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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM214A-CCDC102B (FusionGDB2 ID:28914)

Fusion Gene Summary for FAM214A-CCDC102B

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM214A-CCDC102B
Fusion gene ID: 28914
HgeneTgene
Gene symbol

FAM214A

CCDC102B

Gene ID

56204

79839

Gene namefamily with sequence similarity 214 member Acoiled-coil domain containing 102B
SynonymsKIAA1370ACY1L|AN|C18orf14|HsT1731
Cytomap

15q21.2-q21.3

18q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM214Acoiled-coil domain-containing protein 102B
Modification date2020031320200327
UniProtAcc

Q32MH5

Q68D86

Ensembl transtripts involved in fusion geneENST00000261844, ENST00000546305, 
ENST00000562351, 		ENST00000358653, 
ENST00000577772, ENST00000584156, 
ENST00000319445, ENST00000360242, 
Fusion gene scores* DoF score8 X 6 X 5=2405 X 5 X 4=100
# samples 85
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM214A [Title/Abstract] AND CCDC102B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM214A(52885775)-CCDC102B(66721267), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM214A-CCDC102B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM214A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC102B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SG-A6Z4-01AFAM214Achr15

52885775

-CCDC102Bchr18

66721267

+


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Fusion Gene ORF analysis for FAM214A-CCDC102B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261844ENST00000358653FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
5CDS-intronENST00000261844ENST00000577772FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
5CDS-intronENST00000261844ENST00000584156FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
5CDS-intronENST00000546305ENST00000358653FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
5CDS-intronENST00000546305ENST00000577772FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
5CDS-intronENST00000546305ENST00000584156FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
Frame-shiftENST00000546305ENST00000319445FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
Frame-shiftENST00000546305ENST00000360242FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
In-frameENST00000261844ENST00000319445FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
In-frameENST00000261844ENST00000360242FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
intron-3CDSENST00000562351ENST00000319445FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
intron-3CDSENST00000562351ENST00000360242FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
intron-intronENST00000562351ENST00000358653FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
intron-intronENST00000562351ENST00000577772FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+
intron-intronENST00000562351ENST00000584156FAM214Achr15

52885775

-CCDC102Bchr18

66721267

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261844FAM214Achr1552885775-ENST00000319445CCDC102Bchr1866721267+412129611413068975
ENST00000261844FAM214Achr1552885775-ENST00000360242CCDC102Bchr1866721267+412129611413068975

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261844ENST00000319445FAM214Achr1552885775-CCDC102Bchr1866721267+0.0002376840.99976236
ENST00000261844ENST00000360242FAM214Achr1552885775-CCDC102Bchr1866721267+0.0002376840.99976236

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Fusion Genomic Features for FAM214A-CCDC102B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM214Achr1552885774-CCDC102Bchr1866721266+3.69E-060.9999963
FAM214Achr1552885774-CCDC102Bchr1866721266+3.69E-060.9999963

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM214A-CCDC102B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:52885775/chr18:66721267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM214A

Q32MH5

CCDC102B

Q68D86


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC102Bchr15:52885775chr18:66721267ENST0000058415606268_3370484.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST0000058415606363_5130484.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST000005841560672_1420484.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC102Bchr15:52885775chr18:66721267ENST0000031944568268_337478514.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST0000031944568363_513478514.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST000003194456872_142478514.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST0000036024268268_337478514.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST0000036024268363_513478514.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC102Bchr15:52885775chr18:66721267ENST000003602426872_142478514.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for FAM214A-CCDC102B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28914_28914_1_FAM214A-CCDC102B_FAM214A_chr15_52885775_ENST00000261844_CCDC102B_chr18_66721267_ENST00000319445_length(transcript)=4121nt_BP=2961nt
TAAACTTGGCCGCGGTTGCCGCAGGAAGGCTAGCCAGAGGGTAATTACACAGCATTTTGAAAGCGAAGCAGAAGCCGTAGAATCAGCGGC
GAGCCTGTTGAAAGAACCCACAGGTGCATTTCACAGCACTCTGGGCGAAAATTGGATGTGAAAATGAAGCCAGACCGAGATACTCTGGAT
GAATATTTTGAATATGATGCAGAGGAGTTCTTGGTCTCTTTGGCCTTGCTGATAACAGAAGGACGAACACCTGAATGTTCTGTAAAAGGT
CGAACAGAAAGCTTTCATTGCCCTCCAGCACAGTCTTGTTACCCAGTAACTACCAAACATGAATGTAGTGACAAGCTGGCCCAGTGCCGC
CAAGCCAGACGAACTAGGTCTGAGGTCACATTGTTGTGGAAGAATAACCTTCCAATCATGGTGGAAATGATGCTACTACCAGACTGCTGC
TACAGCGATGATGGGCCCACCACAGAGGGAATTGATCTAAATGATCCTGCGATTAAGCAAGATGCATTATTATTAGAAAGATGGATCTTG
GAGCCAGTTCCTCGACAGAATGGTGACCGATTTATTGAAGAGAAGACGCTTCTGTTGGCTGTCCGCTCATTTGTGTTTTTTTCTCAGTTA
AGTGCATGGCTGAGTGTTTCTCATGGTGCTATTCCACGAAATATTCTCTACAGAATCAGTGCTGCTGATGTAGACCTACAGTGGAATTTT
TCACAGACTCCAATTGAGCATGTGTTTCCTGTTCCCAATGTTTCTCACAATGTTGCCTTGAAAGTCAGTGTTCAGTCCTTGCCCAGACAA
TCTAATTATCCAGTTTTGACGTGCAGTATTCACACTAATATTGGCCTTTATGAGAAAAGAATTCAACAACATAAACTTAAAACTCATCAG
CACCATAACCCAAATGAAGCAGAACAATGTGGTACAAACAGTTCACAGCGTCTGTGTAGCAAACAAACTTGGACCATGGCACCTGAAAGT
GTGTTACATGCAAAAAGTGGCCCAAGTCCAGAATATACTGCAGCTGTCAAAAATATCAAACTATATCCAGGCACTGGCAGTAAATCTGAC
CATGGGACATCTCAAGCCAATATTCTAGGCTTTAGTGGTATAGGTGATATAAAATCACAAGAAACATCAGTGAGAACTTTAAAATCATTT
TCAATGGTTGATTCCAGTATCTCTAACCGCCAGAGTTTCTGGCAGTCAGCTGGTGAGACTAACCCTTTAATAGGCTCTTTAATTCAGGAG
CGGCAAGAAATCATTGCAAGAATTGCCCAACATTTGATTCATTGTGATCCAAGCACTTCACATGTTTCTGGACGTCCATTTAATACTCAA
GAGTCTAGTTCACTCCATTCAAAACTTTTCCGGGTTTCACAAGAAAATGAGAACGTGGGAAAAGGTAAAGAAGCTTTCTCCATGACTTTT
GGTAGTCCAGAGTTTAGTTCCCCAGAAGACACCAATGAGGGGAAAATTCGACTAAAACCAGAAACTCCTCGAAGTGAAACTTGTATTTCT
AATGACTTTTATTCTCATATGCCTGTTGGAGAGACTAATCCTTTGATAGGCTCTTTACTCCAGGAGCGGCAAGATGTTATTGCAAGGATT
GCTCAACACTTGGAGCACATTGATCCAACAGCATCACATATCCCCCGGCAGTCATTCAACATGCATGACTCCAGTTCGGTTGCATCTAAA
GTGTTTAGGAGTTCATATGAAGACAAAAATTTGTTGAAGAAAAATAAGGATGAGTCCTCAGTTTCCATTTCTCACACAAAATGTTCCTTG
TTAGGAGACATCAGTGATGGGAAAAACTTAGTACCTAATAAATGTTTTACTTCTTTTAAAAATAATAGTAAAGAAAAGTGTTCTTTGAAA
CATCAAACAAGAAATCAGTGTCAGAACAATCCTAGTGAAATCATCCAAAGTACGTATCAGGAGACACAGAACAAAAGTTCTAGTTTATCA
ACTTCCTCAATTTTGTCTCAGCACAAAGAAAATAACTTAGATTTGACAAGCAGATTCAAGGAGCAAGAAATGAGCAATGGAATTGATAAA
CAGTATTCAAATTGCACCACTATTGACAAACAGATTTGTACAAATAAGTATAAGGAAAAAATAATAAATGAGAACTATAATCCAAAATTC
TTTGGCAATCTTCAGTCTGATGATTCCAAAAAAAATGACTCAAAAATAAAAGTTACTGTGTTGGAAATGTCTGAATATTTGAACAAATAT
GAAAGCATGTCCTCAAATAAAGACTCAAAAAGGCCTAAGACATGTGAGCAAAATACTCAACTTAATAGCATAGAGAATTATCTCAATAAA
GATAATGAAGGTTTCAAATGTAAAAAGTCAGACCAATTAAAAAATGAACAAGATAAGCAAGAAGATCCAACTAATGAAAAATCCCAAAAC
TATTCTCAGAGAAGAAGTATAAAAGACTGTTTGTCTACATGTGAGCAACCAAAAAATACAGAGGTATTGAGGACTACACTGAAACATTCA
AATGTGTGGCGAAAACATAATTTTCATTCCTTGGATGGAACTTCAACCAGAGCCTTTCATCCTCAAACTGGATTGCCTCTTCTTTCAAGC
CCTGTTCCTCAAAGAAAAACACAATCAGGTTGCTTTGATCTGGATTCTTCATTACTACATCTGAAAAGCTTCTCATCTAGAAGTCCTCGA
CCATGTTTAAACATTGAAGATGATCCAGATATTCATGAAAAACCATTTTTGAGTTCTAGTGCTCCACCTATAACAAGTCTTAGTCTCCTA
GGAAATTTTGAGGAATCTGTCTTGAACTATCGTTTCGATCCTCTCGGCATTGTTGATGGTTTTACTGCCGAGGTAGGGGCAAGTGGTGCT
TTCTGCCCCACACATTTGACTCTTCCAGTTGAAGTGTCATTCTACAGTGTTTCAGATGACAATGCTCCCTCTCCTTATATGCTTGATGAT
TCCCTGAATCAGATCCGTAAGCTCCAGAGGTCTCTGGATGAAGAGAAAGAAAGAAATGAAAACTTAGAGACTGAACTCAGGCACTTGCAA
AACTGGTAATTTTTTCACAAAATATGCTGAATTAAAGATTAGGGCCTTAAAGACATTTCCATATCCTTTTCTTAAATATCAGTAAAATTG
TTTTTATTAACTAGAAATATTAATGAAAAAAACGTAGACAATACACAAATTAATGGGCTTCTTCACTTCTTCTAATTTTTGCCTAACAGA
TACTGCATATTCTCAAAAAGACAATTTAAATGTCATTTAAAAACAACTTTAATTCTAAGATGTGTAAATATTTTGAAAGTCAAAAAGGGC
TTTCAGAATACTTTTTACATAAAATCTGAAAGAGTTATAATATCGGTAAGAAAAAGTAAGTTGAAAACCATACAAGACGCTGGGTCATTA
ATAAGAAAACCATTGACTTTAAGTATAAAGTACTGGTTTGTTTAAATAATTGGTAAACTTTTATGTACGTGTTGTCTATGTGGTGGGGAT
GGCAGGTTGTATTAACAAAAATGAATCATTCTAGAGGTGTAACAATACATTTCTTATATAATTTTATAAGTCATTTCTAATCTTTGTATA
AAACAGAAGTGAGCAGATGAATCAGAAAAAAGTGTTTTGTATTTTAAAGTAACAGATAACCAGTGATTGAATCTAAGACAGGCTGTAAGC
ATCGCTGAGAAACTAAAAGGACTTTTGACTTTTATCTGGATAGACATTTCTACAGTAAAATCATGGAAAGGCATCAGCATTGCAAAGTAG
CATCTAGGTAGAAATCAGGCCAAAATTAAGCTGTGGTTTCCCTCTGAGTAGTGGGAATAGAGAAAATTAGGAAATTGTGGTTATGTGAAT
ATTTCTTTAAAACTTTTATGTACATTATAGTTTATTGCTTCATATTTAAGTTTAGTTTTTAAGGTAAAATGTTATTTTGAACAAAAAGAC
ACTTATAATTTTCCATACCTATTTTCAACTGAAGGCAACTTGTAAGATTTAACTCAGTCAATAACATACTGGTTTTACTCATCTCCCCCT

>28914_28914_1_FAM214A-CCDC102B_FAM214A_chr15_52885775_ENST00000261844_CCDC102B_chr18_66721267_ENST00000319445_length(amino acids)=975AA_BP=940
MDVKMKPDRDTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECSDKLAQCRQARRTRSEVTLLWKNNL
PIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAWLSVSHGAIPRNILY
RISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHNPNEAEQCGTNSSQR
LCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVRTLKSFSMVDSSISNRQSFWQSA
GETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSPEFSSPEDTNEGKIR
LKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFRSSYEDKNLLKKNKD
ESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTS
RFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESMSSNKDSKRPKTCEQ
NTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVWRKHNFHSLDGTSTR
AFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPPITSLSLLGNFEESVLNYRFDPLGI

--------------------------------------------------------------
>28914_28914_2_FAM214A-CCDC102B_FAM214A_chr15_52885775_ENST00000261844_CCDC102B_chr18_66721267_ENST00000360242_length(transcript)=4121nt_BP=2961nt
TAAACTTGGCCGCGGTTGCCGCAGGAAGGCTAGCCAGAGGGTAATTACACAGCATTTTGAAAGCGAAGCAGAAGCCGTAGAATCAGCGGC
GAGCCTGTTGAAAGAACCCACAGGTGCATTTCACAGCACTCTGGGCGAAAATTGGATGTGAAAATGAAGCCAGACCGAGATACTCTGGAT
GAATATTTTGAATATGATGCAGAGGAGTTCTTGGTCTCTTTGGCCTTGCTGATAACAGAAGGACGAACACCTGAATGTTCTGTAAAAGGT
CGAACAGAAAGCTTTCATTGCCCTCCAGCACAGTCTTGTTACCCAGTAACTACCAAACATGAATGTAGTGACAAGCTGGCCCAGTGCCGC
CAAGCCAGACGAACTAGGTCTGAGGTCACATTGTTGTGGAAGAATAACCTTCCAATCATGGTGGAAATGATGCTACTACCAGACTGCTGC
TACAGCGATGATGGGCCCACCACAGAGGGAATTGATCTAAATGATCCTGCGATTAAGCAAGATGCATTATTATTAGAAAGATGGATCTTG
GAGCCAGTTCCTCGACAGAATGGTGACCGATTTATTGAAGAGAAGACGCTTCTGTTGGCTGTCCGCTCATTTGTGTTTTTTTCTCAGTTA
AGTGCATGGCTGAGTGTTTCTCATGGTGCTATTCCACGAAATATTCTCTACAGAATCAGTGCTGCTGATGTAGACCTACAGTGGAATTTT
TCACAGACTCCAATTGAGCATGTGTTTCCTGTTCCCAATGTTTCTCACAATGTTGCCTTGAAAGTCAGTGTTCAGTCCTTGCCCAGACAA
TCTAATTATCCAGTTTTGACGTGCAGTATTCACACTAATATTGGCCTTTATGAGAAAAGAATTCAACAACATAAACTTAAAACTCATCAG
CACCATAACCCAAATGAAGCAGAACAATGTGGTACAAACAGTTCACAGCGTCTGTGTAGCAAACAAACTTGGACCATGGCACCTGAAAGT
GTGTTACATGCAAAAAGTGGCCCAAGTCCAGAATATACTGCAGCTGTCAAAAATATCAAACTATATCCAGGCACTGGCAGTAAATCTGAC
CATGGGACATCTCAAGCCAATATTCTAGGCTTTAGTGGTATAGGTGATATAAAATCACAAGAAACATCAGTGAGAACTTTAAAATCATTT
TCAATGGTTGATTCCAGTATCTCTAACCGCCAGAGTTTCTGGCAGTCAGCTGGTGAGACTAACCCTTTAATAGGCTCTTTAATTCAGGAG
CGGCAAGAAATCATTGCAAGAATTGCCCAACATTTGATTCATTGTGATCCAAGCACTTCACATGTTTCTGGACGTCCATTTAATACTCAA
GAGTCTAGTTCACTCCATTCAAAACTTTTCCGGGTTTCACAAGAAAATGAGAACGTGGGAAAAGGTAAAGAAGCTTTCTCCATGACTTTT
GGTAGTCCAGAGTTTAGTTCCCCAGAAGACACCAATGAGGGGAAAATTCGACTAAAACCAGAAACTCCTCGAAGTGAAACTTGTATTTCT
AATGACTTTTATTCTCATATGCCTGTTGGAGAGACTAATCCTTTGATAGGCTCTTTACTCCAGGAGCGGCAAGATGTTATTGCAAGGATT
GCTCAACACTTGGAGCACATTGATCCAACAGCATCACATATCCCCCGGCAGTCATTCAACATGCATGACTCCAGTTCGGTTGCATCTAAA
GTGTTTAGGAGTTCATATGAAGACAAAAATTTGTTGAAGAAAAATAAGGATGAGTCCTCAGTTTCCATTTCTCACACAAAATGTTCCTTG
TTAGGAGACATCAGTGATGGGAAAAACTTAGTACCTAATAAATGTTTTACTTCTTTTAAAAATAATAGTAAAGAAAAGTGTTCTTTGAAA
CATCAAACAAGAAATCAGTGTCAGAACAATCCTAGTGAAATCATCCAAAGTACGTATCAGGAGACACAGAACAAAAGTTCTAGTTTATCA
ACTTCCTCAATTTTGTCTCAGCACAAAGAAAATAACTTAGATTTGACAAGCAGATTCAAGGAGCAAGAAATGAGCAATGGAATTGATAAA
CAGTATTCAAATTGCACCACTATTGACAAACAGATTTGTACAAATAAGTATAAGGAAAAAATAATAAATGAGAACTATAATCCAAAATTC
TTTGGCAATCTTCAGTCTGATGATTCCAAAAAAAATGACTCAAAAATAAAAGTTACTGTGTTGGAAATGTCTGAATATTTGAACAAATAT
GAAAGCATGTCCTCAAATAAAGACTCAAAAAGGCCTAAGACATGTGAGCAAAATACTCAACTTAATAGCATAGAGAATTATCTCAATAAA
GATAATGAAGGTTTCAAATGTAAAAAGTCAGACCAATTAAAAAATGAACAAGATAAGCAAGAAGATCCAACTAATGAAAAATCCCAAAAC
TATTCTCAGAGAAGAAGTATAAAAGACTGTTTGTCTACATGTGAGCAACCAAAAAATACAGAGGTATTGAGGACTACACTGAAACATTCA
AATGTGTGGCGAAAACATAATTTTCATTCCTTGGATGGAACTTCAACCAGAGCCTTTCATCCTCAAACTGGATTGCCTCTTCTTTCAAGC
CCTGTTCCTCAAAGAAAAACACAATCAGGTTGCTTTGATCTGGATTCTTCATTACTACATCTGAAAAGCTTCTCATCTAGAAGTCCTCGA
CCATGTTTAAACATTGAAGATGATCCAGATATTCATGAAAAACCATTTTTGAGTTCTAGTGCTCCACCTATAACAAGTCTTAGTCTCCTA
GGAAATTTTGAGGAATCTGTCTTGAACTATCGTTTCGATCCTCTCGGCATTGTTGATGGTTTTACTGCCGAGGTAGGGGCAAGTGGTGCT
TTCTGCCCCACACATTTGACTCTTCCAGTTGAAGTGTCATTCTACAGTGTTTCAGATGACAATGCTCCCTCTCCTTATATGCTTGATGAT
TCCCTGAATCAGATCCGTAAGCTCCAGAGGTCTCTGGATGAAGAGAAAGAAAGAAATGAAAACTTAGAGACTGAACTCAGGCACTTGCAA
AACTGGTAATTTTTTCACAAAATATGCTGAATTAAAGATTAGGGCCTTAAAGACATTTCCATATCCTTTTCTTAAATATCAGTAAAATTG
TTTTTATTAACTAGAAATATTAATGAAAAAAACGTAGACAATACACAAATTAATGGGCTTCTTCACTTCTTCTAATTTTTGCCTAACAGA
TACTGCATATTCTCAAAAAGACAATTTAAATGTCATTTAAAAACAACTTTAATTCTAAGATGTGTAAATATTTTGAAAGTCAAAAAGGGC
TTTCAGAATACTTTTTACATAAAATCTGAAAGAGTTATAATATCGGTAAGAAAAAGTAAGTTGAAAACCATACAAGACGCTGGGTCATTA
ATAAGAAAACCATTGACTTTAAGTATAAAGTACTGGTTTGTTTAAATAATTGGTAAACTTTTATGTACGTGTTGTCTATGTGGTGGGGAT
GGCAGGTTGTATTAACAAAAATGAATCATTCTAGAGGTGTAACAATACATTTCTTATATAATTTTATAAGTCATTTCTAATCTTTGTATA
AAACAGAAGTGAGCAGATGAATCAGAAAAAAGTGTTTTGTATTTTAAAGTAACAGATAACCAGTGATTGAATCTAAGACAGGCTGTAAGC
ATCGCTGAGAAACTAAAAGGACTTTTGACTTTTATCTGGATAGACATTTCTACAGTAAAATCATGGAAAGGCATCAGCATTGCAAAGTAG
CATCTAGGTAGAAATCAGGCCAAAATTAAGCTGTGGTTTCCCTCTGAGTAGTGGGAATAGAGAAAATTAGGAAATTGTGGTTATGTGAAT
ATTTCTTTAAAACTTTTATGTACATTATAGTTTATTGCTTCATATTTAAGTTTAGTTTTTAAGGTAAAATGTTATTTTGAACAAAAAGAC
ACTTATAATTTTCCATACCTATTTTCAACTGAAGGCAACTTGTAAGATTTAACTCAGTCAATAACATACTGGTTTTACTCATCTCCCCCT

>28914_28914_2_FAM214A-CCDC102B_FAM214A_chr15_52885775_ENST00000261844_CCDC102B_chr18_66721267_ENST00000360242_length(amino acids)=975AA_BP=940
MDVKMKPDRDTLDEYFEYDAEEFLVSLALLITEGRTPECSVKGRTESFHCPPAQSCYPVTTKHECSDKLAQCRQARRTRSEVTLLWKNNL
PIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQDALLLERWILEPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAWLSVSHGAIPRNILY
RISAADVDLQWNFSQTPIEHVFPVPNVSHNVALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHNPNEAEQCGTNSSQR
LCSKQTWTMAPESVLHAKSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIKSQETSVRTLKSFSMVDSSISNRQSFWQSA
GETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVSGRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSPEFSSPEDTNEGKIR
LKPETPRSETCISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFRSSYEDKNLLKKNKD
ESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTS
RFKEQEMSNGIDKQYSNCTTIDKQICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESMSSNKDSKRPKTCEQ
NTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNTEVLRTTLKHSNVWRKHNFHSLDGTSTR
AFHPQTGLPLLSSPVPQRKTQSGCFDLDSSLLHLKSFSSRSPRPCLNIEDDPDIHEKPFLSSSAPPITSLSLLGNFEESVLNYRFDPLGI

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Fusion Gene PPI Analysis for FAM214A-CCDC102B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM214A-CCDC102B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM214A-CCDC102B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource