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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL19-C16orf71 (FusionGDB2 ID:29616)

Fusion Gene Summary for FBXL19-C16orf71

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL19-C16orf71
Fusion gene ID: 29616
HgeneTgene
Gene symbol

FBXL19

C16orf71

Gene ID

54620

146562

Gene nameF-box and leucine rich repeat protein 19chromosome 16 open reading frame 71
SynonymsCXXC11|Fbl19|JHDM1C-
Cytomap

16p11.2

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 19jumonji C domain-containing histone demethylase 1Cuncharacterized protein C16orf71
Modification date2020031320200313
UniProtAcc

Q6PCT2

.
Ensembl transtripts involved in fusion geneENST00000471231, ENST00000338343, 
ENST00000380310, ENST00000562319, 
ENST00000565690, 		ENST00000299320, 
ENST00000590191, 
Fusion gene scores* DoF score9 X 7 X 7=4412 X 2 X 2=8
# samples 92
** MAII scorelog2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: FBXL19 [Title/Abstract] AND C16orf71 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL19(30939284)-C16orf71(4790154), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL19

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

22660580


check buttonFusion gene breakpoints across FBXL19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C16orf71 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A0K8-01AFBXL19chr16

30939284

+C16orf71chr16

4790154

+


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Fusion Gene ORF analysis for FBXL19-C16orf71

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000471231ENST00000299320FBXL19chr16

30939284

+C16orf71chr16

4790154

+
5UTR-3CDSENST00000471231ENST00000590191FBXL19chr16

30939284

+C16orf71chr16

4790154

+
In-frameENST00000338343ENST00000299320FBXL19chr16

30939284

+C16orf71chr16

4790154

+
In-frameENST00000338343ENST00000590191FBXL19chr16

30939284

+C16orf71chr16

4790154

+
In-frameENST00000380310ENST00000299320FBXL19chr16

30939284

+C16orf71chr16

4790154

+
In-frameENST00000380310ENST00000590191FBXL19chr16

30939284

+C16orf71chr16

4790154

+
In-frameENST00000562319ENST00000299320FBXL19chr16

30939284

+C16orf71chr16

4790154

+
In-frameENST00000562319ENST00000590191FBXL19chr16

30939284

+C16orf71chr16

4790154

+
intron-3CDSENST00000565690ENST00000299320FBXL19chr16

30939284

+C16orf71chr16

4790154

+
intron-3CDSENST00000565690ENST00000590191FBXL19chr16

30939284

+C16orf71chr16

4790154

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338343FBXL19chr1630939284+ENST00000299320C16orf71chr164790154+29821014512300749
ENST00000338343FBXL19chr1630939284+ENST00000590191C16orf71chr164790154+29901014512309752
ENST00000562319FBXL19chr1630939284+ENST00000299320C16orf71chr164790154+2813845472131694
ENST00000562319FBXL19chr1630939284+ENST00000590191C16orf71chr164790154+2821845472140697
ENST00000380310FBXL19chr1630939284+ENST00000299320C16orf71chr164790154+2813845472131694
ENST00000380310FBXL19chr1630939284+ENST00000590191C16orf71chr164790154+2821845472140697

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338343ENST00000299320FBXL19chr1630939284+C16orf71chr164790154+0.131222160.8687779
ENST00000338343ENST00000590191FBXL19chr1630939284+C16orf71chr164790154+0.130478170.8695218
ENST00000562319ENST00000299320FBXL19chr1630939284+C16orf71chr164790154+0.117589430.8824106
ENST00000562319ENST00000590191FBXL19chr1630939284+C16orf71chr164790154+0.116326180.88367385
ENST00000380310ENST00000299320FBXL19chr1630939284+C16orf71chr164790154+0.117589430.8824106
ENST00000380310ENST00000590191FBXL19chr1630939284+C16orf71chr164790154+0.116326180.88367385

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Fusion Genomic Features for FBXL19-C16orf71


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXL19chr1630939284+C16orf71chr164790153+0.16571150.8342885
FBXL19chr1630939284+C16orf71chr164790153+0.16571150.8342885

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXL19-C16orf71


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:30939284/chr16:4790154)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL19

Q6PCT2

.
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034). {ECO:0000250, ECO:0000269|PubMed:29276034}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+51122_25229695.0Compositional biasNote=Poly-Ser
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+51133_47229695.0Compositional biasNote=Arg-rich
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+51132_78229695.0Zinc fingerCXXC-type
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+51185_151229695.0Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511186_302229695.0Compositional biasNote=Pro-rich
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511324_342229695.0Compositional biasNote=Ser-rich
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511375_425229695.0Compositional biasNote=Pro-rich
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511418_464229695.0DomainNote=F-box
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511492_517229695.0RepeatNote=LRR 1
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511518_541229695.0RepeatNote=LRR 2
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511581_606229695.0RepeatNote=LRR 3
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511607_636229695.0RepeatNote=LRR 4
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511637_661229695.0RepeatNote=LRR 5
HgeneFBXL19chr16:30939284chr16:4790154ENST00000380310+511662_694229695.0RepeatNote=LRR 6


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Fusion Gene Sequence for FBXL19-C16orf71


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29616_29616_1_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000338343_C16orf71_chr16_4790154_ENST00000299320_length(transcript)=2982nt_BP=1014nt
GGGAGGGGAGCTGGGACTCGGACCCGGGACTGAGTGGGCCCCGGGCAGAAGCTGAGCACCCTGCGCCCAAGGAGCCCCCGTTGGCCTGGG
GGGGCTGAGGGACTGAGCCTCCCAGAGCAGGACCTCCCCCTGGAAGGGCCGCGCCGCAGCCCGTGGGAGGGCCTCGCCCCCGGCGCCCCC
CATCTCCACTCGCCGCCGTCCCGGCCTCCGCCGGAGGGAGGGGCCGAGCGCCCTCGGGGGGCCGTGGACCCCGGCGTTCTGAGCGTTCCG
CGCCCCGCGCCGCCCGGCCCCCCCGCCGCCGATGGCCGCCGACCCGCCGGGAGCTGCCGAGAAGGGAGAGATGGCTCCCGGGACACGTGT
GAGCCCTCGGCGTTGCTGACGCCCCCAATGTCGTCGAGCAGCCGGGGGCCGGGGGCCGGAGCGCGCCGACGCCGAACCCGCTGCCGCCGC
TGCCGGGCCTGTGTGCGAACTGAGTGCGGGGATTGCCACTTCTGCCGAGACATGAAGAAGTTCGGGGGGCCCGGGCGCATGAAGCAGTCG
TGCCTGCTCCGGCAGTGCACTGCCCCCGTGCTCCCACACACAGCTGTGTGCCTCTTGTGTGGGGAGGCTGGGAAGGAGGACACGGTGGAG
GGAGAGGAAGAGAAATTTGGTTTGAGCCTCATGGAGTGTACAATCTGCAACGAGATCGTCCACCCCGGCTGCCTGAAGATGGGGAAGGCT
GAGGGTGTCATCAATGCAGAGATCCCCAACTGCTGGGAGTGCCCTCGCTGCACCCAGGAAGGCCGCACCAGCAAGGATTCAGGTGAGGGG
CCTGGCCGCCGTAGGGCCGACAACGGCGAGGAGGGCGCCAGCTTGGGGAGCGGATGGAAGCTGACAGAGGAGCCACCGCTTCCACCGCCC
CCGCCCAGGCGCAAGGGCCCCCTGCCTGCCGGGCCCCCCCCGGAGGACGTGCCTGGGCCCCCCAAACGAAAGGAAAGGGAGGCAGGGAAT
GAGCCTCCCACCCCAAGGAAAAAGCCAGTTCTGGTGCCTGCAGAATTGGCCACAGAACCTGGGTGCAGACAGAACACAAGGACAAAGGAT
GCATCCTCTCAGGAAGGAAGAGACCCTGGCAGGCCTTTTGAAAGCTCTGGTGAGGTCAGCGCTCTTCTTGGGATGGCCGAGGAGCCCCCC
AGGTGGCTGGAAGGCGACCTTGGAAGCCTGTCTTTCAACACCAAAGGATCCCAGGGTCCTCCCTGGGACCCACAGGCCGAAGCCACTCTC
TCCTGCCATGAAGGAGACCCAAAGGCAGAGCCCCTCAGCACTGCCTCACAAGAATCTGTGAACCGCCGGGCCCTCCGACAGGAGAGAAGG
AAGATGATAGAGACGGACATCCTCCAGAAAGTCACCCGGGATGCCTGCGGCCCGACCAGCAGTGACAAAGGTGGGGTGAAGGAGGCGCCC
TGCCACGCTGCGGAGTCAGCTCCCAGATCCAAAATGCCCCTCGTGGAGCCTCCGGAGGGACCACCAGTGCTCTCGCTCCAGCAACTTGAA
GCGTGGGATTTGGATGACATCCTTCAGAGTCTGGCGGGACAAGAAGACAACCAGGGAAATCGTGCACCTGGAACTGTGTGGTGGGCAGCT
GACCACCGCCAAGTTCAAGACCGCATGGTGCCGAGCGCCCACAACAGGCTCATGGAACAGCTGGCCCTCCTGTGCACCACGCAGTCCAAG
GCCTCTGCTTGTGCCCGGAAGGTGCCTGCCGACACTCCCCAGGACACCAAAGAGGCAGATTCAGGAAGCAGATGTGCCTCAAGGAAGCAG
GGCTCCCAGGCTGGGCCAGGCCCGCAGCTGGCCCAGGGCATGAGGCTTAACGCAGAGTCCCCCACCATCTTTATTGACCTGCGGCAGATG
GAGCTACCAGACCACCTGTCCCCAGAAAGCTCCAGCCACAGCTCCTCTGACAGTGAGGAGGAGGAGGAGGAAGAGATGGCAGCTCTGGGA
GACGCAGAGGGGGCATCTCCTTCCTCCCTGGGGCTACGGACCTGTACCGGGAAAAGCCAGCTTCTCCAGCAGCTCAGGGCCTTTCAGAAG
GGGACAGCCCAGCCCGAGCTGCCTGCCAGCAAGGGGCCCGCGGGTGGGAGGGCTCAGGCCCCTGAAGACACAGCTGGATCACGAACTGGG
AGGAAGCAACACATGAAGCTCTGTGCCAAGGGGCAGAGCGCCCAGGCTCGACTCCCAAGAGGCAGGCCCAGAGCCCTGGGGGATGTTCCT
GAGCCAGGGGCAGCCAGGGAGGCCCTGATGCCTCCTCTGGAGCAACTATAGCTGCCTCAGGATGTGTCCTGCTGTCTGCCCCGTGGGAAG
AGCAGAGAAATCATCACCACCTTGGGCCCCACGGTGCCACGGGCTCAGGCAGCACAGTAGGGCGCCGGGCCTTTGGGACAGTGTCCCAGC
TTCCCCTGGGGTTCACCCCTGGCTGCCAGGCCACTGAGGATGGGCAGGGGTCTCTTCTCATCAAGCCTTGTACCAGGCAAAAGACAGGCC
CTGCTTGGCCGTGGTCACTGGCCGCCAAGATCAGGGCTACAGATGTCTGCTCTCTGGACCCCACGTGATCTGGCCACTGGGGACCCCCAC
CCGACCCCACTCCCAATGATGAGGGGCATTTTCATTGCAAGTCAAAGGCAAGACAGGCTTCCATAAAGTCCCAGGAGGTCCCTCCTGTAG
GGCACAAGGCCAGGCTGCCTCCCAGCCCCCAGGCCCTCTCCCACCTACAGAGACCCTCCCCTGCCCCCTCCACTCCGGGGCCTGTGCCGC
CAGAACCGGGCTCTGCCCCCATACGCTGCCCTCGCAGCCTGGCGGCCTCCGCTGTGGCTGCCTAGCTGTCAAGAGCAAAGGCTTTTTTTT
TCTTCAACCCCATTTTCTTCCATTTCTCCCACCTTTTTAATGCCAGTAACCTCACTGAGAATGTTTTACAGTGATGGAAAATAAACTCTG

>29616_29616_1_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000338343_C16orf71_chr16_4790154_ENST00000299320_length(amino acids)=749AA_BP=321
MSTLRPRSPRWPGGAEGLSLPEQDLPLEGPRRSPWEGLAPGAPHLHSPPSRPPPEGGAERPRGAVDPGVLSVPRPAPPGPPAADGRRPAG
SCREGRDGSRDTCEPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVC
LLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGS
GWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKPVLVPAELATEPGCRQNTRTKDASSQEGRDPGRPFESSG
EVSALLGMAEEPPRWLEGDLGSLSFNTKGSQGPPWDPQAEATLSCHEGDPKAEPLSTASQESVNRRALRQERRKMIETDILQKVTRDACG
PTSSDKGGVKEAPCHAAESAPRSKMPLVEPPEGPPVLSLQQLEAWDLDDILQSLAGQEDNQGNRAPGTVWWAADHRQVQDRMVPSAHNRL
MEQLALLCTTQSKASACARKVPADTPQDTKEADSGSRCASRKQGSQAGPGPQLAQGMRLNAESPTIFIDLRQMELPDHLSPESSSHSSSD
SEEEEEEEMAALGDAEGASPSSLGLRTCTGKSQLLQQLRAFQKGTAQPELPASKGPAGGRAQAPEDTAGSRTGRKQHMKLCAKGQSAQAR

--------------------------------------------------------------
>29616_29616_2_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000338343_C16orf71_chr16_4790154_ENST00000590191_length(transcript)=2990nt_BP=1014nt
GGGAGGGGAGCTGGGACTCGGACCCGGGACTGAGTGGGCCCCGGGCAGAAGCTGAGCACCCTGCGCCCAAGGAGCCCCCGTTGGCCTGGG
GGGGCTGAGGGACTGAGCCTCCCAGAGCAGGACCTCCCCCTGGAAGGGCCGCGCCGCAGCCCGTGGGAGGGCCTCGCCCCCGGCGCCCCC
CATCTCCACTCGCCGCCGTCCCGGCCTCCGCCGGAGGGAGGGGCCGAGCGCCCTCGGGGGGCCGTGGACCCCGGCGTTCTGAGCGTTCCG
CGCCCCGCGCCGCCCGGCCCCCCCGCCGCCGATGGCCGCCGACCCGCCGGGAGCTGCCGAGAAGGGAGAGATGGCTCCCGGGACACGTGT
GAGCCCTCGGCGTTGCTGACGCCCCCAATGTCGTCGAGCAGCCGGGGGCCGGGGGCCGGAGCGCGCCGACGCCGAACCCGCTGCCGCCGC
TGCCGGGCCTGTGTGCGAACTGAGTGCGGGGATTGCCACTTCTGCCGAGACATGAAGAAGTTCGGGGGGCCCGGGCGCATGAAGCAGTCG
TGCCTGCTCCGGCAGTGCACTGCCCCCGTGCTCCCACACACAGCTGTGTGCCTCTTGTGTGGGGAGGCTGGGAAGGAGGACACGGTGGAG
GGAGAGGAAGAGAAATTTGGTTTGAGCCTCATGGAGTGTACAATCTGCAACGAGATCGTCCACCCCGGCTGCCTGAAGATGGGGAAGGCT
GAGGGTGTCATCAATGCAGAGATCCCCAACTGCTGGGAGTGCCCTCGCTGCACCCAGGAAGGCCGCACCAGCAAGGATTCAGGTGAGGGG
CCTGGCCGCCGTAGGGCCGACAACGGCGAGGAGGGCGCCAGCTTGGGGAGCGGATGGAAGCTGACAGAGGAGCCACCGCTTCCACCGCCC
CCGCCCAGGCGCAAGGGCCCCCTGCCTGCCGGGCCCCCCCCGGAGGACGTGCCTGGGCCCCCCAAACGAAAGGAAAGGGAGGCAGGGAAT
GAGCCTCCCACCCCAAGGAAAAAGCCAGTTCTGGTGCCTGCAGAATTGGCCACAGAACCTGGGTGCAGACAGAACACAAGGACAAAGGAT
GCATCCTCTCAGGAAGGAAGAGACCCTGGCAGGCCTTTTGAAAGCTCTGGTGAGGTCAGCGCTCTTCTTGGGATGGCCGAGGAGCCCCCC
AGGTGGCTGGAAGGCGACCTTGGAAGCCTGTCTTTCAACACCAAAGGATCCCAGGGTCCTCCCTGGGACCCACAGGCCGAAGCCACTCTC
TCCTGCCATGAAGGAGACCCAAAGGCAGAGCCCCTCAGCACTGCCTCACAAGAATCTGTGAACCGCCGGGCCCTCCGACAGGAGAGAAGG
AAGATGATAGAGACGGACATCCTCCAGAAAGTCACCCGGGATGCCTGCGGCCCGACCAGCAGTGACAAAGGTGGGGTGAAGGAGGCGCCC
TGCCACGCTGCGGAGTCAGCTCCCAGATCCAAAATGCCCCTCGTGGAGCCTCCGGAGGGACCACCAGTGCTCTCGCTCCAGCAACTTGAA
GCGTGGGATTTGGATGACATCCTTCAGAGTCTGGCGGGACAAGAAGACAACCAGGGAAATCGTGCACCTGGAACTGTGTGGTGGGCAGCT
GACCACCGCCAAGTTCAAGACCGCATGGTGCCGAGCGCCCACAACAGGCTCATGGAACAGCTGGCCCTCCTGTGCACCACGCAGTCCAAG
GCCTCTGCTTGTGCCCGGAAGGTGCCTGCCGACACTCCCCAGGACACCAAAGAGGCAGATTCAGGAAGCAGATGTGCCTCAAGGAAGCAG
GGCTCCCAGGCTGGGCCAGGCCCGCAGCTGGCCCAGGGCATGAGGCTTAACGCAGAGTCCCCCACCATCTTTATTGACCTGCGGCAGATG
GAGCTACCAGACCACCTGTCCCCAGAAAGGTCCGGAGGCTCCAGCCACAGCTCCTCTGACAGTGAGGAGGAGGAGGAGGAAGAGATGGCA
GCTCTGGGAGACGCAGAGGGGGCATCTCCTTCCTCCCTGGGGCTACGGACCTGTACCGGGAAAAGCCAGCTTCTCCAGCAGCTCAGGGCC
TTTCAGAAGGGGACAGCCCAGCCCGAGCTGCCTGCCAGCAAGGGGCCCGCGGGTGGGAGGGCTCAGGCCCCTGAAGACACAGCTGGATCA
CGAACTGGGAGGAAGCAACACATGAAGCTCTGTGCCAAGGGGCAGAGCGCCCAGGCTCGACTCCCAAGAGGCAGGCCCAGAGCCCTGGGG
GATGTTCCTGAGCCAGGGGCAGCCAGGGAGGCCCTGATGCCTCCTCTGGAGCAACTATAGCTGCCTCAGGATGTGTCCTGCTGTCTGCCC
CGTGGGAAGAGCAGAGAAATCATCACCACCTTGGGCCCCACGGTGCCACGGGCTCAGGCAGCACAGTAGGGCGCCGGGCCTTTGGGACAG
TGTCCCAGCTTCCCCTGGGGTTCACCCCTGGCTGCCAGGCCACTGAGGATGGGCAGGGGTCTCTTCTCATCAAGCCTTGTACCAGGCAAA
AGACAGGCCCTGCTTGGCCGTGGTCACTGGCCGCCAAGATCAGGGCTACAGATGTCTGCTCTCTGGACCCCACGTGATCTGGCCACTGGG
GACCCCCACCCGACCCCACTCCCAATGATGAGGGGCATTTTCATTGCAAGTCAAAGGCAAGACAGGCTTCCATAAAGTCCCAGGAGGTCC
CTCCTGTAGGGCACAAGGCCAGGCTGCCTCCCAGCCCCCAGGCCCTCTCCCACCTACAGAGACCCTCCCCTGCCCCCTCCACTCCGGGGC
CTGTGCCGCCAGAACCGGGCTCTGCCCCCATACGCTGCCCTCGCAGCCTGGCGGCCTCCGCTGTGGCTGCCTAGCTGTCAAGAGCAAAGG
CTTTTTTTTTCTTCAACCCCATTTTCTTCCATTTCTCCCACCTTTTTAATGCCAGTAACCTCACTGAGAATGTTTTACAGTGATGGAAAA

>29616_29616_2_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000338343_C16orf71_chr16_4790154_ENST00000590191_length(amino acids)=752AA_BP=321
MSTLRPRSPRWPGGAEGLSLPEQDLPLEGPRRSPWEGLAPGAPHLHSPPSRPPPEGGAERPRGAVDPGVLSVPRPAPPGPPAADGRRPAG
SCREGRDGSRDTCEPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVC
LLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGS
GWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKPVLVPAELATEPGCRQNTRTKDASSQEGRDPGRPFESSG
EVSALLGMAEEPPRWLEGDLGSLSFNTKGSQGPPWDPQAEATLSCHEGDPKAEPLSTASQESVNRRALRQERRKMIETDILQKVTRDACG
PTSSDKGGVKEAPCHAAESAPRSKMPLVEPPEGPPVLSLQQLEAWDLDDILQSLAGQEDNQGNRAPGTVWWAADHRQVQDRMVPSAHNRL
MEQLALLCTTQSKASACARKVPADTPQDTKEADSGSRCASRKQGSQAGPGPQLAQGMRLNAESPTIFIDLRQMELPDHLSPERSGGSSHS
SSDSEEEEEEEMAALGDAEGASPSSLGLRTCTGKSQLLQQLRAFQKGTAQPELPASKGPAGGRAQAPEDTAGSRTGRKQHMKLCAKGQSA

--------------------------------------------------------------
>29616_29616_3_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000380310_C16orf71_chr16_4790154_ENST00000299320_length(transcript)=2813nt_BP=845nt
AAACTCATCTCCAGCCCTCCTTCCTATGACCTCTCCACCCTGGGGAACTGGCCCTCCTTCCTAGACCCTGCTTCCCCTTGAAAGCCCCCA
CCCCCGCCTGCAGTCGCCGCCCTCCAGGCCCCTCCCCTGGAGCGCTGGAGGGCCCCTTAGCCCCATGGATGGGTATGAAAGTCCCCGGAA
AGGGGGAATCTGGGCCCTCGGCGTTGCTGACGCCCCCAATGTCGTCGAGCAGCCGGGGGCCGGGGGCCGGAGCGCGCCGACGCCGAACCC
GCTGCCGCCGCTGCCGGGCCTGTGTGCGAACTGAGTGCGGGGATTGCCACTTCTGCCGAGACATGAAGAAGTTCGGGGGGCCCGGGCGCA
TGAAGCAGTCGTGCCTGCTCCGGCAGTGCACTGCCCCCGTGCTCCCACACACAGCTGTGTGCCTCTTGTGTGGGGAGGCTGGGAAGGAGG
ACACGGTGGAGGGAGAGGAAGAGAAATTTGGTTTGAGCCTCATGGAGTGTACAATCTGCAACGAGATCGTCCACCCCGGCTGCCTGAAGA
TGGGGAAGGCTGAGGGTGTCATCAATGCAGAGATCCCCAACTGCTGGGAGTGCCCTCGCTGCACCCAGGAAGGCCGCACCAGCAAGGATT
CAGGTGAGGGGCCTGGCCGCCGTAGGGCCGACAACGGCGAGGAGGGCGCCAGCTTGGGGAGCGGATGGAAGCTGACAGAGGAGCCACCGC
TTCCACCGCCCCCGCCCAGGCGCAAGGGCCCCCTGCCTGCCGGGCCCCCCCCGGAGGACGTGCCTGGGCCCCCCAAACGAAAGGAAAGGG
AGGCAGGGAATGAGCCTCCCACCCCAAGGAAAAAGCCAGTTCTGGTGCCTGCAGAATTGGCCACAGAACCTGGGTGCAGACAGAACACAA
GGACAAAGGATGCATCCTCTCAGGAAGGAAGAGACCCTGGCAGGCCTTTTGAAAGCTCTGGTGAGGTCAGCGCTCTTCTTGGGATGGCCG
AGGAGCCCCCCAGGTGGCTGGAAGGCGACCTTGGAAGCCTGTCTTTCAACACCAAAGGATCCCAGGGTCCTCCCTGGGACCCACAGGCCG
AAGCCACTCTCTCCTGCCATGAAGGAGACCCAAAGGCAGAGCCCCTCAGCACTGCCTCACAAGAATCTGTGAACCGCCGGGCCCTCCGAC
AGGAGAGAAGGAAGATGATAGAGACGGACATCCTCCAGAAAGTCACCCGGGATGCCTGCGGCCCGACCAGCAGTGACAAAGGTGGGGTGA
AGGAGGCGCCCTGCCACGCTGCGGAGTCAGCTCCCAGATCCAAAATGCCCCTCGTGGAGCCTCCGGAGGGACCACCAGTGCTCTCGCTCC
AGCAACTTGAAGCGTGGGATTTGGATGACATCCTTCAGAGTCTGGCGGGACAAGAAGACAACCAGGGAAATCGTGCACCTGGAACTGTGT
GGTGGGCAGCTGACCACCGCCAAGTTCAAGACCGCATGGTGCCGAGCGCCCACAACAGGCTCATGGAACAGCTGGCCCTCCTGTGCACCA
CGCAGTCCAAGGCCTCTGCTTGTGCCCGGAAGGTGCCTGCCGACACTCCCCAGGACACCAAAGAGGCAGATTCAGGAAGCAGATGTGCCT
CAAGGAAGCAGGGCTCCCAGGCTGGGCCAGGCCCGCAGCTGGCCCAGGGCATGAGGCTTAACGCAGAGTCCCCCACCATCTTTATTGACC
TGCGGCAGATGGAGCTACCAGACCACCTGTCCCCAGAAAGCTCCAGCCACAGCTCCTCTGACAGTGAGGAGGAGGAGGAGGAAGAGATGG
CAGCTCTGGGAGACGCAGAGGGGGCATCTCCTTCCTCCCTGGGGCTACGGACCTGTACCGGGAAAAGCCAGCTTCTCCAGCAGCTCAGGG
CCTTTCAGAAGGGGACAGCCCAGCCCGAGCTGCCTGCCAGCAAGGGGCCCGCGGGTGGGAGGGCTCAGGCCCCTGAAGACACAGCTGGAT
CACGAACTGGGAGGAAGCAACACATGAAGCTCTGTGCCAAGGGGCAGAGCGCCCAGGCTCGACTCCCAAGAGGCAGGCCCAGAGCCCTGG
GGGATGTTCCTGAGCCAGGGGCAGCCAGGGAGGCCCTGATGCCTCCTCTGGAGCAACTATAGCTGCCTCAGGATGTGTCCTGCTGTCTGC
CCCGTGGGAAGAGCAGAGAAATCATCACCACCTTGGGCCCCACGGTGCCACGGGCTCAGGCAGCACAGTAGGGCGCCGGGCCTTTGGGAC
AGTGTCCCAGCTTCCCCTGGGGTTCACCCCTGGCTGCCAGGCCACTGAGGATGGGCAGGGGTCTCTTCTCATCAAGCCTTGTACCAGGCA
AAAGACAGGCCCTGCTTGGCCGTGGTCACTGGCCGCCAAGATCAGGGCTACAGATGTCTGCTCTCTGGACCCCACGTGATCTGGCCACTG
GGGACCCCCACCCGACCCCACTCCCAATGATGAGGGGCATTTTCATTGCAAGTCAAAGGCAAGACAGGCTTCCATAAAGTCCCAGGAGGT
CCCTCCTGTAGGGCACAAGGCCAGGCTGCCTCCCAGCCCCCAGGCCCTCTCCCACCTACAGAGACCCTCCCCTGCCCCCTCCACTCCGGG
GCCTGTGCCGCCAGAACCGGGCTCTGCCCCCATACGCTGCCCTCGCAGCCTGGCGGCCTCCGCTGTGGCTGCCTAGCTGTCAAGAGCAAA
GGCTTTTTTTTTCTTCAACCCCATTTTCTTCCATTTCTCCCACCTTTTTAATGCCAGTAACCTCACTGAGAATGTTTTACAGTGATGGAA

>29616_29616_3_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000380310_C16orf71_chr16_4790154_ENST00000299320_length(amino acids)=694AA_BP=266
MALLPRPCFPLKAPTPACSRRPPGPSPGALEGPLAPWMGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDC
HFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCW
ECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKPVLV
PAELATEPGCRQNTRTKDASSQEGRDPGRPFESSGEVSALLGMAEEPPRWLEGDLGSLSFNTKGSQGPPWDPQAEATLSCHEGDPKAEPL
STASQESVNRRALRQERRKMIETDILQKVTRDACGPTSSDKGGVKEAPCHAAESAPRSKMPLVEPPEGPPVLSLQQLEAWDLDDILQSLA
GQEDNQGNRAPGTVWWAADHRQVQDRMVPSAHNRLMEQLALLCTTQSKASACARKVPADTPQDTKEADSGSRCASRKQGSQAGPGPQLAQ
GMRLNAESPTIFIDLRQMELPDHLSPESSSHSSSDSEEEEEEEMAALGDAEGASPSSLGLRTCTGKSQLLQQLRAFQKGTAQPELPASKG

--------------------------------------------------------------
>29616_29616_4_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000380310_C16orf71_chr16_4790154_ENST00000590191_length(transcript)=2821nt_BP=845nt
AAACTCATCTCCAGCCCTCCTTCCTATGACCTCTCCACCCTGGGGAACTGGCCCTCCTTCCTAGACCCTGCTTCCCCTTGAAAGCCCCCA
CCCCCGCCTGCAGTCGCCGCCCTCCAGGCCCCTCCCCTGGAGCGCTGGAGGGCCCCTTAGCCCCATGGATGGGTATGAAAGTCCCCGGAA
AGGGGGAATCTGGGCCCTCGGCGTTGCTGACGCCCCCAATGTCGTCGAGCAGCCGGGGGCCGGGGGCCGGAGCGCGCCGACGCCGAACCC
GCTGCCGCCGCTGCCGGGCCTGTGTGCGAACTGAGTGCGGGGATTGCCACTTCTGCCGAGACATGAAGAAGTTCGGGGGGCCCGGGCGCA
TGAAGCAGTCGTGCCTGCTCCGGCAGTGCACTGCCCCCGTGCTCCCACACACAGCTGTGTGCCTCTTGTGTGGGGAGGCTGGGAAGGAGG
ACACGGTGGAGGGAGAGGAAGAGAAATTTGGTTTGAGCCTCATGGAGTGTACAATCTGCAACGAGATCGTCCACCCCGGCTGCCTGAAGA
TGGGGAAGGCTGAGGGTGTCATCAATGCAGAGATCCCCAACTGCTGGGAGTGCCCTCGCTGCACCCAGGAAGGCCGCACCAGCAAGGATT
CAGGTGAGGGGCCTGGCCGCCGTAGGGCCGACAACGGCGAGGAGGGCGCCAGCTTGGGGAGCGGATGGAAGCTGACAGAGGAGCCACCGC
TTCCACCGCCCCCGCCCAGGCGCAAGGGCCCCCTGCCTGCCGGGCCCCCCCCGGAGGACGTGCCTGGGCCCCCCAAACGAAAGGAAAGGG
AGGCAGGGAATGAGCCTCCCACCCCAAGGAAAAAGCCAGTTCTGGTGCCTGCAGAATTGGCCACAGAACCTGGGTGCAGACAGAACACAA
GGACAAAGGATGCATCCTCTCAGGAAGGAAGAGACCCTGGCAGGCCTTTTGAAAGCTCTGGTGAGGTCAGCGCTCTTCTTGGGATGGCCG
AGGAGCCCCCCAGGTGGCTGGAAGGCGACCTTGGAAGCCTGTCTTTCAACACCAAAGGATCCCAGGGTCCTCCCTGGGACCCACAGGCCG
AAGCCACTCTCTCCTGCCATGAAGGAGACCCAAAGGCAGAGCCCCTCAGCACTGCCTCACAAGAATCTGTGAACCGCCGGGCCCTCCGAC
AGGAGAGAAGGAAGATGATAGAGACGGACATCCTCCAGAAAGTCACCCGGGATGCCTGCGGCCCGACCAGCAGTGACAAAGGTGGGGTGA
AGGAGGCGCCCTGCCACGCTGCGGAGTCAGCTCCCAGATCCAAAATGCCCCTCGTGGAGCCTCCGGAGGGACCACCAGTGCTCTCGCTCC
AGCAACTTGAAGCGTGGGATTTGGATGACATCCTTCAGAGTCTGGCGGGACAAGAAGACAACCAGGGAAATCGTGCACCTGGAACTGTGT
GGTGGGCAGCTGACCACCGCCAAGTTCAAGACCGCATGGTGCCGAGCGCCCACAACAGGCTCATGGAACAGCTGGCCCTCCTGTGCACCA
CGCAGTCCAAGGCCTCTGCTTGTGCCCGGAAGGTGCCTGCCGACACTCCCCAGGACACCAAAGAGGCAGATTCAGGAAGCAGATGTGCCT
CAAGGAAGCAGGGCTCCCAGGCTGGGCCAGGCCCGCAGCTGGCCCAGGGCATGAGGCTTAACGCAGAGTCCCCCACCATCTTTATTGACC
TGCGGCAGATGGAGCTACCAGACCACCTGTCCCCAGAAAGGTCCGGAGGCTCCAGCCACAGCTCCTCTGACAGTGAGGAGGAGGAGGAGG
AAGAGATGGCAGCTCTGGGAGACGCAGAGGGGGCATCTCCTTCCTCCCTGGGGCTACGGACCTGTACCGGGAAAAGCCAGCTTCTCCAGC
AGCTCAGGGCCTTTCAGAAGGGGACAGCCCAGCCCGAGCTGCCTGCCAGCAAGGGGCCCGCGGGTGGGAGGGCTCAGGCCCCTGAAGACA
CAGCTGGATCACGAACTGGGAGGAAGCAACACATGAAGCTCTGTGCCAAGGGGCAGAGCGCCCAGGCTCGACTCCCAAGAGGCAGGCCCA
GAGCCCTGGGGGATGTTCCTGAGCCAGGGGCAGCCAGGGAGGCCCTGATGCCTCCTCTGGAGCAACTATAGCTGCCTCAGGATGTGTCCT
GCTGTCTGCCCCGTGGGAAGAGCAGAGAAATCATCACCACCTTGGGCCCCACGGTGCCACGGGCTCAGGCAGCACAGTAGGGCGCCGGGC
CTTTGGGACAGTGTCCCAGCTTCCCCTGGGGTTCACCCCTGGCTGCCAGGCCACTGAGGATGGGCAGGGGTCTCTTCTCATCAAGCCTTG
TACCAGGCAAAAGACAGGCCCTGCTTGGCCGTGGTCACTGGCCGCCAAGATCAGGGCTACAGATGTCTGCTCTCTGGACCCCACGTGATC
TGGCCACTGGGGACCCCCACCCGACCCCACTCCCAATGATGAGGGGCATTTTCATTGCAAGTCAAAGGCAAGACAGGCTTCCATAAAGTC
CCAGGAGGTCCCTCCTGTAGGGCACAAGGCCAGGCTGCCTCCCAGCCCCCAGGCCCTCTCCCACCTACAGAGACCCTCCCCTGCCCCCTC
CACTCCGGGGCCTGTGCCGCCAGAACCGGGCTCTGCCCCCATACGCTGCCCTCGCAGCCTGGCGGCCTCCGCTGTGGCTGCCTAGCTGTC
AAGAGCAAAGGCTTTTTTTTTCTTCAACCCCATTTTCTTCCATTTCTCCCACCTTTTTAATGCCAGTAACCTCACTGAGAATGTTTTACA

>29616_29616_4_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000380310_C16orf71_chr16_4790154_ENST00000590191_length(amino acids)=697AA_BP=266
MALLPRPCFPLKAPTPACSRRPPGPSPGALEGPLAPWMGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDC
HFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCW
ECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKPVLV
PAELATEPGCRQNTRTKDASSQEGRDPGRPFESSGEVSALLGMAEEPPRWLEGDLGSLSFNTKGSQGPPWDPQAEATLSCHEGDPKAEPL
STASQESVNRRALRQERRKMIETDILQKVTRDACGPTSSDKGGVKEAPCHAAESAPRSKMPLVEPPEGPPVLSLQQLEAWDLDDILQSLA
GQEDNQGNRAPGTVWWAADHRQVQDRMVPSAHNRLMEQLALLCTTQSKASACARKVPADTPQDTKEADSGSRCASRKQGSQAGPGPQLAQ
GMRLNAESPTIFIDLRQMELPDHLSPERSGGSSHSSSDSEEEEEEEMAALGDAEGASPSSLGLRTCTGKSQLLQQLRAFQKGTAQPELPA

--------------------------------------------------------------
>29616_29616_5_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000562319_C16orf71_chr16_4790154_ENST00000299320_length(transcript)=2813nt_BP=845nt
AAACTCATCTCCAGCCCTCCTTCCTATGACCTCTCCACCCTGGGGAACTGGCCCTCCTTCCTAGACCCTGCTTCCCCTTGAAAGCCCCCA
CCCCCGCCTGCAGTCGCCGCCCTCCAGGCCCCTCCCCTGGAGCGCTGGAGGGCCCCTTAGCCCCATGGATGGGTATGAAAGTCCCCGGAA
AGGGGGAATCTGGGCCCTCGGCGTTGCTGACGCCCCCAATGTCGTCGAGCAGCCGGGGGCCGGGGGCCGGAGCGCGCCGACGCCGAACCC
GCTGCCGCCGCTGCCGGGCCTGTGTGCGAACTGAGTGCGGGGATTGCCACTTCTGCCGAGACATGAAGAAGTTCGGGGGGCCCGGGCGCA
TGAAGCAGTCGTGCCTGCTCCGGCAGTGCACTGCCCCCGTGCTCCCACACACAGCTGTGTGCCTCTTGTGTGGGGAGGCTGGGAAGGAGG
ACACGGTGGAGGGAGAGGAAGAGAAATTTGGTTTGAGCCTCATGGAGTGTACAATCTGCAACGAGATCGTCCACCCCGGCTGCCTGAAGA
TGGGGAAGGCTGAGGGTGTCATCAATGCAGAGATCCCCAACTGCTGGGAGTGCCCTCGCTGCACCCAGGAAGGCCGCACCAGCAAGGATT
CAGGTGAGGGGCCTGGCCGCCGTAGGGCCGACAACGGCGAGGAGGGCGCCAGCTTGGGGAGCGGATGGAAGCTGACAGAGGAGCCACCGC
TTCCACCGCCCCCGCCCAGGCGCAAGGGCCCCCTGCCTGCCGGGCCCCCCCCGGAGGACGTGCCTGGGCCCCCCAAACGAAAGGAAAGGG
AGGCAGGGAATGAGCCTCCCACCCCAAGGAAAAAGCCAGTTCTGGTGCCTGCAGAATTGGCCACAGAACCTGGGTGCAGACAGAACACAA
GGACAAAGGATGCATCCTCTCAGGAAGGAAGAGACCCTGGCAGGCCTTTTGAAAGCTCTGGTGAGGTCAGCGCTCTTCTTGGGATGGCCG
AGGAGCCCCCCAGGTGGCTGGAAGGCGACCTTGGAAGCCTGTCTTTCAACACCAAAGGATCCCAGGGTCCTCCCTGGGACCCACAGGCCG
AAGCCACTCTCTCCTGCCATGAAGGAGACCCAAAGGCAGAGCCCCTCAGCACTGCCTCACAAGAATCTGTGAACCGCCGGGCCCTCCGAC
AGGAGAGAAGGAAGATGATAGAGACGGACATCCTCCAGAAAGTCACCCGGGATGCCTGCGGCCCGACCAGCAGTGACAAAGGTGGGGTGA
AGGAGGCGCCCTGCCACGCTGCGGAGTCAGCTCCCAGATCCAAAATGCCCCTCGTGGAGCCTCCGGAGGGACCACCAGTGCTCTCGCTCC
AGCAACTTGAAGCGTGGGATTTGGATGACATCCTTCAGAGTCTGGCGGGACAAGAAGACAACCAGGGAAATCGTGCACCTGGAACTGTGT
GGTGGGCAGCTGACCACCGCCAAGTTCAAGACCGCATGGTGCCGAGCGCCCACAACAGGCTCATGGAACAGCTGGCCCTCCTGTGCACCA
CGCAGTCCAAGGCCTCTGCTTGTGCCCGGAAGGTGCCTGCCGACACTCCCCAGGACACCAAAGAGGCAGATTCAGGAAGCAGATGTGCCT
CAAGGAAGCAGGGCTCCCAGGCTGGGCCAGGCCCGCAGCTGGCCCAGGGCATGAGGCTTAACGCAGAGTCCCCCACCATCTTTATTGACC
TGCGGCAGATGGAGCTACCAGACCACCTGTCCCCAGAAAGCTCCAGCCACAGCTCCTCTGACAGTGAGGAGGAGGAGGAGGAAGAGATGG
CAGCTCTGGGAGACGCAGAGGGGGCATCTCCTTCCTCCCTGGGGCTACGGACCTGTACCGGGAAAAGCCAGCTTCTCCAGCAGCTCAGGG
CCTTTCAGAAGGGGACAGCCCAGCCCGAGCTGCCTGCCAGCAAGGGGCCCGCGGGTGGGAGGGCTCAGGCCCCTGAAGACACAGCTGGAT
CACGAACTGGGAGGAAGCAACACATGAAGCTCTGTGCCAAGGGGCAGAGCGCCCAGGCTCGACTCCCAAGAGGCAGGCCCAGAGCCCTGG
GGGATGTTCCTGAGCCAGGGGCAGCCAGGGAGGCCCTGATGCCTCCTCTGGAGCAACTATAGCTGCCTCAGGATGTGTCCTGCTGTCTGC
CCCGTGGGAAGAGCAGAGAAATCATCACCACCTTGGGCCCCACGGTGCCACGGGCTCAGGCAGCACAGTAGGGCGCCGGGCCTTTGGGAC
AGTGTCCCAGCTTCCCCTGGGGTTCACCCCTGGCTGCCAGGCCACTGAGGATGGGCAGGGGTCTCTTCTCATCAAGCCTTGTACCAGGCA
AAAGACAGGCCCTGCTTGGCCGTGGTCACTGGCCGCCAAGATCAGGGCTACAGATGTCTGCTCTCTGGACCCCACGTGATCTGGCCACTG
GGGACCCCCACCCGACCCCACTCCCAATGATGAGGGGCATTTTCATTGCAAGTCAAAGGCAAGACAGGCTTCCATAAAGTCCCAGGAGGT
CCCTCCTGTAGGGCACAAGGCCAGGCTGCCTCCCAGCCCCCAGGCCCTCTCCCACCTACAGAGACCCTCCCCTGCCCCCTCCACTCCGGG
GCCTGTGCCGCCAGAACCGGGCTCTGCCCCCATACGCTGCCCTCGCAGCCTGGCGGCCTCCGCTGTGGCTGCCTAGCTGTCAAGAGCAAA
GGCTTTTTTTTTCTTCAACCCCATTTTCTTCCATTTCTCCCACCTTTTTAATGCCAGTAACCTCACTGAGAATGTTTTACAGTGATGGAA

>29616_29616_5_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000562319_C16orf71_chr16_4790154_ENST00000299320_length(amino acids)=694AA_BP=266
MALLPRPCFPLKAPTPACSRRPPGPSPGALEGPLAPWMGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDC
HFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCW
ECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKPVLV
PAELATEPGCRQNTRTKDASSQEGRDPGRPFESSGEVSALLGMAEEPPRWLEGDLGSLSFNTKGSQGPPWDPQAEATLSCHEGDPKAEPL
STASQESVNRRALRQERRKMIETDILQKVTRDACGPTSSDKGGVKEAPCHAAESAPRSKMPLVEPPEGPPVLSLQQLEAWDLDDILQSLA
GQEDNQGNRAPGTVWWAADHRQVQDRMVPSAHNRLMEQLALLCTTQSKASACARKVPADTPQDTKEADSGSRCASRKQGSQAGPGPQLAQ
GMRLNAESPTIFIDLRQMELPDHLSPESSSHSSSDSEEEEEEEMAALGDAEGASPSSLGLRTCTGKSQLLQQLRAFQKGTAQPELPASKG

--------------------------------------------------------------
>29616_29616_6_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000562319_C16orf71_chr16_4790154_ENST00000590191_length(transcript)=2821nt_BP=845nt
AAACTCATCTCCAGCCCTCCTTCCTATGACCTCTCCACCCTGGGGAACTGGCCCTCCTTCCTAGACCCTGCTTCCCCTTGAAAGCCCCCA
CCCCCGCCTGCAGTCGCCGCCCTCCAGGCCCCTCCCCTGGAGCGCTGGAGGGCCCCTTAGCCCCATGGATGGGTATGAAAGTCCCCGGAA
AGGGGGAATCTGGGCCCTCGGCGTTGCTGACGCCCCCAATGTCGTCGAGCAGCCGGGGGCCGGGGGCCGGAGCGCGCCGACGCCGAACCC
GCTGCCGCCGCTGCCGGGCCTGTGTGCGAACTGAGTGCGGGGATTGCCACTTCTGCCGAGACATGAAGAAGTTCGGGGGGCCCGGGCGCA
TGAAGCAGTCGTGCCTGCTCCGGCAGTGCACTGCCCCCGTGCTCCCACACACAGCTGTGTGCCTCTTGTGTGGGGAGGCTGGGAAGGAGG
ACACGGTGGAGGGAGAGGAAGAGAAATTTGGTTTGAGCCTCATGGAGTGTACAATCTGCAACGAGATCGTCCACCCCGGCTGCCTGAAGA
TGGGGAAGGCTGAGGGTGTCATCAATGCAGAGATCCCCAACTGCTGGGAGTGCCCTCGCTGCACCCAGGAAGGCCGCACCAGCAAGGATT
CAGGTGAGGGGCCTGGCCGCCGTAGGGCCGACAACGGCGAGGAGGGCGCCAGCTTGGGGAGCGGATGGAAGCTGACAGAGGAGCCACCGC
TTCCACCGCCCCCGCCCAGGCGCAAGGGCCCCCTGCCTGCCGGGCCCCCCCCGGAGGACGTGCCTGGGCCCCCCAAACGAAAGGAAAGGG
AGGCAGGGAATGAGCCTCCCACCCCAAGGAAAAAGCCAGTTCTGGTGCCTGCAGAATTGGCCACAGAACCTGGGTGCAGACAGAACACAA
GGACAAAGGATGCATCCTCTCAGGAAGGAAGAGACCCTGGCAGGCCTTTTGAAAGCTCTGGTGAGGTCAGCGCTCTTCTTGGGATGGCCG
AGGAGCCCCCCAGGTGGCTGGAAGGCGACCTTGGAAGCCTGTCTTTCAACACCAAAGGATCCCAGGGTCCTCCCTGGGACCCACAGGCCG
AAGCCACTCTCTCCTGCCATGAAGGAGACCCAAAGGCAGAGCCCCTCAGCACTGCCTCACAAGAATCTGTGAACCGCCGGGCCCTCCGAC
AGGAGAGAAGGAAGATGATAGAGACGGACATCCTCCAGAAAGTCACCCGGGATGCCTGCGGCCCGACCAGCAGTGACAAAGGTGGGGTGA
AGGAGGCGCCCTGCCACGCTGCGGAGTCAGCTCCCAGATCCAAAATGCCCCTCGTGGAGCCTCCGGAGGGACCACCAGTGCTCTCGCTCC
AGCAACTTGAAGCGTGGGATTTGGATGACATCCTTCAGAGTCTGGCGGGACAAGAAGACAACCAGGGAAATCGTGCACCTGGAACTGTGT
GGTGGGCAGCTGACCACCGCCAAGTTCAAGACCGCATGGTGCCGAGCGCCCACAACAGGCTCATGGAACAGCTGGCCCTCCTGTGCACCA
CGCAGTCCAAGGCCTCTGCTTGTGCCCGGAAGGTGCCTGCCGACACTCCCCAGGACACCAAAGAGGCAGATTCAGGAAGCAGATGTGCCT
CAAGGAAGCAGGGCTCCCAGGCTGGGCCAGGCCCGCAGCTGGCCCAGGGCATGAGGCTTAACGCAGAGTCCCCCACCATCTTTATTGACC
TGCGGCAGATGGAGCTACCAGACCACCTGTCCCCAGAAAGGTCCGGAGGCTCCAGCCACAGCTCCTCTGACAGTGAGGAGGAGGAGGAGG
AAGAGATGGCAGCTCTGGGAGACGCAGAGGGGGCATCTCCTTCCTCCCTGGGGCTACGGACCTGTACCGGGAAAAGCCAGCTTCTCCAGC
AGCTCAGGGCCTTTCAGAAGGGGACAGCCCAGCCCGAGCTGCCTGCCAGCAAGGGGCCCGCGGGTGGGAGGGCTCAGGCCCCTGAAGACA
CAGCTGGATCACGAACTGGGAGGAAGCAACACATGAAGCTCTGTGCCAAGGGGCAGAGCGCCCAGGCTCGACTCCCAAGAGGCAGGCCCA
GAGCCCTGGGGGATGTTCCTGAGCCAGGGGCAGCCAGGGAGGCCCTGATGCCTCCTCTGGAGCAACTATAGCTGCCTCAGGATGTGTCCT
GCTGTCTGCCCCGTGGGAAGAGCAGAGAAATCATCACCACCTTGGGCCCCACGGTGCCACGGGCTCAGGCAGCACAGTAGGGCGCCGGGC
CTTTGGGACAGTGTCCCAGCTTCCCCTGGGGTTCACCCCTGGCTGCCAGGCCACTGAGGATGGGCAGGGGTCTCTTCTCATCAAGCCTTG
TACCAGGCAAAAGACAGGCCCTGCTTGGCCGTGGTCACTGGCCGCCAAGATCAGGGCTACAGATGTCTGCTCTCTGGACCCCACGTGATC
TGGCCACTGGGGACCCCCACCCGACCCCACTCCCAATGATGAGGGGCATTTTCATTGCAAGTCAAAGGCAAGACAGGCTTCCATAAAGTC
CCAGGAGGTCCCTCCTGTAGGGCACAAGGCCAGGCTGCCTCCCAGCCCCCAGGCCCTCTCCCACCTACAGAGACCCTCCCCTGCCCCCTC
CACTCCGGGGCCTGTGCCGCCAGAACCGGGCTCTGCCCCCATACGCTGCCCTCGCAGCCTGGCGGCCTCCGCTGTGGCTGCCTAGCTGTC
AAGAGCAAAGGCTTTTTTTTTCTTCAACCCCATTTTCTTCCATTTCTCCCACCTTTTTAATGCCAGTAACCTCACTGAGAATGTTTTACA

>29616_29616_6_FBXL19-C16orf71_FBXL19_chr16_30939284_ENST00000562319_C16orf71_chr16_4790154_ENST00000590191_length(amino acids)=697AA_BP=266
MALLPRPCFPLKAPTPACSRRPPGPSPGALEGPLAPWMGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDC
HFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCW
ECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKPVLV
PAELATEPGCRQNTRTKDASSQEGRDPGRPFESSGEVSALLGMAEEPPRWLEGDLGSLSFNTKGSQGPPWDPQAEATLSCHEGDPKAEPL
STASQESVNRRALRQERRKMIETDILQKVTRDACGPTSSDKGGVKEAPCHAAESAPRSKMPLVEPPEGPPVLSLQQLEAWDLDDILQSLA
GQEDNQGNRAPGTVWWAADHRQVQDRMVPSAHNRLMEQLALLCTTQSKASACARKVPADTPQDTKEADSGSRCASRKQGSQAGPGPQLAQ
GMRLNAESPTIFIDLRQMELPDHLSPERSGGSSHSSSDSEEEEEEEMAALGDAEGASPSSLGLRTCTGKSQLLQQLRAFQKGTAQPELPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXL19-C16orf71


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL19-C16orf71


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL19-C16orf71


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource