Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FAM83G-ERCC6 (FusionGDB2 ID:29234)

Fusion Gene Summary for FAM83G-ERCC6

Fusion gene summary

Fusion gene information	Fusion gene name: FAM83G-ERCC6
	Fusion gene ID: 29234
		Hgene	Tgene
	Gene symbol	FAM83G	ERCC6
	Gene ID	644815	2074
	Gene name	family with sequence similarity 83 member G	ERCC excision repair 6, chromatin remodeling factor
	Synonyms	PAWS1	ARMD5\|CKN2\|COFS\|COFS1\|CSB\|CSB-PGBD3\|POF11\|RAD26\|UVSS1
	Cytomap	17p11.2	10q11.23
	Type of gene	protein-coding	protein-coding
	Description	protein FAM83Gprotein associated with SMAD1	DNA excision repair protein ERCC-6ERCC6-PGBD3 fusion proteinATP-dependent helicase ERCC6Chimeric CSB-PGBD3 proteinChimeric ERCC6-PGBD3 proteinCockayne syndrome group B proteincockayne syndrome protein CSBexcision repair cross-complementation group
	Modification date	20200313	20200322
	UniProtAcc	A6ND36	Q5T890
	Ensembl transtripts involved in fusion gene	ENST00000345041, ENST00000388995, ENST00000585154,	ENST00000465653, ENST00000355832, ENST00000542458,
Fusion gene scores	* DoF score	8 X 4 X 7=224	4 X 3 X 3=36
	# samples	8	4
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FAM83G [Title/Abstract] AND ERCC6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FAM83G(18891560)-ERCC6(50669602), # samples:2
Anticipated loss of major functional domain due to fusion event.	FAM83G-ERCC6 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. FAM83G-ERCC6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FAM83G	GO:0030509	BMP signaling pathway	24554596
Tgene	ERCC6	GO:0000012	single strand break repair	29545921
Tgene	ERCC6	GO:0006979	response to oxidative stress	16107709
Tgene	ERCC6	GO:0009411	response to UV	16916636
Tgene	ERCC6	GO:0032784	regulation of DNA-templated transcription, elongation	9326587
Tgene	ERCC6	GO:0032786	positive regulation of DNA-templated transcription, elongation	9326587
Tgene	ERCC6	GO:0097680	double-strand break repair via classical nonhomologous end joining	29545921

Fusion gene breakpoints across FAM83G (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERCC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BC-A217-01A	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-

Top

Fusion Gene ORF analysis for FAM83G-ERCC6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000345041	ENST00000465653	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
5CDS-5UTR	ENST00000388995	ENST00000465653	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
5CDS-5UTR	ENST00000585154	ENST00000465653	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
Frame-shift	ENST00000345041	ENST00000355832	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
Frame-shift	ENST00000345041	ENST00000542458	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
Frame-shift	ENST00000585154	ENST00000355832	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
Frame-shift	ENST00000585154	ENST00000542458	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
In-frame	ENST00000388995	ENST00000355832	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-
In-frame	ENST00000388995	ENST00000542458	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000388995	FAM83G	chr17	18891560	-	ENST00000355832	ERCC6	chr10	50669602	-	5065	914	889	1617	242
ENST00000388995	FAM83G	chr17	18891560	-	ENST00000542458	ERCC6	chr10	50669602	-	1645	914	889	1617	242

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000388995	ENST00000355832	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-	0.00069526	0.9993048
ENST00000388995	ENST00000542458	FAM83G	chr17	18891560	-	ERCC6	chr10	50669602	-	0.005200092	0.99479985

Top

Fusion Genomic Features for FAM83G-ERCC6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FAM83G-ERCC6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:18891560/chr10:50669602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM83G A6ND36	ERCC6 Q5T890
FUNCTION: May regulate the bone morphogenetic proteins (BMP) pathway. {ECO:0000269\|PubMed:24554596}.	FUNCTION: May be involved in early DNA damage response. {ECO:0000269\|PubMed:24507776}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

1400_1428

1259

1494.0

Region

Ubiquitin-binding domain (UBD)

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

1429_1493

1259

1494.0

Region

Winged-helix domain (WHD)

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FAM83G

chr17:18891560

chr10:50669602

ENST00000345041

470_511

230

824.0

Compositional bias

Note=Pro-rich

Hgene

FAM83G

chr17:18891560

chr10:50669602

ENST00000345041

583_586

230

824.0

Compositional bias

Note=Poly-Asp

Hgene

FAM83G

chr17:18891560

chr10:50669602

ENST00000388995

470_511

230

824.0

Compositional bias

Note=Pro-rich

Hgene

FAM83G

chr17:18891560

chr10:50669602

ENST00000388995

583_586

230

824.0

Compositional bias

Note=Poly-Asp

Hgene

FAM83G

chr17:18891560

chr10:50669602

ENST00000585154

470_511

230

824.0

Compositional bias

Note=Pro-rich

Hgene

FAM83G

chr17:18891560

chr10:50669602

ENST00000585154

583_586

230

824.0

Compositional bias

Note=Poly-Asp

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

356_394

1259

1494.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

442_446

1259

1494.0

Compositional bias

Note=Gly-rich

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

519_695

1259

1494.0

Domain

Helicase ATP-binding

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

843_1002

1259

1494.0

Domain

Helicase C-terminal

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

646_649

1259

1494.0

Motif

DEAH box

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

532_539

1259

1494.0

Nucleotide binding

ATP

Tgene

ERCC6

chr17:18891560

chr10:50669602

ENST00000355832

1_510

1259

1494.0

Region

N-terminal domain%3B essential for its chromatin remodeling activity

Top

Fusion Gene Sequence for FAM83G-ERCC6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>29234_29234_1_FAM83G-ERCC6_FAM83G_chr17_18891560_ENST00000388995_ERCC6_chr10_50669602_ENST00000355832_length(transcript)=5065nt_BP=914nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCC
CGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTGCCCCAGCTGGGCCGGAGCTAGGAGCTGGAC
CTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACT
GGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCT
TCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATG
GGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGC
CCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGC
GGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCG
GCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAGTTGGCGTGCACAGTGTCATGAAGCACGATGCCATCATGGATGGAGCCAGCCCAGATTATGTACTGGTGGAGGCAGA
AGCCAACCGAGTGGCCCAGGATGCCCTGAAAGCACTGAGGCTCTCTCGTCAGCGGTGTCTGGGAGCAGTGTCTGGTGTTCCCACCTGGAC
TGGCCACAGGGGGATTTCTGGTGCACCAGCAGGAAAAAAGAGTAGATTTGGTAAGAAAAGGAATTCTAACTTCTCTGTGCAGCATCCTTC
ATCAACATCTCCAACAGAGAAGTGCCAGGATGGCATCATGAAAAAGGAGGGAAAAGATAATGTCCCTGAGCATTTTAGTGGAAGAGCAGA
AGATGCAGACTCTTCATCCGGGCCCCTCGCTTCCTCCTCACTCTTGGCTAAAATGAGAGCTAGAAACCACCTGATTCTGCCAGAGCGTTT
AGAAAGTGAAAGCGGGCACCTGCAGGAAGCTTCTGCCCTGCTGCCCACCACAGAACACGATGACCTTCTGGTGGAGATGAGAAACTTCAT
CGCTTTCCAGGCCCACACTGATGGCCAGGCCAGCACCAGGGAGATACTGCAGGAGTTTGAATCCAAGTTATCTGCATCACAGTCTTGTGT
CTTCCGAGAACTATTGAGAAATCTGTGCACTTTCCATAGAACTTCTGGTGGTGAAGGAATTTGGAAACTCAAGCCAGAATACTGCTAAAC
AACATTGCTTCCTAAACTTTCAAGTCCCTTTTTCTAACGGGCATTTCTGATTATTAATTTATTATTAATAATCATGTTTGTCAATGGAAG
TTGGCTGCACTTGATGTTTGTTTGCATGATGTCTACCTCAGAATTAAAACTTTAAGGAAGAAGAAACTCTTCTCTGAAAGTTAAAAGTTT
TAATAATGCTAGCTAAAGGAGAAAATACTTGGATTGATTTTTTTTTTTTTGGCAATCTAATTATATTGTAAATCAGGTACCTAACAGTTA
CTCCTTGGAGCACATTTGTTCCTTTACCCAAAAGATGCTGTCAGGGAGCACAGTTAGAAGTTTGCAGAACAGAAATCTCAATATTTTTTT
TTATTGGTGCTAAAAACAGGTCTTACATTCAGTCAGACCTGTTCAATAAGTTCATCAATATCTGATAACAGCATTATTTTGATGCTTAAA
CTTTAAACATTTATATTTACCATTTGCCACCCACAAAGGTCAGGTTTGTTATTTGTTGTTTGATAATTATATTAATTTTCTTGGAAAGAT
CCTCTTTTCAAGGTACTGGTAAATTGGTGAGTATTTTTATTAGTAAAGCATGAAATAGTATGGTAATAAATGATAAGACATGTATTTGTG
GAAAGCTGTAGGGTATTCAGTTTACCCTGGCTTTCCTTTAAGCAGAGGGCATCTTTTTCTCTCCTACAGTCACAAAATGTGTTATCATTA
AAAAAAATCAAATTAAAGCCAAAAGTAGGTACATAAAAACCACACACATGCATGCACACAAACATCACTGCAGCCCACAGCAGACCCAGC
CGTTGTTACCATGAAGTGACACCACTCCAGGCCTCTCTTGTCTGCAGGCTGGCAGGCTGTCTTCTCTCCAGTTGCCTTCGTCTTGCGCCT
GCCTTTGCATTCCTTGCGACGGGCTTTCTTGTTTCTGCGGTTTGGATTCCAGCCAAGGCTGTTTGTATCTCACTACTGTTTATGTGTTTG
TGGTTCTGTGATGGTGTTGCTTTGATCCTCAGTTTATTTTCTTACCCATGTTTTTCTTGTTTCCTTCTCAGGATGATTTTATCATCTCAT
CTTTGAAGTGTTGTTTTCCGAAATTCATCGTATTCCTGAAATTTCTTCTTAGCTGTCTTAGTGCAGTTTGTTTCTTGGATTTGTATTCTC
TGGCATGCTCTTTTCCTCTCTCTCATTTTTCTGTAGTATGCCTGCCCTCCTACCCTGCTATTTCTTTACATCTCTCTCATGCTTAACATG
GATAGCTGTGTCCAGATCTTCTGTCTGCTCATCCATGTGACTCAGAGAGGAGGGTTCTGGGCAGGGGGGCCTTGCCGGACTGCATGAGAG
GACATGAGTTTTGCTTTCTCTGCTCTAATATTTTGCTTAAGCCAAGAATCCTTTTCTTAGAGATGTTCTATATGATTCCTGTCAGGATTT
TCTAGTTTTTTTTGGATTATAGCTTGTTCATTTCTTTTGTTTTTAGTTTGGTTTATATATAATGAGGGAAGAAGATGATTACATTATTTT
TGTCACTTTGCCATCATTGTTTAGAAGTCATAGAAAGAATTTTTAAATAGGCCAATAAGTCTTAAACTTGAGTACTTGGCTTAGAAGAAA
GTCAAAACTCCTTCCTTTTTGACTAAGTGGTTTGTTTCTGGGGAGCTCTTAATTTCTATTTTTATAATCATTAGCCTATAAGGAAATTGT
GTCTTCCTTGTTCTCAGGGTGATCTGCTGACCTTGTTCACTCATGAAGCATTTGGGTATCATACTTATAGTGTCTGAAACATAAACTGTA
TTGAGCTAGACAAGGTATAGCCTCCTCTTCAAGTAGCAAATACTATCAAAAGCTATAATGCAGTAGGAGCAAGGTGGTCCTTGTTCCAGT
TTTTGTCTCAGTTCTGCTGCTGATGTACCATGATCTTGGGAAGGTGGTGTCTCAGTGTGGAGATCTGACACATTGTTACCGTGCCTCCTG
GCTGGAGGGACTTGGAGAACAATGCAGTTAAGTAGAATGGTTTTAACAATACAGAGAAATTTATTCATTTAGATAAAAATCTGATTTTTA
GAACTTTAAAAGCTTTGTACAGTGTAAATAGATTTAATGTATTTAACATGCTTTATCAGCACAAATAAAGGATTTTAAAATTTTGTCAAA
AAATTAAATGTTAATACTATCACCATTAAAAATGTTCAAGCAATAGTCTGCCTCCCCACCCCCACACCATCTTGCACCTGTTCCACAGCT
AAGTACAGCCCTAGGTTTGGTGTGTATTCTCCATGCATTTAGAGAATCACATGACACAGACTGCTGCTATAATGTCATTTTCCCATTCTT
CCTTTACTAATAAAATTTTTGAGTTTTACCTGGACGTCTGGCTGCTCAGCTTAAGACTACTTCTCAGCCTCTCTTATAGTTAATTGTGGC
CATATGACTAAGTTTTAAACTTCCCAATTGGCCCTTTAAAGAAGCAGGGTATGCACTCTCCTTGACATTCCCCTTTCTTGCTGGCTGGGA
GGCCAATGGGAGCTTCAGTAGTGACCTGGCATCTCAAGAGATGGAAGTGATGTGTTGAGGAAGGAGAAGTTGGCCTGCCAGTCTTGAACT
GCTCTCCTTTGACCTGTTATTTAAGAGTAAAATAAAATACTGACTTGCTTAAGCTACTGTCTTTTGAAGTCTATTATAGCAATTAGTTTG
CTTTAAATATGTAATTTATATTAATGGCCTTATACCATCCTTATTTTGCAACTAACTTTTCATTTAATATTATATGCAAGACATTTCTAT
TCCTGTAAGTATAGCTCTGCCTGCACAGAATTGTTGGATTAATGATGTAGATTTTAAATGTCAGTGGATGTAGCAGAATTGCTTGCATCA
ATTCACCCTCCATAAAAGGACCCATTTCTCCAAACCCTTGCCAACAGTAAGTGGTATCAATATCGATAGGTTGTTTTGTTTTGTTTTAAC
CAGTCTCGTGATTGAAAGTACCTTGTTTTCACTTGAATTTCCCTGATTACGTACAAAATCAAACATTTCCATGTTTATTGGCCATTTGTA
GATCTCTACCGTACATTGCCTATTAGTGTTATGTTGGCCTAGTTTTCCTGTGGGTTGTTTATCTTTTAGGATTGCTCCCCTAAACAAAAA
CAAAAAGGCAGTTATTCCAATGATCAACAAATATTCTTTTCTCCACCAGTTTAAAATGTCAGCTTTCAACTCATCACATGCTAAGTTGTC
TATTTCTGTCCTGTGGATCCAGGTGTTGGTTCTACCAACCACACTCCTCACGCTGTCATTTGGTGCTTTGCATTGTGTTTTGCCATTCAT
GGGCAAGTTCCTTTTCCTTTCTCCCCCTCTTCAGTGTCTTATACTTGGGTGTTTTCTGTTCCAGCTGAATCAAGAATTAGTTTATTAAAT

>29234_29234_1_FAM83G-ERCC6_FAM83G_chr17_18891560_ENST00000388995_ERCC6_chr10_50669602_ENST00000355832_length(amino acids)=242AA_BP=8
MHAPGAPQVGVHSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKKSRFGKKRNSNFSV
QHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEM

--------------------------------------------------------------
>29234_29234_2_FAM83G-ERCC6_FAM83G_chr17_18891560_ENST00000388995_ERCC6_chr10_50669602_ENST00000542458_length(transcript)=1645nt_BP=914nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCC
CGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTGCCCCAGCTGGGCCGGAGCTAGGAGCTGGAC
CTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACT
GGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCT
TCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATG
GGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGC
CCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGC
GGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCG
GCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAGTTGGCGTGCACAGTGTCATGAAGCACGATGCCATCATGGATGGAGCCAGCCCAGATTATGTACTGGTGGAGGCAGA
AGCCAACCGAGTGGCCCAGGATGCCCTGAAAGCACTGAGGCTCTCTCGTCAGCGGTGTCTGGGAGCAGTGTCTGGTGTTCCCACCTGGAC
TGGCCACAGGGGGATTTCTGGTGCACCAGCAGGAAAAAAGAGTAGATTTGGTAAGAAAAGGAATTCTAACTTCTCTGTGCAGCATCCTTC
ATCAACATCTCCAACAGAGAAGTGCCAGGATGGCATCATGAAAAAGGAGGGAAAAGATAATGTCCCTGAGCATTTTAGTGGAAGAGCAGA
AGATGCAGACTCTTCATCCGGGCCCCTCGCTTCCTCCTCACTCTTGGCTAAAATGAGAGCTAGAAACCACCTGATTCTGCCAGAGCGTTT
AGAAAGTGAAAGCGGGCACCTGCAGGAAGCTTCTGCCCTGCTGCCCACCACAGAACACGATGACCTTCTGGTGGAGATGAGAAACTTCAT
CGCTTTCCAGGCCCACACTGATGGCCAGGCCAGCACCAGGGAGATACTGCAGGAGTTTGAATCCAAGTTATCTGCATCACAGTCTTGTGT
CTTCCGAGAACTATTGAGAAATCTGTGCACTTTCCATAGAACTTCTGGTGGTGAAGGAATTTGGAAACTCAAGCCAGAATACTGCTAAAC

>29234_29234_2_FAM83G-ERCC6_FAM83G_chr17_18891560_ENST00000388995_ERCC6_chr10_50669602_ENST00000542458_length(amino acids)=242AA_BP=8
MHAPGAPQVGVHSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKKSRFGKKRNSNFSV
QHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FAM83G-ERCC6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FAM83G-ERCC6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FAM83G-ERCC6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source