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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL2-FBXL2 (FusionGDB2 ID:29690)

Fusion Gene Summary for FBXL2-FBXL2

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL2-FBXL2
Fusion gene ID: 29690
HgeneTgene
Gene symbol

FBXL2

FBXL2

Gene ID

25827

25827

Gene nameF-box and leucine rich repeat protein 2F-box and leucine rich repeat protein 2
SynonymsFBL2|FBL3FBL2|FBL3
Cytomap

3p22.3

3p22.3

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 2F-box protein FBL2/FBL3F-box protein containing leucine-rich repeatsF-box/LRR-repeat protein 2F-box protein FBL2/FBL3F-box protein containing leucine-rich repeats
Modification date2020032020200320
UniProtAcc

Q9UKC9

Q96IG2

Ensembl transtripts involved in fusion geneENST00000283627, ENST00000484457, 
ENST00000538181, ENST00000446237, 
ENST00000542085, ENST00000507198, 
ENST00000538892, 		ENST00000283627, 
ENST00000446237, ENST00000484457, 
ENST00000507198, ENST00000538181, 
ENST00000538892, ENST00000542085, 
Fusion gene scores* DoF score3 X 4 X 2=244 X 5 X 2=40
# samples 45
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXL2 [Title/Abstract] AND FBXL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL2(33414815)-FBXL2(33415197), # samples:1
FBXL2(33430929)-FBXL2(33430554), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL2

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23604317

HgeneFBXL2

GO:0016567

protein ubiquitination

23604317

HgeneFBXL2

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

23604317

TgeneFBXL2

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23604317

TgeneFBXL2

GO:0016567

protein ubiquitination

23604317

TgeneFBXL2

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

23604317


check buttonFusion gene breakpoints across FBXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA558641FBXL2chr3

33414815

+FBXL2chr3

33415197

-
ChiTaRS5.0N/AAW752436FBXL2chr3

33430929

+FBXL2chr3

33430554

+


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Fusion Gene ORF analysis for FBXL2-FBXL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000283627ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
3UTR-intronENST00000283627ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
3UTR-intronENST00000283627ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
3UTR-intronENST00000283627ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
3UTR-intronENST00000283627ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
3UTR-intronENST00000283627ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
3UTR-intronENST00000283627ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000484457ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5CDS-intronENST00000538181ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000446237ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
5UTR-intronENST00000542085ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000283627ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000283627ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000283627ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000283627ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000283627ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000283627ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000283627ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000446237ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000484457ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000507198ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000507198ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538181ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000283627FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000446237FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000484457FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000507198FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000538181FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000538892FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000538892ENST00000542085FBXL2chr3

33414815

+FBXL2chr3

33415197

-
intron-intronENST00000538892ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000283627FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000446237FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000484457FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000507198FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000538181FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000538892FBXL2chr3

33430929

+FBXL2chr3

33430554

+
intron-intronENST00000542085ENST00000542085FBXL2chr3

33430929

+FBXL2chr3

33430554

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FBXL2-FBXL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXL2-FBXL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33414815/:33415197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL2

Q9UKC9

FBXL2

Q96IG2

FUNCTION: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). {ECO:0000250|UniProtKB:Q8BH16, ECO:0000269|PubMed:22020328, ECO:0000269|PubMed:22323446, ECO:0000269|PubMed:23604317}.FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FBXL2-FBXL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FBXL2-FBXL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL2-FBXL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL2-FBXL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource