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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FBXL20-CEP112 (FusionGDB2 ID:29640)

Fusion Gene Summary for FBXL20-CEP112

Fusion gene summary

Fusion gene information	Fusion gene name: FBXL20-CEP112
	Fusion gene ID: 29640
		Hgene	Tgene
	Gene symbol	FBXL20	CEP112
	Gene ID	84961	201134
	Gene name	F-box and leucine rich repeat protein 20	centrosomal protein 112
	Synonyms	Fbl2\|Fbl20	CCDC46\|MACOCO
	Cytomap	17q12	17q24.1
	Type of gene	protein-coding	protein-coding
	Description	F-box/LRR-repeat protein 20F-box protein FBL2	centrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46
	Modification date	20200313	20200313
	UniProtAcc	Q96IG2	Q8N8E3
	Ensembl transtripts involved in fusion gene	ENST00000577399, ENST00000264658, ENST00000394294, ENST00000583610,	ENST00000317442, ENST00000580482, ENST00000392769, ENST00000535342, ENST00000537949, ENST00000541355,
Fusion gene scores	* DoF score	58 X 21 X 16=19488	22 X 17 X 10=3740
	# samples	61	21
	** MAII score	log2(61/19488*10)=-4.99763298545608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/3740*10)=-4.15457703710888 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FBXL20 [Title/Abstract] AND CEP112 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FBXL20(37558426)-CEP112(64026141), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FBXL20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CEP112 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0EY-01A	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-

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Fusion Gene ORF analysis for FBXL20-CEP112

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000577399	ENST00000317442	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
5CDS-intron	ENST00000577399	ENST00000580482	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
In-frame	ENST00000577399	ENST00000392769	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
In-frame	ENST00000577399	ENST00000535342	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
In-frame	ENST00000577399	ENST00000537949	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
In-frame	ENST00000577399	ENST00000541355	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000264658	ENST00000392769	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000264658	ENST00000535342	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000264658	ENST00000537949	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000264658	ENST00000541355	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000394294	ENST00000392769	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000394294	ENST00000535342	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000394294	ENST00000537949	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000394294	ENST00000541355	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000583610	ENST00000392769	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000583610	ENST00000535342	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000583610	ENST00000537949	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-3CDS	ENST00000583610	ENST00000541355	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-intron	ENST00000264658	ENST00000317442	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-intron	ENST00000264658	ENST00000580482	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-intron	ENST00000394294	ENST00000317442	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-intron	ENST00000394294	ENST00000580482	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-intron	ENST00000583610	ENST00000317442	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-
intron-intron	ENST00000583610	ENST00000580482	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000577399	FBXL20	chr17	37558426	-	ENST00000535342	CEP112	chr17	64026141	-	2434	351	198	2000	600
ENST00000577399	FBXL20	chr17	37558426	-	ENST00000392769	CEP112	chr17	64026141	-	2431	351	198	2000	600
ENST00000577399	FBXL20	chr17	37558426	-	ENST00000541355	CEP112	chr17	64026141	-	1938	351	198	1787	529
ENST00000577399	FBXL20	chr17	37558426	-	ENST00000537949	CEP112	chr17	64026141	-	2059	351	198	2000	600

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000577399	ENST00000535342	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-	0.004922805	0.9950772
ENST00000577399	ENST00000392769	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-	0.004995229	0.99500483
ENST00000577399	ENST00000541355	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-	0.008125862	0.99187416
ENST00000577399	ENST00000537949	FBXL20	chr17	37558426	-	CEP112	chr17	64026141	-	0.013000554	0.98699945

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Fusion Genomic Features for FBXL20-CEP112

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXL20-CEP112

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37558426/chr17:64026141)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBXL20 Q96IG2	CEP112 Q8N8E3
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CEP112

chr17:37558426

chr17:64026141

ENST00000317442

277_954

212.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

22_68

437.0

Domain

F-box

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

22_68

405.0

Domain

F-box

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

22_68

411.6666666666667

Domain

F-box

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

101_126

437.0

Repeat

Note=LRR 2

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

127_152

437.0

Repeat

Note=LRR 3

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

153_178

437.0

Repeat

Note=LRR 4

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

179_204

437.0

Repeat

Note=LRR 5

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

205_230

437.0

Repeat

Note=LRR 6

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

231_256

437.0

Repeat

Note=LRR 7

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

257_282

437.0

Repeat

Note=LRR 8

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

283_308

437.0

Repeat

Note=LRR 9

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

309_334

437.0

Repeat

Note=LRR 10

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

335_363

437.0

Repeat

Note=LRR 11

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

364_388

437.0

Repeat

Note=LRR 12

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

389_414

437.0

Repeat

Note=LRR 13

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000264658

74_100

437.0

Repeat

Note=LRR 1

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

101_126

405.0

Repeat

Note=LRR 2

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

127_152

405.0

Repeat

Note=LRR 3

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

153_178

405.0

Repeat

Note=LRR 4

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

179_204

405.0

Repeat

Note=LRR 5

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

205_230

405.0

Repeat

Note=LRR 6

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

231_256

405.0

Repeat

Note=LRR 7

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

257_282

405.0

Repeat

Note=LRR 8

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

283_308

405.0

Repeat

Note=LRR 9

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

309_334

405.0

Repeat

Note=LRR 10

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

335_363

405.0

Repeat

Note=LRR 11

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

364_388

405.0

Repeat

Note=LRR 12

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

389_414

405.0

Repeat

Note=LRR 13

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000394294

74_100

405.0

Repeat

Note=LRR 1

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

101_126

411.6666666666667

Repeat

Note=LRR 2

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

127_152

411.6666666666667

Repeat

Note=LRR 3

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

153_178

411.6666666666667

Repeat

Note=LRR 4

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

179_204

411.6666666666667

Repeat

Note=LRR 5

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

205_230

411.6666666666667

Repeat

Note=LRR 6

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

231_256

411.6666666666667

Repeat

Note=LRR 7

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

257_282

411.6666666666667

Repeat

Note=LRR 8

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

283_308

411.6666666666667

Repeat

Note=LRR 9

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

309_334

411.6666666666667

Repeat

Note=LRR 10

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

335_363

411.6666666666667

Repeat

Note=LRR 11

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

364_388

411.6666666666667

Repeat

Note=LRR 12

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

389_414

411.6666666666667

Repeat

Note=LRR 13

Hgene

FBXL20

chr17:37558426

chr17:64026141

ENST00000583610

74_100

411.6666666666667

Repeat

Note=LRR 1

Tgene

CEP112

chr17:37558426

chr17:64026141

ENST00000392769

277_954

406

956.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CEP112

chr17:37558426

chr17:64026141

ENST00000535342

277_954

406

956.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for FBXL20-CEP112

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>29640_29640_1_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000392769_length(transcript)=2431nt_BP=351nt
GCCAAAGGAAGGGTTGCCCGGCTCCAGCCCTGCACCCCCGACCCCCGGCCTCAGGTGCAGCTCCGCAGCCATCCCCGGACCAGGGCGGGC
ACTTGGCCTGTTGCTCAGCGCAACCACCCTCGCCCTCCCGAGCCATGCACAGGGAGACAAGCGTCCGGCCCCGGCCCCCCAGGCCTCCCT
GCAGCACCCCGTAATGTAATGCACTGGGGCGGGGGAGGCGGGGGAGGCGGCGGCGGCGGCAACCGCGGAGGCGCGGCGGCAGCCGCACTG
CCCCAATCTAGACACATCCAGAAGAGGAGGAAAATGGCTCCGAGCAGGGACCGCCTGCTGCACTTTGGGTTCAAGGCGACAAACCACATG
ATCAAAGAACTGGAGGCCCGTGTCCAGCAGCTGACTGGAGAAGCAGAGAACAGTAATTTACAGAGGCAGAAATTAATTCAAGAAAAAGCA
GAACTTGAAAGATGTTACCAGATAACGTGTAGTGAATTACAAGAAGTAAAGGCAAGGCGTAACACACTGCATAAAGAGAAGGACCATCTT
GTAAATGATTATGAGCAAAACATGAAACTGTTACAAACCAAATATGATGCTGATATAAACCTTCTAAAACAAGAACATGCTCTTTCAGCT
TCTAAGGCATCTAGTATGATTGAAGAATTAGAGCAGAATGTCTGTCAATTAAAACAGCAGTTACAGGAATCAGAACTTCAAAGAAAGCAA
CAACTAAGGGATCAAGAAAATAAGTTTCAGATGGAGAAAAGTCATTTAAAACACATCTATGAAAAAAAGGCTCATGACTTGCAGAGTGAA
CTTGATAAAGGAAAAGAAGATACTCAAAAGAAAATTCATAAATTTGAGGAAGCTTTGAAGGAAAAAGAGGAGCAGCTAACTCGTGTGACT
GAAGTTCAGAGGTTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCT
GAAATGAAAGAGCAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAA
CTGGAGGACATCAGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCAT
AACGCAGAGAAGGATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAA
AATCAAATTCAGGAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAAT
GTGAACTCACAGCGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTC
GTCAATAAACTGAAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGCC
AACAGCAAGCTGAAGCAGATTGAGAAGGAATACACTCAGAAGCTTGCCAAATCTTCACAGATCATAGCAGAACTTCAGACAACCATTTCC
TCTCTGAAAGAAGAGAACAGCCAGCAGCAGCTTGCTGCAGAAAGGCGGCTCCAGGATGTTAGACAAAAGTTTGAAGATGAGAAGAAGCAG
CTGATTAGAGATAATGACCAAGCAATCAAGGTTTTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTA
CAACACAAAGAATTGGAGTCACAGGAACAGATAACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTA
AGACAAGAACTTGAAGACACCATTTCCTCCCTAAAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACT
ACATATCAAGGCAGAAGGTAACTGCACGAGAGAATGCAACGGATGCAATTTCCAGGCTGTGCTGTGGACTTCTTCCAGCAGGTTTGAAGA
TTTGGATATTGTAAACTGTGAGATCAGTGGCATTTTTTAAATCCTTAAATGTAATTAAGATCATAAAAACATGCATCATTCATACACTAG
TGGGGTGGTTTTATTTGTGTCTGCCTAAGTTATTTTTTTAACATTCCTTTATTTCCGATTTTCATGTTTGTGTGCATTTGAGTATGTGCT
GAGAACTGCTTATATTGGGCAAAGTGATTTCCTATGATATGCCTTGTTAATCCTTTTGCATAGAATTTTACCAGTTGCGTACGATCAAAA
TCACGTTTGTAGTATCATATCAAAAATTCTAACCTGTTTACATTGTTTTCATGTTCATGTTCCTATGTTATTAAAATATTATTTTGTACT

>29640_29640_1_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000392769_length(amino acids)=600AA_BP=51
MHWGGGGGGGGGGGNRGGAAAAALPQSRHIQKRRKMAPSRDRLLHFGFKATNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY
QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQE
NKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQM
EKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEF
KKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQ
IEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELE

--------------------------------------------------------------
>29640_29640_2_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000535342_length(transcript)=2434nt_BP=351nt
GCCAAAGGAAGGGTTGCCCGGCTCCAGCCCTGCACCCCCGACCCCCGGCCTCAGGTGCAGCTCCGCAGCCATCCCCGGACCAGGGCGGGC
ACTTGGCCTGTTGCTCAGCGCAACCACCCTCGCCCTCCCGAGCCATGCACAGGGAGACAAGCGTCCGGCCCCGGCCCCCCAGGCCTCCCT
GCAGCACCCCGTAATGTAATGCACTGGGGCGGGGGAGGCGGGGGAGGCGGCGGCGGCGGCAACCGCGGAGGCGCGGCGGCAGCCGCACTG
CCCCAATCTAGACACATCCAGAAGAGGAGGAAAATGGCTCCGAGCAGGGACCGCCTGCTGCACTTTGGGTTCAAGGCGACAAACCACATG
ATCAAAGAACTGGAGGCCCGTGTCCAGCAGCTGACTGGAGAAGCAGAGAACAGTAATTTACAGAGGCAGAAATTAATTCAAGAAAAAGCA
GAACTTGAAAGATGTTACCAGATAACGTGTAGTGAATTACAAGAAGTAAAGGCAAGGCGTAACACACTGCATAAAGAGAAGGACCATCTT
GTAAATGATTATGAGCAAAACATGAAACTGTTACAAACCAAATATGATGCTGATATAAACCTTCTAAAACAAGAACATGCTCTTTCAGCT
TCTAAGGCATCTAGTATGATTGAAGAATTAGAGCAGAATGTCTGTCAATTAAAACAGCAGTTACAGGAATCAGAACTTCAAAGAAAGCAA
CAACTAAGGGATCAAGAAAATAAGTTTCAGATGGAGAAAAGTCATTTAAAACACATCTATGAAAAAAAGGCTCATGACTTGCAGAGTGAA
CTTGATAAAGGAAAAGAAGATACTCAAAAGAAAATTCATAAATTTGAGGAAGCTTTGAAGGAAAAAGAGGAGCAGCTAACTCGTGTGACT
GAAGTTCAGAGGTTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCT
GAAATGAAAGAGCAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAA
CTGGAGGACATCAGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCAT
AACGCAGAGAAGGATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAA
AATCAAATTCAGGAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAAT
GTGAACTCACAGCGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTC
GTCAATAAACTGAAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGCC
AACAGCAAGCTGAAGCAGATTGAGAAGGAATACACTCAGAAGCTTGCCAAATCTTCACAGATCATAGCAGAACTTCAGACAACCATTTCC
TCTCTGAAAGAAGAGAACAGCCAGCAGCAGCTTGCTGCAGAAAGGCGGCTCCAGGATGTTAGACAAAAGTTTGAAGATGAGAAGAAGCAG
CTGATTAGAGATAATGACCAAGCAATCAAGGTTTTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTA
CAACACAAAGAATTGGAGTCACAGGAACAGATAACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTA
AGACAAGAACTTGAAGACACCATTTCCTCCCTAAAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACT
ACATATCAAGGCAGAAGGTAACTGCACGAGAGAATGCAACGGATGCAATTTCCAGGCTGTGCTGTGGACTTCTTCCAGCAGGTTTGAAGA
TTTGGATATTGTAAACTGTGAGATCAGTGGCATTTTTTAAATCCTTAAATGTAATTAAGATCATAAAAACATGCATCATTCATACACTAG
TGGGGTGGTTTTATTTGTGTCTGCCTAAGTTATTTTTTTAACATTCCTTTATTTCCGATTTTCATGTTTGTGTGCATTTGAGTATGTGCT
GAGAACTGCTTATATTGGGCAAAGTGATTTCCTATGATATGCCTTGTTAATCCTTTTGCATAGAATTTTACCAGTTGCGTACGATCAAAA
TCACGTTTGTAGTATCATATCAAAAATTCTAACCTGTTTACATTGTTTTCATGTTCATGTTCCTATGTTATTAAAATATTATTTTGTACT

>29640_29640_2_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000535342_length(amino acids)=600AA_BP=51
MHWGGGGGGGGGGGNRGGAAAAALPQSRHIQKRRKMAPSRDRLLHFGFKATNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY
QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQE
NKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQM
EKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEF
KKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQ
IEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELE

--------------------------------------------------------------
>29640_29640_3_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000537949_length(transcript)=2059nt_BP=351nt
GCCAAAGGAAGGGTTGCCCGGCTCCAGCCCTGCACCCCCGACCCCCGGCCTCAGGTGCAGCTCCGCAGCCATCCCCGGACCAGGGCGGGC
ACTTGGCCTGTTGCTCAGCGCAACCACCCTCGCCCTCCCGAGCCATGCACAGGGAGACAAGCGTCCGGCCCCGGCCCCCCAGGCCTCCCT
GCAGCACCCCGTAATGTAATGCACTGGGGCGGGGGAGGCGGGGGAGGCGGCGGCGGCGGCAACCGCGGAGGCGCGGCGGCAGCCGCACTG
CCCCAATCTAGACACATCCAGAAGAGGAGGAAAATGGCTCCGAGCAGGGACCGCCTGCTGCACTTTGGGTTCAAGGCGACAAACCACATG
ATCAAAGAACTGGAGGCCCGTGTCCAGCAGCTGACTGGAGAAGCAGAGAACAGTAATTTACAGAGGCAGAAATTAATTCAAGAAAAAGCA
GAACTTGAAAGATGTTACCAGATAACGTGTAGTGAATTACAAGAAGTAAAGGCAAGGCGTAACACACTGCATAAAGAGAAGGACCATCTT
GTAAATGATTATGAGCAAAACATGAAACTGTTACAAACCAAATATGATGCTGATATAAACCTTCTAAAACAAGAACATGCTCTTTCAGCT
TCTAAGGCATCTAGTATGATTGAAGAATTAGAGCAGAATGTCTGTCAATTAAAACAGCAGTTACAGGAATCAGAACTTCAAAGAAAGCAA
CAACTAAGGGATCAAGAAAATAAGTTTCAGATGGAGAAAAGTCATTTAAAACACATCTATGAAAAAAAGGCTCATGACTTGCAGAGTGAA
CTTGATAAAGGAAAAGAAGATACTCAAAAGAAAATTCATAAATTTGAGGAAGCTTTGAAGGAAAAAGAGGAGCAGCTAACTCGTGTGACT
GAAGTTCAGAGGTTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCT
GAAATGAAAGAGCAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAA
CTGGAGGACATCAGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCAT
AACGCAGAGAAGGATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAA
AATCAAATTCAGGAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAAT
GTGAACTCACAGCGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTC
GTCAATAAACTGAAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGCC
AACAGCAAGCTGAAGCAGATTGAGAAGGAATACACTCAGAAGCTTGCCAAATCTTCACAGATCATAGCAGAACTTCAGACAACCATTTCC
TCTCTGAAAGAAGAGAACAGCCAGCAGCAGCTTGCTGCAGAAAGGCGGCTCCAGGATGTTAGACAAAAGTTTGAAGATGAGAAGAAGCAG
CTGATTAGAGATAATGACCAAGCAATCAAGGTTTTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTA
CAACACAAAGAATTGGAGTCACAGGAACAGATAACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTA
AGACAAGAACTTGAAGACACCATTTCCTCCCTAAAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACT

>29640_29640_3_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000537949_length(amino acids)=600AA_BP=51
MHWGGGGGGGGGGGNRGGAAAAALPQSRHIQKRRKMAPSRDRLLHFGFKATNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY
QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQE
NKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQM
EKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEF
KKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQ
IEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELE

--------------------------------------------------------------
>29640_29640_4_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000541355_length(transcript)=1938nt_BP=351nt
GCCAAAGGAAGGGTTGCCCGGCTCCAGCCCTGCACCCCCGACCCCCGGCCTCAGGTGCAGCTCCGCAGCCATCCCCGGACCAGGGCGGGC
ACTTGGCCTGTTGCTCAGCGCAACCACCCTCGCCCTCCCGAGCCATGCACAGGGAGACAAGCGTCCGGCCCCGGCCCCCCAGGCCTCCCT
GCAGCACCCCGTAATGTAATGCACTGGGGCGGGGGAGGCGGGGGAGGCGGCGGCGGCGGCAACCGCGGAGGCGCGGCGGCAGCCGCACTG
CCCCAATCTAGACACATCCAGAAGAGGAGGAAAATGGCTCCGAGCAGGGACCGCCTGCTGCACTTTGGGTTCAAGGCGACAAACCACATG
ATCAAAGAACTGGAGGCCCGTGTCCAGCAGCTGACTGGAGAAGCAGAGAACAGTAATTTACAGAGGCAGAAATTAATTCAAGAAAAAGCA
GAACTTGAAAGATGTTACCAGATAACGTGTAGTGAATTACAAGAAGTAAAGGCAAGGCGTAACACACTGCATAAAGAGAAGGACCATCTT
GTAAATGATTATGAGCAAAACATGAAACTGTTACAAACCAAATATGATGCTGATATAAACCTTCTAAAACAAGAACATGCTCTTTCAGCT
TCTAAGGCATCTAGTATGATTGAAGAATTAGAGCAGAATGTCTGTCAATTAAAACAGCAGTTACAGGAATCAGAACTTCAAAGAAAGCAA
CAACTAAGGGATCAAGAAAATAAGTTTCAGATGGAGAAAAGTCATTTAAAACACATCTATGAAAAAAAGGCTCATGACTTGCAGAGTGAA
CTTGATAAAGGAAAAGAAGATACTCAAAAGAAAATTCATAAATTTGAGGAAGCTTTGAAGGAAAAAGAGGAGCAGCTAACTCGTGTGACT
GAAGTTCAGAGGTTGCAGGCCCAGCAGGCAGATGCCGCTCTGGAAGAGTTTAAGCGGCAGGTGGAACTGAACTCAGAGAAAGTCTATGCT
GAAATGAAAGAGCAGATGGAAAAAGTGGAGGCAGATCTAACTAGATCCAAATCTCTTCGTGAGAAACAATCAAAGGAGTTTTTATGGCAA
CTGGAGGACATCAGACAGCGGTATGAACAACAGATAGTAGAGCTGAAGCTGGAGCATGAACAGGAGAAGACGCACCTATTACAGCAGCAT
AACGCAGAGAAGGATAGCCTAGTCCGAGACCATGAACGGGAAATTGAAAACCTGGAAAAACAGCTTCGCGCTGCCAATATGGAGCACGAA
AATCAAATTCAGGAGTTCAAGAAACGAGATGCACAGGTTATTGCCGACATGGAGGCCCAGGTTCACAAGTTGAGAGAAGAATTGATCAAT
GTGAACTCACAGCGGAAACAGCAGCTGGTAGAGCTTGGTCTTCTTCGTGAAGAGGAAAAGCAAAGGGCTACAAGGGAACATGAGATTGTC
GTCAATAAACTGAAGGCTGAATCAGAAAAGATGAAAATAGAGCTGAAAAAGACTCATGCTGCTGAGACAGAGATGACACTGGAAAAGGTT
TTACAAGATGAATTAGAAAACCGTTCTAATCAGGTGCGATGTGCAGAGAAAAAATTACAACACAAAGAATTGGAGTCACAGGAACAGATA
ACTTACATACGACAAGAATATGAAACAAAATTGAAAGGATTGATGCCAGCATCCCTAAGACAAGAACTTGAAGACACCATTTCCTCCCTA
AAATCACAGGTTAATTTTCTGCAAAAGAGAGCTTCCATCCTTCAGGAAGAACTGACTACATATCAAGGCAGAAGGTAACTGCACGAGAGA
ATGCAACGGATGCAATTTCCAGGCTGTGCTGTGGACTTCTTCCAGCAGGTTTGAAGATTTGGATATTGTAAACTGTGAGATCAGTGGCAT

>29640_29640_4_FBXL20-CEP112_FBXL20_chr17_37558426_ENST00000577399_CEP112_chr17_64026141_ENST00000541355_length(amino acids)=529AA_BP=51
MHWGGGGGGGGGGGNRGGAAAAALPQSRHIQKRRKMAPSRDRLLHFGFKATNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY
QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQE
NKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQM
EKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEF
KKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKVLQDELE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FBXL20-CEP112

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FBXL20-CEP112

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FBXL20-CEP112

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source