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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FAM45A-GRK5 (FusionGDB2 ID:29041)

Fusion Gene Summary for FAM45A-GRK5

Fusion gene summary

Fusion gene information	Fusion gene name: FAM45A-GRK5
	Fusion gene ID: 29041
		Hgene	Tgene
	Gene symbol	FAM45A	GRK5
	Gene ID	404636	2869
	Gene name	DENN domain containing 10	G protein-coupled receptor kinase 5
	Synonyms	FAM45A	FP2025\|GPRK5
	Cytomap	10q26.11	10q26.11
	Type of gene	protein-coding	protein-coding
	Description	DENN domain-containing protein 10family with sequence similarity 45 member Aprotein FAM45A	G protein-coupled receptor kinase 5g protein-coupled receptor kinase GRK5
	Modification date	20200313	20200313
	UniProtAcc	.	P34947
	Ensembl transtripts involved in fusion gene	ENST00000489988, ENST00000535029, ENST00000361432, ENST00000544016,	ENST00000369108, ENST00000392870, ENST00000473264,
Fusion gene scores	* DoF score	3 X 3 X 2=18	19 X 19 X 6=2166
	# samples	3	19
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(19/2166*10)=-3.51096191927738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM45A [Title/Abstract] AND GRK5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM45A(120892121)-GRK5(121207634), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GRK5	GO:0007217	tachykinin receptor signaling pathway	17986524
Tgene	GRK5	GO:0043066	negative regulation of apoptotic process	20124405
Tgene	GRK5	GO:0046777	protein autophosphorylation	14976207

Fusion gene breakpoints across FAM45A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GRK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A928	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+

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Fusion Gene ORF analysis for FAM45A-GRK5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000489988	ENST00000369108	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
3UTR-3CDS	ENST00000489988	ENST00000392870	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
3UTR-3CDS	ENST00000535029	ENST00000369108	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
3UTR-3CDS	ENST00000535029	ENST00000392870	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
3UTR-intron	ENST00000489988	ENST00000473264	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
3UTR-intron	ENST00000535029	ENST00000473264	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
5CDS-intron	ENST00000361432	ENST00000473264	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
5CDS-intron	ENST00000544016	ENST00000473264	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
In-frame	ENST00000361432	ENST00000369108	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
In-frame	ENST00000361432	ENST00000392870	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
In-frame	ENST00000544016	ENST00000369108	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+
In-frame	ENST00000544016	ENST00000392870	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000544016

FAM45A

chr10

120892121

ENST00000392870

GRK5

chr10

121207634

1853

794

350

1300

316

ENST00000544016

FAM45A

chr10

120892121

ENST00000369108

GRK5

chr10

121207634

1352

794

350

1300

316

ENST00000361432

FAM45A

chr10

120892121

ENST00000392870

GRK5

chr10

121207634

1982

923

1429

467

ENST00000361432

FAM45A

chr10

120892121

ENST00000369108

GRK5

chr10

121207634

1481

923

1429

467

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000544016	ENST00000392870	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+	0.000893103	0.9991068
ENST00000544016	ENST00000369108	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+	0.002214909	0.9977851
ENST00000361432	ENST00000392870	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+	0.00121168	0.9987883
ENST00000361432	ENST00000369108	FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+	0.002795266	0.9972047

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Fusion Genomic Features for FAM45A-GRK5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+	2.92E-09	1
FAM45A	chr10	120892121	+	GRK5	chr10	121207634	+	2.92E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM45A-GRK5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:120892121/chr10:121207634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GRK5 P34947
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269\|PubMed:19661922, ECO:0000269\|PubMed:19801552, ECO:0000269\|PubMed:20038610, ECO:0000269\|PubMed:20124405, ECO:0000269\|PubMed:21728385}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM45A

chr10:120892121

chr10:121207634

ENST00000361432

165_299

299

358.0

Domain

cDENN

Hgene

FAM45A

chr10:120892121

chr10:121207634

ENST00000361432

1_140

299

358.0

Domain

uDENN

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

449_514

422

591.0

Domain

AGC-kinase C-terminal

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

546_565

422

591.0

Region

Note=Sufficient for membrane localization

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM45A

chr10:120892121

chr10:121207634

ENST00000361432

301_357

299

358.0

Domain

dDENN

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

186_448

422

591.0

Domain

Protein kinase

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

53_171

422

591.0

Domain

RGS

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

388_395

422

591.0

Motif

Nuclear localization signal

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

192_200

422

591.0

Nucleotide binding

ATP

Tgene

GRK5

chr10:120892121

chr10:121207634

ENST00000392870

1_185

422

591.0

Region

Note=N-terminal

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Fusion Gene Sequence for FAM45A-GRK5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>29041_29041_1_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000361432_GRK5_chr10_121207634_ENST00000369108_length(transcript)=1481nt_BP=923nt
AGAGCTGCGCGCCGCGGCGGCGGAAGATGGCTGCGGCCGAGGTGGCGGACACTCAGCTGATGCTTGGAGTCGGGCTGATCGAAAAGGACA
CAAATGGAGAAGTTCTGTGGGTGTGGTGTTATCCTTCCACGACAGCCACATTAAGGAACCTGCTGCTGAGAAAATGCTGCCTTACAGATG
AAAACAAACTTCTCCATCCCTTTGTCTTTGGTCAGTACAGAAGAACATGGTTTTATATCACAACAATTGAAGTTCCAGATTCTTCCATTT
TGAAAAAGGTGACTCATTTTTCTATTGTCCTGACCGCCAAAGATTTTAACCCAGAGAAGTATGCTGCCTTCACTAGGATATTGTGTAGAA
TGTACCTGAAACATGGGAGCCCAGTTAAAATGATGGAGAGTTATATTGCAGTTCTCACAAAGGGGATATGCCAGAGTGAAGAAAACGGCT
CTTTCCTTAGTAAGGATTTTGATGCCCGAAAGGCCTACCTGGCTGGCTCCATCAAAGACATTGTATCTCAGTTTGGAATGGAAACTGTTA
TCTTACACACAGCACTGATGCTAAAGAAAAGAATTGTGGTGTATCACCCCAAGATAGAAGCGGTCCAGGAGTTCACCAGGACTCTGCCTG
CCCTGGTGTGGCACCGACAGGACTGGACCATCCTTCACTCTTACGTGCACCTCAACGCCGATGAGCTGGAAGCCCTGCAGATGTGCACAG
GTTACGTCGCTGGATTTGTAGACTTGGAGGTGAGCAACAGACCAGACCTCTATGATGTGTTTGTGAATCTGGCAGAGAGTGAGATTACCA
TTGCTCCCCTTGCAAAAGAGGCCATGGCAATGGGCAAACTGCACAAAGAAATGGGTCAGCTAATTGTTCAGTCTGCAGAAGATCCAGAGA
AATCAGAGAGCCACGTTATACAGCTGCTCACGAAAGATGCGAAGCAGAGGCTGGGCTGCCAGGAGGAGGGGGCTGCAGAGGTCAAGAGAC
ACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAGCCGGGATGTTGGACCCTCCCTTCGTTCCAGACCCCCGCGCTGTGTACTGTA
AGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGGGCGTCAATCTGGACCACACAGACGACGACTTCTACTCCAAGTTCTCCACGG
GCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAACAGAATGCTTTAAGGAGCTGAACGTGTTTGGACCTAATGGTACCCTCCCGC
CAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGAAAGGGCTGCTCCAGAGACTCTTCAAGCGGCAGCATCAGAACAATTCCAAGA
GTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAAACTCAAACCATGTCAGCTCGAACTCCACCGGAAGCAGCTAGTTTCGGCTCT

>29041_29041_1_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000361432_GRK5_chr10_121207634_ENST00000369108_length(amino acids)=467AA_BP=0
MAAAEVADTQLMLGVGLIEKDTNGEVLWVWCYPSTTATLRNLLLRKCCLTDENKLLHPFVFGQYRRTWFYITTIEVPDSSILKKVTHFSI
VLTAKDFNPEKYAAFTRILCRMYLKHGSPVKMMESYIAVLTKGICQSEENGSFLSKDFDARKAYLAGSIKDIVSQFGMETVILHTALMLK
KRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDLEVSNRPDLYDVFVNLAESEITIAPLAKEAM
AMGKLHKEMGQLIVQSAEDPEKSESHVIQLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF
STVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSF

--------------------------------------------------------------
>29041_29041_2_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000361432_GRK5_chr10_121207634_ENST00000392870_length(transcript)=1982nt_BP=923nt
AGAGCTGCGCGCCGCGGCGGCGGAAGATGGCTGCGGCCGAGGTGGCGGACACTCAGCTGATGCTTGGAGTCGGGCTGATCGAAAAGGACA
CAAATGGAGAAGTTCTGTGGGTGTGGTGTTATCCTTCCACGACAGCCACATTAAGGAACCTGCTGCTGAGAAAATGCTGCCTTACAGATG
AAAACAAACTTCTCCATCCCTTTGTCTTTGGTCAGTACAGAAGAACATGGTTTTATATCACAACAATTGAAGTTCCAGATTCTTCCATTT
TGAAAAAGGTGACTCATTTTTCTATTGTCCTGACCGCCAAAGATTTTAACCCAGAGAAGTATGCTGCCTTCACTAGGATATTGTGTAGAA
TGTACCTGAAACATGGGAGCCCAGTTAAAATGATGGAGAGTTATATTGCAGTTCTCACAAAGGGGATATGCCAGAGTGAAGAAAACGGCT
CTTTCCTTAGTAAGGATTTTGATGCCCGAAAGGCCTACCTGGCTGGCTCCATCAAAGACATTGTATCTCAGTTTGGAATGGAAACTGTTA
TCTTACACACAGCACTGATGCTAAAGAAAAGAATTGTGGTGTATCACCCCAAGATAGAAGCGGTCCAGGAGTTCACCAGGACTCTGCCTG
CCCTGGTGTGGCACCGACAGGACTGGACCATCCTTCACTCTTACGTGCACCTCAACGCCGATGAGCTGGAAGCCCTGCAGATGTGCACAG
GTTACGTCGCTGGATTTGTAGACTTGGAGGTGAGCAACAGACCAGACCTCTATGATGTGTTTGTGAATCTGGCAGAGAGTGAGATTACCA
TTGCTCCCCTTGCAAAAGAGGCCATGGCAATGGGCAAACTGCACAAAGAAATGGGTCAGCTAATTGTTCAGTCTGCAGAAGATCCAGAGA
AATCAGAGAGCCACGTTATACAGCTGCTCACGAAAGATGCGAAGCAGAGGCTGGGCTGCCAGGAGGAGGGGGCTGCAGAGGTCAAGAGAC
ACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAGCCGGGATGTTGGACCCTCCCTTCGTTCCAGACCCCCGCGCTGTGTACTGTA
AGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGGGCGTCAATCTGGACCACACAGACGACGACTTCTACTCCAAGTTCTCCACGG
GCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAACAGAATGCTTTAAGGAGCTGAACGTGTTTGGACCTAATGGTACCCTCCCGC
CAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGAAAGGGCTGCTCCAGAGACTCTTCAAGCGGCAGCATCAGAACAATTCCAAGA
GTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAAACTCAAACCATGTCAGCTCGAACTCCACCGGAAGCAGCTAGTTTCGGCTCT
GGCCTCCAAGTCCACAGTGGAACCAGCCCAGACCCTTCTCCTTAGAAGTGGAAGTAGTGGAGCCCCTGCTCTGGTGGGGCTGCCAGGGGA
GACCCCGGGAGCCGGGGAAGGAGGCCGTCCATCCCGTCGACGTAGAACCTCGAGGTTTCTCAAAGAAATTTCCACTCAGGTCTGTTTTCC
GAGGCGGCCCCGGCCGGGGTGGATTGGATTTGTCTTTGGTGAACATTGCAATAGAAATCCAATTGGATACGACAACTTGCACGTATTTTA
ATAGCGTCATAACTAGAACTGAATTTTGTCTTTATGATTTTTAAAGAAAAGTTTTGTAAATTTCTCTACTGTCTCAGTTTACATTTTGTA
TATTTGTATTTAAATGAAAGTGAGACTTTGAGGGTGTATATTTTCTGTGCAGCCACTGTTAAGCCATGTGTTCCAAGGCATTTTAGCGGG
GAGGGGGTTATCAAAAAAAAAAAAATGTGACTCAAGACTTCCAGAGCCTCAAATGAGAAAATGTCTTTATTAAATGTAGAAAGTGATCCA

>29041_29041_2_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000361432_GRK5_chr10_121207634_ENST00000392870_length(amino acids)=467AA_BP=0
MAAAEVADTQLMLGVGLIEKDTNGEVLWVWCYPSTTATLRNLLLRKCCLTDENKLLHPFVFGQYRRTWFYITTIEVPDSSILKKVTHFSI
VLTAKDFNPEKYAAFTRILCRMYLKHGSPVKMMESYIAVLTKGICQSEENGSFLSKDFDARKAYLAGSIKDIVSQFGMETVILHTALMLK
KRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDLEVSNRPDLYDVFVNLAESEITIAPLAKEAM
AMGKLHKEMGQLIVQSAEDPEKSESHVIQLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF
STVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSF

--------------------------------------------------------------
>29041_29041_3_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000544016_GRK5_chr10_121207634_ENST00000369108_length(transcript)=1352nt_BP=794nt
AGAGCTGCGCGCCGCGGCGGCGGAAGATGGCTGCGGCCGAGGTGGCGGACACTCAGCTGATGCTTGGAGTCGGGCTGATCGTGACCATCT
TTCCACCGTAGAAAAGGACACAAATGGAGAAGTTCTGTGGGTGTGGTGTTATCCTTCCACGACAGCCACATTAAGGAACCTGCTGCTGAG
AAAATGCTGCCTTACAGATGAAAACAAACTTCTCCATCCCTTTGTCTTTGGTCAGTACAGAAGAACATGGTTTTATATCACAACAATTGA
AGTTCCAGATTCTTCCATTTTGAAAAAGGTGACTCATTTTTCTATTGTCCTGACCGCCAAAGATTTTAACCCAGAGAAGTATGCTGCCTT
CACTAGGATATTGTGTAGACATTGTATCTCAGTTTGGAATGGAAACTGTTATCTTACACACAGCACTGATGCTAAAGAAAAGAATTGTGG
TGTATCACCCCAAGATAGAAGCGGTCCAGGAGTTCACCAGGACTCTGCCTGCCCTGGTGTGGCACCGACAGGACTGGACCATCCTTCACT
CTTACGTGCACCTCAACGCCGATGAGCTGGAAGCCCTGCAGATGTGCACAGGTTACGTCGCTGGATTTGTAGACTTGGAGGTGAGCAACA
GACCAGACCTCTATGATGTGTTTGTGAATCTGGCAGAGAGTGAGATTACCATTGCTCCCCTTGCAAAAGAGGCCATGGCAATGGGCAAAC
TGCACAAAGAAATGGGTCAGCTAATTGTTCAGTCTGCAGAAGATCCAGAGAAATCAGAGAGCCACGTTATACAGCTGCTCACGAAAGATG
CGAAGCAGAGGCTGGGCTGCCAGGAGGAGGGGGCTGCAGAGGTCAAGAGACACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAG
CCGGGATGTTGGACCCTCCCTTCGTTCCAGACCCCCGCGCTGTGTACTGTAAGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGG
GCGTCAATCTGGACCACACAGACGACGACTTCTACTCCAAGTTCTCCACGGGCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAA
CAGAATGCTTTAAGGAGCTGAACGTGTTTGGACCTAATGGTACCCTCCCGCCAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGA
AAGGGCTGCTCCAGAGACTCTTCAAGCGGCAGCATCAGAACAATTCCAAGAGTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAA
ACTCAAACCATGTCAGCTCGAACTCCACCGGAAGCAGCTAGTTTCGGCTCTGGCCTCCAAGTCCACAGTGGAACCAGCCCAGACCCTTCT

>29041_29041_3_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000544016_GRK5_chr10_121207634_ENST00000369108_length(amino acids)=316AA_BP=0
MLPSLGYCVDIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDLE
VSNRPDLYDVFVNLAESEITIAPLAKEAMAMGKLHKEMGQLIVQSAEDPEKSESHVIQLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------
>29041_29041_4_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000544016_GRK5_chr10_121207634_ENST00000392870_length(transcript)=1853nt_BP=794nt
AGAGCTGCGCGCCGCGGCGGCGGAAGATGGCTGCGGCCGAGGTGGCGGACACTCAGCTGATGCTTGGAGTCGGGCTGATCGTGACCATCT
TTCCACCGTAGAAAAGGACACAAATGGAGAAGTTCTGTGGGTGTGGTGTTATCCTTCCACGACAGCCACATTAAGGAACCTGCTGCTGAG
AAAATGCTGCCTTACAGATGAAAACAAACTTCTCCATCCCTTTGTCTTTGGTCAGTACAGAAGAACATGGTTTTATATCACAACAATTGA
AGTTCCAGATTCTTCCATTTTGAAAAAGGTGACTCATTTTTCTATTGTCCTGACCGCCAAAGATTTTAACCCAGAGAAGTATGCTGCCTT
CACTAGGATATTGTGTAGACATTGTATCTCAGTTTGGAATGGAAACTGTTATCTTACACACAGCACTGATGCTAAAGAAAAGAATTGTGG
TGTATCACCCCAAGATAGAAGCGGTCCAGGAGTTCACCAGGACTCTGCCTGCCCTGGTGTGGCACCGACAGGACTGGACCATCCTTCACT
CTTACGTGCACCTCAACGCCGATGAGCTGGAAGCCCTGCAGATGTGCACAGGTTACGTCGCTGGATTTGTAGACTTGGAGGTGAGCAACA
GACCAGACCTCTATGATGTGTTTGTGAATCTGGCAGAGAGTGAGATTACCATTGCTCCCCTTGCAAAAGAGGCCATGGCAATGGGCAAAC
TGCACAAAGAAATGGGTCAGCTAATTGTTCAGTCTGCAGAAGATCCAGAGAAATCAGAGAGCCACGTTATACAGCTGCTCACGAAAGATG
CGAAGCAGAGGCTGGGCTGCCAGGAGGAGGGGGCTGCAGAGGTCAAGAGACACCCCTTCTTCAGGAACATGAACTTCAAGCGCTTAGAAG
CCGGGATGTTGGACCCTCCCTTCGTTCCAGACCCCCGCGCTGTGTACTGTAAGGACGTGCTGGACATCGAGCAGTTCTCCACTGTGAAGG
GCGTCAATCTGGACCACACAGACGACGACTTCTACTCCAAGTTCTCCACGGGCTCTGTGTCCATCCCATGGCAAAACGAGATGATAGAAA
CAGAATGCTTTAAGGAGCTGAACGTGTTTGGACCTAATGGTACCCTCCCGCCAGATCTGAACAGAAACCACCCTCCGGAACCGCCCAAGA
AAGGGCTGCTCCAGAGACTCTTCAAGCGGCAGCATCAGAACAATTCCAAGAGTTCGCCCAGCTCCAAGACCAGTTTTAACCACCACATAA
ACTCAAACCATGTCAGCTCGAACTCCACCGGAAGCAGCTAGTTTCGGCTCTGGCCTCCAAGTCCACAGTGGAACCAGCCCAGACCCTTCT
CCTTAGAAGTGGAAGTAGTGGAGCCCCTGCTCTGGTGGGGCTGCCAGGGGAGACCCCGGGAGCCGGGGAAGGAGGCCGTCCATCCCGTCG
ACGTAGAACCTCGAGGTTTCTCAAAGAAATTTCCACTCAGGTCTGTTTTCCGAGGCGGCCCCGGCCGGGGTGGATTGGATTTGTCTTTGG
TGAACATTGCAATAGAAATCCAATTGGATACGACAACTTGCACGTATTTTAATAGCGTCATAACTAGAACTGAATTTTGTCTTTATGATT
TTTAAAGAAAAGTTTTGTAAATTTCTCTACTGTCTCAGTTTACATTTTGTATATTTGTATTTAAATGAAAGTGAGACTTTGAGGGTGTAT
ATTTTCTGTGCAGCCACTGTTAAGCCATGTGTTCCAAGGCATTTTAGCGGGGAGGGGGTTATCAAAAAAAAAAAAATGTGACTCAAGACT

>29041_29041_4_FAM45A-GRK5_FAM45A_chr10_120892121_ENST00000544016_GRK5_chr10_121207634_ENST00000392870_length(amino acids)=316AA_BP=0
MLPSLGYCVDIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDLE
VSNRPDLYDVFVNLAESEITIAPLAKEAMAMGKLHKEMGQLIVQSAEDPEKSESHVIQLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

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Fusion Gene PPI Analysis for FAM45A-GRK5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	GRK5	chr10:120892121	chr10:121207634	ENST00000392870		11	16	20_39	422.0	591.0	calmodulin

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FAM45A-GRK5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FAM45A-GRK5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source