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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL7-NMNAT3 (FusionGDB2 ID:29730)

Fusion Gene Summary for FBXL7-NMNAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL7-NMNAT3
Fusion gene ID: 29730
HgeneTgene
Gene symbol

FBXL7

NMNAT3

Gene ID

23194

349565

Gene nameF-box and leucine rich repeat protein 7nicotinamide nucleotide adenylyltransferase 3
SynonymsFBL6|FBL7FKSG76|PNAT-3|PNAT3
Cytomap

5p15.1

3q23

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 7F-box protein Fbl7nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN adenylyltransferase 3NMN/NaMN adenylyltransferase 3NaMN adenylyltransferase 3nicotinamide mononucleotide adenylyltransferase 3nicotinate-nucleotide adenylyltransferase 3pyridine nuc
Modification date2020031320200313
UniProtAcc

Q9UJT9

Q96T66

Ensembl transtripts involved in fusion geneENST00000329673, ENST00000504595, 
ENST00000510662, 
ENST00000339837, 
ENST00000406164, ENST00000406824, 
ENST00000507242, ENST00000511444, 
ENST00000512391, ENST00000296202, 
ENST00000413939, ENST00000514703, 
Fusion gene scores* DoF score17 X 7 X 9=10717 X 5 X 5=175
# samples 198
** MAII scorelog2(19/1071*10)=-2.49488715641931
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXL7 [Title/Abstract] AND NMNAT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL7(15616181)-NMNAT3(139297897), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL7

GO:0000209

protein polyubiquitination

25778398

HgeneFBXL7

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

25778398


check buttonFusion gene breakpoints across FBXL7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NMNAT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-HU-A4GP-11AFBXL7chr5

15616181

+NMNAT3chr3

139297897

-


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Fusion Gene ORF analysis for FBXL7-NMNAT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000329673ENST00000339837FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000329673ENST00000406164FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000329673ENST00000406824FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000329673ENST00000507242FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000329673ENST00000511444FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000329673ENST00000512391FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000504595ENST00000339837FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000504595ENST00000406164FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000504595ENST00000406824FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000504595ENST00000507242FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000504595ENST00000511444FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-5UTRENST00000504595ENST00000512391FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-intronENST00000329673ENST00000296202FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-intronENST00000329673ENST00000413939FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-intronENST00000329673ENST00000514703FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-intronENST00000504595ENST00000296202FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-intronENST00000504595ENST00000413939FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5CDS-intronENST00000504595ENST00000514703FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-5UTRENST00000510662ENST00000339837FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-5UTRENST00000510662ENST00000406164FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-5UTRENST00000510662ENST00000406824FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-5UTRENST00000510662ENST00000507242FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-5UTRENST00000510662ENST00000511444FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-5UTRENST00000510662ENST00000512391FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-intronENST00000510662ENST00000296202FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-intronENST00000510662ENST00000413939FBXL7chr5

15616181

+NMNAT3chr3

139297897

-
5UTR-intronENST00000510662ENST00000514703FBXL7chr5

15616181

+NMNAT3chr3

139297897

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FBXL7-NMNAT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXL7-NMNAT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:15616181/:139297897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL7

Q9UJT9

NMNAT3

Q96T66

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735). {ECO:0000250|UniProtKB:Q5BJ29, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735}.FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FBXL7-NMNAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FBXL7-NMNAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL7-NMNAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL7-NMNAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource