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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBN1-B2M (FusionGDB2 ID:29553)

Fusion Gene Summary for FBN1-B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: FBN1-B2M
Fusion gene ID: 29553
HgeneTgene
Gene symbol

FBN1

B2M

Gene ID

2200

567

Gene namefibrillin 1beta-2-microglobulin
SynonymsACMICD|ECTOL1|FBN|GPHYSD2|MASS|MFLS|MFS1|OCTD|SGS|SSKS|WMS|WMS2IMD43
Cytomap

15q21.1

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionfibrillin-1asprosinepididymis secretory sperm binding proteinfibrillin 15fibrillin-1 preproproteinbeta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2020031320200329
UniProtAcc

P35555

P61769

Ensembl transtripts involved in fusion geneENST00000316623, ENST00000560355, 
ENST00000561429, 		ENST00000559220, 
ENST00000544417, ENST00000558401, 
ENST00000559916, 
Fusion gene scores* DoF score15 X 17 X 7=178564 X 31 X 17=33728
# samples 1771
** MAII scorelog2(17/1785*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(71/33728*10)=-5.56998393724517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBN1 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBN1(48888480)-B2M(45007621), # samples:1
Anticipated loss of major functional domain due to fusion event.FBN1-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBN1

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneFBN1

GO:0045671

negative regulation of osteoclast differentiation

24039232

HgeneFBN1

GO:2001205

negative regulation of osteoclast development

24039232

TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:0007611

learning or memory

26147761

TgeneB2M

GO:0050680

negative regulation of epithelial cell proliferation

28213472

TgeneB2M

GO:0050768

negative regulation of neurogenesis

26147761

TgeneB2M

GO:0090647

modulation of age-related behavioral decline

26147761

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039

TgeneB2M

GO:1990000

amyloid fibril formation

28468825

TgeneB2M

GO:2000774

positive regulation of cellular senescence

28213472

TgeneB2M

GO:2000978

negative regulation of forebrain neuron differentiation

26147761


check buttonFusion gene breakpoints across FBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CZ-5468-01AFBN1chr15

48888480

-B2Mchr15

45007621

+


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Fusion Gene ORF analysis for FBN1-B2M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316623ENST00000559220FBN1chr15

48888480

-B2Mchr15

45007621

+
Frame-shiftENST00000316623ENST00000544417FBN1chr15

48888480

-B2Mchr15

45007621

+
In-frameENST00000316623ENST00000558401FBN1chr15

48888480

-B2Mchr15

45007621

+
In-frameENST00000316623ENST00000559916FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-3CDSENST00000560355ENST00000544417FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-3CDSENST00000560355ENST00000558401FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-3CDSENST00000560355ENST00000559916FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-3CDSENST00000561429ENST00000544417FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-3CDSENST00000561429ENST00000558401FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-3CDSENST00000561429ENST00000559916FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-intronENST00000560355ENST00000559220FBN1chr15

48888480

-B2Mchr15

45007621

+
intron-intronENST00000561429ENST00000559220FBN1chr15

48888480

-B2Mchr15

45007621

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316623FBN1chr1548888480-ENST00000558401B2Mchr1545007621+2572994841286400
ENST00000316623FBN1chr1548888480-ENST00000559916B2Mchr1545007621+1974994841286400

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316623ENST00000558401FBN1chr1548888480-B2Mchr1545007621+0.0001798550.9998202
ENST00000316623ENST00000559916FBN1chr1548888480-B2Mchr1545007621+0.0004770740.9995229

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Fusion Genomic Features for FBN1-B2M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBN1chr1548888479-B2Mchr1545007620+5.24E-050.99994767
FBN1chr1548888479-B2Mchr1545007620+5.24E-050.99994767

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBN1-B2M


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:48888480/chr15:45007621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBN1

P35555

B2M

P61769

FUNCTION: [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation. {ECO:0000269|PubMed:27087445}.FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666115_1461792872.0DomainEGF-like 2
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666147_1781792872.0DomainEGF-like 3
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-66681_1121792872.0DomainEGF-like 1
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-66645_811792872.0RegionFibrillin unique N-terminal (FUN) domain
TgeneB2Mchr15:48888480chr15:45007621ENST000005584010425_11322498.0DomainNote=Ig-like C1-type
TgeneB2Mchr15:48888480chr15:45007621ENST000005599160325_11322120.0DomainNote=Ig-like C1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666402_4461792872.0Compositional biasNote=Pro-rich
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661028_10691792872.0DomainEGF-like 15%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661070_11121792872.0DomainEGF-like 16%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661113_11541792872.0DomainEGF-like 17%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661155_11961792872.0DomainEGF-like 18%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661197_12371792872.0DomainEGF-like 19%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661238_12791792872.0DomainEGF-like 20%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661280_13211792872.0DomainEGF-like 21%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661322_13621792872.0DomainEGF-like 22%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661363_14031792872.0DomainEGF-like 23%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661404_14451792872.0DomainEGF-like 24%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661446_14861792872.0DomainEGF-like 25%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661487_15271792872.0DomainEGF-like 26%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661532_15891792872.0DomainNote=TB 6
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661606_16471792872.0DomainEGF-like 27%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661648_16881792872.0DomainEGF-like 28%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661693_17481792872.0DomainNote=TB 7
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661766_18071792872.0DomainEGF-like 29%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661808_18481792872.0DomainEGF-like 30%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661849_18901792872.0DomainEGF-like 31%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666184_2361792872.0DomainNote=TB 1
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661891_19291792872.0DomainEGF-like 32%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661930_19721792872.0DomainEGF-like 33%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661973_20121792872.0DomainEGF-like 34%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662013_20541792872.0DomainEGF-like 35%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662059_21111792872.0DomainNote=TB 8
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662127_21651792872.0DomainEGF-like 36%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662166_22051792872.0DomainEGF-like 37%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662206_22461792872.0DomainEGF-like 38%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662247_22901792872.0DomainEGF-like 39%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662291_23321792872.0DomainEGF-like 40%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662337_23901792872.0DomainNote=TB 9
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662402_24431792872.0DomainEGF-like 41%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662444_24841792872.0DomainEGF-like 42%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666246_2871792872.0DomainEGF-like 4%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662485_25231792872.0DomainEGF-like 43%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662524_25661792872.0DomainEGF-like 44%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662567_26061792872.0DomainEGF-like 45%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662607_26471792872.0DomainEGF-like 46%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6662648_26871792872.0DomainEGF-like 47%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666288_3291792872.0DomainEGF-like 5%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666334_3891792872.0DomainNote=TB 2
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666449_4891792872.0DomainEGF-like 6
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666490_5291792872.0DomainEGF-like 7%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666530_5711792872.0DomainEGF-like 8%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666572_6121792872.0DomainEGF-like 9%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666613_6531792872.0DomainEGF-like 10%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666659_7111792872.0DomainNote=TB 3
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666723_7641792872.0DomainEGF-like 11%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666765_8061792872.0DomainEGF-like 12%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666807_8461792872.0DomainEGF-like 13%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666851_9021792872.0DomainNote=TB 4
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666910_9511792872.0DomainEGF-like 14%3B calcium-binding
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666956_10081792872.0DomainNote=TB 5
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661541_15431792872.0MotifCell attachment site
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-6661528_27311792872.0RegionC-terminal domain
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666195_2211792872.0RegionHybrid domain 1
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-66645_4501792872.0RegionN-terminal domain


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Fusion Gene Sequence for FBN1-B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29553_29553_1_FBN1-B2M_FBN1_chr15_48888480_ENST00000316623_B2M_chr15_45007621_ENST00000558401_length(transcript)=2572nt_BP=994nt
GTGGTGATGAGGGCGACGAAGGAGGGGGTGTCATTTTCTTTTTCTTTCTTTTTTTAAAAAAAGTATTTCTCTCGCGAGAAACCGCTGCGC
GGACGATACTTGAAGAGGTGGGGAAAGGAGGGGGCTGCGGGAGCCGCGGCAGAGACTGTGGGTGCCACAAGCGGACAGGAGCCACAGCTG
GGACAGCTGCGAGCGGAGCCGAGCAGTGGCTGTAGCGGCCACGACTGGGAGCAGCCGCCGCCGCCTCCTCGGGAGTCGGAGCCGCCGCTT
CTCCACTGGCAGGGGCCGCCTGAAGTGGGAGCAGCGCCTGGAGAAGGCGGGAGGAGCCCGGCCCGGGGGACGGGCGGCGGGATAGCGGGA
CCCCGGCGGCGCGGTGCGCTTCAGGGCGCAGCGGCGGCCGCAGACCGAGCCCCGGGCGCGGCAAGAGGCGGCGGGAGCCGGTGGCGGCTC
GGCATCATGCGTCGAGGGCGTCTGCTGGAGATCGCCCTGGGATTTACCGTGCTTTTAGCGTCCTACACGAGCCATGGGGCGGACGCCAAT
TTGGAGGCTGGGAACGTGAAGGAAACCAGAGCCAGTCGGGCCAAGAGAAGAGGCGGTGGAGGACACGACGCGCTTAAAGGACCCAATGTC
TGTGGATCACGTTATAATGCTTACTGTTGCCCTGGATGGAAAACCTTACCTGGCGGAAATCAGTGTATTGTCCCCATTTGCCGGCATTCC
TGTGGGGATGGATTTTGTTCGAGGCCAAATATGTGCACTTGCCCATCTGGTCAGATAGCTCCTTCCTGTGGCTCCAGATCCATACAACAC
TGCAATATTCGCTGTATGAATGGAGGTAGCTGCAGTGACGATCACTGTCTATGCCAGAAAGGATACATAGGGACTCACTGTGGACAACCT
GTTTGTGAAAGTGGCTGTCTCAATGGAGGAAGGTGTGTGGCCCCAAATCGATGTGCATGCACTTACGGATTTACTGGACCCCAGTGTGAA
AGAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCAT
CCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCT
TTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAG
ATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCT
TGCTTTTTAATATTGATATGCTTATACACTTACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTA
TAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTG
GGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTA
AGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTT
GTTATAATGAATGAAACATTTTGTCATATAAGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGT
TTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAAC
AGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTC
ACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTAT
ATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTT
TAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTA
AGTCCCTTCTATAAAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATAC
CTAATACAATGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACAC
AACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACT

>29553_29553_1_FBN1-B2M_FBN1_chr15_48888480_ENST00000316623_B2M_chr15_45007621_ENST00000558401_length(amino acids)=400AA_BP=303
MRGRYLKRWGKEGAAGAAAETVGATSGQEPQLGQLRAEPSSGCSGHDWEQPPPPPRESEPPLLHWQGPPEVGAAPGEGGRSPARGTGGGI
AGPRRRGALQGAAAAADRAPGAARGGGSRWRLGIMRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGP
NVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCG
QPVCESGCLNGGRCVAPNRCACTYGFTGPQCERGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD

--------------------------------------------------------------
>29553_29553_2_FBN1-B2M_FBN1_chr15_48888480_ENST00000316623_B2M_chr15_45007621_ENST00000559916_length(transcript)=1974nt_BP=994nt
GTGGTGATGAGGGCGACGAAGGAGGGGGTGTCATTTTCTTTTTCTTTCTTTTTTTAAAAAAAGTATTTCTCTCGCGAGAAACCGCTGCGC
GGACGATACTTGAAGAGGTGGGGAAAGGAGGGGGCTGCGGGAGCCGCGGCAGAGACTGTGGGTGCCACAAGCGGACAGGAGCCACAGCTG
GGACAGCTGCGAGCGGAGCCGAGCAGTGGCTGTAGCGGCCACGACTGGGAGCAGCCGCCGCCGCCTCCTCGGGAGTCGGAGCCGCCGCTT
CTCCACTGGCAGGGGCCGCCTGAAGTGGGAGCAGCGCCTGGAGAAGGCGGGAGGAGCCCGGCCCGGGGGACGGGCGGCGGGATAGCGGGA
CCCCGGCGGCGCGGTGCGCTTCAGGGCGCAGCGGCGGCCGCAGACCGAGCCCCGGGCGCGGCAAGAGGCGGCGGGAGCCGGTGGCGGCTC
GGCATCATGCGTCGAGGGCGTCTGCTGGAGATCGCCCTGGGATTTACCGTGCTTTTAGCGTCCTACACGAGCCATGGGGCGGACGCCAAT
TTGGAGGCTGGGAACGTGAAGGAAACCAGAGCCAGTCGGGCCAAGAGAAGAGGCGGTGGAGGACACGACGCGCTTAAAGGACCCAATGTC
TGTGGATCACGTTATAATGCTTACTGTTGCCCTGGATGGAAAACCTTACCTGGCGGAAATCAGTGTATTGTCCCCATTTGCCGGCATTCC
TGTGGGGATGGATTTTGTTCGAGGCCAAATATGTGCACTTGCCCATCTGGTCAGATAGCTCCTTCCTGTGGCTCCAGATCCATACAACAC
TGCAATATTCGCTGTATGAATGGAGGTAGCTGCAGTGACGATCACTGTCTATGCCAGAAAGGATACATAGGGACTCACTGTGGACAACCT
GTTTGTGAAAGTGGCTGTCTCAATGGAGGAAGGTGTGTGGCCCCAAATCGATGTGCATGCACTTACGGATTTACTGGACCCCAGTGTGAA
AGAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCAT
CCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCT
TTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAG
ATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGAC
TATTTATAGACAGCTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGG
GTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAG
GAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTG
GACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGC
TCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTA
TAACTTGATATAATGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTT

>29553_29553_2_FBN1-B2M_FBN1_chr15_48888480_ENST00000316623_B2M_chr15_45007621_ENST00000559916_length(amino acids)=400AA_BP=303
MRGRYLKRWGKEGAAGAAAETVGATSGQEPQLGQLRAEPSSGCSGHDWEQPPPPPRESEPPLLHWQGPPEVGAAPGEGGRSPARGTGGGI
AGPRRRGALQGAAAAADRAPGAARGGGSRWRLGIMRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGP
NVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCG
QPVCESGCLNGGRCVAPNRCACTYGFTGPQCERGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBN1-B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFBN1chr15:48888480chr15:45007621ENST00000316623-666119_329179.333333333333342872.0MFAP4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBN1-B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBN1-B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource