGAACTCCTGGGCTCAAGCGATCCTCCCAAAGCCCTGAGATTACAGGCGTGAGCCAGCGCGCCGGACACAACCTC
CTACTTTCATGAAAGAGTGGGCACTTCCAACAGGAGGAAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCAT
TGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGA
GTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCG
GATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAG
GGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGT
GGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAA
CAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGA

>28906_28906_8_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=198AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FAM213A-IGJ

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FAM213A-IGJ

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FAM213A-IGJ

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source