|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FBLN1-MAP3K4 (FusionGDB2 ID:29533) |
Fusion Gene Summary for FBLN1-MAP3K4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBLN1-MAP3K4 | Fusion gene ID: 29533 | Hgene | Tgene | Gene symbol | FBLN1 | MAP3K4 | Gene ID | 2192 | 4216 |
| Gene name | fibulin 1 | mitogen-activated protein kinase kinase kinase 4 | |
| Synonyms | FBLN|FIBL1 | MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412 | |
| Cytomap | 22q13.31 | 6q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibulin-1 | mitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predicte | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P23142 | Q9Y6R4 | |
| Ensembl transtripts involved in fusion gene | ENST00000262722, ENST00000327858, ENST00000340923, ENST00000348697, ENST00000402984, ENST00000442170, ENST00000476366, | ENST00000348824, ENST00000366919, ENST00000366920, ENST00000392142, ENST00000446500, | |
| Fusion gene scores | * DoF score | 15 X 14 X 8=1680 | 5 X 5 X 2=50 |
| # samples | 17 | 5 | |
| ** MAII score | log2(17/1680*10)=-3.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: FBLN1 [Title/Abstract] AND MAP3K4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FBLN1(45948280)-MAP3K4(161498792), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBLN1 | GO:0001933 | negative regulation of protein phosphorylation | 11792823 |
| Hgene | FBLN1 | GO:0007162 | negative regulation of cell adhesion | 11792823 |
| Hgene | FBLN1 | GO:0007229 | integrin-mediated signaling pathway | 11792823 |
| Hgene | FBLN1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11792823 |
| Hgene | FBLN1 | GO:0072378 | blood coagulation, fibrin clot formation | 7642629 |
| Hgene | FBLN1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 11792823 |
| Hgene | FBLN1 | GO:2000146 | negative regulation of cell motility | 11792823 |
| Hgene | FBLN1 | GO:2000647 | negative regulation of stem cell proliferation | 11238726 |
| Tgene | MAP3K4 | GO:0000186 | activation of MAPKK activity | 9305639|9827804 |
| Tgene | MAP3K4 | GO:0043507 | positive regulation of JUN kinase activity | 9305639 |
| Tgene | MAP3K4 | GO:1900745 | positive regulation of p38MAPK cascade | 9305639 |
| Fusion gene breakpoints across FBLN1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MAP3K4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | CV372922 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
Top |
Fusion Gene ORF analysis for FBLN1-MAP3K4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000262722 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000262722 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000262722 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000262722 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000262722 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000327858 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000327858 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000327858 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000327858 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000327858 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000340923 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000340923 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000340923 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000340923 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000340923 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000348697 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000348697 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000348697 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000348697 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000348697 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000402984 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000402984 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000402984 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000402984 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000402984 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000442170 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000442170 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000442170 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000442170 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000442170 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000476366 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000476366 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000476366 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000476366 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| intron-intron | ENST00000476366 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for FBLN1-MAP3K4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for FBLN1-MAP3K4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45948280/:161498792) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBLN1 | MAP3K4 |
| FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. | FUNCTION: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for FBLN1-MAP3K4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for FBLN1-MAP3K4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FBLN1-MAP3K4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FBLN1-MAP3K4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies