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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FANCI-ATF7 (FusionGDB2 ID:29336)

Fusion Gene Summary for FANCI-ATF7

check button Fusion gene summary
Fusion gene informationFusion gene name: FANCI-ATF7
Fusion gene ID: 29336
HgeneTgene
Gene symbol

FANCI

ATF7

Gene ID

55215

11016

Gene nameFA complementation group Iactivating transcription factor 7
SynonymsKIAA1794ATFA
Cytomap

15q26.1

12q13.13

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group I proteinFanconi anemia complementation group Icyclic AMP-dependent transcription factor ATF-7transcription factor ATF-A
Modification date2020031320200313
UniProtAcc

Q9NVI1

Q5U623

Ensembl transtripts involved in fusion geneENST00000567996, ENST00000300027, 
ENST00000310775, ENST00000451393, 
ENST00000566615, 		ENST00000328463, 
ENST00000415113, ENST00000420353, 
ENST00000456903, ENST00000546661, 
ENST00000548118, ENST00000548446, 
ENST00000591397, 
Fusion gene scores* DoF score5 X 5 X 4=10017 X 13 X 6=1326
# samples 619
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1326*10)=-2.80300945178164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FANCI [Title/Abstract] AND ATF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFANCI(89807882)-ATF7(54014358), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFANCI

GO:0031398

positive regulation of protein ubiquitination

18029348

TgeneATF7

GO:0006355

regulation of transcription, DNA-templated

8288576


check buttonFusion gene breakpoints across FANCI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG574762FANCIchr15

89807882

+ATF7chr12

54014358

+


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Fusion Gene ORF analysis for FANCI-ATF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000567996ENST00000328463FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000415113FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000420353FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000456903FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000546661FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000548118FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000548446FANCIchr15

89807882

+ATF7chr12

54014358

+
5CDS-intronENST00000567996ENST00000591397FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000328463FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000415113FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000420353FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000456903FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000546661FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000548118FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000548446FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000300027ENST00000591397FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000328463FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000415113FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000420353FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000456903FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000546661FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000548118FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000548446FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000310775ENST00000591397FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000328463FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000415113FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000420353FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000456903FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000546661FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000548118FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000548446FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000451393ENST00000591397FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000328463FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000415113FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000420353FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000456903FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000546661FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000548118FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000548446FANCIchr15

89807882

+ATF7chr12

54014358

+
intron-intronENST00000566615ENST00000591397FANCIchr15

89807882

+ATF7chr12

54014358

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FANCI-ATF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FANCI-ATF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:89807882/:54014358)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FANCI

Q9NVI1

ATF7

Q5U623

FUNCTION: Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. {ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657}.FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FANCI-ATF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FANCI-ATF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FANCI-ATF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FANCI-ATF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource