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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FBL-ZNF829 (FusionGDB2 ID:29552)

Fusion Gene Summary for FBL-ZNF829

Fusion gene summary

Fusion gene information	Fusion gene name: FBL-ZNF829
	Fusion gene ID: 29552
		Hgene	Tgene
	Gene symbol	FBL	ZNF829
	Gene ID	2091	374899
	Gene name	fibrillarin	zinc finger protein 829
	Synonyms	FIB\|FLRN\|Nop1\|RNU3IP1	-
	Cytomap	19q13.2	19q13.12
	Type of gene	protein-coding	protein-coding
	Description	rRNA 2'-O-methyltransferase fibrillarin34 kDa nucleolar scleroderma antigen34-kD nucleolar scleroderma antigenRNA, U3 small nucleolar interacting protein 1histone-glutamine methyltransferase	zinc finger protein 829
	Modification date	20200313	20200313
	UniProtAcc	P22087	.
	Ensembl transtripts involved in fusion gene	ENST00000221801, ENST00000593503,	ENST00000391711, ENST00000520965,
Fusion gene scores	* DoF score	11 X 9 X 4=396	3 X 3 X 3=27
	# samples	11	4
	** MAII score	log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FBL [Title/Abstract] AND ZNF829 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FBL(40327196)-ZNF829(37406153), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FBL	GO:0031167	rRNA methylation	30540930
Hgene	FBL	GO:1990258	histone glutamine methylation	24352239\|30540930

Fusion gene breakpoints across FBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF829 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A8NG-01A	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-
ChimerDB4	ESCA	TCGA-L5-A8NG	FBL	chr19	40327195	-	ZNF829	chr19	37406153	-
ChimerDB4	ESCA	TCGA-L5-A8NG	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-

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Fusion Gene ORF analysis for FBL-ZNF829

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000221801	ENST00000391711	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-
5CDS-5UTR	ENST00000221801	ENST00000391711	FBL	chr19	40327195	-	ZNF829	chr19	37406153	-
5UTR-3CDS	ENST00000593503	ENST00000520965	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-
5UTR-3CDS	ENST00000593503	ENST00000520965	FBL	chr19	40327195	-	ZNF829	chr19	37406153	-
5UTR-5UTR	ENST00000593503	ENST00000391711	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-
5UTR-5UTR	ENST00000593503	ENST00000391711	FBL	chr19	40327195	-	ZNF829	chr19	37406153	-
In-frame	ENST00000221801	ENST00000520965	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-
In-frame	ENST00000221801	ENST00000520965	FBL	chr19	40327195	-	ZNF829	chr19	37406153	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000221801	FBL	chr19	40327196	-	ENST00000520965	ZNF829	chr19	37406153	-	5660	909	114	2291	725
ENST00000221801	FBL	chr19	40327195	-	ENST00000520965	ZNF829	chr19	37406153	-	5660	909	114	2291	725

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000221801	ENST00000520965	FBL	chr19	40327196	-	ZNF829	chr19	37406153	-	0.0004104	0.9995896
ENST00000221801	ENST00000520965	FBL	chr19	40327195	-	ZNF829	chr19	37406153	-	0.0004104	0.9995896

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Fusion Genomic Features for FBL-ZNF829

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBL-ZNF829

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:40327196/chr19:37406153)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBL P22087	.
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930, PubMed:32017898). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930). {ECO:0000250\|UniProtKB:P15646, ECO:0000269\|PubMed:24352239, ECO:0000269\|PubMed:30540930, ECO:0000269\|PubMed:32017898}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBL

chr19:40327195

chr19:37406153

ENST00000221801

8_77

265

322.0

Compositional bias

Note=DMA/Gly-rich

Hgene

FBL

chr19:40327196

chr19:37406153

ENST00000221801

8_77

265

322.0

Compositional bias

Note=DMA/Gly-rich

Hgene

FBL

chr19:40327195

chr19:37406153

ENST00000221801

172_173

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327195

chr19:37406153

ENST00000221801

191_192

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327195

chr19:37406153

ENST00000221801

216_217

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327195

chr19:37406153

ENST00000221801

236_239

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327196

chr19:37406153

ENST00000221801

172_173

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327196

chr19:37406153

ENST00000221801

191_192

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327196

chr19:37406153

ENST00000221801

216_217

265

322.0

Region

S-adenosyl-L-methionine binding

Hgene

FBL

chr19:40327196

chr19:37406153

ENST00000221801

236_239

265

322.0

Region

S-adenosyl-L-methionine binding

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

17_20

433.0

Compositional bias

Note=Poly-Glu

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

17_20

433.0

Compositional bias

Note=Poly-Glu

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

35_106

433.0

Domain

KRAB

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

35_106

433.0

Domain

KRAB

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

156_178

433.0

Zinc finger

C2H2-type 1

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

184_206

433.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

212_234

433.0

Zinc finger

C2H2-type 3

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

240_262

433.0

Zinc finger

C2H2-type 4

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

268_290

433.0

Zinc finger

C2H2-type 5

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

296_318

433.0

Zinc finger

C2H2-type 6

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

324_346

433.0

Zinc finger

C2H2-type 7

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

352_374

433.0

Zinc finger

C2H2-type 8

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

380_402

433.0

Zinc finger

C2H2-type 9

Tgene

ZNF829

chr19:40327195

chr19:37406153

ENST00000391711

408_430

433.0

Zinc finger

C2H2-type 10

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

156_178

433.0

Zinc finger

C2H2-type 1

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

184_206

433.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

212_234

433.0

Zinc finger

C2H2-type 3

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

240_262

433.0

Zinc finger

C2H2-type 4

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

268_290

433.0

Zinc finger

C2H2-type 5

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

296_318

433.0

Zinc finger

C2H2-type 6

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

324_346

433.0

Zinc finger

C2H2-type 7

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

352_374

433.0

Zinc finger

C2H2-type 8

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

380_402

433.0

Zinc finger

C2H2-type 9

Tgene

ZNF829

chr19:40327196

chr19:37406153

ENST00000391711

408_430

433.0

Zinc finger

C2H2-type 10

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBL

chr19:40327195

chr19:37406153

ENST00000221801

274_306

265

322.0

Region

Helical

Hgene

FBL

chr19:40327196

chr19:37406153

ENST00000221801

274_306

265

322.0

Region

Helical

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Fusion Gene Sequence for FBL-ZNF829

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>29552_29552_1_FBL-ZNF829_FBL_chr19_40327195_ENST00000221801_ZNF829_chr19_37406153_ENST00000520965_length(transcript)=5660nt_BP=909nt
GCGTCACGCAGCGCACGTCGCCGCGCGCCTGCGCTCTTTTCCACGTGCGAAAGCCCCGGACTCGTGGAGTTGTGAACGCCGCGGACTCCG
GAGCCGCACAAACCAGGGCTCGCCATGAAGCCAGGATTCAGTCCCCGTGGGGGTGGCTTTGGCGGCCGAGGGGGCTTTGGTGACCGTGGT
GGTCGTGGAGGCCGAGGGGGCTTTGGCGGGGGCCGAGGTCGAGGCGGAGGCTTTAGAGGTCGTGGACGAGGAGGAGGTGGAGGCGGCGGC
GGCGGTGGAGGAGGAGGAAGAGGTGGTGGAGGCTTCCATTCTGGTGGCAACCGGGGTCGTGGTCGGGGAGGAAAAAGAGGAAACCAGTCG
GGGAAGAATGTGATGGTGGAGCCGCATCGGCATGAGGGTGTCTTCATTTGTCGAGGAAAGGAAGATGCACTGGTCACCAAGAACCTGGTC
CCTGGGGAATCAGTTTATGGAGAGAAGAGAGTCTCGATTTCGGAAGGAGATGACAAAATTGAGTACCGAGCCTGGAACCCCTTCCGCTCC
AAGCTAGCAGCAGCAATCCTGGGTGGTGTGGACCAGATCCACATCAAACCGGGGGCTAAGGTTCTCTACCTCGGGGCTGCCTCGGGCACC
ACGGTCTCCCATGTCTCTGACATCGTTGGTCCGGATGGTCTAGTCTATGCAGTCGAGTTCTCCCACCGCTCTGGCCGTGACCTCATTAAC
TTGGCCAAGAAGAGGACCAACATCATTCCTGTGATCGAGGATGCTCGACACCCACACAAATACCGCATGCTCATCGCAATGGTGGATGTG
ATCTTTGCTGATGTGGCCCAGCCAGACCAGACCCGGATTGTGGCCCTGAATGCCCACACCTTCCTGCGTAATGGAGGACACTTTGTGATT
TCCATTAAGGAAACCTCTCTGAGGTCTGGTCAGATTCCAACCCTGGACAGCAGTGAACACAACCTTTCCCCTGAGCCACTGGAATTGGAC
AGAATGCCCCATTCTCCTCTGATCTCCATTCCTCATGTGTGGTGTCACCCAGAAGAGGAGGAAAGAATGCATGATGAACTTCTACAAGCA
GTATCCAAGGGGCCGGTGATGTTCAGGGATGTTTCCATAGACTTCTCTCAAGAGGAATGGGAATGCCTGGACGCTGATCAGATGAATTTA
TACAAAGAAGTGATGTTGGAGAATTTCAGCAACCTGGTTTCAGTGGGACTTTCCAATTCTAAGCCAGCTGTGATCTCCTTATTGGAACAA
GGAAAAGAGCCCTGGATGGTTGATAGAGAGCTGACTAGAGGCCTGTGTTCAGATCTGGAATCAATGTGTGAGACCAAAATATTATCTCTA
AAGAAGAGACATTTCAGTCAAGTAATAATTACCCGTGAAGACATGTCTACTTTTATTCAGCCCACATTTCTTATTCCACCTCAAAAAACT
ATGAGTGAAGAGAAACCATGGGAATGTAAGATATGTGGAAAGACCTTTAATCAAAACTCACAATTTATCCAACATCAGAGAATTCATTTT
GGTGAAAAACACTATGAATCTAAGGAGTATGGGAAGTCCTTTAGTCGTGGCTCACTCGTTACTCGACATCAGAGGATTCACACTGGTAAA
AAACCCTATGAATGTAAGGAATGTGGCAAGGCTTTTAGTTGTAGTTCATATTTTTCTCAACATCAGAGGATTCACACTGGTGAGAAACCC
TATGAATGTAAGGAATGTGGAAAAGCCTTTAAGTATTGCTCAAACCTTAATGATCATCAGAGAATTCACACTGGTGAGAAACCCTATGAA
TGTAAAGTATGTGGAAAAGCCTTTACTAAAAGTTCACAACTTTTTCTACATCTGAGAATTCATACTGGTGAGAAACCTTATGAATGTAAA
GAATGTGGGAAAGCCTTTACTCAACACTCAAGGCTTATTCAGCATCAGAGAATGCATACTGGTGAGAAACCTTATGAATGTAAGCAGTGT
GGGAAGGCCTTTAATAGTGCCTCAACACTTACTAACCATCACAGAATTCATGCTGGTGAGAAGCTCTATGAATGTGAAGAATGTAGAAAG
GCCTTTATTCAGAGCTCAGAACTTATTCAACATCAGAGAATCCATACAGATGAAAAACCATATGAATGTAATGAATGTGGGAAGGCCTTT
AATAAAGGCTCAAATCTTACTCGACATCAGAGAATTCACACTGGTGAGAAACCCTATGACTGTAAGGAATGTGGAAAGGCTTTTGGTAGT
CGCTCTGACCTCATTCGCCATGAGGGAATTCATACTGGTTGAATGACAGTAAAGTAAGACCATTTTGTTAACCTTTATAATAATTTTTTT
AAAACAGGTAAGGAGAACAAATTAGGATACATATTATCAAAGGTTCTCCTATGTATTCGTTTTTAAACGATACGATAACAAAGTACCAAG
TACCAAAACCTTGGTGGCTTAAAACAAGAGAAATTTATTCTCTCATAGTTTAGAGCCTGGAAATCTAAACTCAAGGGTGCTGATCGTTTT
GGTTCCTTCTGAGGACTCTGAGGATCTGTTCTATGCCTTTTTCCTAACCTCTGTTAACAGCTGGCAGTCCTTGGCATTCCATGGCTTTTA
CATACACCATTCCAATCTCTGCCTCCATCTTCACATTGCATTCTCGCTGTGTATCTCTGTGTATGTCTTTTATTTGGACACCAGTCAGGT
TAGATTGGGGTTACCTGGTGACCTCATCTTAACTTGATTATATCTGCCAAGACCCTGTTTCCAAGTAAGGTCACATTTACCGGTACCAGG
GGTTAGGACTTCAGCATATCTTTTTAGGGGATACAGTTCAACCCATAATACCCTGTTAGAATGATTTTGTCTAATATATTTGTAATTTCC
TTTTATACATAAGTTGTTAGTCAAATTTATTTTATTTTATTTTATTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGG
TGTGATCTCAGCTCACTGCAACCTCCAGCTCCTGAGTTCAAGCGATTCTTGTGCCTCAGCCTCTCAAGTAGTTGGGATTACAGGCATGCG
CCACCATGCCCGGCTAATTTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGCGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACT
CCTGACTTCAAGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCGTGATGGCCAAAACAGACTTTATAC
CAACAAAAATTAAAAAGGACAAAGAAGGTCATTTATAATGATAAAGGATAAATTCAACAAGAAGATAAAACAATCCTAAATATGTATGCA
CCCAACACTGCAACACCCAGATCCATAACACAGATACTACTAGACCTAAGAAAAGAGATAGACAGCAATACAACAATAGCAGGGGACTTC
ACCACTCCATTGACAGCACTAGACAGATCACTGGGACAGAAATCAACAAAGAAACTCTGGACTTAAATTGGACTCTACACCAAATGGACC
CAACAGACATCTGAAGAACATTCTACCCAACAACCACAGAATATATACTCTTCTCTTCTGTGCATGGAACATTCTCAAAAATAGGTCATA
TACTGGACCACAAAGCAAGTATCAATAAATTTTAAAAAAACAAAATCATATCTAACATCTTCTCTGACCATAGTGGAATAAAACTAGATA
TCAATACCAAGAGGAACTCTCAAAACAGATACATGGAATTTAAACAGCTTGCTCCTGAATGATTTTTGGATCAATGATGAAACTAAGGTG
GAAATTTAAAATTTTTTGAAATAAATGAAAATAGAGACAAAACACATGAAAACATCTGAGATACAGCAAAAGCAGTGCTAAGAGAGGATT
TTATAGCATTAAATGCCTACACCAAAAAGATAGAAAAATCTCAAATGAATAGCCTAACGTCACATCTCAAGGAACTAGGAAAAAACAAAA
CAAACTCAACCCAAAGCTGGCAGAAGAAAAGCAATAACAAATATCAGAGCAGGCAAAAATGAGACTGAGAACAAAGGAATGCAAAAGATC
AATAAAAGAAAAAGTTGGTTCTTTGCAAAGATAAAACTGACAGACCACTAGCTAGATTAACCAAGAAAAAAAGAAGATTCAAATAAATAC
AATCAGAAATGATAAGGTGATATTATAACTGATAACACAGACATATAAAATATCAGCAGAAACTATATGCACATATTAGAAAACCTAGAG
GAAGTGGATAAATTCCTAGAAACACATAACCTTCCAAGATTGAACCAGGGAGAAATAGGAATCCTCAACAGACTACTGAGTATTGAAATT
GAATCAGTAATAGAAAAAAATCTTGCAAAAACAAAAAGCCCAGGACCAGACAGATTCACAGCTGAATTCTACTAGACATGCAAGGAAGAA
CTAGTAACAGCACTATTGAAACTATTCCAAAAATTATAGGAGGGAATCCTCCCTAACTCATTCTACAAAGCCAGTATCATCCTGATACTG
AAGCCAGGCAAGGATAAAACACACAAAAAAACTACAAGCCAATATCCCTGATGAAAATAGACACAAAAATCTTCAGCAAAATACTAGCAA
ACCAAATCAAACAGTACATAAAAAAGATAGTAACAGCACAGTCAAGTGGATTTTATTCCTGGGGTGTAAGGATGGCTCAACATATGCAAC
TCAATACATGATTCATCACATACACAGAATTAAAAATAAGCCAGGCACTCACACCTGTAATCCCAGCACTTTGCAAGGCCAAGGCGGGCA
GATCACATGATGTCAAGAGTTTGAGACCAGTCTGGCTGACATGGCGAAACCCTGTCTCTACTAAAAATAGAAAAATTGGCTGGGCATGGT
GGCAGGCACTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTACTTGAACCTGAGAAGCGGAGGTTGCAGTGAGCTGAGATAGT
GCCATTGCACTCCAGCCTGGGCAACAGAGCAAATTGCTTGAATGTGGGAGGTGGAGGTTGCAGTGAGCCGAGATTATGCCATTGCACTCC
AGCCGGGGGAGCAACAAAGCCAGACTCCATCTCAAAAAAAAACCAAAAAAAATCCTATTTAGTACAAGGTACATTATTTAGGTAATGAGT
CCATTAAAAGCCAACACTTTCCCCACTACACTATATGTGTATGTAACACAACTGCCCTTGTAACTTCCTAAACCTATAATTAAGAAACAA
TAAAAGGCAAATTAAGAATGCTTTTTTAAAAGGTGGGGGCATTATGCTAATAAGTTACTGTGGATTTCAGAGTGCAGAGTAGAAAGATCA
CAAGAATTTAGTGTGGTAGGTGGGAACAGAAAATGGGTGTATAAATTTTATTGACGTGGGAGTACTGGATATTGTAGAGACAGATATCAT
CAGGGCAAGGAGATTAAAGATTTTTGCATTGACGGTTTGACACTATATTGTGGTAATAACACTGTATGTGTTGGGAGATAGAACAGGAAA
CATCTTCCCTGGAATATGTATACTATTAAATGTTTTATCAAACTTTTGATCAAACAAGACAGCACAATTTATAATTTCATTTCTATTTCT

>29552_29552_1_FBL-ZNF829_FBL_chr19_40327195_ENST00000221801_ZNF829_chr19_37406153_ENST00000520965_length(amino acids)=725AA_BP=379
MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEP
HRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDI
VGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKETSLR
SGQIPTLDSSEHNLSPEPLELDRMPHSPLISIPHVWCHPEEEERMHDELLQAVSKGPVMFRDVSIDFSQEEWECLDADQMNLYKEVMLEN
FSNLVSVGLSNSKPAVISLLEQGKEPWMVDRELTRGLCSDLESMCETKILSLKKRHFSQVIITREDMSTFIQPTFLIPPQKTMSEEKPWE
CKICGKTFNQNSQFIQHQRIHFGEKHYESKEYGKSFSRGSLVTRHQRIHTGKKPYECKECGKAFSCSSYFSQHQRIHTGEKPYECKECGK
AFKYCSNLNDHQRIHTGEKPYECKVCGKAFTKSSQLFLHLRIHTGEKPYECKECGKAFTQHSRLIQHQRMHTGEKPYECKQCGKAFNSAS
TLTNHHRIHAGEKLYECEECRKAFIQSSELIQHQRIHTDEKPYECNECGKAFNKGSNLTRHQRIHTGEKPYDCKECGKAFGSRSDLIRHE

--------------------------------------------------------------
>29552_29552_2_FBL-ZNF829_FBL_chr19_40327196_ENST00000221801_ZNF829_chr19_37406153_ENST00000520965_length(transcript)=5660nt_BP=909nt
GCGTCACGCAGCGCACGTCGCCGCGCGCCTGCGCTCTTTTCCACGTGCGAAAGCCCCGGACTCGTGGAGTTGTGAACGCCGCGGACTCCG
GAGCCGCACAAACCAGGGCTCGCCATGAAGCCAGGATTCAGTCCCCGTGGGGGTGGCTTTGGCGGCCGAGGGGGCTTTGGTGACCGTGGT
GGTCGTGGAGGCCGAGGGGGCTTTGGCGGGGGCCGAGGTCGAGGCGGAGGCTTTAGAGGTCGTGGACGAGGAGGAGGTGGAGGCGGCGGC
GGCGGTGGAGGAGGAGGAAGAGGTGGTGGAGGCTTCCATTCTGGTGGCAACCGGGGTCGTGGTCGGGGAGGAAAAAGAGGAAACCAGTCG
GGGAAGAATGTGATGGTGGAGCCGCATCGGCATGAGGGTGTCTTCATTTGTCGAGGAAAGGAAGATGCACTGGTCACCAAGAACCTGGTC
CCTGGGGAATCAGTTTATGGAGAGAAGAGAGTCTCGATTTCGGAAGGAGATGACAAAATTGAGTACCGAGCCTGGAACCCCTTCCGCTCC
AAGCTAGCAGCAGCAATCCTGGGTGGTGTGGACCAGATCCACATCAAACCGGGGGCTAAGGTTCTCTACCTCGGGGCTGCCTCGGGCACC
ACGGTCTCCCATGTCTCTGACATCGTTGGTCCGGATGGTCTAGTCTATGCAGTCGAGTTCTCCCACCGCTCTGGCCGTGACCTCATTAAC
TTGGCCAAGAAGAGGACCAACATCATTCCTGTGATCGAGGATGCTCGACACCCACACAAATACCGCATGCTCATCGCAATGGTGGATGTG
ATCTTTGCTGATGTGGCCCAGCCAGACCAGACCCGGATTGTGGCCCTGAATGCCCACACCTTCCTGCGTAATGGAGGACACTTTGTGATT
TCCATTAAGGAAACCTCTCTGAGGTCTGGTCAGATTCCAACCCTGGACAGCAGTGAACACAACCTTTCCCCTGAGCCACTGGAATTGGAC
AGAATGCCCCATTCTCCTCTGATCTCCATTCCTCATGTGTGGTGTCACCCAGAAGAGGAGGAAAGAATGCATGATGAACTTCTACAAGCA
GTATCCAAGGGGCCGGTGATGTTCAGGGATGTTTCCATAGACTTCTCTCAAGAGGAATGGGAATGCCTGGACGCTGATCAGATGAATTTA
TACAAAGAAGTGATGTTGGAGAATTTCAGCAACCTGGTTTCAGTGGGACTTTCCAATTCTAAGCCAGCTGTGATCTCCTTATTGGAACAA
GGAAAAGAGCCCTGGATGGTTGATAGAGAGCTGACTAGAGGCCTGTGTTCAGATCTGGAATCAATGTGTGAGACCAAAATATTATCTCTA
AAGAAGAGACATTTCAGTCAAGTAATAATTACCCGTGAAGACATGTCTACTTTTATTCAGCCCACATTTCTTATTCCACCTCAAAAAACT
ATGAGTGAAGAGAAACCATGGGAATGTAAGATATGTGGAAAGACCTTTAATCAAAACTCACAATTTATCCAACATCAGAGAATTCATTTT
GGTGAAAAACACTATGAATCTAAGGAGTATGGGAAGTCCTTTAGTCGTGGCTCACTCGTTACTCGACATCAGAGGATTCACACTGGTAAA
AAACCCTATGAATGTAAGGAATGTGGCAAGGCTTTTAGTTGTAGTTCATATTTTTCTCAACATCAGAGGATTCACACTGGTGAGAAACCC
TATGAATGTAAGGAATGTGGAAAAGCCTTTAAGTATTGCTCAAACCTTAATGATCATCAGAGAATTCACACTGGTGAGAAACCCTATGAA
TGTAAAGTATGTGGAAAAGCCTTTACTAAAAGTTCACAACTTTTTCTACATCTGAGAATTCATACTGGTGAGAAACCTTATGAATGTAAA
GAATGTGGGAAAGCCTTTACTCAACACTCAAGGCTTATTCAGCATCAGAGAATGCATACTGGTGAGAAACCTTATGAATGTAAGCAGTGT
GGGAAGGCCTTTAATAGTGCCTCAACACTTACTAACCATCACAGAATTCATGCTGGTGAGAAGCTCTATGAATGTGAAGAATGTAGAAAG
GCCTTTATTCAGAGCTCAGAACTTATTCAACATCAGAGAATCCATACAGATGAAAAACCATATGAATGTAATGAATGTGGGAAGGCCTTT
AATAAAGGCTCAAATCTTACTCGACATCAGAGAATTCACACTGGTGAGAAACCCTATGACTGTAAGGAATGTGGAAAGGCTTTTGGTAGT
CGCTCTGACCTCATTCGCCATGAGGGAATTCATACTGGTTGAATGACAGTAAAGTAAGACCATTTTGTTAACCTTTATAATAATTTTTTT
AAAACAGGTAAGGAGAACAAATTAGGATACATATTATCAAAGGTTCTCCTATGTATTCGTTTTTAAACGATACGATAACAAAGTACCAAG
TACCAAAACCTTGGTGGCTTAAAACAAGAGAAATTTATTCTCTCATAGTTTAGAGCCTGGAAATCTAAACTCAAGGGTGCTGATCGTTTT
GGTTCCTTCTGAGGACTCTGAGGATCTGTTCTATGCCTTTTTCCTAACCTCTGTTAACAGCTGGCAGTCCTTGGCATTCCATGGCTTTTA
CATACACCATTCCAATCTCTGCCTCCATCTTCACATTGCATTCTCGCTGTGTATCTCTGTGTATGTCTTTTATTTGGACACCAGTCAGGT
TAGATTGGGGTTACCTGGTGACCTCATCTTAACTTGATTATATCTGCCAAGACCCTGTTTCCAAGTAAGGTCACATTTACCGGTACCAGG
GGTTAGGACTTCAGCATATCTTTTTAGGGGATACAGTTCAACCCATAATACCCTGTTAGAATGATTTTGTCTAATATATTTGTAATTTCC
TTTTATACATAAGTTGTTAGTCAAATTTATTTTATTTTATTTTATTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGG
TGTGATCTCAGCTCACTGCAACCTCCAGCTCCTGAGTTCAAGCGATTCTTGTGCCTCAGCCTCTCAAGTAGTTGGGATTACAGGCATGCG
CCACCATGCCCGGCTAATTTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGCGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACT
CCTGACTTCAAGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCGTGATGGCCAAAACAGACTTTATAC
CAACAAAAATTAAAAAGGACAAAGAAGGTCATTTATAATGATAAAGGATAAATTCAACAAGAAGATAAAACAATCCTAAATATGTATGCA
CCCAACACTGCAACACCCAGATCCATAACACAGATACTACTAGACCTAAGAAAAGAGATAGACAGCAATACAACAATAGCAGGGGACTTC
ACCACTCCATTGACAGCACTAGACAGATCACTGGGACAGAAATCAACAAAGAAACTCTGGACTTAAATTGGACTCTACACCAAATGGACC
CAACAGACATCTGAAGAACATTCTACCCAACAACCACAGAATATATACTCTTCTCTTCTGTGCATGGAACATTCTCAAAAATAGGTCATA
TACTGGACCACAAAGCAAGTATCAATAAATTTTAAAAAAACAAAATCATATCTAACATCTTCTCTGACCATAGTGGAATAAAACTAGATA
TCAATACCAAGAGGAACTCTCAAAACAGATACATGGAATTTAAACAGCTTGCTCCTGAATGATTTTTGGATCAATGATGAAACTAAGGTG
GAAATTTAAAATTTTTTGAAATAAATGAAAATAGAGACAAAACACATGAAAACATCTGAGATACAGCAAAAGCAGTGCTAAGAGAGGATT
TTATAGCATTAAATGCCTACACCAAAAAGATAGAAAAATCTCAAATGAATAGCCTAACGTCACATCTCAAGGAACTAGGAAAAAACAAAA
CAAACTCAACCCAAAGCTGGCAGAAGAAAAGCAATAACAAATATCAGAGCAGGCAAAAATGAGACTGAGAACAAAGGAATGCAAAAGATC
AATAAAAGAAAAAGTTGGTTCTTTGCAAAGATAAAACTGACAGACCACTAGCTAGATTAACCAAGAAAAAAAGAAGATTCAAATAAATAC
AATCAGAAATGATAAGGTGATATTATAACTGATAACACAGACATATAAAATATCAGCAGAAACTATATGCACATATTAGAAAACCTAGAG
GAAGTGGATAAATTCCTAGAAACACATAACCTTCCAAGATTGAACCAGGGAGAAATAGGAATCCTCAACAGACTACTGAGTATTGAAATT
GAATCAGTAATAGAAAAAAATCTTGCAAAAACAAAAAGCCCAGGACCAGACAGATTCACAGCTGAATTCTACTAGACATGCAAGGAAGAA
CTAGTAACAGCACTATTGAAACTATTCCAAAAATTATAGGAGGGAATCCTCCCTAACTCATTCTACAAAGCCAGTATCATCCTGATACTG
AAGCCAGGCAAGGATAAAACACACAAAAAAACTACAAGCCAATATCCCTGATGAAAATAGACACAAAAATCTTCAGCAAAATACTAGCAA
ACCAAATCAAACAGTACATAAAAAAGATAGTAACAGCACAGTCAAGTGGATTTTATTCCTGGGGTGTAAGGATGGCTCAACATATGCAAC
TCAATACATGATTCATCACATACACAGAATTAAAAATAAGCCAGGCACTCACACCTGTAATCCCAGCACTTTGCAAGGCCAAGGCGGGCA
GATCACATGATGTCAAGAGTTTGAGACCAGTCTGGCTGACATGGCGAAACCCTGTCTCTACTAAAAATAGAAAAATTGGCTGGGCATGGT
GGCAGGCACTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTACTTGAACCTGAGAAGCGGAGGTTGCAGTGAGCTGAGATAGT
GCCATTGCACTCCAGCCTGGGCAACAGAGCAAATTGCTTGAATGTGGGAGGTGGAGGTTGCAGTGAGCCGAGATTATGCCATTGCACTCC
AGCCGGGGGAGCAACAAAGCCAGACTCCATCTCAAAAAAAAACCAAAAAAAATCCTATTTAGTACAAGGTACATTATTTAGGTAATGAGT
CCATTAAAAGCCAACACTTTCCCCACTACACTATATGTGTATGTAACACAACTGCCCTTGTAACTTCCTAAACCTATAATTAAGAAACAA
TAAAAGGCAAATTAAGAATGCTTTTTTAAAAGGTGGGGGCATTATGCTAATAAGTTACTGTGGATTTCAGAGTGCAGAGTAGAAAGATCA
CAAGAATTTAGTGTGGTAGGTGGGAACAGAAAATGGGTGTATAAATTTTATTGACGTGGGAGTACTGGATATTGTAGAGACAGATATCAT
CAGGGCAAGGAGATTAAAGATTTTTGCATTGACGGTTTGACACTATATTGTGGTAATAACACTGTATGTGTTGGGAGATAGAACAGGAAA
CATCTTCCCTGGAATATGTATACTATTAAATGTTTTATCAAACTTTTGATCAAACAAGACAGCACAATTTATAATTTCATTTCTATTTCT

>29552_29552_2_FBL-ZNF829_FBL_chr19_40327196_ENST00000221801_ZNF829_chr19_37406153_ENST00000520965_length(amino acids)=725AA_BP=379
MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEP
HRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDI
VGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKETSLR
SGQIPTLDSSEHNLSPEPLELDRMPHSPLISIPHVWCHPEEEERMHDELLQAVSKGPVMFRDVSIDFSQEEWECLDADQMNLYKEVMLEN
FSNLVSVGLSNSKPAVISLLEQGKEPWMVDRELTRGLCSDLESMCETKILSLKKRHFSQVIITREDMSTFIQPTFLIPPQKTMSEEKPWE
CKICGKTFNQNSQFIQHQRIHFGEKHYESKEYGKSFSRGSLVTRHQRIHTGKKPYECKECGKAFSCSSYFSQHQRIHTGEKPYECKECGK
AFKYCSNLNDHQRIHTGEKPYECKVCGKAFTKSSQLFLHLRIHTGEKPYECKECGKAFTQHSRLIQHQRMHTGEKPYECKQCGKAFNSAS
TLTNHHRIHAGEKLYECEECRKAFIQSSELIQHQRIHTDEKPYECNECGKAFNKGSNLTRHQRIHTGEKPYDCKECGKAFGSRSDLIRHE

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Top

Fusion Gene PPI Analysis for FBL-ZNF829

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FBL-ZNF829

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FBL-ZNF829

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source