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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM53B-LY86 (FusionGDB2 ID:29098)

Fusion Gene Summary for FAM53B-LY86

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM53B-LY86
Fusion gene ID: 29098
HgeneTgene
Gene symbol

FAM53B

LY86

Gene ID

9679

9450

Gene namefamily with sequence similarity 53 member Blymphocyte antigen 86
SynonymsKIAA0140|bA12J10.2|smpMD-1|MD1|MMD-1|dJ80N2.1
Cytomap

10q26.13

6p25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM53Bprotein simpletsimplet homologlymphocyte antigen 86MD-1, RP105-associatedly-86protein MD-1
Modification date2020031320200313
UniProtAcc

Q14153

O95711

Ensembl transtripts involved in fusion geneENST00000280780, ENST00000337318, 
ENST00000392754, 		ENST00000230568, 
ENST00000379953, 
Fusion gene scores* DoF score9 X 5 X 6=2702 X 5 X 2=20
# samples 114
** MAII scorelog2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/20*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM53B [Title/Abstract] AND LY86 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM53B(126384726)-LY86(6654776), # samples:1
FAM53B(126384727)-LY86(6654777), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM53B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LY86 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1326-01AFAM53Bchr10

126384727

-LY86chr6

6654777

+
ChimerDB4OVTCGA-25-1326FAM53Bchr10

126384726

-LY86chr6

6654776

+


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Fusion Gene ORF analysis for FAM53B-LY86

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000280780ENST00000230568FAM53Bchr10

126384727

-LY86chr6

6654777

+
Frame-shiftENST00000280780ENST00000230568FAM53Bchr10

126384726

-LY86chr6

6654776

+
Frame-shiftENST00000337318ENST00000230568FAM53Bchr10

126384727

-LY86chr6

6654777

+
Frame-shiftENST00000337318ENST00000230568FAM53Bchr10

126384726

-LY86chr6

6654776

+
Frame-shiftENST00000392754ENST00000379953FAM53Bchr10

126384727

-LY86chr6

6654777

+
Frame-shiftENST00000392754ENST00000379953FAM53Bchr10

126384726

-LY86chr6

6654776

+
In-frameENST00000280780ENST00000379953FAM53Bchr10

126384727

-LY86chr6

6654777

+
In-frameENST00000280780ENST00000379953FAM53Bchr10

126384726

-LY86chr6

6654776

+
In-frameENST00000337318ENST00000379953FAM53Bchr10

126384727

-LY86chr6

6654777

+
In-frameENST00000337318ENST00000379953FAM53Bchr10

126384726

-LY86chr6

6654776

+
In-frameENST00000392754ENST00000230568FAM53Bchr10

126384727

-LY86chr6

6654777

+
In-frameENST00000392754ENST00000230568FAM53Bchr10

126384726

-LY86chr6

6654776

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337318FAM53Bchr10126384726-ENST00000379953LY86chr66654776+785345526224100
ENST00000392754FAM53Bchr10126384726-ENST00000230568LY86chr66654776+93885039395118
ENST00000280780FAM53Bchr10126384726-ENST00000379953LY86chr66654776+10045644981166
ENST00000337318FAM53Bchr10126384727-ENST00000379953LY86chr66654777+785345526224100
ENST00000392754FAM53Bchr10126384727-ENST00000230568LY86chr66654777+93885039395118
ENST00000280780FAM53Bchr10126384727-ENST00000379953LY86chr66654777+10045644981166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337318ENST00000379953FAM53Bchr10126384726-LY86chr66654776+0.91310950.08689051
ENST00000392754ENST00000230568FAM53Bchr10126384726-LY86chr66654776+0.26650770.7334923
ENST00000280780ENST00000379953FAM53Bchr10126384726-LY86chr66654776+0.92937650.07062346
ENST00000337318ENST00000379953FAM53Bchr10126384727-LY86chr66654777+0.91310950.08689051
ENST00000392754ENST00000230568FAM53Bchr10126384727-LY86chr66654777+0.26650770.7334923
ENST00000280780ENST00000379953FAM53Bchr10126384727-LY86chr66654777+0.92937650.07062346

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Fusion Genomic Features for FAM53B-LY86


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM53Bchr10126384726-LY86chr66654776+0.0132667070.9867334
FAM53Bchr10126384726-LY86chr66654776+0.0132667070.9867334
FAM53Bchr10126384726-LY86chr66654776+0.0132667070.9867334
FAM53Bchr10126384726-LY86chr66654776+0.0132667070.9867334

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM53B-LY86


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:126384726/chr6:6654776)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM53B

Q14153

LY86

O95711

FUNCTION: Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}.FUNCTION: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM53Bchr10:126384726chr6:6654776ENST00000280780-35281_28444306.0MotifNuclear localization signal
HgeneFAM53Bchr10:126384726chr6:6654776ENST00000337318-35281_28444423.0MotifNuclear localization signal
HgeneFAM53Bchr10:126384726chr6:6654776ENST00000392754-35281_28444423.0MotifNuclear localization signal
HgeneFAM53Bchr10:126384727chr6:6654777ENST00000280780-35281_28444306.0MotifNuclear localization signal
HgeneFAM53Bchr10:126384727chr6:6654777ENST00000337318-35281_28444423.0MotifNuclear localization signal
HgeneFAM53Bchr10:126384727chr6:6654777ENST00000392754-35281_28444423.0MotifNuclear localization signal


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Fusion Gene Sequence for FAM53B-LY86


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29098_29098_1_FAM53B-LY86_FAM53B_chr10_126384726_ENST00000280780_LY86_chr6_6654776_ENST00000379953_length(transcript)=1004nt_BP=564nt
CACGCAGCCGCGGTCTGGCGGCTCCGCGGCGGCGGCGGGTGCGGGCGGCCTGGCCGGTGCCGGTTAAAGGGACGAGTTGCAAACACTTCA
GGAAGTGACAAGTCGATTTCCTCCTCCCCGGGAGTCGCTCGTACAAAGCGCTCGGCGCCGGCAGGCGAGCGTGCGCGCGGCGGACGCGCG
GCGGGCACCCCGGACGACTTGGCGAGCGCTGGCGGTGACGGCGCGGGGTCCGCGCCCGGAGCGCCCCGCCGCGCACAGGAGTTGACCACA
TTTGGCCATTTCCCAGAAGGGCCCCACCCCAAGGGTGAGTGGCCAATGGGGAGCTGTTTCTGCTGACATCAATTCCCCAGGAGGTACTCA
CCCCAAGTCTGCCCAAGTGAAGATGGCTGATACCCACCCTGGGATGGAGCCCAGCGCCTGAGGCCCTTATCATGGTGATGGTCCTAAGTG
AAAGCCTCAGCACCCGGGGAGCTGACTCCATTGCATGTGGGACCTTCAGCCGTGAACTGCACACGCCAAAGAAGATGAGTCAAGGACCTA
CACTTTTCTCTTGTGGAATTATGGGGAGAATACCAGGTTTTGCTGGAACTGTACACTGAAAAACGGTCCACCGTGGCCTGTGCCAATGCT
ACTATCATGTGCTCCTGACTGTGGCCTGTAGCAAAAATCACAGCCAGCTGCATCTCGTGGGACCTCCAAGCTCCTCTGACTGAACCTACT
GTGGGAGGAGAAGCAGCTGATGACAGAGAGAGGCTCTACAAAGAAGCGCCCCCAAAGAGTGCAGCTGCTAATTTTAGTCCCAGGACCAGA
CATCCCCAGACTCCACAGATGTAATGAAGTCCCCGAATGTATCTGTTTCTAAGGAGCCTCTTGGCAGTCCTTAAGCAGTCTTGAGGGTCC
ATCCTTTTTCTCTAATTGGTCGCCTCCCACCAGACTCACCTGCTTTTCAACTTTTTAGGAGTGCTTCCTCACAGTTACCAAGAATAAAGA

>29098_29098_1_FAM53B-LY86_FAM53B_chr10_126384726_ENST00000280780_LY86_chr6_6654776_ENST00000379953_length(amino acids)=166AA_BP=
MKVPHAMESAPRVLRLSLRTITMIRASGAGLHPRVGISHLHLGRLGVSTSWGIDVSRNSSPLATHPWGGALLGNGQMWSTPVRGGALRAR

--------------------------------------------------------------
>29098_29098_2_FAM53B-LY86_FAM53B_chr10_126384726_ENST00000337318_LY86_chr6_6654776_ENST00000379953_length(transcript)=785nt_BP=345nt
GGCGCGGGGTCCGCGCCCGGAGCGCCCCGCCGCGCACAGGAGTTGACCACATTTGGCCATTTCCCAGAAGGGCCCCACCCCAAGGGTGAG
TGGCCAATGGGGAGCTGTTTCTGCTGACATCAATTCCCCAGGAGGTACTCACCCCAAGTCTGCCCAAGTGAAGATGGCTGATACCCACCC
TGGGATGGAGCCCAGCGCCTGAGGCCCTTATCATGGTGATGGTCCTAAGTGAAAGCCTCAGCACCCGGGGAGCTGACTCCATTGCATGTG
GGACCTTCAGCCGTGAACTGCACACGCCAAAGAAGATGAGTCAAGGACCTACACTTTTCTCTTGTGGAATTATGGGGAGAATACCAGGTT
TTGCTGGAACTGTACACTGAAAAACGGTCCACCGTGGCCTGTGCCAATGCTACTATCATGTGCTCCTGACTGTGGCCTGTAGCAAAAATC
ACAGCCAGCTGCATCTCGTGGGACCTCCAAGCTCCTCTGACTGAACCTACTGTGGGAGGAGAAGCAGCTGATGACAGAGAGAGGCTCTAC
AAAGAAGCGCCCCCAAAGAGTGCAGCTGCTAATTTTAGTCCCAGGACCAGACATCCCCAGACTCCACAGATGTAATGAAGTCCCCGAATG
TATCTGTTTCTAAGGAGCCTCTTGGCAGTCCTTAAGCAGTCTTGAGGGTCCATCCTTTTTCTCTAATTGGTCGCCTCCCACCAGACTCAC

>29098_29098_2_FAM53B-LY86_FAM53B_chr10_126384726_ENST00000337318_LY86_chr6_6654776_ENST00000379953_length(amino acids)=100AA_BP=1
MSSAASPPTVGSVRGAWRSHEMQLAVIFATGHSQEHMIVALAQATVDRFSVYSSSKTWYSPHNSTREKCRSLTHLLWRVQFTAEGPTCNG

--------------------------------------------------------------
>29098_29098_3_FAM53B-LY86_FAM53B_chr10_126384726_ENST00000392754_LY86_chr6_6654776_ENST00000230568_length(transcript)=938nt_BP=850nt
GTACTGTACTTAGGACGATGGTGAACAAAGAAAAGCTCTTTGCAGCGTTTGATGAATGGGATTCTGCCTCCTATAGGCCACACTCCGAGT
CTTCCATACGGTACAATCTCCGGACTCGGTGGTGTTAGGAAAGTGGCCCCCGGAATGGCTTGCATTCCGGGTCTGGGATCCTGGGGTGGG
CATTTGTGCCGTCGCCTTCGCCGCCGCGCTCGCCTTGCAGGAGCGGGTGCAGATGGAGCCAGGCTGACGGTTGTTCAACAGGAACAAATG
TTTGTTCAATTGTTGGATGGTGGAGAAAAGGGACTGTTTCCTATTGACTGCTGCAGGAGTTGGAATGGCATTGTTTATTGGCCTGGGAAG
CCAGGCAAGCGTCTTGTGCTGCTTACAACATATTAGCAGACTTCCAAATGACATGCTAGCATATGTGTTCCCAGCAGTCCCCACCGGCTG
GCAGGGAGATTCCTCCTTGCTCCAGATCCTGGACTCGTTTAAAAGATGCCACCTGGTTTGAGGACTTGGGAAGGAATGGAGTCAGCCGAC
CAGGGAGTTGACCACATTTGGCCATTTCCCAGAAGGGCCCCACCCCAAGGGTGAGTGGCCAATGGGGAGCTGTTTCTGCTGACATCAATT
CCCCAGGAGGTACTCACCCCAAGTCTGCCCAAGTGAAGATGGCTGATACCCACCCTGGGATGGAGCCCAGCGCCTGAGGCCCTTATCATG
GTGATGGTCCTAAGTGAAAGCCTCAGCACCCGGGGAGCTGACTCCATTGCATGTGGGACCTTCAGCCGTGAACTGCACACGCCAAAGAAG
ATGAGTCAAGGACCTACACTTTTCTCTTGTGGAATTATGGGGAGAATACCAGGTTTTGCTGGAACTGTACACTGAAAAACGGTCCACCGT

>29098_29098_3_FAM53B-LY86_FAM53B_chr10_126384726_ENST00000392754_LY86_chr6_6654776_ENST00000230568_length(amino acids)=118AA_BP=
MQRLMNGILPPIGHTPSLPYGTISGLGGVRKVAPGMACIPGLGSWGGHLCRRLRRRARLAGAGADGARLTVVQQEQMFVQLLDGGEKGLF

--------------------------------------------------------------
>29098_29098_4_FAM53B-LY86_FAM53B_chr10_126384727_ENST00000280780_LY86_chr6_6654777_ENST00000379953_length(transcript)=1004nt_BP=564nt
CACGCAGCCGCGGTCTGGCGGCTCCGCGGCGGCGGCGGGTGCGGGCGGCCTGGCCGGTGCCGGTTAAAGGGACGAGTTGCAAACACTTCA
GGAAGTGACAAGTCGATTTCCTCCTCCCCGGGAGTCGCTCGTACAAAGCGCTCGGCGCCGGCAGGCGAGCGTGCGCGCGGCGGACGCGCG
GCGGGCACCCCGGACGACTTGGCGAGCGCTGGCGGTGACGGCGCGGGGTCCGCGCCCGGAGCGCCCCGCCGCGCACAGGAGTTGACCACA
TTTGGCCATTTCCCAGAAGGGCCCCACCCCAAGGGTGAGTGGCCAATGGGGAGCTGTTTCTGCTGACATCAATTCCCCAGGAGGTACTCA
CCCCAAGTCTGCCCAAGTGAAGATGGCTGATACCCACCCTGGGATGGAGCCCAGCGCCTGAGGCCCTTATCATGGTGATGGTCCTAAGTG
AAAGCCTCAGCACCCGGGGAGCTGACTCCATTGCATGTGGGACCTTCAGCCGTGAACTGCACACGCCAAAGAAGATGAGTCAAGGACCTA
CACTTTTCTCTTGTGGAATTATGGGGAGAATACCAGGTTTTGCTGGAACTGTACACTGAAAAACGGTCCACCGTGGCCTGTGCCAATGCT
ACTATCATGTGCTCCTGACTGTGGCCTGTAGCAAAAATCACAGCCAGCTGCATCTCGTGGGACCTCCAAGCTCCTCTGACTGAACCTACT
GTGGGAGGAGAAGCAGCTGATGACAGAGAGAGGCTCTACAAAGAAGCGCCCCCAAAGAGTGCAGCTGCTAATTTTAGTCCCAGGACCAGA
CATCCCCAGACTCCACAGATGTAATGAAGTCCCCGAATGTATCTGTTTCTAAGGAGCCTCTTGGCAGTCCTTAAGCAGTCTTGAGGGTCC
ATCCTTTTTCTCTAATTGGTCGCCTCCCACCAGACTCACCTGCTTTTCAACTTTTTAGGAGTGCTTCCTCACAGTTACCAAGAATAAAGA

>29098_29098_4_FAM53B-LY86_FAM53B_chr10_126384727_ENST00000280780_LY86_chr6_6654777_ENST00000379953_length(amino acids)=166AA_BP=
MKVPHAMESAPRVLRLSLRTITMIRASGAGLHPRVGISHLHLGRLGVSTSWGIDVSRNSSPLATHPWGGALLGNGQMWSTPVRGGALRAR

--------------------------------------------------------------
>29098_29098_5_FAM53B-LY86_FAM53B_chr10_126384727_ENST00000337318_LY86_chr6_6654777_ENST00000379953_length(transcript)=785nt_BP=345nt
GGCGCGGGGTCCGCGCCCGGAGCGCCCCGCCGCGCACAGGAGTTGACCACATTTGGCCATTTCCCAGAAGGGCCCCACCCCAAGGGTGAG
TGGCCAATGGGGAGCTGTTTCTGCTGACATCAATTCCCCAGGAGGTACTCACCCCAAGTCTGCCCAAGTGAAGATGGCTGATACCCACCC
TGGGATGGAGCCCAGCGCCTGAGGCCCTTATCATGGTGATGGTCCTAAGTGAAAGCCTCAGCACCCGGGGAGCTGACTCCATTGCATGTG
GGACCTTCAGCCGTGAACTGCACACGCCAAAGAAGATGAGTCAAGGACCTACACTTTTCTCTTGTGGAATTATGGGGAGAATACCAGGTT
TTGCTGGAACTGTACACTGAAAAACGGTCCACCGTGGCCTGTGCCAATGCTACTATCATGTGCTCCTGACTGTGGCCTGTAGCAAAAATC
ACAGCCAGCTGCATCTCGTGGGACCTCCAAGCTCCTCTGACTGAACCTACTGTGGGAGGAGAAGCAGCTGATGACAGAGAGAGGCTCTAC
AAAGAAGCGCCCCCAAAGAGTGCAGCTGCTAATTTTAGTCCCAGGACCAGACATCCCCAGACTCCACAGATGTAATGAAGTCCCCGAATG
TATCTGTTTCTAAGGAGCCTCTTGGCAGTCCTTAAGCAGTCTTGAGGGTCCATCCTTTTTCTCTAATTGGTCGCCTCCCACCAGACTCAC

>29098_29098_5_FAM53B-LY86_FAM53B_chr10_126384727_ENST00000337318_LY86_chr6_6654777_ENST00000379953_length(amino acids)=100AA_BP=1
MSSAASPPTVGSVRGAWRSHEMQLAVIFATGHSQEHMIVALAQATVDRFSVYSSSKTWYSPHNSTREKCRSLTHLLWRVQFTAEGPTCNG

--------------------------------------------------------------
>29098_29098_6_FAM53B-LY86_FAM53B_chr10_126384727_ENST00000392754_LY86_chr6_6654777_ENST00000230568_length(transcript)=938nt_BP=850nt
GTACTGTACTTAGGACGATGGTGAACAAAGAAAAGCTCTTTGCAGCGTTTGATGAATGGGATTCTGCCTCCTATAGGCCACACTCCGAGT
CTTCCATACGGTACAATCTCCGGACTCGGTGGTGTTAGGAAAGTGGCCCCCGGAATGGCTTGCATTCCGGGTCTGGGATCCTGGGGTGGG
CATTTGTGCCGTCGCCTTCGCCGCCGCGCTCGCCTTGCAGGAGCGGGTGCAGATGGAGCCAGGCTGACGGTTGTTCAACAGGAACAAATG
TTTGTTCAATTGTTGGATGGTGGAGAAAAGGGACTGTTTCCTATTGACTGCTGCAGGAGTTGGAATGGCATTGTTTATTGGCCTGGGAAG
CCAGGCAAGCGTCTTGTGCTGCTTACAACATATTAGCAGACTTCCAAATGACATGCTAGCATATGTGTTCCCAGCAGTCCCCACCGGCTG
GCAGGGAGATTCCTCCTTGCTCCAGATCCTGGACTCGTTTAAAAGATGCCACCTGGTTTGAGGACTTGGGAAGGAATGGAGTCAGCCGAC
CAGGGAGTTGACCACATTTGGCCATTTCCCAGAAGGGCCCCACCCCAAGGGTGAGTGGCCAATGGGGAGCTGTTTCTGCTGACATCAATT
CCCCAGGAGGTACTCACCCCAAGTCTGCCCAAGTGAAGATGGCTGATACCCACCCTGGGATGGAGCCCAGCGCCTGAGGCCCTTATCATG
GTGATGGTCCTAAGTGAAAGCCTCAGCACCCGGGGAGCTGACTCCATTGCATGTGGGACCTTCAGCCGTGAACTGCACACGCCAAAGAAG
ATGAGTCAAGGACCTACACTTTTCTCTTGTGGAATTATGGGGAGAATACCAGGTTTTGCTGGAACTGTACACTGAAAAACGGTCCACCGT

>29098_29098_6_FAM53B-LY86_FAM53B_chr10_126384727_ENST00000392754_LY86_chr6_6654777_ENST00000230568_length(amino acids)=118AA_BP=
MQRLMNGILPPIGHTPSLPYGTISGLGGVRKVAPGMACIPGLGSWGGHLCRRLRRRARLAGAGADGARLTVVQQEQMFVQLLDGGEKGLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM53B-LY86


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM53B-LY86


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM53B-LY86


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource