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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:FBN1-TEX9 (FusionGDB2 ID:29566)

Fusion Gene Summary for FBN1-TEX9

Fusion gene summary

Fusion gene information	Fusion gene name: FBN1-TEX9
	Fusion gene ID: 29566
		Hgene	Tgene
	Gene symbol	FBN1	TEX9
	Gene ID	2200	374618
	Gene name	fibrillin 1	testis expressed 9
	Synonyms	ACMICD\|ECTOL1\|FBN\|GPHYSD2\|MASS\|MFLS\|MFS1\|OCTD\|SGS\|SSKS\|WMS\|WMS2	-
	Cytomap	15q21.1	15q21.3
	Type of gene	protein-coding	protein-coding
	Description	fibrillin-1asprosinepididymis secretory sperm binding proteinfibrillin 15fibrillin-1 preproprotein	testis-expressed protein 9testis-expressed sequence 9 protein
	Modification date	20200313	20200313
	UniProtAcc	P35555	.
	Ensembl transtripts involved in fusion gene	ENST00000316623, ENST00000560355, ENST00000561429,	ENST00000559142, ENST00000560582, ENST00000352903, ENST00000537232, ENST00000558083, ENST00000561221,
Fusion gene scores	* DoF score	15 X 17 X 7=1785	3 X 5 X 3=45
	# samples	17	4
	** MAII score	log2(17/1785*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FBN1 [Title/Abstract] AND TEX9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FBN1(48905207)-TEX9(56686363), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FBN1	GO:0033627	cell adhesion mediated by integrin	12807887\|17158881
Hgene	FBN1	GO:0045671	negative regulation of osteoclast differentiation	24039232
Hgene	FBN1	GO:2001205	negative regulation of osteoclast development	24039232

Fusion gene breakpoints across FBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TEX9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-TS-A8AF-01A	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
ChimerDB4	MESO	TCGA-TS-A8AF	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+

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Fusion Gene ORF analysis for FBN1-TEX9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000316623	ENST00000559142	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
5CDS-intron	ENST00000316623	ENST00000560582	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
In-frame	ENST00000316623	ENST00000352903	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
In-frame	ENST00000316623	ENST00000537232	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
In-frame	ENST00000316623	ENST00000558083	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
In-frame	ENST00000316623	ENST00000561221	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000560355	ENST00000352903	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000560355	ENST00000537232	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000560355	ENST00000558083	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000560355	ENST00000561221	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000561429	ENST00000352903	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000561429	ENST00000537232	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000561429	ENST00000558083	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-3CDS	ENST00000561429	ENST00000561221	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-intron	ENST00000560355	ENST00000559142	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-intron	ENST00000560355	ENST00000560582	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-intron	ENST00000561429	ENST00000559142	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+
intron-intron	ENST00000561429	ENST00000560582	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000316623	FBN1	chr15	48905207	-	ENST00000352903	TEX9	chr15	56686363	+	1541	703	84	1307	407
ENST00000316623	FBN1	chr15	48905207	-	ENST00000537232	TEX9	chr15	56686363	+	1664	703	84	1307	407
ENST00000316623	FBN1	chr15	48905207	-	ENST00000561221	TEX9	chr15	56686363	+	2424	703	84	983	299
ENST00000316623	FBN1	chr15	48905207	-	ENST00000558083	TEX9	chr15	56686363	+	4467	703	84	983	299

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316623	ENST00000352903	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+	0.002112322	0.9978877
ENST00000316623	ENST00000537232	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+	0.001767578	0.9982324
ENST00000316623	ENST00000561221	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+	0.002149266	0.9978508
ENST00000316623	ENST00000558083	FBN1	chr15	48905207	-	TEX9	chr15	56686363	+	0.001488269	0.99851173

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Fusion Genomic Features for FBN1-TEX9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FBN1	chr15	48905206	-	TEX9	chr15	56686362	+	0.05213624	0.9478638
FBN1	chr15	48905206	-	TEX9	chr15	56686362	+	0.05213624	0.9478638
FBN1	chr15	48905206	-	TEX9	chr15	56686362	+	0.05213624	0.9478638
FBN1	chr15	48905206	-	TEX9	chr15	56686362	+	0.05213624	0.9478638

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBN1-TEX9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:48905207/chr15:56686363)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBN1 P35555	.
FUNCTION: [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250\|UniProtKB:Q61554, ECO:0000269\|PubMed:11461921, ECO:0000269\|PubMed:12807887, ECO:0000269\|PubMed:15062093, ECO:0000269\|PubMed:17158881, ECO:0000269\|PubMed:1860873, ECO:0000269\|PubMed:24039232, ECO:0000303\|PubMed:27026396}.; FUNCTION: [Asprosin]: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation. {ECO:0000269\|PubMed:27087445}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

45_81

2872.0

Region

Fibrillin unique N-terminal (FUN) domain

Tgene

TEX9

chr15:48905207

chr15:56686363

ENST00000352903

188_351

190

443.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

402_446

2872.0

Compositional bias

Note=Pro-rich

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1028_1069

2872.0

Domain

EGF-like 15%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1070_1112

2872.0

Domain

EGF-like 16%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1113_1154

2872.0

Domain

EGF-like 17%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1155_1196

2872.0

Domain

EGF-like 18%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

115_146

2872.0

Domain

EGF-like 2

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1197_1237

2872.0

Domain

EGF-like 19%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1238_1279

2872.0

Domain

EGF-like 20%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1280_1321

2872.0

Domain

EGF-like 21%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1322_1362

2872.0

Domain

EGF-like 22%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1363_1403

2872.0

Domain

EGF-like 23%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1404_1445

2872.0

Domain

EGF-like 24%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1446_1486

2872.0

Domain

EGF-like 25%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

147_178

2872.0

Domain

EGF-like 3

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1487_1527

2872.0

Domain

EGF-like 26%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1532_1589

2872.0

Domain

Note=TB 6

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1606_1647

2872.0

Domain

EGF-like 27%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1648_1688

2872.0

Domain

EGF-like 28%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1693_1748

2872.0

Domain

Note=TB 7

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1766_1807

2872.0

Domain

EGF-like 29%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1808_1848

2872.0

Domain

EGF-like 30%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1849_1890

2872.0

Domain

EGF-like 31%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

184_236

2872.0

Domain

Note=TB 1

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1891_1929

2872.0

Domain

EGF-like 32%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1930_1972

2872.0

Domain

EGF-like 33%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1973_2012

2872.0

Domain

EGF-like 34%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2013_2054

2872.0

Domain

EGF-like 35%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2059_2111

2872.0

Domain

Note=TB 8

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2127_2165

2872.0

Domain

EGF-like 36%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2166_2205

2872.0

Domain

EGF-like 37%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2206_2246

2872.0

Domain

EGF-like 38%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2247_2290

2872.0

Domain

EGF-like 39%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2291_2332

2872.0

Domain

EGF-like 40%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2337_2390

2872.0

Domain

Note=TB 9

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2402_2443

2872.0

Domain

EGF-like 41%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2444_2484

2872.0

Domain

EGF-like 42%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

246_287

2872.0

Domain

EGF-like 4%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2485_2523

2872.0

Domain

EGF-like 43%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2524_2566

2872.0

Domain

EGF-like 44%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2567_2606

2872.0

Domain

EGF-like 45%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2607_2647

2872.0

Domain

EGF-like 46%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

2648_2687

2872.0

Domain

EGF-like 47%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

288_329

2872.0

Domain

EGF-like 5%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

334_389

2872.0

Domain

Note=TB 2

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

449_489

2872.0

Domain

EGF-like 6

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

490_529

2872.0

Domain

EGF-like 7%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

530_571

2872.0

Domain

EGF-like 8%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

572_612

2872.0

Domain

EGF-like 9%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

613_653

2872.0

Domain

EGF-like 10%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

659_711

2872.0

Domain

Note=TB 3

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

723_764

2872.0

Domain

EGF-like 11%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

765_806

2872.0

Domain

EGF-like 12%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

807_846

2872.0

Domain

EGF-like 13%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

81_112

2872.0

Domain

EGF-like 1

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

851_902

2872.0

Domain

Note=TB 4

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

910_951

2872.0

Domain

EGF-like 14%3B calcium-binding

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

956_1008

2872.0

Domain

Note=TB 5

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1541_1543

2872.0

Motif

Cell attachment site

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

1528_2731

2872.0

Region

C-terminal domain

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

195_221

2872.0

Region

Hybrid domain 1

Hgene

FBN1

chr15:48905207

chr15:56686363

ENST00000316623

45_450

2872.0

Region

N-terminal domain

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Fusion Gene Sequence for FBN1-TEX9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>29566_29566_1_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000352903_length(transcript)=1541nt_BP=703nt
GTGGTGATGAGGGCGACGAAGGAGGGGGTGTCATTTTCTTTTTCTTTCTTTTTTTAAAAAAAGTATTTCTCTCGCGAGAAACCGCTGCGC
GGACGATACTTGAAGAGGTGGGGAAAGGAGGGGGCTGCGGGAGCCGCGGCAGAGACTGTGGGTGCCACAAGCGGACAGGAGCCACAGCTG
GGACAGCTGCGAGCGGAGCCGAGCAGTGGCTGTAGCGGCCACGACTGGGAGCAGCCGCCGCCGCCTCCTCGGGAGTCGGAGCCGCCGCTT
CTCCACTGGCAGGGGCCGCCTGAAGTGGGAGCAGCGCCTGGAGAAGGCGGGAGGAGCCCGGCCCGGGGGACGGGCGGCGGGATAGCGGGA
CCCCGGCGGCGCGGTGCGCTTCAGGGCGCAGCGGCGGCCGCAGACCGAGCCCCGGGCGCGGCAAGAGGCGGCGGGAGCCGGTGGCGGCTC
GGCATCATGCGTCGAGGGCGTCTGCTGGAGATCGCCCTGGGATTTACCGTGCTTTTAGCGTCCTACACGAGCCATGGGGCGGACGCCAAT
TTGGAGGCTGGGAACGTGAAGGAAACCAGAGCCAGTCGGGCCAAGAGAAGAGGCGGTGGAGGACACGACGCGCTTAAAGGACCCAATGTC
TGTGGATCACGTTATAATGCTTACTGTTGCCCTGGATGGAAAACCTTACCTGGCGGAAATCAGTGTATTGTCCAAGCACAGATCAGATTT
CTAAAGGCCAAACTCCATGTTATGCAGGAGGAATTGGATAATGTTGTATGTGAATGCAATAAAAAGGAGGATGAAATTCAGAATTTAAAG
TCTCAAGTAAAAAATTTTGAAGAAGATTTTATGAGACAGCAGCGAACAATTAATATGCAACAGTCTCAAGTAGAAAAATACAAAACTCTT
TTCGAAGAAGCAAACAAAAAGTATGATGGATTACAGCAACAGTTGTCTTCAGTAGAAAGGGAATTAGAAAATAAAAGAAGACTGCAAAAA
CAGGCTGCAAGTAGTCAAAGTGCCACAGAGGTTCGCTTGAATAGAGCTCTAGAAGAAGCAGAAAAGTATAAACTGGAGTTAAGTAAATTA
AGGCAAAATAACAAGGACATAGCAAATGAAGAACACAAAAAAATTGAAGTGTTAAAATCAGAAAACAAGAAGCTAGAAAAACAAAAAGGA
GAATTAATGATAGGGTTCAAGAAACAGTTAAAATTAATTGATGTTTTAAAAAGGCAAAAGATGCATATTGAAGCTGCCAAGATGCTATCT
TTCACTGAGGAGGAATTTATGAAAGCACTTGAATGGGGAAATTCATAAGTGATCTACTTCAGTTAGTCTCTATGACAATAAGAAAACTAA
GGCTCAGAGAAAAAGCCAAAACTAGTACTTGCATGACACCTAGTCAAGTCCTAGTAGTATTCGACTTTCATTTTGTGGATCAATTTTTAT
TTGGAAAATAGCAGCAATTCTCGTAGGAGTCAGATTAAAACGTCTACAACTACCTTGAATAACTTCAACTATCAGGATAATTAAAACTGC

>29566_29566_1_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000352903_length(amino acids)=407AA_BP=207
MRGRYLKRWGKEGAAGAAAETVGATSGQEPQLGQLRAEPSSGCSGHDWEQPPPPPRESEPPLLHWQGPPEVGAAPGEGGRSPARGTGGGI
AGPRRRGALQGAAAAADRAPGAARGGGSRWRLGIMRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGP
NVCGSRYNAYCCPGWKTLPGGNQCIVQAQIRFLKAKLHVMQEELDNVVCECNKKEDEIQNLKSQVKNFEEDFMRQQRTINMQQSQVEKYK
TLFEEANKKYDGLQQQLSSVERELENKRRLQKQAASSQSATEVRLNRALEEAEKYKLELSKLRQNNKDIANEEHKKIEVLKSENKKLEKQ

--------------------------------------------------------------
>29566_29566_2_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000537232_length(transcript)=1664nt_BP=703nt
GTGGTGATGAGGGCGACGAAGGAGGGGGTGTCATTTTCTTTTTCTTTCTTTTTTTAAAAAAAGTATTTCTCTCGCGAGAAACCGCTGCGC
GGACGATACTTGAAGAGGTGGGGAAAGGAGGGGGCTGCGGGAGCCGCGGCAGAGACTGTGGGTGCCACAAGCGGACAGGAGCCACAGCTG
GGACAGCTGCGAGCGGAGCCGAGCAGTGGCTGTAGCGGCCACGACTGGGAGCAGCCGCCGCCGCCTCCTCGGGAGTCGGAGCCGCCGCTT
CTCCACTGGCAGGGGCCGCCTGAAGTGGGAGCAGCGCCTGGAGAAGGCGGGAGGAGCCCGGCCCGGGGGACGGGCGGCGGGATAGCGGGA
CCCCGGCGGCGCGGTGCGCTTCAGGGCGCAGCGGCGGCCGCAGACCGAGCCCCGGGCGCGGCAAGAGGCGGCGGGAGCCGGTGGCGGCTC
GGCATCATGCGTCGAGGGCGTCTGCTGGAGATCGCCCTGGGATTTACCGTGCTTTTAGCGTCCTACACGAGCCATGGGGCGGACGCCAAT
TTGGAGGCTGGGAACGTGAAGGAAACCAGAGCCAGTCGGGCCAAGAGAAGAGGCGGTGGAGGACACGACGCGCTTAAAGGACCCAATGTC
TGTGGATCACGTTATAATGCTTACTGTTGCCCTGGATGGAAAACCTTACCTGGCGGAAATCAGTGTATTGTCCAAGCACAGATCAGATTT
CTAAAGGCCAAACTCCATGTTATGCAGGAGGAATTGGATAATGTTGTATGTGAATGCAATAAAAAGGAGGATGAAATTCAGAATTTAAAG
TCTCAAGTAAAAAATTTTGAAGAAGATTTTATGAGACAGCAGCGAACAATTAATATGCAACAGTCTCAAGTAGAAAAATACAAAACTCTT
TTCGAAGAAGCAAACAAAAAGTATGATGGATTACAGCAACAGTTGTCTTCAGTAGAAAGGGAATTAGAAAATAAAAGAAGACTGCAAAAA
CAGGCTGCAAGTAGTCAAAGTGCCACAGAGGTTCGCTTGAATAGAGCTCTAGAAGAAGCAGAAAAGTATAAACTGGAGTTAAGTAAATTA
AGGCAAAATAACAAGGACATAGCAAATGAAGAACACAAAAAAATTGAAGTGTTAAAATCAGAAAACAAGAAGCTAGAAAAACAAAAAGGA
GAATTAATGATAGGGTTCAAGAAACAGTTAAAATTAATTGATGTTTTAAAAAGGCAAAAGATGCATATTGAAGCTGCCAAGATGCTATCT
TTCACTGAGGAGGAATTTATGAAAGCACTTGAATGGGGAAATTCATAAGTGATCTACTTCAGTTAGTCTCTATGACAATAAGAAAACTAA
GGCTCAGAGAAAAAGCCAAAACTAGTACTTGCATGACACCTAGTCAAGTCCTAGTAGTATTCGACTTTCATTTTGTGGATCAATTTTTAT
TTGGAAAATAGCAGCAATTCTCGTAGGAGTCAGATTAAAACGTCTACAACTACCTTGAATAACTTCAACTATCAGGATAATTAAAACTGC
AAACCACTGGACAAACAGGACATTGTTTGTGCTACTTTCTTTTTCAAAGGACAGCGCTATATGGCTTAGCAAATGAAGTCTCTCCACCTT

>29566_29566_2_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000537232_length(amino acids)=407AA_BP=207
MRGRYLKRWGKEGAAGAAAETVGATSGQEPQLGQLRAEPSSGCSGHDWEQPPPPPRESEPPLLHWQGPPEVGAAPGEGGRSPARGTGGGI
AGPRRRGALQGAAAAADRAPGAARGGGSRWRLGIMRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGP
NVCGSRYNAYCCPGWKTLPGGNQCIVQAQIRFLKAKLHVMQEELDNVVCECNKKEDEIQNLKSQVKNFEEDFMRQQRTINMQQSQVEKYK
TLFEEANKKYDGLQQQLSSVERELENKRRLQKQAASSQSATEVRLNRALEEAEKYKLELSKLRQNNKDIANEEHKKIEVLKSENKKLEKQ

--------------------------------------------------------------
>29566_29566_3_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000558083_length(transcript)=4467nt_BP=703nt
GTGGTGATGAGGGCGACGAAGGAGGGGGTGTCATTTTCTTTTTCTTTCTTTTTTTAAAAAAAGTATTTCTCTCGCGAGAAACCGCTGCGC
GGACGATACTTGAAGAGGTGGGGAAAGGAGGGGGCTGCGGGAGCCGCGGCAGAGACTGTGGGTGCCACAAGCGGACAGGAGCCACAGCTG
GGACAGCTGCGAGCGGAGCCGAGCAGTGGCTGTAGCGGCCACGACTGGGAGCAGCCGCCGCCGCCTCCTCGGGAGTCGGAGCCGCCGCTT
CTCCACTGGCAGGGGCCGCCTGAAGTGGGAGCAGCGCCTGGAGAAGGCGGGAGGAGCCCGGCCCGGGGGACGGGCGGCGGGATAGCGGGA
CCCCGGCGGCGCGGTGCGCTTCAGGGCGCAGCGGCGGCCGCAGACCGAGCCCCGGGCGCGGCAAGAGGCGGCGGGAGCCGGTGGCGGCTC
GGCATCATGCGTCGAGGGCGTCTGCTGGAGATCGCCCTGGGATTTACCGTGCTTTTAGCGTCCTACACGAGCCATGGGGCGGACGCCAAT
TTGGAGGCTGGGAACGTGAAGGAAACCAGAGCCAGTCGGGCCAAGAGAAGAGGCGGTGGAGGACACGACGCGCTTAAAGGACCCAATGTC
TGTGGATCACGTTATAATGCTTACTGTTGCCCTGGATGGAAAACCTTACCTGGCGGAAATCAGTGTATTGTCCAAGCACAGATCAGATTT
CTAAAGGCCAAACTCCATGTTATGCAGGAGGAATTGGATAATGTTGTATGTGAATGCAATAAAAAGGAGGATGAAATTCAGAATTTAAAG
TCTCAAGTAAAAAATTTTGAAGAAGATTTTATGAGACAGCAGCGAACAATTAATATGCAACAGTCTCAAGTAGAAAAATACAAAACTCTT
TTCGAAGAAGCAAACAAAAAGTATGATGGATTACAGCAACAGTTGTCTTCAGTAGAAAGGGTAATTATTTGGTATTTTTCCTAACTTAAT
GCCACAGATACAAGAAAATTATTAAGGTTACACATTTGTATAGATGCCATTTTGACAGTTCAGTTATTTTATTAGTATTTACTGAAAACT
CTTTCCCCTTACATAGAATATTTTTAACAACTTTATTGAGATGTAATTCACCCTTTTAAAGTATGCAATTCAATGGCTTTTGGTGTATTC
ATAGAATTGTGCAACTATCACCACAACCATTTTCATAATCCCTAAAAGATACTTCATACCCTTTAGCCACCACACCCTGACCCTGCTCCC
CTCAATCCCTTACAGCCCTAGGCAACCACTATTCTATTTTATGTCTCAATAAATTTGTCTATTCTGGAAATCACATATACGTGGAATCAT
ATAATATGTGGTCTTTTGTGACTGACTTTTACTTAAGATATTTTCAAGGTTCATTCATGTTGCAGCCCCTATCAGTATTTTATTTCTTTT
TATTGGCAAGTAACATTCTGTTATATGGATATAACACATTTAATTTATCTGTTTATCAGTTCGTAGCTTTAGGTTATTTGGGTTGTTTCT
ACTGTCTGACAATTTTAAATACTTTGAATATTCATGTACAAGTTTTTGTGTGCACGTATGTTTCTATTTCTCTTGGTTATATAGCCAGGA
ATGGAATTGCTGGGTCATATGGAAATCCTATGTTGACCTTTTGAGGAATTGCTGACTGTTTTCCAACCTGCCTGTACCATTTTACATTCC
TACCAGTAGTGCATGAAGCTCCTAATTTCTACACATCCTCACCAACATCTGCTAGATTATCTTTTTGATTATAGCCATACTGCAAGTGTA
AAAGGGTTACCTCATTGTGGTTTTGATTTGCATTTCCCTAATAACTAATGATGTTGAACATCTTTTCATGTGCTTATTGGCATTTGTATA
TTTTCTTTGGAGAAATGTCTGTTAAGGTCTTTGCCCATTTTTTAAATTGGATTTGAAAAAATTACTGAATAATAAGAACTTTTAAGTTCT
TTATGTGTTTAGATACAAGTCCCTTATCAGGTATATTTTGCAAATAGTTTTCCCCTACAGTGGGTTGTCTTTCACTTTCTTTATGGTACT
CTAAAGGCACAAAAGTTTTAAATTTTGATGAAGTCCAGTTTATCTAATATTTATTTGGTTTCCTGTGCTTTTGGTGTCATATTTAAGGGG
AGAATGTATTTTAAATAAACTATCCTAGCTTATATTAGTGTGCCATTGTGAAAATAAAAATATACTGTTTGAGATTGCTTTGTAAAATGT
AGTGACGATAAGAATTATGTAATATAGCATATCCCGAGATTTAGTAAGAAAATGTGCCCCCTTTATTAGTACCCTTACATTTCTCGTTTG
TATGGTCATATTTAAAAACCCTGCTTTTTAAACATTTTGGTCTTGTATAATTAGCTTTATCTTGTAATAAATTTTAATATCAAAATCACT
TAGACAAAATTTATATGCAGTAAATTCACACTTTTTAGTGTACAATTCTATGAGTTTTGACAAATGTATGCAGTAATATAACTATCACTA
TAATTGAGACATAGAACAGTTCCATCAGCCCCCCAAAATTCCCTGTGAATTTAGTGAAGGCCTTCCCTAATTCCACCACCAGGCAACCAC
TGATCTGTGTTTGGTTCTTAAATTTTGGACTTTTCCCAAATGTCACATAAATAGAATCGCATTGGATATAGACTTTTGAATCTGTTTTTT
TTTTTTTTTTTTCAGTTAGCATAAAACATTTGATATGGTTTGGCTGTGTCCCCACCCAAATTTCATCTTGAATTCCCACTTGTTGCGGGA
GGGAGCCGGTGGGAGGTAATTGAATCATGGGGGCAAGTCTTTCCTGTGCTGTTCTTGTGATGGCGAAAAAGTCTCAGGAGATCTGATGGT
TTTAAAAGGGAGAGTTTCCCAGTGCAAACTTTCTTGTCTGCTGCTATGTGAGACATGCCTTTTACTTTCCAACATGATTGTGAGGCCTCC
CCAGCCATGTGGAACTGTGAGTCCAATAAACCTCTCTCTTTTGTAAATTGCCCAGTCTTGGGTGTGTCTTACCAGCAGCATGACGATGAA
CTAATCCAGTAAATTGGTACTAGTAGAGTCAGGCGCTACTGAAAAGATACCAAAAAGTGTTGAAGTGACCTTGGAACTGGGTAAGAGGCA
GAGGTTGGAAAAGTTTGGAGGGCTCAGAAAAATACAGGAAAATATGGGAAAGTTTGGAACTCCCTAGAGACTTGTTGAATGGCTTTGACC
AATATACTGATAATGATATGGACAATGAAATCCAGGCTGAGGTGATCTCAGATGGAGATGAGGAACTTGTTAGGAACTAGAGCAAATGTG
ACTCTTGTTATGTTTTAGCAAAGAGACTGGTGGCATTTTGTCCCTCCCCTAGAGATCTGTGGAACTTTGAACTTGAGAGAGATGATTTAG
GGTATCTGGTGGAACAAATTTCTAAGCAGCAAAGCACTCAAGAGGTGACTTGGTGCTGTTAAAGGCATCCAGTTTTGAAAGGGAAACAGA
GCACAAAAGGTTGGAAAATTTGCAGCCTGAGAATGCAGTGGAAAAGAAAATCCCATTTTCTGAGGAGAAATTCAAGCCGGCTGCAGAAAT
TTGCATAAGTCTTGAGGAGCTGAATGTTAATCCCCAGGACAATGGGGAAAATGTCTCCCAAGGTATGCAGAGGTCTTCACGGCAGCGCCT
CCCATCACAGGCCCAGAGACCTAGGAGGCATGATTGGTTTTGAAATGTGAGGACATGAGATTTGGGAGGGTCTTGGGGTAGAATATGGTT
TGGCTGTGTCCCCACCCAAATTTCATCTTGAATTCCCATGTGTTGTGGGAGGGACCCAGTGGGAGGTCATTGAATCACAGGGGCAGGTCT
TTCCTGTGCTGTTCTCATGAGAGTGAATAAGTCTCAGGAGATTTGATGGTTTTAAAAATGGGAATTTCCCTGCACAAGCTCTCGTCTGCC
ACCATGTGAGATGTGCCTTTACCTTCCAGCATGATTGTGAGGCCTCCCCAGCCATGTGAAACTGTGAGTGCAGTAAATCTCTTTCTTTTG
TAAATTGCCCAGTCTTGGGTATGTCTTTATCAGCAGCATGAAAACGGACTAATACAACATTCAATATTTATCCCTATTATAGTCCATTCC
TTTTTATTGCTGAGTAGTGTAAACTATGAATGAATGTACTTCAGTTTGTTTCCCCACTCATCTAGTAATAAAAGTTAATTATAGTATTTA
ATAGTCTGAACTTGTGTTTCCAGTATGGTAGCCACTTACCATATGTGGCTAAATTGCGATGTGCTATAACTATAAAGTAAAAATCAGATT
TTGAAGAATTCATGTAAAACAGAATGAAGAATGTAAAATATCTCAAAATCTCTTTAATATTTTTTGTATTGGTTATATGTTGAAATAATA

>29566_29566_3_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000558083_length(amino acids)=299AA_BP=207
MRGRYLKRWGKEGAAGAAAETVGATSGQEPQLGQLRAEPSSGCSGHDWEQPPPPPRESEPPLLHWQGPPEVGAAPGEGGRSPARGTGGGI
AGPRRRGALQGAAAAADRAPGAARGGGSRWRLGIMRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGP
NVCGSRYNAYCCPGWKTLPGGNQCIVQAQIRFLKAKLHVMQEELDNVVCECNKKEDEIQNLKSQVKNFEEDFMRQQRTINMQQSQVEKYK

--------------------------------------------------------------
>29566_29566_4_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000561221_length(transcript)=2424nt_BP=703nt
GTGGTGATGAGGGCGACGAAGGAGGGGGTGTCATTTTCTTTTTCTTTCTTTTTTTAAAAAAAGTATTTCTCTCGCGAGAAACCGCTGCGC
GGACGATACTTGAAGAGGTGGGGAAAGGAGGGGGCTGCGGGAGCCGCGGCAGAGACTGTGGGTGCCACAAGCGGACAGGAGCCACAGCTG
GGACAGCTGCGAGCGGAGCCGAGCAGTGGCTGTAGCGGCCACGACTGGGAGCAGCCGCCGCCGCCTCCTCGGGAGTCGGAGCCGCCGCTT
CTCCACTGGCAGGGGCCGCCTGAAGTGGGAGCAGCGCCTGGAGAAGGCGGGAGGAGCCCGGCCCGGGGGACGGGCGGCGGGATAGCGGGA
CCCCGGCGGCGCGGTGCGCTTCAGGGCGCAGCGGCGGCCGCAGACCGAGCCCCGGGCGCGGCAAGAGGCGGCGGGAGCCGGTGGCGGCTC
GGCATCATGCGTCGAGGGCGTCTGCTGGAGATCGCCCTGGGATTTACCGTGCTTTTAGCGTCCTACACGAGCCATGGGGCGGACGCCAAT
TTGGAGGCTGGGAACGTGAAGGAAACCAGAGCCAGTCGGGCCAAGAGAAGAGGCGGTGGAGGACACGACGCGCTTAAAGGACCCAATGTC
TGTGGATCACGTTATAATGCTTACTGTTGCCCTGGATGGAAAACCTTACCTGGCGGAAATCAGTGTATTGTCCAAGCACAGATCAGATTT
CTAAAGGCCAAACTCCATGTTATGCAGGAGGAATTGGATAATGTTGTATGTGAATGCAATAAAAAGGAGGATGAAATTCAGAATTTAAAG
TCTCAAGTAAAAAATTTTGAAGAAGATTTTATGAGACAGCAGCGAACAATTAATATGCAACAGTCTCAAGTAGAAAAATACAAAACTCTT
TTCGAAGAAGCAAACAAAAAGTATGATGGATTACAGCAACAGTTGTCTTCAGTAGAAAGGGTAATTATTTGGTATTTTTCCTAACTTAAT
GCCACAGATACAAGAAAATTATTAAGGTTACACATTTGTATAGATGCCATTTTGACAGTTCAGTTATTTTATTAGTATTTACTGAAAACT
CTTTCCCCTTACATAGAATATTTTTAACAACTTTATTGAGATGTAATTCACCCTTTTAAAGTATGCAATTCAATGGCTTTTGGTGTATTC
ATAGAATTGTGCAACTATCACCACAACCATTTTCATAATCCCTAAAAGATACTTCATACCCTTTAGCCACCACACCCTGACCCTGCTCCC
CTCAATCCCTTACAGCCCTAGGCAACCACTATTCTATTTTATGTCTCAATAAATTTGTCTATTCTGGAAATCACATATACGTGGAATCAT
ATAATATGTGGTCTTTTGTGACTGACTTTTACTTAAGATATTTTCAAGGTTCATTCATGTTGCAGCCCCTATCAGTATTTTATTTCTTTT
TATTGGCAAGTAACATTCTGTTATATGGATATAACACATTTAATTTATCTGTTTATCAGTTCGTAGCTTTAGGTTATTTGGGTTGTTTCT
ACTGTCTGACAATTTTAAATACTTTGAATATTCATGTACAAGTTTTTGTGTGCACGTATGTTTCTATTTCTCTTGGTTATATAGCCAGGA
ATGGAATTGCTGGGTCATATGGAAATCCTATGTTGACCTTTTGAGGAATTGCTGACTGTTTTCCAACCTGCCTGTACCATTTTACATTCC
TACCAGTAGTGCATGAAGCTCCTAATTTCTACACATCCTCACCAACATCTGCTAGATTATCTTTTTGATTATAGCCATACTGCAAGTGTA
AAAGGGTTACCTCATTGTGGTTTTGATTTGCATTTCCCTAATAACTAATGATGTTGAACATCTTTTCATGTGCTTATTGGCATTTGTATA
TTTTCTTTGGAGAAATGTCTGTTAAGGTCTTTGCCCATTTTTTAAATTGGATTTGAAAAAATTACTGAATAATAAGAACTTTTAAGTTCT
TTATGTGTTTAGATACAAGTCCCTTATCAGGTATATTTTGCAAATAGTTTTCCCCTACAGTGGGTTGTCTTTCACTTTCTTTATGGTACT
CTAAAGGCACAAAAGTTTTAAATTTTGATGAAGTCCAGTTTATCTAATATTTATTTGGTTTCCTGTGCTTTTGGTGTCATATTTAAGGGG
AGAATGTATTTTAAATAAACTATCCTAGCTTATATTAGTGTGCCATTGTGAAAATAAAAATATACTGTTTGAGATTGCTTTGTAAAATGT
AGTGACGATAAGAATTATGTAATATAGCATATCCCGAGATTTAGTAAGAAAATGTGCCCCCTTTATTAGTACCCTTACATTTCTCGTTTG

>29566_29566_4_FBN1-TEX9_FBN1_chr15_48905207_ENST00000316623_TEX9_chr15_56686363_ENST00000561221_length(amino acids)=299AA_BP=207
MRGRYLKRWGKEGAAGAAAETVGATSGQEPQLGQLRAEPSSGCSGHDWEQPPPPPRESEPPLLHWQGPPEVGAAPGEGGRSPARGTGGGI
AGPRRRGALQGAAAAADRAPGAARGGGSRWRLGIMRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGP
NVCGSRYNAYCCPGWKTLPGGNQCIVQAQIRFLKAKLHVMQEELDNVVCECNKKEDEIQNLKSQVKNFEEDFMRQQRTINMQQSQVEKYK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBN1-TEX9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	FBN1	chr15:48905207	chr15:56686363	ENST00000316623	-	3	66	119_329	82.33333333333333	2872.0	MFAP4

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FBN1-TEX9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FBN1-TEX9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source