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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAT1-KIAA1430 (FusionGDB2 ID:29457)

Fusion Gene Summary for FAT1-KIAA1430

check button Fusion gene summary
Fusion gene informationFusion gene name: FAT1-KIAA1430
Fusion gene ID: 29457
HgeneTgene
Gene symbol

FAT1

KIAA1430

Gene ID

2195

57587

Gene nameFAT atypical cadherin 1cilia and flagella associated protein 97
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1KIAA1430|hmw
Cytomap

4q35.2

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologcilia- and flagella-associated protein 97
Modification date2020031320200313
UniProtAcc

Q14517

.
Ensembl transtripts involved in fusion geneENST00000441802, ENST00000512347, 
ENST00000296775, ENST00000502992, 
ENST00000514798, ENST00000458385, 
Fusion gene scores* DoF score16 X 17 X 8=21764 X 3 X 4=48
# samples 204
** MAII scorelog2(20/2176*10)=-3.44360665147561
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAT1 [Title/Abstract] AND KIAA1430 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAT1(187554838)-KIAA1430(186085333), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIAA1430 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-DQ-7588-01AFAT1chr4

187554838

-KIAA1430chr4

186085333

-
ChimerDB4HNSCTCGA-DQ-7588FAT1chr4

187554837

-KIAA1430chr4

186085333

-
ChimerDB4HNSCTCGA-DQ-7588FAT1chr4

187554838

-KIAA1430chr4

186085333

-


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Fusion Gene ORF analysis for FAT1-KIAA1430

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000441802ENST00000296775FAT1chr4

187554837

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000296775FAT1chr4

187554838

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000502992FAT1chr4

187554837

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000502992FAT1chr4

187554838

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000514798FAT1chr4

187554837

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000514798FAT1chr4

187554838

-KIAA1430chr4

186085333

-
In-frameENST00000441802ENST00000458385FAT1chr4

187554837

-KIAA1430chr4

186085333

-
In-frameENST00000441802ENST00000458385FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-3CDSENST00000512347ENST00000458385FAT1chr4

187554837

-KIAA1430chr4

186085333

-
intron-3CDSENST00000512347ENST00000458385FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000296775FAT1chr4

187554837

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000296775FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000502992FAT1chr4

187554837

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000502992FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000514798FAT1chr4

187554837

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000514798FAT1chr4

187554838

-KIAA1430chr4

186085333

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441802FAT1chr4187554837-ENST00000458385KIAA1430chr4186085333-7945453321048111533
ENST00000441802FAT1chr4187554838-ENST00000458385KIAA1430chr4186085333-7945453321048111533

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441802ENST00000458385FAT1chr4187554837-KIAA1430chr4186085333-0.0001057540.99989426
ENST00000441802ENST00000458385FAT1chr4187554838-KIAA1430chr4186085333-0.0001057540.99989426

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Fusion Genomic Features for FAT1-KIAA1430


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAT1-KIAA1430


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:187554838/chr4:186085333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

.
FUNCTION: [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271035_113914414589.0DomainCadherin 9
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271140_124514414589.0DomainCadherin 10
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271246_135714414589.0DomainCadherin 11
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727150_25714414589.0DomainCadherin 2
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-72735_14914414589.0DomainCadherin 1
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727368_46314414589.0DomainCadherin 3
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727464_56914414589.0DomainCadherin 4
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727570_67314414589.0DomainCadherin 5
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727718_82214414589.0DomainCadherin 6
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727823_92714414589.0DomainCadherin 7
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-727928_103414414589.0DomainCadherin 8
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271035_113914414589.0DomainCadherin 9
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271140_124514414589.0DomainCadherin 10
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271246_135714414589.0DomainCadherin 11
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727150_25714414589.0DomainCadherin 2
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-72735_14914414589.0DomainCadherin 1
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727368_46314414589.0DomainCadherin 3
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727464_56914414589.0DomainCadherin 4
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727570_67314414589.0DomainCadherin 5
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727718_82214414589.0DomainCadherin 6
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727823_92714414589.0DomainCadherin 7
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727928_103414414589.0DomainCadherin 8
TgeneKIAA1430chr4:187554837chr4:186085333ENST0000029677504374_4500454.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554837chr4:186085333ENST0000051479804374_4500454.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554838chr4:186085333ENST0000029677504374_4500454.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554838chr4:186085333ENST0000051479804374_4500454.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554837chr4:186085333ENST0000029677504170_2360454.0Compositional biasNote=Ser-rich
TgeneKIAA1430chr4:187554837chr4:186085333ENST0000051479804170_2360454.0Compositional biasNote=Ser-rich
TgeneKIAA1430chr4:187554838chr4:186085333ENST0000029677504170_2360454.0Compositional biasNote=Ser-rich
TgeneKIAA1430chr4:187554838chr4:186085333ENST0000051479804170_2360454.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271359_145614414589.0DomainCadherin 12
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271457_156214414589.0DomainCadherin 13
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271563_166714414589.0DomainCadherin 14
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271668_176514414589.0DomainCadherin 15
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271766_187914414589.0DomainCadherin 16
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271880_197914414589.0DomainCadherin 17
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7271980_208114414589.0DomainCadherin 18
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272082_218214414589.0DomainCadherin 19
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272183_228314414589.0DomainCadherin 20
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272284_239014414589.0DomainCadherin 21
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272391_249214414589.0DomainCadherin 22
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272493_259614414589.0DomainCadherin 23
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272597_270314414589.0DomainCadherin 24
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272704_280914414589.0DomainCadherin 25
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272810_291814414589.0DomainCadherin 26
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7272919_302314414589.0DomainCadherin 27
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273024_312514414589.0DomainCadherin 28
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273126_323014414589.0DomainCadherin 29
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273231_333514414589.0DomainCadherin 30
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273336_344014414589.0DomainCadherin 31
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273441_354514414589.0DomainCadherin 32
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273546_364714414589.0DomainCadherin 33
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273790_382714414589.0DomainEGF-like 1
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7273829_400914414589.0DomainLaminin G-like
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274013_405014414589.0DomainEGF-like 2
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274052_408814414589.0DomainEGF-like 3
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274089_412514414589.0DomainEGF-like 4
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274127_416314414589.0DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271359_145614414589.0DomainCadherin 12
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271457_156214414589.0DomainCadherin 13
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271563_166714414589.0DomainCadherin 14
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271668_176514414589.0DomainCadherin 15
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271766_187914414589.0DomainCadherin 16
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271880_197914414589.0DomainCadherin 17
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271980_208114414589.0DomainCadherin 18
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272082_218214414589.0DomainCadherin 19
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272183_228314414589.0DomainCadherin 20
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272284_239014414589.0DomainCadherin 21
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272391_249214414589.0DomainCadherin 22
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272493_259614414589.0DomainCadherin 23
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272597_270314414589.0DomainCadherin 24
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272704_280914414589.0DomainCadherin 25
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272810_291814414589.0DomainCadherin 26
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272919_302314414589.0DomainCadherin 27
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273024_312514414589.0DomainCadherin 28
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273126_323014414589.0DomainCadherin 29
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273231_333514414589.0DomainCadherin 30
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273336_344014414589.0DomainCadherin 31
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273441_354514414589.0DomainCadherin 32
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273546_364714414589.0DomainCadherin 33
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273790_382714414589.0DomainEGF-like 1
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273829_400914414589.0DomainLaminin G-like
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274013_405014414589.0DomainEGF-like 2
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274052_408814414589.0DomainEGF-like 3
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274089_412514414589.0DomainEGF-like 4
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274127_416314414589.0DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274204_421414414589.0MotifNuclear localization signal
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274378_438214414589.0MotifPTB-like motif
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274204_421414414589.0MotifNuclear localization signal
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274378_438214414589.0MotifPTB-like motif
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-72722_418114414589.0Topological domainExtracellular
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274203_458814414589.0Topological domainCytoplasmic
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-72722_418114414589.0Topological domainExtracellular
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274203_458814414589.0Topological domainCytoplasmic
HgeneFAT1chr4:187554837chr4:186085333ENST00000441802-7274182_420214414589.0TransmembraneHelical
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274182_420214414589.0TransmembraneHelical
TgeneKIAA1430chr4:187554837chr4:186085333ENST0000045838525374_450440533.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554838chr4:186085333ENST0000045838525374_450440533.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554837chr4:186085333ENST0000045838525170_236440533.0Compositional biasNote=Ser-rich
TgeneKIAA1430chr4:187554838chr4:186085333ENST0000045838525170_236440533.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for FAT1-KIAA1430


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29457_29457_1_FAT1-KIAA1430_FAT1_chr4_187554837_ENST00000441802_KIAA1430_chr4_186085333_ENST00000458385_length(transcript)=7945nt_BP=4533nt
AGCGTGAGGCGCCGGCGCCGAGCTGGGCGGCCGGGCGCGGGGAGAGGGCGCGGGAGCGGCTCGTGCGGCAGGTACCATGCGGACGCGCGA
GCCCGGCGAGGGCCCCGGCAGGCCCGGTCCCTGCTCGGGGGCGCGCTGAGACGGCGGGTGAGCTCCACGAGAGCGCCGTCGCCACTTCGG
GCCAACTTTGCGATTCCCGACAGTTAAGCAATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGAC
AGTGATGGCAGCCAACGACTTGAACAGACTCCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAG
ACTTATGTGGGGCATCCTGTCAAGATGGGTGTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAA
AACCTGTTCAAAGCTGAAGAGTACATTCTCGGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGA
GAAGTGAAGGATCACTACACATTGATAGTGAAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTG
GATACAAATGACTTGAGACCGTTATTCTCACCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGA
GTCAGCGCCACGGATGCAGACATAGGAACCAACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACC
AGTGGTGTGATAGTGTTAACTGGTAGACTTGATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAG
TTGTATGGGAGCAGTGGCATCAGCAGCATGGCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTG
ACATTGTCACCATCAGAACTGGACAGGGACCCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCA
TCTTTAAGCATCGTGGCAGGTGACCTTCTCCAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATC
GGTGGCATTGATTGGGACAGTCATCCTTTCGGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTT
AAAGTCATTCACGTGACTTCTCCACAGTTCAAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCT
CCTCCCAACACACCTGTGGTCATGGTAAAGGCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAA
TTCAGTTTAAATTACAACACTGGTCTCATTTCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACA
AGTGACAGAAAAGCGTCCACCAAGGTCTTGGTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCT
GCTTTTGATGAGAACGTGCCCATTGGTACTACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATAC
AGTATCGCAAATTTAAATCATGTGCCGTTTGCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATG
CCTCGGGTTTATACTCTGAGGATTCGTGCATCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAAT
AACTTGAATGACAACACACCTTTGTTTGAGAAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACT
GTTTCTGCTATTGATGCAGATGAACTTCAGTTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAAC
TCGGGGGTATTGTCATTAAAGCGATCGCTAATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGA
GAAAATTTTGCCACACCATTATATATCAACATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCC
AAAATGCTGGCAGAGAAGCTCCTGCAGGCAAATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAAT
GCTCACATACCGCAGTTTAGAAGCACTCTTCCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAAC
TCCACTGACCTTGACACTGGCTTCAATGGAAAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAA
ACAGGAATGCTGAAAATTTTATCTCCTCTTGACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCC
CAGAAGGCTGCGTGGCGTCTTCTACATGTCGTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAA
GTGAGTGAAGACAAGGAGGTACATAGTGAAATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCA
ATTGTTACAGACACAGACACATTTTCAATTGACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAG
CACTCCTTAAAGATTGAGGCCAGGGACCAAGCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTT
AATGACAACCCACCTACATTTATTCCACCTAATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAA
GCCCACGATCCTGATTTAGGTCAGTCTGGTCAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGT
GGAGCAGTTAGGATCGTCCAGCAGTTGGACTTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTT
TCTCTGTCTTCTACTTGCTATGTTGAAGTTGAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAG
GGGACAGTGAAAGAAGATGCACCTGTTGGTTCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGA
TACTCCATTAGAGATGGCTCTGGCGTTGGTGTTTTCAAAATAGGTGAAGAGACAGGTGTCATAGAGACGTCAGATCGACTGGACCGTGAA
TCGACCTCCCATTATTGGCTAACAGTCTTTGCAACCGATCAGGGTGTCGTGCCTCTTTCATCGTTCATAGAGATCTACATAGAGGTTGAG
GATGTCAATGACAATGCACCACAGACATCAGAGCCTGTTTATTACCCAGAAATCATGGAAAATTCTCCTAAAGATGTATCTGTGGTCCAG
ATCGAGGCATTTGATCCAGATTCGAGCTCTAATGACAAGCTCATGTACAAAATTACAAGTGGAAATCCACAAGGATTCTTTTCAATACAT
CCTAAAACAGGTCTCATCACAACTACGTCAAGGAAGCTAGACCGAGAACAGCAAGATGAACACATATTAGAGGTTACTGTGACAGACAAT
GGTAGTCCCCCCAAATCAACCATTGCAAGAGTCATTGTGAAAATCCTTGATGAAAATGACAACAAACCTCAGTTTCTGCAAAAGTTCTAC
AAAATCAGACTCCCTGAGCGGGAAAAGCCAGACCGAGAAAGAAATGCCAGACGGGAGCCGCTCTATCACGTCATAGCCACCGACAAGGAT
GAGGGCCCCAATGCAGAAATCTCCTACAGCATCGAAGACGGGAATGAGCATGGCAAATTTTTCATCGAACCGAAAACTGGAGTGGTTTCG
TCCAAGAGGTTTTCAGCAGCTGGAGAATATGATATTCTTTCAATTAAGGCAGTTGACAATGGTCGCCCTCAAAAGTCATCAACCACCAGA
CTCCATATTGAATGGATCTCCAAGCCCAAACCGTCCCTGGAGCCCATTTCATTTGAAGAATCATTTTTTACCTTTACTGTGATGGAAAGT
GACCCCGTTGCTCACATGATTGGAGTAATATCTGTGGAGCCTCCTGGCATACCCCTTTGGTTTGACATCACTGGTGGCAACTACGACAGT
CACTTCGATGTGGACAAGGGAACTGGAACCATCATTGTTGCCAAACCTCTTGATGCAGAACAGAAGTCAAACTACAACCTCACAGTCGAG
GCTACAGATGGAACCACCACTATCCTCACTCAGGCTTTATTGAAAAGGCTTGAGGCCGTGAAACCAACAGTTGGTATGAAACGTTCAGAA
CAACTGATGGACTATCATCGCAATATGGGCTATCTCAACTCATCACCATTGTCAAGACGGGCCAGATCCACTCTTGGCCAATATAGCCCA
TTAAGAGCTTCCAGGACATCCAGTGCTACGAGTGGTCTCAGTTGTAGGAGTGAGCGATCAGCGGTTGACCCCTCCAGTGGCCACCCTCGA
AGAAGACCTAAACCCCCTAATGTCCGTACAGCTTGGTTATAAAACACTTTTTTACTTTAAACATTGTTCACACAACTTTTCTTGAAGTGC
TCGTGCATATTCCTATAATTCTCTGTGTAAACATCTAGAATACCGTTTTAGCAATTGAAGGTGTACAACAGTGAGTTGTAATGTATTGTT
ATTCAGTGCAAAATTATTGTCAAAAAACGATTTAATGTAAAAAGTGTTTCCTGAGGATGTATTTATATGAGATGTATGTGTTCTTAATAG
AGAAATAGTGGTATGCATGTGTATCTTCTAATTATTCAGTTGTCATGCTGTCAAAATAGTAGTGATAGTATCATTGCATGTCGTACCCAA
GATGGTCACTATAGTTTTCAATTTGTGTTATTTTCATTTCTTTATAAGTGTTATACCATGAGCTCAGCTCCTAAATTTGGCTGGCTTTGT
TTTTCATTTGCTTTAGAACTTATGTGGCATGACATAGCTCGATTGTATGAGATTTAACACTTATTATGAAACAAATCTTGAAATTTGTTT
TCACTGGTAGAGCTGATCTAGATTTGATGAGCAGATTGAGAGACGCTTCTATTGGAGCAATTCTTGTAATTCACCAGAGGTATCTAGTTG
TTGTATAAGTGCACTGAGTTAGATCTTAAAAGTTTGATCAATCATTCCAAACCATTTCAAATATGAATATTAGAAAGTTCAACTTAGAAG
CTTCCCTTTTGTGTTTTCATGCATTCAGGTAAAGTCCTATTTATGACTCTTAGAAATGAGGTAGGTTTTAGAGCTAGTCTTCTAACTCGT
GAATAGTTTAAGGACCACATCAGTTGCAAACCAAGTATTTGTTGAATCAGTAAAATGGCACTATCAGCATGAAGAGCCGAGAAGCAGATC
CTGAGGTGTGTCGGACAGTGTTTTAGGTAATTCAGTATTTATTATGTTATTAGAGAAGACTTAGCGTAAGAAAGAAATGCTTTAGAAATT
CCAGCAAGTATTTATAAGGCCTGAAAAAACTAAAATTTGAACAAAAAGGGAAATAAATCACACATTTGTTGAGGCTGCTGCTTTAAGTAT
TAGCTAATTTTCTTGTTTTGGTTTACTTTGATTTATTTGATTGAACCCTGGAAGTATTATTTTTACCAGTCCCACATTTAAAGACCTAGT
AATCTTGATGGAATTGGTAATGGCAGATAGGGTTTAATGTTGTTGACTTTTCAAATTAGAATTTTTTTTCTATGAAACTTAGGCTTTTAT
ATAACAAAGTATGTTATCTCATTGTTACCGCCGTTTTTCACTACTAGCCTTTTCAGTATGCCCTTAAAATGTATTGGAAAGGTTCCATGT
TAAATGACAAATATCTTTTTCAGTATGAATTTTTGATCTGTAGCCACAATAAGATTTTCATTTTTCAGTGCTCAGGCTCTGTAGCATGTA
TGCTGAATGCTTTTTTCCTTAGCACCTTTAACAGTAAGGTGTTACTGCATTTTACAAAACATCAATTCAACATGTCTTGGATTTAGTTTG
TATTCATAGATTTTGTTAAGGATCAGGCCTGTGAACATGGGCACAGTGAGGTTAAATAATTCACCTGGCCACAACCTGGCTTTGAGGTTC
TGCTTTTGGGGGCCATAATTTTCATTCAATGTTATTCGATGCTCTGTTCTGGTGAACAAGTTACTATACCTGCTGTGTATATAAGCTTGA
GCTATACTAAACCAAGGCTTTATTTTCTTTTGTTTTTTAACTTACTGTACTTTTACTGTTTATATAACCTATATTTCAAGAGAGAGAAGA
TAATGCTGAATTTTAAATTTAGCATTTGAACATCTGTCCAATAGTGAATTAATCAGTTTTTTTAAAATTGATTTTTAAGTTGTTCCAGAA
AAAAATATATATATATGTTTTATATATATAATCTTTTTATATATATAAAAAATCTTTTTTATAAATTTTATTTTAAAAATCTTTTAAAAA
AGATTTTTATATATATATAAAGATTATATATTTATATATAGTCTTTTCTGTTCATAATGGCATTAGTCTCTGAGTACATTTTATATTATC
TTTGTTGCCACATGTCAGGATACAACACAATAGTTTTATAAATAACAACTGTACTTTGATTTTAGGTACTAATTTAATGCTTTAGTTTTT
ACTACTTTGAAAGGGGAGGTTCATCTAAGTATTACTGATAACAGGGATCCAACTTAAAGTAAAAGTTGGAAAGGGCAAGAGTCTTTTAAG
CGGAACTTCAATTCTGTTGTCATGGTTACTTATATATAATGAATATAAATAGACAAATAGGACTTGGAAAATGTGGTATATTCTAAGTCA
AGATGCTATGAAGTTGTTATAGTTTAAGGGACATTCTTAAGAAGGAATTACTTAAGTACATTACTCTTCTCATTTCAAGGACATGAAAAA
GTAAAGGATGGTCTGGCACTATTTTATTTTATTTTTTTTTTGACTTGTACTGAATATATGTACTTTGAAGATTTACATCTATAACTAGAA
AGTATGCTAATCCGAGGTCTGGTTATTAGGCCAGATTCTTGTTCAGTTATTTTTTAAACTAATGTTGCCTCCTTTTTAGTAAGATTCTAC
GAAAGTTTTTTAACTATTAAAGTTATTTCTTAAGGGGTAGCTCTTATACTTCCTCTGCTCTCTTTTTCAGTTTCCATAAAAAGCTGTTTT
CTTAGCTATTACTCCAAATAAAGTTCTTTGGTTTGCTTAAAAATGTAGTGTAATGCAGTTGTTTTCTCTCCGCTAACCTGAGTGTCCACA
GTAGATATCGAGACAGCTTTAGGAAGGTGACGGTCATGGGTAAGTGACGGCTGTGCCTGTCATCTTCAGATTCTTCAAATACTGCAAACT
ATGAAACATGTTAAGACCAATATAAACCCAAAGATGTGAGTTGATTATACTTTAATAATTACATTCATAAAAAGTTTACTATCTTCAATG
CCAAAAAAGTCTTAACCTATAAATGATTATATACAATCTTAGAAAATGTGCTTAACAGTTATGGCTTCTTTATTTCTATGAGGAAAGATT
AGTAAGAAACTTAAAATTAACATCCTTTTAAGATTTTCTGTTCCATTTTAATGTATTTTAGGCATTTAGAACTAGCCTGGCATAATGAAG

>29457_29457_1_FAT1-KIAA1430_FAT1_chr4_187554837_ENST00000441802_KIAA1430_chr4_186085333_ENST00000458385_length(amino acids)=1533AA_BP=1441
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP
DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPK
PSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT
QALLKRLEAVKPTVGMKRSEQLMDYHRNMGYLNSSPLSRRARSTLGQYSPLRASRTSSATSGLSCRSERSAVDPSSGHPRRRPKPPNVRT

--------------------------------------------------------------
>29457_29457_2_FAT1-KIAA1430_FAT1_chr4_187554838_ENST00000441802_KIAA1430_chr4_186085333_ENST00000458385_length(transcript)=7945nt_BP=4533nt
AGCGTGAGGCGCCGGCGCCGAGCTGGGCGGCCGGGCGCGGGGAGAGGGCGCGGGAGCGGCTCGTGCGGCAGGTACCATGCGGACGCGCGA
GCCCGGCGAGGGCCCCGGCAGGCCCGGTCCCTGCTCGGGGGCGCGCTGAGACGGCGGGTGAGCTCCACGAGAGCGCCGTCGCCACTTCGG
GCCAACTTTGCGATTCCCGACAGTTAAGCAATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGAC
AGTGATGGCAGCCAACGACTTGAACAGACTCCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAG
ACTTATGTGGGGCATCCTGTCAAGATGGGTGTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAA
AACCTGTTCAAAGCTGAAGAGTACATTCTCGGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGA
GAAGTGAAGGATCACTACACATTGATAGTGAAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTG
GATACAAATGACTTGAGACCGTTATTCTCACCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGA
GTCAGCGCCACGGATGCAGACATAGGAACCAACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACC
AGTGGTGTGATAGTGTTAACTGGTAGACTTGATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAG
TTGTATGGGAGCAGTGGCATCAGCAGCATGGCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTG
ACATTGTCACCATCAGAACTGGACAGGGACCCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCA
TCTTTAAGCATCGTGGCAGGTGACCTTCTCCAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATC
GGTGGCATTGATTGGGACAGTCATCCTTTCGGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTT
AAAGTCATTCACGTGACTTCTCCACAGTTCAAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCT
CCTCCCAACACACCTGTGGTCATGGTAAAGGCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAA
TTCAGTTTAAATTACAACACTGGTCTCATTTCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACA
AGTGACAGAAAAGCGTCCACCAAGGTCTTGGTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCT
GCTTTTGATGAGAACGTGCCCATTGGTACTACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATAC
AGTATCGCAAATTTAAATCATGTGCCGTTTGCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATG
CCTCGGGTTTATACTCTGAGGATTCGTGCATCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAAT
AACTTGAATGACAACACACCTTTGTTTGAGAAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACT
GTTTCTGCTATTGATGCAGATGAACTTCAGTTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAAC
TCGGGGGTATTGTCATTAAAGCGATCGCTAATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGA
GAAAATTTTGCCACACCATTATATATCAACATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCC
AAAATGCTGGCAGAGAAGCTCCTGCAGGCAAATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAAT
GCTCACATACCGCAGTTTAGAAGCACTCTTCCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAAC
TCCACTGACCTTGACACTGGCTTCAATGGAAAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAA
ACAGGAATGCTGAAAATTTTATCTCCTCTTGACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCC
CAGAAGGCTGCGTGGCGTCTTCTACATGTCGTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAA
GTGAGTGAAGACAAGGAGGTACATAGTGAAATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCA
ATTGTTACAGACACAGACACATTTTCAATTGACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAG
CACTCCTTAAAGATTGAGGCCAGGGACCAAGCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTT
AATGACAACCCACCTACATTTATTCCACCTAATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAA
GCCCACGATCCTGATTTAGGTCAGTCTGGTCAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGT
GGAGCAGTTAGGATCGTCCAGCAGTTGGACTTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTT
TCTCTGTCTTCTACTTGCTATGTTGAAGTTGAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAG
GGGACAGTGAAAGAAGATGCACCTGTTGGTTCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGA
TACTCCATTAGAGATGGCTCTGGCGTTGGTGTTTTCAAAATAGGTGAAGAGACAGGTGTCATAGAGACGTCAGATCGACTGGACCGTGAA
TCGACCTCCCATTATTGGCTAACAGTCTTTGCAACCGATCAGGGTGTCGTGCCTCTTTCATCGTTCATAGAGATCTACATAGAGGTTGAG
GATGTCAATGACAATGCACCACAGACATCAGAGCCTGTTTATTACCCAGAAATCATGGAAAATTCTCCTAAAGATGTATCTGTGGTCCAG
ATCGAGGCATTTGATCCAGATTCGAGCTCTAATGACAAGCTCATGTACAAAATTACAAGTGGAAATCCACAAGGATTCTTTTCAATACAT
CCTAAAACAGGTCTCATCACAACTACGTCAAGGAAGCTAGACCGAGAACAGCAAGATGAACACATATTAGAGGTTACTGTGACAGACAAT
GGTAGTCCCCCCAAATCAACCATTGCAAGAGTCATTGTGAAAATCCTTGATGAAAATGACAACAAACCTCAGTTTCTGCAAAAGTTCTAC
AAAATCAGACTCCCTGAGCGGGAAAAGCCAGACCGAGAAAGAAATGCCAGACGGGAGCCGCTCTATCACGTCATAGCCACCGACAAGGAT
GAGGGCCCCAATGCAGAAATCTCCTACAGCATCGAAGACGGGAATGAGCATGGCAAATTTTTCATCGAACCGAAAACTGGAGTGGTTTCG
TCCAAGAGGTTTTCAGCAGCTGGAGAATATGATATTCTTTCAATTAAGGCAGTTGACAATGGTCGCCCTCAAAAGTCATCAACCACCAGA
CTCCATATTGAATGGATCTCCAAGCCCAAACCGTCCCTGGAGCCCATTTCATTTGAAGAATCATTTTTTACCTTTACTGTGATGGAAAGT
GACCCCGTTGCTCACATGATTGGAGTAATATCTGTGGAGCCTCCTGGCATACCCCTTTGGTTTGACATCACTGGTGGCAACTACGACAGT
CACTTCGATGTGGACAAGGGAACTGGAACCATCATTGTTGCCAAACCTCTTGATGCAGAACAGAAGTCAAACTACAACCTCACAGTCGAG
GCTACAGATGGAACCACCACTATCCTCACTCAGGCTTTATTGAAAAGGCTTGAGGCCGTGAAACCAACAGTTGGTATGAAACGTTCAGAA
CAACTGATGGACTATCATCGCAATATGGGCTATCTCAACTCATCACCATTGTCAAGACGGGCCAGATCCACTCTTGGCCAATATAGCCCA
TTAAGAGCTTCCAGGACATCCAGTGCTACGAGTGGTCTCAGTTGTAGGAGTGAGCGATCAGCGGTTGACCCCTCCAGTGGCCACCCTCGA
AGAAGACCTAAACCCCCTAATGTCCGTACAGCTTGGTTATAAAACACTTTTTTACTTTAAACATTGTTCACACAACTTTTCTTGAAGTGC
TCGTGCATATTCCTATAATTCTCTGTGTAAACATCTAGAATACCGTTTTAGCAATTGAAGGTGTACAACAGTGAGTTGTAATGTATTGTT
ATTCAGTGCAAAATTATTGTCAAAAAACGATTTAATGTAAAAAGTGTTTCCTGAGGATGTATTTATATGAGATGTATGTGTTCTTAATAG
AGAAATAGTGGTATGCATGTGTATCTTCTAATTATTCAGTTGTCATGCTGTCAAAATAGTAGTGATAGTATCATTGCATGTCGTACCCAA
GATGGTCACTATAGTTTTCAATTTGTGTTATTTTCATTTCTTTATAAGTGTTATACCATGAGCTCAGCTCCTAAATTTGGCTGGCTTTGT
TTTTCATTTGCTTTAGAACTTATGTGGCATGACATAGCTCGATTGTATGAGATTTAACACTTATTATGAAACAAATCTTGAAATTTGTTT
TCACTGGTAGAGCTGATCTAGATTTGATGAGCAGATTGAGAGACGCTTCTATTGGAGCAATTCTTGTAATTCACCAGAGGTATCTAGTTG
TTGTATAAGTGCACTGAGTTAGATCTTAAAAGTTTGATCAATCATTCCAAACCATTTCAAATATGAATATTAGAAAGTTCAACTTAGAAG
CTTCCCTTTTGTGTTTTCATGCATTCAGGTAAAGTCCTATTTATGACTCTTAGAAATGAGGTAGGTTTTAGAGCTAGTCTTCTAACTCGT
GAATAGTTTAAGGACCACATCAGTTGCAAACCAAGTATTTGTTGAATCAGTAAAATGGCACTATCAGCATGAAGAGCCGAGAAGCAGATC
CTGAGGTGTGTCGGACAGTGTTTTAGGTAATTCAGTATTTATTATGTTATTAGAGAAGACTTAGCGTAAGAAAGAAATGCTTTAGAAATT
CCAGCAAGTATTTATAAGGCCTGAAAAAACTAAAATTTGAACAAAAAGGGAAATAAATCACACATTTGTTGAGGCTGCTGCTTTAAGTAT
TAGCTAATTTTCTTGTTTTGGTTTACTTTGATTTATTTGATTGAACCCTGGAAGTATTATTTTTACCAGTCCCACATTTAAAGACCTAGT
AATCTTGATGGAATTGGTAATGGCAGATAGGGTTTAATGTTGTTGACTTTTCAAATTAGAATTTTTTTTCTATGAAACTTAGGCTTTTAT
ATAACAAAGTATGTTATCTCATTGTTACCGCCGTTTTTCACTACTAGCCTTTTCAGTATGCCCTTAAAATGTATTGGAAAGGTTCCATGT
TAAATGACAAATATCTTTTTCAGTATGAATTTTTGATCTGTAGCCACAATAAGATTTTCATTTTTCAGTGCTCAGGCTCTGTAGCATGTA
TGCTGAATGCTTTTTTCCTTAGCACCTTTAACAGTAAGGTGTTACTGCATTTTACAAAACATCAATTCAACATGTCTTGGATTTAGTTTG
TATTCATAGATTTTGTTAAGGATCAGGCCTGTGAACATGGGCACAGTGAGGTTAAATAATTCACCTGGCCACAACCTGGCTTTGAGGTTC
TGCTTTTGGGGGCCATAATTTTCATTCAATGTTATTCGATGCTCTGTTCTGGTGAACAAGTTACTATACCTGCTGTGTATATAAGCTTGA
GCTATACTAAACCAAGGCTTTATTTTCTTTTGTTTTTTAACTTACTGTACTTTTACTGTTTATATAACCTATATTTCAAGAGAGAGAAGA
TAATGCTGAATTTTAAATTTAGCATTTGAACATCTGTCCAATAGTGAATTAATCAGTTTTTTTAAAATTGATTTTTAAGTTGTTCCAGAA
AAAAATATATATATATGTTTTATATATATAATCTTTTTATATATATAAAAAATCTTTTTTATAAATTTTATTTTAAAAATCTTTTAAAAA
AGATTTTTATATATATATAAAGATTATATATTTATATATAGTCTTTTCTGTTCATAATGGCATTAGTCTCTGAGTACATTTTATATTATC
TTTGTTGCCACATGTCAGGATACAACACAATAGTTTTATAAATAACAACTGTACTTTGATTTTAGGTACTAATTTAATGCTTTAGTTTTT
ACTACTTTGAAAGGGGAGGTTCATCTAAGTATTACTGATAACAGGGATCCAACTTAAAGTAAAAGTTGGAAAGGGCAAGAGTCTTTTAAG
CGGAACTTCAATTCTGTTGTCATGGTTACTTATATATAATGAATATAAATAGACAAATAGGACTTGGAAAATGTGGTATATTCTAAGTCA
AGATGCTATGAAGTTGTTATAGTTTAAGGGACATTCTTAAGAAGGAATTACTTAAGTACATTACTCTTCTCATTTCAAGGACATGAAAAA
GTAAAGGATGGTCTGGCACTATTTTATTTTATTTTTTTTTTGACTTGTACTGAATATATGTACTTTGAAGATTTACATCTATAACTAGAA
AGTATGCTAATCCGAGGTCTGGTTATTAGGCCAGATTCTTGTTCAGTTATTTTTTAAACTAATGTTGCCTCCTTTTTAGTAAGATTCTAC
GAAAGTTTTTTAACTATTAAAGTTATTTCTTAAGGGGTAGCTCTTATACTTCCTCTGCTCTCTTTTTCAGTTTCCATAAAAAGCTGTTTT
CTTAGCTATTACTCCAAATAAAGTTCTTTGGTTTGCTTAAAAATGTAGTGTAATGCAGTTGTTTTCTCTCCGCTAACCTGAGTGTCCACA
GTAGATATCGAGACAGCTTTAGGAAGGTGACGGTCATGGGTAAGTGACGGCTGTGCCTGTCATCTTCAGATTCTTCAAATACTGCAAACT
ATGAAACATGTTAAGACCAATATAAACCCAAAGATGTGAGTTGATTATACTTTAATAATTACATTCATAAAAAGTTTACTATCTTCAATG
CCAAAAAAGTCTTAACCTATAAATGATTATATACAATCTTAGAAAATGTGCTTAACAGTTATGGCTTCTTTATTTCTATGAGGAAAGATT
AGTAAGAAACTTAAAATTAACATCCTTTTAAGATTTTCTGTTCCATTTTAATGTATTTTAGGCATTTAGAACTAGCCTGGCATAATGAAG

>29457_29457_2_FAT1-KIAA1430_FAT1_chr4_187554838_ENST00000441802_KIAA1430_chr4_186085333_ENST00000458385_length(amino acids)=1533AA_BP=1441
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP
DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPK
PSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT
QALLKRLEAVKPTVGMKRSEQLMDYHRNMGYLNSSPLSRRARSTLGQYSPLRASRTSSATSGLSCRSERSAVDPSSGHPRRRPKPPNVRT

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Fusion Gene PPI Analysis for FAT1-KIAA1430


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAT1-KIAA1430


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAT1-KIAA1430


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource