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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM214A-ARPP19 (FusionGDB2 ID:28913)

Fusion Gene Summary for FAM214A-ARPP19

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM214A-ARPP19
Fusion gene ID: 28913
HgeneTgene
Gene symbol

FAM214A

ARPP19

Gene ID

56204

10776

Gene namefamily with sequence similarity 214 member AcAMP regulated phosphoprotein 19
SynonymsKIAA1370ARPP-16|ARPP-19|ARPP16|ENSAL
Cytomap

15q21.2-q21.3

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM214AcAMP-regulated phosphoprotein 19cAMP-regulated phosphoprotein 19kDacyclic AMP phosphoprotein, 19 kD
Modification date2020031320200313
UniProtAcc

Q32MH5

P56211

Ensembl transtripts involved in fusion geneENST00000261844, ENST00000562351, 
ENST00000546305, 		ENST00000561650, 
ENST00000561971, ENST00000563277, 
ENST00000563566, ENST00000567669, 
ENST00000568196, ENST00000249822, 
ENST00000564163, ENST00000565288, 
ENST00000566423, ENST00000569281, 
ENST00000569723, 
Fusion gene scores* DoF score8 X 6 X 5=2405 X 6 X 2=60
# samples 85
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM214A [Title/Abstract] AND ARPP19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM214A(52970203)-ARPP19(52849419), # samples:1
FAM214A(52970203)-ARPP19(52856443), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM214A-ARPP19 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARPP19

GO:0045722

positive regulation of gluconeogenesis

9653196


check buttonFusion gene breakpoints across FAM214A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARPP19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4729FAM214Achr15

52970203

-ARPP19chr15

52849419

-
ChimerDB4HNSCTCGA-CN-4729FAM214Achr15

52970203

-ARPP19chr15

52856443

-


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Fusion Gene ORF analysis for FAM214A-ARPP19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261844ENST00000561650FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-5UTRENST00000261844ENST00000561971FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-5UTRENST00000261844ENST00000561971FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-5UTRENST00000261844ENST00000563277FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-5UTRENST00000261844ENST00000563566FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-5UTRENST00000261844ENST00000563566FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-5UTRENST00000261844ENST00000567669FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-5UTRENST00000261844ENST00000568196FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-intronENST00000261844ENST00000249822FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000561650FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000563277FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000564163FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-intronENST00000261844ENST00000564163FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000565288FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-intronENST00000261844ENST00000565288FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000566423FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000567669FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000568196FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000569281FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-intronENST00000261844ENST00000569281FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5CDS-intronENST00000261844ENST00000569723FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5CDS-intronENST00000261844ENST00000569723FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-3CDSENST00000562351ENST00000249822FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-3CDSENST00000562351ENST00000566423FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-5UTRENST00000562351ENST00000561650FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-5UTRENST00000562351ENST00000561971FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-5UTRENST00000562351ENST00000561971FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-5UTRENST00000562351ENST00000563277FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-5UTRENST00000562351ENST00000563566FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-5UTRENST00000562351ENST00000563566FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-5UTRENST00000562351ENST00000567669FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-5UTRENST00000562351ENST00000568196FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-intronENST00000562351ENST00000249822FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000561650FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000563277FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000564163FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-intronENST00000562351ENST00000564163FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000565288FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-intronENST00000562351ENST00000565288FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000566423FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000567669FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000568196FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000569281FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-intronENST00000562351ENST00000569281FAM214Achr15

52970203

-ARPP19chr15

52856443

-
5UTR-intronENST00000562351ENST00000569723FAM214Achr15

52970203

-ARPP19chr15

52849419

-
5UTR-intronENST00000562351ENST00000569723FAM214Achr15

52970203

-ARPP19chr15

52856443

-
Frame-shiftENST00000261844ENST00000249822FAM214Achr15

52970203

-ARPP19chr15

52849419

-
Frame-shiftENST00000261844ENST00000566423FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-3CDSENST00000546305ENST00000249822FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-3CDSENST00000546305ENST00000566423FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-5UTRENST00000546305ENST00000561650FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-5UTRENST00000546305ENST00000561971FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-5UTRENST00000546305ENST00000561971FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-5UTRENST00000546305ENST00000563277FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-5UTRENST00000546305ENST00000563566FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-5UTRENST00000546305ENST00000563566FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-5UTRENST00000546305ENST00000567669FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-5UTRENST00000546305ENST00000568196FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-intronENST00000546305ENST00000249822FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000561650FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000563277FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000564163FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-intronENST00000546305ENST00000564163FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000565288FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-intronENST00000546305ENST00000565288FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000566423FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000567669FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000568196FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000569281FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-intronENST00000546305ENST00000569281FAM214Achr15

52970203

-ARPP19chr15

52856443

-
intron-intronENST00000546305ENST00000569723FAM214Achr15

52970203

-ARPP19chr15

52849419

-
intron-intronENST00000546305ENST00000569723FAM214Achr15

52970203

-ARPP19chr15

52856443

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAM214A-ARPP19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM214A-ARPP19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:52970203/:52849419)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM214A

Q32MH5

ARPP19

P56211

FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM214A-ARPP19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM214A-ARPP19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM214A-ARPP19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM214A-ARPP19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource