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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGO2-POM121C (FusionGDB2 ID:2912)

Fusion Gene Summary for AGO2-POM121C

check button Fusion gene summary
Fusion gene informationFusion gene name: AGO2-POM121C
Fusion gene ID: 2912
HgeneTgene
Gene symbol

AGO2

POM121C

Gene ID

27161

100101267

Gene nameargonaute RISC catalytic component 2POM121 transmembrane nucleoporin C
SynonymsCASC7|EIF2C2|LINC00980|PPD|Q10POM121-2
Cytomap

8q24.3

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein argonaute-2PAZ Piwi domain proteinargonaute 2, RISC catalytic componentcancer susceptibility candidate 7cancer susceptibility candidate 7 (non-protein coding)eukaryotic translation initiation factor 2C, 2long intergenic non-protein coding RNnuclear envelope pore membrane protein POM 121CPOM121 membrane glycoprotein Cnuclear pore membrane protein 121-2pore membrane protein of 121 kDa C
Modification date2020032720200313
UniProtAcc

Q9UKV8

.
Ensembl transtripts involved in fusion geneENST00000220592, ENST00000519980, 
ENST00000517293, 		ENST00000473168, 
ENST00000257665, ENST00000453279, 
Fusion gene scores* DoF score13 X 13 X 12=20285 X 5 X 3=75
# samples 285
** MAII scorelog2(28/2028*10)=-2.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGO2 [Title/Abstract] AND POM121C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGO2(141645584)-POM121C(75055735), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGO2

GO:0010501

RNA secondary structure unwinding

19966796

HgeneAGO2

GO:0031054

pre-miRNA processing

16424907|17671087|18178619|19966796

HgeneAGO2

GO:0035087

siRNA loading onto RISC involved in RNA interference

19966796

HgeneAGO2

GO:0035196

production of miRNAs involved in gene silencing by miRNA

19966796|23661684

HgeneAGO2

GO:0035278

miRNA mediated inhibition of translation

17671087|19801630

HgeneAGO2

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

15260970|17524464

HgeneAGO2

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619|19966796

HgeneAGO2

GO:0045766

positive regulation of angiogenesis

27208409

HgeneAGO2

GO:0045947

negative regulation of translational initiation

17524464|19801630

HgeneAGO2

GO:0090625

mRNA cleavage involved in gene silencing by siRNA

15260970

HgeneAGO2

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027


check buttonFusion gene breakpoints across AGO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POM121C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-57-1585-01AAGO2chr8

141645584

-POM121Cchr7

75055735

-


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Fusion Gene ORF analysis for AGO2-POM121C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000220592ENST00000473168AGO2chr8

141645584

-POM121Cchr7

75055735

-
5CDS-intronENST00000519980ENST00000473168AGO2chr8

141645584

-POM121Cchr7

75055735

-
5UTR-3CDSENST00000517293ENST00000257665AGO2chr8

141645584

-POM121Cchr7

75055735

-
5UTR-3CDSENST00000517293ENST00000453279AGO2chr8

141645584

-POM121Cchr7

75055735

-
5UTR-intronENST00000517293ENST00000473168AGO2chr8

141645584

-POM121Cchr7

75055735

-
In-frameENST00000220592ENST00000257665AGO2chr8

141645584

-POM121Cchr7

75055735

-
In-frameENST00000220592ENST00000453279AGO2chr8

141645584

-POM121Cchr7

75055735

-
In-frameENST00000519980ENST00000257665AGO2chr8

141645584

-POM121Cchr7

75055735

-
In-frameENST00000519980ENST00000453279AGO2chr8

141645584

-POM121Cchr7

75055735

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000220592AGO2chr8141645584-ENST00000453279POM121Cchr775055735-46291352372618793
ENST00000220592AGO2chr8141645584-ENST00000257665POM121Cchr775055735-46291352372618793
ENST00000519980AGO2chr8141645584-ENST00000453279POM121Cchr775055735-4556621642545793
ENST00000519980AGO2chr8141645584-ENST00000257665POM121Cchr775055735-4556621642545793

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220592ENST00000453279AGO2chr8141645584-POM121Cchr775055735-0.086023510.9139765
ENST00000220592ENST00000257665AGO2chr8141645584-POM121Cchr775055735-0.086023510.9139765
ENST00000519980ENST00000453279AGO2chr8141645584-POM121Cchr775055735-0.088665430.9113346
ENST00000519980ENST00000257665AGO2chr8141645584-POM121Cchr775055735-0.088665430.9113346

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Fusion Genomic Features for AGO2-POM121C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AGO2-POM121C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:141645584/chr7:75055735)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGO2

Q9UKV8

.
FUNCTION: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOM121Cchr8:141645584chr7:75055735ENST00000257665413728_9244021230.0Compositional biasNote=Thr-rich
TgenePOM121Cchr8:141645584chr7:75055735ENST00000453279615322_444160988.0Compositional biasNote=Ser-rich
TgenePOM121Cchr8:141645584chr7:75055735ENST00000453279615728_924160988.0Compositional biasNote=Thr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119235_3487860.0DomainPAZ
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119517_8187860.0DomainPiwi
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118235_3487826.0DomainPAZ
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118517_8187826.0DomainPiwi
TgenePOM121Cchr8:141645584chr7:75055735ENST00000257665413131_1914021230.0Compositional biasNote=Pro-rich
TgenePOM121Cchr8:141645584chr7:75055735ENST00000257665413322_4444021230.0Compositional biasNote=Ser-rich
TgenePOM121Cchr8:141645584chr7:75055735ENST00000453279615131_191160988.0Compositional biasNote=Pro-rich
TgenePOM121Cchr8:141645584chr7:75055735ENST000002576654131_3984021230.0RegionNote=Required for targeting to the nucleus and nuclear pore complex
TgenePOM121Cchr8:141645584chr7:75055735ENST000002576654131_404021230.0RegionCisternal side
TgenePOM121Cchr8:141645584chr7:75055735ENST0000025766541362_12294021230.0RegionPore side
TgenePOM121Cchr8:141645584chr7:75055735ENST000004532796151_398160988.0RegionNote=Required for targeting to the nucleus and nuclear pore complex
TgenePOM121Cchr8:141645584chr7:75055735ENST000004532796151_40160988.0RegionCisternal side
TgenePOM121Cchr8:141645584chr7:75055735ENST0000045327961562_1229160988.0RegionPore side
TgenePOM121Cchr8:141645584chr7:75055735ENST0000025766541341_614021230.0TransmembraneHelical
TgenePOM121Cchr8:141645584chr7:75055735ENST0000045327961541_61160988.0TransmembraneHelical


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Fusion Gene Sequence for AGO2-POM121C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2912_2912_1_AGO2-POM121C_AGO2_chr8_141645584_ENST00000220592_POM121C_chr7_75055735_ENST00000257665_length(transcript)=4629nt_BP=135nt
GGCCGCGCCGGGGCGGATCGTGCGGCCGGCGGCTCCCTCGCGGCTCGCGGCGTCGGGGCCCGTGGCGCGCGCGCGGCCGCCCCTCGGCCC
CGGAGCCCCTCGGCGGCGCCACCATGTACTCGGGAGCCGGCCCCGCTCTGGAAGAGAAATGGCCCCAGTTCATCACCCTTCTCTAGCCCA
GCCTCATCCCGCTCCCAGACACCGGAGAGGCCAGCAAAGAAAATAAGAGAAGAAGAGCTGTGTCATCATTCCAGTTCTTCAACTCCATTG
GCAGCAGACAAGGAGTCCCAGGGAGAAAAGGCTGCAGATACAACCCCAAGGAAGAAACAAAACTCGAATTCTCAGTCTACACCTGGCAGC
TCTGGGCAGCGTAAGCGGAAAGTTCAGCTGCTGCCTTCTCGGCGAGGGGAACAGCTGACCTTGCCTCCACCTCCCCAGCTTGGCTATTCG
ATCACTGCCGAGGACCTAGACTTAGAGAAGAAGGCTTCATTACAGTGGTTCAACCAGGCCTTGGAGGACAAGAGTGATGCTGCCTCGAAC
TCTGTCACTGAGACCCCACCTACCACTCAGCCTTCATTTACCTTTACCCTGCCTGCTGCTGCAACTGCCTCCCCACCCACCTCCCTCCTG
GCCCCAAGCACCAACCCACTGTTAGAGAGCTTGAAGAAGATGCAGACTCCCCCGAGCCTGCCACCCTGCCCAGAATCTGCTGGAGCAGCA
ACCACTGAGGCCCTCTCACCTCCAAAGACACCCAGCCTCCTACCCCCGCTGGGTTTATCACAGTCAGGGCCGCCAGGGCTGCTCCCCAGC
CCCTCCTTTGACTCCAAACCCCCGACCACTTTGCTGGGGCTGATCCCTGCTCCATCCATGGTACCAGCCACTGACACCAAGGCACCTCCA
ACCCTTCAAGCAGAGACGGCTACCAAACCCCAAGCCACATCTGCCCCGTCCCCCGCCCCCAAGCAAAGCTTCCTGTTTGGAACACAGAAC
ACCTCACCTTCCAGCCCTGCCGCCCCTGCTGCATCTTCAGCATCTCCCATGTTCAAGCCCATTTTCACGGCTCCACCCAAGAGTGAGAAG
GAAGGCCCCACACCGCCTGGCCCTTCAGTCACAGCCACAGCGCCCTCCAGCTCCTCCCTCCCCACGACCACCAGCACCACAGCCCCGACC
TTCCAGCCTGTCTTTAGCAGCATGGGGCCACCTGCATCTGTGCCCTTGCCTGCTCCCTTCTTCAAGCAGACAACTACTCCCGCCACTGCT
CCCACCACAACTGCCCCGCTCTTCACTGGCCTGGCCAGCGCCACCTCTGCTGTGGCTCCCATCACCTCTGCCAGTCCATCCACAGACTCT
GCTTCGAAGCCTGCGTTTGGCTTTGGCATAAACAGTGTGAGCAGCAGCAGTGTGAGTACCACGACCAGCACCGCCACTGCCGCCTCACAG
CCTTTCCTCTTCGGGGCGCCCCAGGCCTCTGCTGCCAGCTTCACCCCGGCCATGGGCTCCATATTCCAGTTTGGCAAACCTCCTGCCTTG
CCCACAACCACCACAGTCACCACCTTCAGCCAGTCCCTGCCCACTGCCGTGCCAACGGCCACCAGCAGCAGCGCTGCCGACTTTAGTGGT
TTTGGCAGCACCCTCGCCACCTCCGCCCCGGCCACCAGCAGCCAGCCCACTCTGACGTTCAGTAACACGAGCACCCCCACGTTCAACATT
CCCTTTGGCTCAAGCGCCAAGTCCCCGCTCCCATCATATCCGGGAGCCAACCCCCAGCCCGCATTTGGGGCCGCTGAGGGGCAGCCACCG
GGGGCCGCCAAGCCAGCCCTTACCCCCAGCTTTGGCAGCTCTTTCACTTTTGGAAACTCTGCAGCCCCGGCCCCGGCTACTGCACCCACA
CCTGCACCTGCGTCCACGATCAAGATCGTGCCTGCGCACGTGCCTACGCCCATCCAGCCTACCTTTGGCGGTGCCACGCACTCGGCGTTT
GGATTGAAAGCCACGGCTTCCGCCTTCGGCGCTCCCGCCAGCTCACAGCCCGCCTTTGGCGGCTCCACTGCTGTCTTCTCCTTCGGTGCA
GCCACCAGCTCCGGCTTTGGAGCCACCACCCAGACCGCCAGCAGCGGGAGCAGCAGCTCGGTGTTTGGCAGCACAACACCATCACCCTTC
ACGTTTGGGGGTTCGGCAGCCCCCGCTGGCAGTGGGAGCTTTGGGATCAACGTGGCCACCCCAGGCTCCAGCGCCACCACCGGAGCTTTC
AGCTTTGGAGCAGGACAGAGTGGGAGCACAGCCACCTCCACCCCCTTCACAGGGGGCTTAGGTCAGAACGCCCTGGGCACCACCGGCCAG
AGCACACCGTTTGCCTTCAACGTGGGCAGCACAACTGAGAGCAAACCTGTGTTTGGAGGCACCGCCACCCCCACCTTTGGTCAGAACACC
CCTGCGCCTGGAGTGGGCACATCGGGCAGCAGCCTCTCCTTTGGGGCATCTTCAGCACCCGCCCAAGGCTTTGTTGGTGTTGGACCGTTC
GGATCGGCGGCCCCTTCATTTTCCATTGGTGCGGGATCCAAGACCCCAGGGGCTCGACAGCGACTGCAGGCCCGAAGGCAGCACACCCGC
AAAAAGTAGCCTTTGTCCCCTGTCCCTGTTCCCCCCACCCCTTCCCTAAATCTGGACCTTGGCACGTGCTAGAAAGAGCCTTGGACCCTT
CCAGCTGCGTAAAGCAAACCTACCCCGGATCTCTGGCTTCAGCCGCCAGGGGGCAGTGGCAGCCCTGGGGCCCTTTCCCTTCTGGAGGAA
GCACAAGCCTCAGGGAAGGGGAAGCAGGATGCGGAGGGCCAAAGCCCGGGACCTCTACTTGAACAGTTCCACTGGGGAGGCTGGAGAACT
AAGGACCTGTACATAGTGTCCGCTGCCCTGACTCCCGCTTAGCGCACCCTTAGGCAGGCGCCCCTTCCACCTTTCCCCGAGAGCCGTCGT
CGCTGGAGGGGGCAGGGTCCAGCCCGCCTGGATCGGTGGTGTGCACCTGATGGGATTTGGGAAATGGGTTATCCCTAAAGCTTTATCTTG
CTTGGCTTAGCTGTGAGAAGTGGTTCTCTTCCTCTGGTCCCTTCTGGGGACTCTGTTTCCCCATTTCTTGCTGCTGTGTCCCTCACCGGT
TCCTTGCAGGATTCCCTCCTTTTTAAATGCCCTTGAATCTAGCTTTGCCTTGGAGACCCCAGTGGGTGCTGCTCCTGCCGTTTTCTTCCT
GCCAAGCCTGAATCAATGTTTCATCTCCAACCCTCTGCCAGTTTGGCCCCTCAGAGCTTGGTGGCTCAAGACTGTTAGCCTGGCAGAGCC
AGGGGTGAAGGGAGAAGCTCTTGGAGCAGGCAGGATGCCCACCGCTGCTTCAGCTGCCTCCTCGCCCAGCTACCCTTTGGCCCCATTGGG
CCCTCGTCTGCCTCTCCAGGATTGTATGTTTCAAGCCTTGTCCTGTGTTCCTTTGTCTGACGCTCTGTGTATTGCTCTTTGAATCGAGTT
TGGAGGAAGAGTTGAGTTGTATGAGTGGCGGCATGTTGGTAGTGCCGGACTTCCTGTTTCAAGTTTTCTGGGGCCTCGCTAATTGAATGT
GGAAAGTAGCACCACTTGACGGCTACAAGTGCCGACTCCTGAATTTTCCCATGGTGTTCTGACTTCAAGGGCTGGCAGCCAGGGAGAATG
GGCCCAGGGGAAGCAAAGACCTCTTCCCTCTGCGGTTTCTGTCCCACTTAACTGACCTCACTGGAGGCTACGTCACCCAAAGTAGATGTT
AGAAAACCTAAATTAATGAACCATATTTTTAAAATCCTATTTTTCCCAAACAGGGCCCTCTGCAGCCCATCCTTTCCTTCCGTCCTTCTG
AAACCACATACCCCAGGCCCAAGCGCCTTGCTGTCACGCCCAACCTCTTTGGGAGAAGTATGAATGCGTGTGTCTAAATTAAAAGAAAAA
AATATTTAAACGTTTTTTAACAAAAATTTATTTTTGTATTTAAGCTAAATTGCCTTTTAAATTCCTTCAAGCTTGGTTCATTGAGGTGGT
TAAGTATAAATGCTATTAACTAGGAATTAGCTGTATAGTTAAGTTATGCCTGTGCAAAGAAGAGGCTCAAATGCTGTCCCCGGCAGCTTT
CCTGGGGGACTAGAGCTCCTTCTGGCCATGTTATATGAAATGTAATTCTTATTTTATAAATAATGTGATGTAGATGTAACCGGTGCCCCC
TCCCCGTTGTGACTGAGGGCGAGTGTTATACCTGGCTGCGTGTGCAGCTGAGGAGGGAGTGAACCTCAAGCCTAAATACCTGTTAGGATT
GGAGGGTCTGGGTGGGCCTGGGCCTAGCAATCAATCAAGCTTCTACCTGTACCTTATGTAAGGTAGACCCTCCTAGTGTCAGTACCTGAG
CTTGTTTACCTCAGTTCCGCAGGCAGGACAGCCGGTCCGGGAACCCTGAGTGAGAGTGAGTGTGGATGTGTACAGTACACACACTGGACG
GCAGCGGGAGGCTGGGACTTTCCATTACAAATAGAGACTTCATTCCTGTTGAGTCTAGTTGGAATTTTTAGTATGAATGTGAGATTTTTC

>2912_2912_1_AGO2-POM121C_AGO2_chr8_141645584_ENST00000220592_POM121C_chr7_75055735_ENST00000257665_length(amino acids)=793AA_BP=
MCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQ
ALEDKSDAASNSVTETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGL
SQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFK
PIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVA
PITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPT
ATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGSSFTFGN
SAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSS
SVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTPFAFNVGSTTESKPVFG

--------------------------------------------------------------
>2912_2912_2_AGO2-POM121C_AGO2_chr8_141645584_ENST00000220592_POM121C_chr7_75055735_ENST00000453279_length(transcript)=4629nt_BP=135nt
GGCCGCGCCGGGGCGGATCGTGCGGCCGGCGGCTCCCTCGCGGCTCGCGGCGTCGGGGCCCGTGGCGCGCGCGCGGCCGCCCCTCGGCCC
CGGAGCCCCTCGGCGGCGCCACCATGTACTCGGGAGCCGGCCCCGCTCTGGAAGAGAAATGGCCCCAGTTCATCACCCTTCTCTAGCCCA
GCCTCATCCCGCTCCCAGACACCGGAGAGGCCAGCAAAGAAAATAAGAGAAGAAGAGCTGTGTCATCATTCCAGTTCTTCAACTCCATTG
GCAGCAGACAAGGAGTCCCAGGGAGAAAAGGCTGCAGATACAACCCCAAGGAAGAAACAAAACTCGAATTCTCAGTCTACACCTGGCAGC
TCTGGGCAGCGTAAGCGGAAAGTTCAGCTGCTGCCTTCTCGGCGAGGGGAACAGCTGACCTTGCCTCCACCTCCCCAGCTTGGCTATTCG
ATCACTGCCGAGGACCTAGACTTAGAGAAGAAGGCTTCATTACAGTGGTTCAACCAGGCCTTGGAGGACAAGAGTGATGCTGCCTCGAAC
TCTGTCACTGAGACCCCACCTACCACTCAGCCTTCATTTACCTTTACCCTGCCTGCTGCTGCAACTGCCTCCCCACCCACCTCCCTCCTG
GCCCCAAGCACCAACCCACTGTTAGAGAGCTTGAAGAAGATGCAGACTCCCCCGAGCCTGCCACCCTGCCCAGAATCTGCTGGAGCAGCA
ACCACTGAGGCCCTCTCACCTCCAAAGACACCCAGCCTCCTACCCCCGCTGGGTTTATCACAGTCAGGGCCGCCAGGGCTGCTCCCCAGC
CCCTCCTTTGACTCCAAACCCCCGACCACTTTGCTGGGGCTGATCCCTGCTCCATCCATGGTACCAGCCACTGACACCAAGGCACCTCCA
ACCCTTCAAGCAGAGACGGCTACCAAACCCCAAGCCACATCTGCCCCGTCCCCCGCCCCCAAGCAAAGCTTCCTGTTTGGAACACAGAAC
ACCTCACCTTCCAGCCCTGCCGCCCCTGCTGCATCTTCAGCATCTCCCATGTTCAAGCCCATTTTCACGGCTCCACCCAAGAGTGAGAAG
GAAGGCCCCACACCGCCTGGCCCTTCAGTCACAGCCACAGCGCCCTCCAGCTCCTCCCTCCCCACGACCACCAGCACCACAGCCCCGACC
TTCCAGCCTGTCTTTAGCAGCATGGGGCCACCTGCATCTGTGCCCTTGCCTGCTCCCTTCTTCAAGCAGACAACTACTCCCGCCACTGCT
CCCACCACAACTGCCCCGCTCTTCACTGGCCTGGCCAGCGCCACCTCTGCTGTGGCTCCCATCACCTCTGCCAGTCCATCCACAGACTCT
GCTTCGAAGCCTGCGTTTGGCTTTGGCATAAACAGTGTGAGCAGCAGCAGTGTGAGTACCACGACCAGCACCGCCACTGCCGCCTCACAG
CCTTTCCTCTTCGGGGCGCCCCAGGCCTCTGCTGCCAGCTTCACCCCGGCCATGGGCTCCATATTCCAGTTTGGCAAACCTCCTGCCTTG
CCCACAACCACCACAGTCACCACCTTCAGCCAGTCCCTGCCCACTGCCGTGCCAACGGCCACCAGCAGCAGCGCTGCCGACTTTAGTGGT
TTTGGCAGCACCCTCGCCACCTCCGCCCCGGCCACCAGCAGCCAGCCCACTCTGACGTTCAGTAACACGAGCACCCCCACGTTCAACATT
CCCTTTGGCTCAAGCGCCAAGTCCCCGCTCCCATCATATCCGGGAGCCAACCCCCAGCCCGCATTTGGGGCCGCTGAGGGGCAGCCACCG
GGGGCCGCCAAGCCAGCCCTTACCCCCAGCTTTGGCAGCTCTTTCACTTTTGGAAACTCTGCAGCCCCGGCCCCGGCTACTGCACCCACA
CCTGCACCTGCGTCCACGATCAAGATCGTGCCTGCGCACGTGCCTACGCCCATCCAGCCTACCTTTGGCGGTGCCACGCACTCGGCGTTT
GGATTGAAAGCCACGGCTTCCGCCTTCGGCGCTCCCGCCAGCTCACAGCCCGCCTTTGGCGGCTCCACTGCTGTCTTCTCCTTCGGTGCA
GCCACCAGCTCCGGCTTTGGAGCCACCACCCAGACCGCCAGCAGCGGGAGCAGCAGCTCGGTGTTTGGCAGCACAACACCATCACCCTTC
ACGTTTGGGGGTTCGGCAGCCCCCGCTGGCAGTGGGAGCTTTGGGATCAACGTGGCCACCCCAGGCTCCAGCGCCACCACCGGAGCTTTC
AGCTTTGGAGCAGGACAGAGTGGGAGCACAGCCACCTCCACCCCCTTCACAGGGGGCTTAGGTCAGAACGCCCTGGGCACCACCGGCCAG
AGCACACCGTTTGCCTTCAACGTGGGCAGCACAACTGAGAGCAAACCTGTGTTTGGAGGCACCGCCACCCCCACCTTTGGTCAGAACACC
CCTGCGCCTGGAGTGGGCACATCGGGCAGCAGCCTCTCCTTTGGGGCATCTTCAGCACCCGCCCAAGGCTTTGTTGGTGTTGGACCGTTC
GGATCGGCGGCCCCTTCATTTTCCATTGGTGCGGGATCCAAGACCCCAGGGGCTCGACAGCGACTGCAGGCCCGAAGGCAGCACACCCGC
AAAAAGTAGCCTTTGTCCCCTGTCCCTGTTCCCCCCACCCCTTCCCTAAATCTGGACCTTGGCACGTGCTAGAAAGAGCCTTGGACCCTT
CCAGCTGCGTAAAGCAAACCTACCCCGGATCTCTGGCTTCAGCCGCCAGGGGGCAGTGGCAGCCCTGGGGCCCTTTCCCTTCTGGAGGAA
GCACAAGCCTCAGGGAAGGGGAAGCAGGATGCGGAGGGCCAAAGCCCGGGACCTCTACTTGAACAGTTCCACTGGGGAGGCTGGAGAACT
AAGGACCTGTACATAGTGTCCGCTGCCCTGACTCCCGCTTAGCGCACCCTTAGGCAGGCGCCCCTTCCACCTTTCCCCGAGAGCCGTCGT
CGCTGGAGGGGGCAGGGTCCAGCCCGCCTGGATCGGTGGTGTGCACCTGATGGGATTTGGGAAATGGGTTATCCCTAAAGCTTTATCTTG
CTTGGCTTAGCTGTGAGAAGTGGTTCTCTTCCTCTGGTCCCTTCTGGGGACTCTGTTTCCCCATTTCTTGCTGCTGTGTCCCTCACCGGT
TCCTTGCAGGATTCCCTCCTTTTTAAATGCCCTTGAATCTAGCTTTGCCTTGGAGACCCCAGTGGGTGCTGCTCCTGCCGTTTTCTTCCT
GCCAAGCCTGAATCAATGTTTCATCTCCAACCCTCTGCCAGTTTGGCCCCTCAGAGCTTGGTGGCTCAAGACTGTTAGCCTGGCAGAGCC
AGGGGTGAAGGGAGAAGCTCTTGGAGCAGGCAGGATGCCCACCGCTGCTTCAGCTGCCTCCTCGCCCAGCTACCCTTTGGCCCCATTGGG
CCCTCGTCTGCCTCTCCAGGATTGTATGTTTCAAGCCTTGTCCTGTGTTCCTTTGTCTGACGCTCTGTGTATTGCTCTTTGAATCGAGTT
TGGAGGAAGAGTTGAGTTGTATGAGTGGCGGCATGTTGGTAGTGCCGGACTTCCTGTTTCAAGTTTTCTGGGGCCTCGCTAATTGAATGT
GGAAAGTAGCACCACTTGACGGCTACAAGTGCCGACTCCTGAATTTTCCCATGGTGTTCTGACTTCAAGGGCTGGCAGCCAGGGAGAATG
GGCCCAGGGGAAGCAAAGACCTCTTCCCTCTGCGGTTTCTGTCCCACTTAACTGACCTCACTGGAGGCTACGTCACCCAAAGTAGATGTT
AGAAAACCTAAATTAATGAACCATATTTTTAAAATCCTATTTTTCCCAAACAGGGCCCTCTGCAGCCCATCCTTTCCTTCCGTCCTTCTG
AAACCACATACCCCAGGCCCAAGCGCCTTGCTGTCACGCCCAACCTCTTTGGGAGAAGTATGAATGCGTGTGTCTAAATTAAAAGAAAAA
AATATTTAAACGTTTTTTAACAAAAATTTATTTTTGTATTTAAGCTAAATTGCCTTTTAAATTCCTTCAAGCTTGGTTCATTGAGGTGGT
TAAGTATAAATGCTATTAACTAGGAATTAGCTGTATAGTTAAGTTATGCCTGTGCAAAGAAGAGGCTCAAATGCTGTCCCCGGCAGCTTT
CCTGGGGGACTAGAGCTCCTTCTGGCCATGTTATATGAAATGTAATTCTTATTTTATAAATAATGTGATGTAGATGTAACCGGTGCCCCC
TCCCCGTTGTGACTGAGGGCGAGTGTTATACCTGGCTGCGTGTGCAGCTGAGGAGGGAGTGAACCTCAAGCCTAAATACCTGTTAGGATT
GGAGGGTCTGGGTGGGCCTGGGCCTAGCAATCAATCAAGCTTCTACCTGTACCTTATGTAAGGTAGACCCTCCTAGTGTCAGTACCTGAG
CTTGTTTACCTCAGTTCCGCAGGCAGGACAGCCGGTCCGGGAACCCTGAGTGAGAGTGAGTGTGGATGTGTACAGTACACACACTGGACG
GCAGCGGGAGGCTGGGACTTTCCATTACAAATAGAGACTTCATTCCTGTTGAGTCTAGTTGGAATTTTTAGTATGAATGTGAGATTTTTC

>2912_2912_2_AGO2-POM121C_AGO2_chr8_141645584_ENST00000220592_POM121C_chr7_75055735_ENST00000453279_length(amino acids)=793AA_BP=
MCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQ
ALEDKSDAASNSVTETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGL
SQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFK
PIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVA
PITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPT
ATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGSSFTFGN
SAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSS
SVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTPFAFNVGSTTESKPVFG

--------------------------------------------------------------
>2912_2912_3_AGO2-POM121C_AGO2_chr8_141645584_ENST00000519980_POM121C_chr7_75055735_ENST00000257665_length(transcript)=4556nt_BP=62nt
CGGCCGCCCCTCGGCCCCGGAGCCCCTCGGCGGCGCCACCATGTACTCGGGAGCCGGCCCCGCTCTGGAAGAGAAATGGCCCCAGTTCAT
CACCCTTCTCTAGCCCAGCCTCATCCCGCTCCCAGACACCGGAGAGGCCAGCAAAGAAAATAAGAGAAGAAGAGCTGTGTCATCATTCCA
GTTCTTCAACTCCATTGGCAGCAGACAAGGAGTCCCAGGGAGAAAAGGCTGCAGATACAACCCCAAGGAAGAAACAAAACTCGAATTCTC
AGTCTACACCTGGCAGCTCTGGGCAGCGTAAGCGGAAAGTTCAGCTGCTGCCTTCTCGGCGAGGGGAACAGCTGACCTTGCCTCCACCTC
CCCAGCTTGGCTATTCGATCACTGCCGAGGACCTAGACTTAGAGAAGAAGGCTTCATTACAGTGGTTCAACCAGGCCTTGGAGGACAAGA
GTGATGCTGCCTCGAACTCTGTCACTGAGACCCCACCTACCACTCAGCCTTCATTTACCTTTACCCTGCCTGCTGCTGCAACTGCCTCCC
CACCCACCTCCCTCCTGGCCCCAAGCACCAACCCACTGTTAGAGAGCTTGAAGAAGATGCAGACTCCCCCGAGCCTGCCACCCTGCCCAG
AATCTGCTGGAGCAGCAACCACTGAGGCCCTCTCACCTCCAAAGACACCCAGCCTCCTACCCCCGCTGGGTTTATCACAGTCAGGGCCGC
CAGGGCTGCTCCCCAGCCCCTCCTTTGACTCCAAACCCCCGACCACTTTGCTGGGGCTGATCCCTGCTCCATCCATGGTACCAGCCACTG
ACACCAAGGCACCTCCAACCCTTCAAGCAGAGACGGCTACCAAACCCCAAGCCACATCTGCCCCGTCCCCCGCCCCCAAGCAAAGCTTCC
TGTTTGGAACACAGAACACCTCACCTTCCAGCCCTGCCGCCCCTGCTGCATCTTCAGCATCTCCCATGTTCAAGCCCATTTTCACGGCTC
CACCCAAGAGTGAGAAGGAAGGCCCCACACCGCCTGGCCCTTCAGTCACAGCCACAGCGCCCTCCAGCTCCTCCCTCCCCACGACCACCA
GCACCACAGCCCCGACCTTCCAGCCTGTCTTTAGCAGCATGGGGCCACCTGCATCTGTGCCCTTGCCTGCTCCCTTCTTCAAGCAGACAA
CTACTCCCGCCACTGCTCCCACCACAACTGCCCCGCTCTTCACTGGCCTGGCCAGCGCCACCTCTGCTGTGGCTCCCATCACCTCTGCCA
GTCCATCCACAGACTCTGCTTCGAAGCCTGCGTTTGGCTTTGGCATAAACAGTGTGAGCAGCAGCAGTGTGAGTACCACGACCAGCACCG
CCACTGCCGCCTCACAGCCTTTCCTCTTCGGGGCGCCCCAGGCCTCTGCTGCCAGCTTCACCCCGGCCATGGGCTCCATATTCCAGTTTG
GCAAACCTCCTGCCTTGCCCACAACCACCACAGTCACCACCTTCAGCCAGTCCCTGCCCACTGCCGTGCCAACGGCCACCAGCAGCAGCG
CTGCCGACTTTAGTGGTTTTGGCAGCACCCTCGCCACCTCCGCCCCGGCCACCAGCAGCCAGCCCACTCTGACGTTCAGTAACACGAGCA
CCCCCACGTTCAACATTCCCTTTGGCTCAAGCGCCAAGTCCCCGCTCCCATCATATCCGGGAGCCAACCCCCAGCCCGCATTTGGGGCCG
CTGAGGGGCAGCCACCGGGGGCCGCCAAGCCAGCCCTTACCCCCAGCTTTGGCAGCTCTTTCACTTTTGGAAACTCTGCAGCCCCGGCCC
CGGCTACTGCACCCACACCTGCACCTGCGTCCACGATCAAGATCGTGCCTGCGCACGTGCCTACGCCCATCCAGCCTACCTTTGGCGGTG
CCACGCACTCGGCGTTTGGATTGAAAGCCACGGCTTCCGCCTTCGGCGCTCCCGCCAGCTCACAGCCCGCCTTTGGCGGCTCCACTGCTG
TCTTCTCCTTCGGTGCAGCCACCAGCTCCGGCTTTGGAGCCACCACCCAGACCGCCAGCAGCGGGAGCAGCAGCTCGGTGTTTGGCAGCA
CAACACCATCACCCTTCACGTTTGGGGGTTCGGCAGCCCCCGCTGGCAGTGGGAGCTTTGGGATCAACGTGGCCACCCCAGGCTCCAGCG
CCACCACCGGAGCTTTCAGCTTTGGAGCAGGACAGAGTGGGAGCACAGCCACCTCCACCCCCTTCACAGGGGGCTTAGGTCAGAACGCCC
TGGGCACCACCGGCCAGAGCACACCGTTTGCCTTCAACGTGGGCAGCACAACTGAGAGCAAACCTGTGTTTGGAGGCACCGCCACCCCCA
CCTTTGGTCAGAACACCCCTGCGCCTGGAGTGGGCACATCGGGCAGCAGCCTCTCCTTTGGGGCATCTTCAGCACCCGCCCAAGGCTTTG
TTGGTGTTGGACCGTTCGGATCGGCGGCCCCTTCATTTTCCATTGGTGCGGGATCCAAGACCCCAGGGGCTCGACAGCGACTGCAGGCCC
GAAGGCAGCACACCCGCAAAAAGTAGCCTTTGTCCCCTGTCCCTGTTCCCCCCACCCCTTCCCTAAATCTGGACCTTGGCACGTGCTAGA
AAGAGCCTTGGACCCTTCCAGCTGCGTAAAGCAAACCTACCCCGGATCTCTGGCTTCAGCCGCCAGGGGGCAGTGGCAGCCCTGGGGCCC
TTTCCCTTCTGGAGGAAGCACAAGCCTCAGGGAAGGGGAAGCAGGATGCGGAGGGCCAAAGCCCGGGACCTCTACTTGAACAGTTCCACT
GGGGAGGCTGGAGAACTAAGGACCTGTACATAGTGTCCGCTGCCCTGACTCCCGCTTAGCGCACCCTTAGGCAGGCGCCCCTTCCACCTT
TCCCCGAGAGCCGTCGTCGCTGGAGGGGGCAGGGTCCAGCCCGCCTGGATCGGTGGTGTGCACCTGATGGGATTTGGGAAATGGGTTATC
CCTAAAGCTTTATCTTGCTTGGCTTAGCTGTGAGAAGTGGTTCTCTTCCTCTGGTCCCTTCTGGGGACTCTGTTTCCCCATTTCTTGCTG
CTGTGTCCCTCACCGGTTCCTTGCAGGATTCCCTCCTTTTTAAATGCCCTTGAATCTAGCTTTGCCTTGGAGACCCCAGTGGGTGCTGCT
CCTGCCGTTTTCTTCCTGCCAAGCCTGAATCAATGTTTCATCTCCAACCCTCTGCCAGTTTGGCCCCTCAGAGCTTGGTGGCTCAAGACT
GTTAGCCTGGCAGAGCCAGGGGTGAAGGGAGAAGCTCTTGGAGCAGGCAGGATGCCCACCGCTGCTTCAGCTGCCTCCTCGCCCAGCTAC
CCTTTGGCCCCATTGGGCCCTCGTCTGCCTCTCCAGGATTGTATGTTTCAAGCCTTGTCCTGTGTTCCTTTGTCTGACGCTCTGTGTATT
GCTCTTTGAATCGAGTTTGGAGGAAGAGTTGAGTTGTATGAGTGGCGGCATGTTGGTAGTGCCGGACTTCCTGTTTCAAGTTTTCTGGGG
CCTCGCTAATTGAATGTGGAAAGTAGCACCACTTGACGGCTACAAGTGCCGACTCCTGAATTTTCCCATGGTGTTCTGACTTCAAGGGCT
GGCAGCCAGGGAGAATGGGCCCAGGGGAAGCAAAGACCTCTTCCCTCTGCGGTTTCTGTCCCACTTAACTGACCTCACTGGAGGCTACGT
CACCCAAAGTAGATGTTAGAAAACCTAAATTAATGAACCATATTTTTAAAATCCTATTTTTCCCAAACAGGGCCCTCTGCAGCCCATCCT
TTCCTTCCGTCCTTCTGAAACCACATACCCCAGGCCCAAGCGCCTTGCTGTCACGCCCAACCTCTTTGGGAGAAGTATGAATGCGTGTGT
CTAAATTAAAAGAAAAAAATATTTAAACGTTTTTTAACAAAAATTTATTTTTGTATTTAAGCTAAATTGCCTTTTAAATTCCTTCAAGCT
TGGTTCATTGAGGTGGTTAAGTATAAATGCTATTAACTAGGAATTAGCTGTATAGTTAAGTTATGCCTGTGCAAAGAAGAGGCTCAAATG
CTGTCCCCGGCAGCTTTCCTGGGGGACTAGAGCTCCTTCTGGCCATGTTATATGAAATGTAATTCTTATTTTATAAATAATGTGATGTAG
ATGTAACCGGTGCCCCCTCCCCGTTGTGACTGAGGGCGAGTGTTATACCTGGCTGCGTGTGCAGCTGAGGAGGGAGTGAACCTCAAGCCT
AAATACCTGTTAGGATTGGAGGGTCTGGGTGGGCCTGGGCCTAGCAATCAATCAAGCTTCTACCTGTACCTTATGTAAGGTAGACCCTCC
TAGTGTCAGTACCTGAGCTTGTTTACCTCAGTTCCGCAGGCAGGACAGCCGGTCCGGGAACCCTGAGTGAGAGTGAGTGTGGATGTGTAC
AGTACACACACTGGACGGCAGCGGGAGGCTGGGACTTTCCATTACAAATAGAGACTTCATTCCTGTTGAGTCTAGTTGGAATTTTTAGTA

>2912_2912_3_AGO2-POM121C_AGO2_chr8_141645584_ENST00000519980_POM121C_chr7_75055735_ENST00000257665_length(amino acids)=793AA_BP=
MCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQ
ALEDKSDAASNSVTETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGL
SQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFK
PIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVA
PITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPT
ATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGSSFTFGN
SAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSS
SVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTPFAFNVGSTTESKPVFG

--------------------------------------------------------------
>2912_2912_4_AGO2-POM121C_AGO2_chr8_141645584_ENST00000519980_POM121C_chr7_75055735_ENST00000453279_length(transcript)=4556nt_BP=62nt
CGGCCGCCCCTCGGCCCCGGAGCCCCTCGGCGGCGCCACCATGTACTCGGGAGCCGGCCCCGCTCTGGAAGAGAAATGGCCCCAGTTCAT
CACCCTTCTCTAGCCCAGCCTCATCCCGCTCCCAGACACCGGAGAGGCCAGCAAAGAAAATAAGAGAAGAAGAGCTGTGTCATCATTCCA
GTTCTTCAACTCCATTGGCAGCAGACAAGGAGTCCCAGGGAGAAAAGGCTGCAGATACAACCCCAAGGAAGAAACAAAACTCGAATTCTC
AGTCTACACCTGGCAGCTCTGGGCAGCGTAAGCGGAAAGTTCAGCTGCTGCCTTCTCGGCGAGGGGAACAGCTGACCTTGCCTCCACCTC
CCCAGCTTGGCTATTCGATCACTGCCGAGGACCTAGACTTAGAGAAGAAGGCTTCATTACAGTGGTTCAACCAGGCCTTGGAGGACAAGA
GTGATGCTGCCTCGAACTCTGTCACTGAGACCCCACCTACCACTCAGCCTTCATTTACCTTTACCCTGCCTGCTGCTGCAACTGCCTCCC
CACCCACCTCCCTCCTGGCCCCAAGCACCAACCCACTGTTAGAGAGCTTGAAGAAGATGCAGACTCCCCCGAGCCTGCCACCCTGCCCAG
AATCTGCTGGAGCAGCAACCACTGAGGCCCTCTCACCTCCAAAGACACCCAGCCTCCTACCCCCGCTGGGTTTATCACAGTCAGGGCCGC
CAGGGCTGCTCCCCAGCCCCTCCTTTGACTCCAAACCCCCGACCACTTTGCTGGGGCTGATCCCTGCTCCATCCATGGTACCAGCCACTG
ACACCAAGGCACCTCCAACCCTTCAAGCAGAGACGGCTACCAAACCCCAAGCCACATCTGCCCCGTCCCCCGCCCCCAAGCAAAGCTTCC
TGTTTGGAACACAGAACACCTCACCTTCCAGCCCTGCCGCCCCTGCTGCATCTTCAGCATCTCCCATGTTCAAGCCCATTTTCACGGCTC
CACCCAAGAGTGAGAAGGAAGGCCCCACACCGCCTGGCCCTTCAGTCACAGCCACAGCGCCCTCCAGCTCCTCCCTCCCCACGACCACCA
GCACCACAGCCCCGACCTTCCAGCCTGTCTTTAGCAGCATGGGGCCACCTGCATCTGTGCCCTTGCCTGCTCCCTTCTTCAAGCAGACAA
CTACTCCCGCCACTGCTCCCACCACAACTGCCCCGCTCTTCACTGGCCTGGCCAGCGCCACCTCTGCTGTGGCTCCCATCACCTCTGCCA
GTCCATCCACAGACTCTGCTTCGAAGCCTGCGTTTGGCTTTGGCATAAACAGTGTGAGCAGCAGCAGTGTGAGTACCACGACCAGCACCG
CCACTGCCGCCTCACAGCCTTTCCTCTTCGGGGCGCCCCAGGCCTCTGCTGCCAGCTTCACCCCGGCCATGGGCTCCATATTCCAGTTTG
GCAAACCTCCTGCCTTGCCCACAACCACCACAGTCACCACCTTCAGCCAGTCCCTGCCCACTGCCGTGCCAACGGCCACCAGCAGCAGCG
CTGCCGACTTTAGTGGTTTTGGCAGCACCCTCGCCACCTCCGCCCCGGCCACCAGCAGCCAGCCCACTCTGACGTTCAGTAACACGAGCA
CCCCCACGTTCAACATTCCCTTTGGCTCAAGCGCCAAGTCCCCGCTCCCATCATATCCGGGAGCCAACCCCCAGCCCGCATTTGGGGCCG
CTGAGGGGCAGCCACCGGGGGCCGCCAAGCCAGCCCTTACCCCCAGCTTTGGCAGCTCTTTCACTTTTGGAAACTCTGCAGCCCCGGCCC
CGGCTACTGCACCCACACCTGCACCTGCGTCCACGATCAAGATCGTGCCTGCGCACGTGCCTACGCCCATCCAGCCTACCTTTGGCGGTG
CCACGCACTCGGCGTTTGGATTGAAAGCCACGGCTTCCGCCTTCGGCGCTCCCGCCAGCTCACAGCCCGCCTTTGGCGGCTCCACTGCTG
TCTTCTCCTTCGGTGCAGCCACCAGCTCCGGCTTTGGAGCCACCACCCAGACCGCCAGCAGCGGGAGCAGCAGCTCGGTGTTTGGCAGCA
CAACACCATCACCCTTCACGTTTGGGGGTTCGGCAGCCCCCGCTGGCAGTGGGAGCTTTGGGATCAACGTGGCCACCCCAGGCTCCAGCG
CCACCACCGGAGCTTTCAGCTTTGGAGCAGGACAGAGTGGGAGCACAGCCACCTCCACCCCCTTCACAGGGGGCTTAGGTCAGAACGCCC
TGGGCACCACCGGCCAGAGCACACCGTTTGCCTTCAACGTGGGCAGCACAACTGAGAGCAAACCTGTGTTTGGAGGCACCGCCACCCCCA
CCTTTGGTCAGAACACCCCTGCGCCTGGAGTGGGCACATCGGGCAGCAGCCTCTCCTTTGGGGCATCTTCAGCACCCGCCCAAGGCTTTG
TTGGTGTTGGACCGTTCGGATCGGCGGCCCCTTCATTTTCCATTGGTGCGGGATCCAAGACCCCAGGGGCTCGACAGCGACTGCAGGCCC
GAAGGCAGCACACCCGCAAAAAGTAGCCTTTGTCCCCTGTCCCTGTTCCCCCCACCCCTTCCCTAAATCTGGACCTTGGCACGTGCTAGA
AAGAGCCTTGGACCCTTCCAGCTGCGTAAAGCAAACCTACCCCGGATCTCTGGCTTCAGCCGCCAGGGGGCAGTGGCAGCCCTGGGGCCC
TTTCCCTTCTGGAGGAAGCACAAGCCTCAGGGAAGGGGAAGCAGGATGCGGAGGGCCAAAGCCCGGGACCTCTACTTGAACAGTTCCACT
GGGGAGGCTGGAGAACTAAGGACCTGTACATAGTGTCCGCTGCCCTGACTCCCGCTTAGCGCACCCTTAGGCAGGCGCCCCTTCCACCTT
TCCCCGAGAGCCGTCGTCGCTGGAGGGGGCAGGGTCCAGCCCGCCTGGATCGGTGGTGTGCACCTGATGGGATTTGGGAAATGGGTTATC
CCTAAAGCTTTATCTTGCTTGGCTTAGCTGTGAGAAGTGGTTCTCTTCCTCTGGTCCCTTCTGGGGACTCTGTTTCCCCATTTCTTGCTG
CTGTGTCCCTCACCGGTTCCTTGCAGGATTCCCTCCTTTTTAAATGCCCTTGAATCTAGCTTTGCCTTGGAGACCCCAGTGGGTGCTGCT
CCTGCCGTTTTCTTCCTGCCAAGCCTGAATCAATGTTTCATCTCCAACCCTCTGCCAGTTTGGCCCCTCAGAGCTTGGTGGCTCAAGACT
GTTAGCCTGGCAGAGCCAGGGGTGAAGGGAGAAGCTCTTGGAGCAGGCAGGATGCCCACCGCTGCTTCAGCTGCCTCCTCGCCCAGCTAC
CCTTTGGCCCCATTGGGCCCTCGTCTGCCTCTCCAGGATTGTATGTTTCAAGCCTTGTCCTGTGTTCCTTTGTCTGACGCTCTGTGTATT
GCTCTTTGAATCGAGTTTGGAGGAAGAGTTGAGTTGTATGAGTGGCGGCATGTTGGTAGTGCCGGACTTCCTGTTTCAAGTTTTCTGGGG
CCTCGCTAATTGAATGTGGAAAGTAGCACCACTTGACGGCTACAAGTGCCGACTCCTGAATTTTCCCATGGTGTTCTGACTTCAAGGGCT
GGCAGCCAGGGAGAATGGGCCCAGGGGAAGCAAAGACCTCTTCCCTCTGCGGTTTCTGTCCCACTTAACTGACCTCACTGGAGGCTACGT
CACCCAAAGTAGATGTTAGAAAACCTAAATTAATGAACCATATTTTTAAAATCCTATTTTTCCCAAACAGGGCCCTCTGCAGCCCATCCT
TTCCTTCCGTCCTTCTGAAACCACATACCCCAGGCCCAAGCGCCTTGCTGTCACGCCCAACCTCTTTGGGAGAAGTATGAATGCGTGTGT
CTAAATTAAAAGAAAAAAATATTTAAACGTTTTTTAACAAAAATTTATTTTTGTATTTAAGCTAAATTGCCTTTTAAATTCCTTCAAGCT
TGGTTCATTGAGGTGGTTAAGTATAAATGCTATTAACTAGGAATTAGCTGTATAGTTAAGTTATGCCTGTGCAAAGAAGAGGCTCAAATG
CTGTCCCCGGCAGCTTTCCTGGGGGACTAGAGCTCCTTCTGGCCATGTTATATGAAATGTAATTCTTATTTTATAAATAATGTGATGTAG
ATGTAACCGGTGCCCCCTCCCCGTTGTGACTGAGGGCGAGTGTTATACCTGGCTGCGTGTGCAGCTGAGGAGGGAGTGAACCTCAAGCCT
AAATACCTGTTAGGATTGGAGGGTCTGGGTGGGCCTGGGCCTAGCAATCAATCAAGCTTCTACCTGTACCTTATGTAAGGTAGACCCTCC
TAGTGTCAGTACCTGAGCTTGTTTACCTCAGTTCCGCAGGCAGGACAGCCGGTCCGGGAACCCTGAGTGAGAGTGAGTGTGGATGTGTAC
AGTACACACACTGGACGGCAGCGGGAGGCTGGGACTTTCCATTACAAATAGAGACTTCATTCCTGTTGAGTCTAGTTGGAATTTTTAGTA

>2912_2912_4_AGO2-POM121C_AGO2_chr8_141645584_ENST00000519980_POM121C_chr7_75055735_ENST00000453279_length(amino acids)=793AA_BP=
MCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQ
ALEDKSDAASNSVTETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGL
SQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFK
PIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVA
PITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPT
ATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGSSFTFGN
SAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSS
SVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTPFAFNVGSTTESKPVFG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AGO2-POM121C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119311_3167.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119524_5667.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119709_7107.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119753_7617.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119790_8127.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118311_3167.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118524_5667.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118709_7107.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118753_7617.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118790_8127.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119587_5907.333333333333333860.0GW182 family members
HgeneAGO2chr8:141645584chr7:75055735ENST00000220592-119650_6607.333333333333333860.0GW182 family members
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118587_5907.333333333333333826.0GW182 family members
HgeneAGO2chr8:141645584chr7:75055735ENST00000519980-118650_6607.333333333333333826.0GW182 family members


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGO2-POM121C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGO2-POM121C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource