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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM32A-TPM4 (FusionGDB2 ID:29012)

Fusion Gene Summary for FAM32A-TPM4

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM32A-TPM4
Fusion gene ID: 29012
HgeneTgene
Gene symbol

FAM32A

TPM4

Gene ID

26017

7171

Gene namefamily with sequence similarity 32 member Atropomyosin 4
SynonymsOTAG-12|OTAG12HEL-S-108
Cytomap

19p13.11

19p13.12-p13.11

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM32Aovarian tumor associated gene-12tropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 108
Modification date2020031320200320
UniProtAcc

Q9Y421

P67936

Ensembl transtripts involved in fusion geneENST00000263384, ENST00000588367, 
ENST00000589852, 		ENST00000300933, 
ENST00000591645, ENST00000344824, 
ENST00000538887, 
Fusion gene scores* DoF score3 X 3 X 3=2714 X 12 X 6=1008
# samples 314
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/1008*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM32A [Title/Abstract] AND TPM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM32A(16296576)-TPM4(16186857), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM32A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TPM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1718-01AFAM32Achr19

16296576

-TPM4chr19

16186857

+
ChimerDB4OVTCGA-30-1718-01AFAM32Achr19

16296576

+TPM4chr19

16186857

+


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Fusion Gene ORF analysis for FAM32A-TPM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263384ENST00000300933FAM32Achr19

16296576

+TPM4chr19

16186857

+
5CDS-intronENST00000263384ENST00000591645FAM32Achr19

16296576

+TPM4chr19

16186857

+
5CDS-intronENST00000588367ENST00000300933FAM32Achr19

16296576

+TPM4chr19

16186857

+
5CDS-intronENST00000588367ENST00000591645FAM32Achr19

16296576

+TPM4chr19

16186857

+
5CDS-intronENST00000589852ENST00000300933FAM32Achr19

16296576

+TPM4chr19

16186857

+
5CDS-intronENST00000589852ENST00000591645FAM32Achr19

16296576

+TPM4chr19

16186857

+
In-frameENST00000263384ENST00000344824FAM32Achr19

16296576

+TPM4chr19

16186857

+
In-frameENST00000263384ENST00000538887FAM32Achr19

16296576

+TPM4chr19

16186857

+
In-frameENST00000588367ENST00000344824FAM32Achr19

16296576

+TPM4chr19

16186857

+
In-frameENST00000588367ENST00000538887FAM32Achr19

16296576

+TPM4chr19

16186857

+
In-frameENST00000589852ENST00000344824FAM32Achr19

16296576

+TPM4chr19

16186857

+
In-frameENST00000589852ENST00000538887FAM32Achr19

16296576

+TPM4chr19

16186857

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000589852FAM32Achr1916296576+ENST00000344824TPM4chr1916186857+15713862301126298
ENST00000589852FAM32Achr1916296576+ENST00000538887TPM4chr1916186857+17273862301126298
ENST00000263384FAM32Achr1916296576+ENST00000344824TPM4chr1916186857+142624113981322
ENST00000263384FAM32Achr1916296576+ENST00000538887TPM4chr1916186857+158224113981322
ENST00000588367FAM32Achr1916296576+ENST00000344824TPM4chr1916186857+14212368976322
ENST00000588367FAM32Achr1916296576+ENST00000538887TPM4chr1916186857+15772368976322

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000589852ENST00000344824FAM32Achr1916296576+TPM4chr1916186857+0.0012320520.9987679
ENST00000589852ENST00000538887FAM32Achr1916296576+TPM4chr1916186857+0.0010738730.9989261
ENST00000263384ENST00000344824FAM32Achr1916296576+TPM4chr1916186857+0.0007687360.9992312
ENST00000263384ENST00000538887FAM32Achr1916296576+TPM4chr1916186857+0.0006494990.9993505
ENST00000588367ENST00000344824FAM32Achr1916296576+TPM4chr1916186857+0.0007275210.9992725
ENST00000588367ENST00000538887FAM32Achr1916296576+TPM4chr1916186857+0.0006150010.999385

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Fusion Genomic Features for FAM32A-TPM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM32Achr1916296576+TPM4chr1916186856+5.21E-121
FAM32Achr1916296576+TPM4chr1916186856+5.21E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM32A-TPM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16296576/chr19:16186857)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM32A

Q9Y421

TPM4

P67936

FUNCTION: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. {ECO:0000269|PubMed:21339736}.FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPM4chr19:16296576chr19:16186857ENST00000300933082_2480249.0Coiled coilOntology_term=ECO:0000250

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM32Achr19:16296576chr19:16186857ENST00000263384+249_8672113.0Compositional biasNote=Lys-rich
HgeneFAM32Achr19:16296576chr19:16186857ENST00000589852+139_865293.0Compositional biasNote=Lys-rich
TgeneTPM4chr19:16296576chr19:16186857ENST00000344824092_24838285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM4chr19:16296576chr19:16186857ENST000005388870102_24838270.0Coiled coilOntology_term=ECO:0000250


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Fusion Gene Sequence for FAM32A-TPM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29012_29012_1_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000263384_TPM4_chr19_16186857_ENST00000344824_length(transcript)=1426nt_BP=241nt
AGCTACCGAAGCACTGGAGAGTGTCATGGAGGCCTACGAGCAGGTCCAAAAGGGACCCCTGAAGCTGAAAGGCGTCGCAGAGCTGGGAGT
GACCAAGCGGAAGAAGAAAAAGAAGGACAAAGACAAAGCGAAACTCCTGGAAGCAATGGGAACGAGCAAAAAGAACGAGGAGGAGAAGCG
GCGCGGCCTGGACAAGCGGACCCCGGCCCAGGCGGCCTTCGAGAAAATGCAGGAGAAGCGGGTGGAGGAGGAGCTGACGCACCTCCAGAA
GAAACTAAAAGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGC
CTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCAC
GGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGA
GGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAA
GCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAA
GAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCT
GTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGA
GAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACA
GAAGAGTCTTGTTCCAACAGAAACTCTGGAGCTCCGTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTT
TGCTGGAAATGTCAAGCAAATTATGAATACATGACCAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCT
TTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTA
AGCATACTTTCTTAAGACGGAGGCCATTTGGTTCCTGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGT

>29012_29012_1_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000263384_TPM4_chr19_16186857_ENST00000344824_length(amino acids)=322AA_BP=76
MESVMEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRVEEELTHLQKKLKG
TEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKME
IQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKL

--------------------------------------------------------------
>29012_29012_2_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000263384_TPM4_chr19_16186857_ENST00000538887_length(transcript)=1582nt_BP=241nt
AGCTACCGAAGCACTGGAGAGTGTCATGGAGGCCTACGAGCAGGTCCAAAAGGGACCCCTGAAGCTGAAAGGCGTCGCAGAGCTGGGAGT
GACCAAGCGGAAGAAGAAAAAGAAGGACAAAGACAAAGCGAAACTCCTGGAAGCAATGGGAACGAGCAAAAAGAACGAGGAGGAGAAGCG
GCGCGGCCTGGACAAGCGGACCCCGGCCCAGGCGGCCTTCGAGAAAATGCAGGAGAAGCGGGTGGAGGAGGAGCTGACGCACCTCCAGAA
GAAACTAAAAGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGC
CTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCAC
GGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGA
GGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAA
GCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAA
GAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCT
GTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGA
GAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACA
GAAGAGTCTTGTTCCAACAGAAACTCTGGAGCTCCGTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTT
TGCTGGAAATGTCAAGCAAATTATGAATACATGACCAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCT
TTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTA
AGCATACTTTCTTAAGACGGAGGCCATTTGGTTCCTGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGT
GGATATAATTAAAACGCTGAAGACCATAACCTTTTGGGTCAACTGTTGGTCAAACTATAGGAGAGACCAGGGACCACCCTACTCCTATTT
ATTCAGCACCACACTACCCAGGAAATACACTAGCAAATTGTGCAATGGAATAAAATCCACACTTTAGATTCTTGCAACTGTATCATATGT

>29012_29012_2_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000263384_TPM4_chr19_16186857_ENST00000538887_length(amino acids)=322AA_BP=76
MESVMEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRVEEELTHLQKKLKG
TEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKME
IQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKL

--------------------------------------------------------------
>29012_29012_3_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000588367_TPM4_chr19_16186857_ENST00000344824_length(transcript)=1421nt_BP=236nt
CCGAAGCACTGGAGAGTGTCATGGAGGCCTACGAGCAGGTCCAAAAGGGACCCCTGAAGCTGAAAGGCGTCGCAGAGCTGGGAGTGACCA
AGCGGAAGAAGAAAAAGAAGGACAAAGACAAAGCGAAACTCCTGGAAGCAATGGGAACGAGCAAAAAGAACGAGGAGGAGAAGCGGCGCG
GCCTGGACAAGCGGACCCCGGCCCAGGCGGCCTTCGAGAAAATGCAGGAGAAGCGGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAAC
TAAAAGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCG
ACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCC
TGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGA
AGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGG
TCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATG
TTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTG
ACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAAC
TTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGA
GTCTTGTTCCAACAGAAACTCTGGAGCTCCGTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTG
GAAATGTCAAGCAAATTATGAATACATGACCAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCTTTTTT
TTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCAT
ACTTTCTTAAGACGGAGGCCATTTGGTTCCTGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGTGGATA

>29012_29012_3_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000588367_TPM4_chr19_16186857_ENST00000344824_length(amino acids)=322AA_BP=76
MESVMEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRVEEELTHLQKKLKG
TEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKME
IQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKL

--------------------------------------------------------------
>29012_29012_4_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000588367_TPM4_chr19_16186857_ENST00000538887_length(transcript)=1577nt_BP=236nt
CCGAAGCACTGGAGAGTGTCATGGAGGCCTACGAGCAGGTCCAAAAGGGACCCCTGAAGCTGAAAGGCGTCGCAGAGCTGGGAGTGACCA
AGCGGAAGAAGAAAAAGAAGGACAAAGACAAAGCGAAACTCCTGGAAGCAATGGGAACGAGCAAAAAGAACGAGGAGGAGAAGCGGCGCG
GCCTGGACAAGCGGACCCCGGCCCAGGCGGCCTTCGAGAAAATGCAGGAGAAGCGGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAAC
TAAAAGGGACAGAGGACGAGCTGGATAAATATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCG
ACGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCC
TGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGA
AGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGG
TCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATG
TTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTG
ACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAAC
TTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGA
GTCTTGTTCCAACAGAAACTCTGGAGCTCCGTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTG
GAAATGTCAAGCAAATTATGAATACATGACCAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCTTTTTT
TTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCAT
ACTTTCTTAAGACGGAGGCCATTTGGTTCCTGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGTGGATA
TAATTAAAACGCTGAAGACCATAACCTTTTGGGTCAACTGTTGGTCAAACTATAGGAGAGACCAGGGACCACCCTACTCCTATTTATTCA
GCACCACACTACCCAGGAAATACACTAGCAAATTGTGCAATGGAATAAAATCCACACTTTAGATTCTTGCAACTGTATCATATGTAATAG

>29012_29012_4_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000588367_TPM4_chr19_16186857_ENST00000538887_length(amino acids)=322AA_BP=76
MESVMEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRVEEELTHLQKKLKG
TEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKME
IQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKL

--------------------------------------------------------------
>29012_29012_5_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000589852_TPM4_chr19_16186857_ENST00000344824_length(transcript)=1571nt_BP=386nt
GCGGAAATAGTGTTTGCAAACAGGAAGTGTGGCACTCCAGCTACCGAAGCACTGGAGAGTGTCATGGAGGCCTACGAGCAGGTCCAAAAG
GGACCCCTGAAGCTGAAAGGCGTCGCAGAGCTGGGAGTGACCAAGCGGTGAGGCCCGAGGGCCCGCGGGATTCCGTCTTCATCCCCCTTA
GACCTTTTCTCGGGACCCCTGGCCCTGATCCTCCGACCCGCCGCCTCCTCATGTCTTTTTCCAGGAAGAAGAAAAAGAAGGACAAAGACA
AAGCGAAACTCCTGGAAGCAATGGGAACGAGCAAAAAGAACGAGGAGGAGAAGCGGCGCGGCCTGGACAAGCGGACCCCGGCCCAGGCGG
CCTTCGAGAAAATGCAGGAGAAGCGGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAAAGGGACAGAGGACGAGCTGGATAAAT
ATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACC
GACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTG
CAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAG
AGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAG
AGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTG
CATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTG
AATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCT
TACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGAGTCTTGTTCCAACAGAAACTCTGGAGCTCC
GTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTGGAAATGTCAAGCAAATTATGAATACATGAC
CAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCTTTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTC
TTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCATACTTTCTTAAGACGGAGGCCATTTGGTTCC
TGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGTGGATATAATTAAAACGCTGAAGACCATAACCTTTT

>29012_29012_5_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000589852_TPM4_chr19_16186857_ENST00000344824_length(amino acids)=298AA_BP=52
MSFSRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRVEEELTHLQKKLKGTEDELDKYSEDLKDAQEKLELTEK
KASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVA
RKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDL

--------------------------------------------------------------
>29012_29012_6_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000589852_TPM4_chr19_16186857_ENST00000538887_length(transcript)=1727nt_BP=386nt
GCGGAAATAGTGTTTGCAAACAGGAAGTGTGGCACTCCAGCTACCGAAGCACTGGAGAGTGTCATGGAGGCCTACGAGCAGGTCCAAAAG
GGACCCCTGAAGCTGAAAGGCGTCGCAGAGCTGGGAGTGACCAAGCGGTGAGGCCCGAGGGCCCGCGGGATTCCGTCTTCATCCCCCTTA
GACCTTTTCTCGGGACCCCTGGCCCTGATCCTCCGACCCGCCGCCTCCTCATGTCTTTTTCCAGGAAGAAGAAAAAGAAGGACAAAGACA
AAGCGAAACTCCTGGAAGCAATGGGAACGAGCAAAAAGAACGAGGAGGAGAAGCGGCGCGGCCTGGACAAGCGGACCCCGGCCCAGGCGG
CCTTCGAGAAAATGCAGGAGAAGCGGGTGGAGGAGGAGCTGACGCACCTCCAGAAGAAACTAAAAGGGACAGAGGACGAGCTGGATAAAT
ATTCCGAGGACCTGAAGGACGCGCAGGAGAAGCTGGAGCTCACGGAGAAGAAGGCCTCCGACGCTGAAGGTGATGTGGCCGCCCTCAACC
GACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTG
CAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAG
AGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAG
AGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTG
CATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTG
AATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCT
TACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGAGTCTTGTTCCAACAGAAACTCTGGAGCTCC
GTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTGGAAATGTCAAGCAAATTATGAATACATGAC
CAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCTTTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTC
TTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCATACTTTCTTAAGACGGAGGCCATTTGGTTCC
TGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGTGGATATAATTAAAACGCTGAAGACCATAACCTTTT
GGGTCAACTGTTGGTCAAACTATAGGAGAGACCAGGGACCACCCTACTCCTATTTATTCAGCACCACACTACCCAGGAAATACACTAGCA
AATTGTGCAATGGAATAAAATCCACACTTTAGATTCTTGCAACTGTATCATATGTAATAGTATCACTTTTTCTACATTTTGGTCAAATAA

>29012_29012_6_FAM32A-TPM4_FAM32A_chr19_16296576_ENST00000589852_TPM4_chr19_16186857_ENST00000538887_length(amino acids)=298AA_BP=52
MSFSRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRVEEELTHLQKKLKGTEDELDKYSEDLKDAQEKLELTEK
KASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVA
RKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM32A-TPM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM32A-TPM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM32A-TPM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource