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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL5-HNRNPUL1 (FusionGDB2 ID:29713)

Fusion Gene Summary for FBXL5-HNRNPUL1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL5-HNRNPUL1
Fusion gene ID: 29713
HgeneTgene
Gene symbol

FBXL5

HNRNPUL1

Gene ID

26234

11100

Gene nameF-box and leucine rich repeat protein 5heterogeneous nuclear ribonucleoprotein U like 1
SynonymsFBL4|FBL5|FLR1E1B-AP5|E1BAP5|HNRPUL1
Cytomap

4p15.32

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 5F-box protein FBL4/FBL5p45SKP2-like proteinheterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5
Modification date2020031320200327
UniProtAcc

Q9UKA1

Q9BUJ2

Ensembl transtripts involved in fusion geneENST00000341285, ENST00000382358, 
ENST00000412094, ENST00000514541, 
ENST00000594207, ENST00000263367, 
ENST00000352456, ENST00000378215, 
ENST00000392006, ENST00000593587, 
ENST00000595018, ENST00000602130, 
Fusion gene scores* DoF score8 X 7 X 6=33630 X 17 X 8=4080
# samples 1032
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/4080*10)=-3.6724253419715
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXL5 [Title/Abstract] AND HNRNPUL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL5(15613889)-HNRNPUL1(41774128), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL5

GO:0016567

protein ubiquitination

17532294|19762596|19762597

HgeneFBXL5

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

17532294|19762596|19762597


check buttonFusion gene breakpoints across FBXL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HNRNPUL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-B8-5549-11AFBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+


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Fusion Gene ORF analysis for FBXL5-HNRNPUL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000341285ENST00000594207FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000382358ENST00000594207FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000412094ENST00000594207FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000263367FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000352456FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000378215FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000392006FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000593587FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000595018FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000341285ENST00000602130FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000263367FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000352456FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000378215FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000392006FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000593587FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000595018FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000382358ENST00000602130FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000263367FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000352456FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000378215FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000392006FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000593587FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000595018FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000412094ENST00000602130FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-3UTRENST00000514541ENST00000594207FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000263367FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000352456FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000378215FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000392006FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000593587FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000595018FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+
intron-5UTRENST00000514541ENST00000602130FBXL5chr4

15613889

-HNRNPUL1chr19

41774128

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FBXL5-HNRNPUL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXL5chr415613888-HNRNPUL1chr1941774127+1.87E-091
FBXL5chr415613888-HNRNPUL1chr1941774127+1.87E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXL5-HNRNPUL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:15613889/:41774128)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL5

Q9UKA1

HNRNPUL1

Q9BUJ2

FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597}.FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FBXL5-HNRNPUL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FBXL5-HNRNPUL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL5-HNRNPUL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL5-HNRNPUL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource