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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXO18-ITGA8 (FusionGDB2 ID:29765)

Fusion Gene Summary for FBXO18-ITGA8

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO18-ITGA8
Fusion gene ID: 29765
HgeneTgene
Gene symbol

FBXO18

ITGA8

Gene ID

84893

8516

Gene nameF-box DNA helicase 1integrin subunit alpha 8
SynonymsFBXO18|Fbx18|hFBH1-
Cytomap

10p15.1

10p13

Type of geneprotein-codingprotein-coding
DescriptionF-box DNA helicase 1F-box only protein, helicase, 18F-box protein, helicase, 18integrin alpha-8integrin, alpha 8
Modification date2020031320200313
UniProtAcc.

P53708

Ensembl transtripts involved in fusion geneENST00000362091, ENST00000379999, 
ENST00000397269, ENST00000470089, 
ENST00000477064, ENST00000378076, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 4=144
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO18 [Title/Abstract] AND ITGA8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXO18(5960441)-ITGA8(15648421), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO18

GO:0006974

cellular response to DNA damage stimulus

19736316|23319600|23361013|25585578

HgeneFBXO18

GO:0008219

cell death

23319600

HgeneFBXO18

GO:0016567

protein ubiquitination

25585578

HgeneFBXO18

GO:0031297

replication fork processing

25585578

HgeneFBXO18

GO:2000042

negative regulation of double-strand break repair via homologous recombination

19736316


check buttonFusion gene breakpoints across FBXO18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4688-01AFBXO18chr10

5960441

-ITGA8chr10

15648421

-
ChimerDB4KIRCTCGA-B0-4688-01AFBXO18chr10

5960441

+ITGA8chr10

15648421

-


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Fusion Gene ORF analysis for FBXO18-ITGA8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000362091ENST00000477064FBXO18chr10

5960441

+ITGA8chr10

15648421

-
5CDS-intronENST00000379999ENST00000477064FBXO18chr10

5960441

+ITGA8chr10

15648421

-
5CDS-intronENST00000397269ENST00000477064FBXO18chr10

5960441

+ITGA8chr10

15648421

-
In-frameENST00000362091ENST00000378076FBXO18chr10

5960441

+ITGA8chr10

15648421

-
In-frameENST00000379999ENST00000378076FBXO18chr10

5960441

+ITGA8chr10

15648421

-
In-frameENST00000397269ENST00000378076FBXO18chr10

5960441

+ITGA8chr10

15648421

-
intron-3CDSENST00000470089ENST00000378076FBXO18chr10

5960441

+ITGA8chr10

15648421

-
intron-intronENST00000470089ENST00000477064FBXO18chr10

5960441

+ITGA8chr10

15648421

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397269FBXO18chr105960441+ENST00000378076ITGA8chr1015648421-6906226916936961175
ENST00000362091FBXO18chr105960441+ENST00000378076ITGA8chr1015648421-6852221511536421175
ENST00000379999FBXO18chr105960441+ENST00000378076ITGA8chr1015648421-699423578937841231

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397269ENST00000378076FBXO18chr105960441+ITGA8chr1015648421-0.0005504550.99944955
ENST00000362091ENST00000378076FBXO18chr105960441+ITGA8chr1015648421-0.0003941660.99960583
ENST00000379999ENST00000378076FBXO18chr105960441+ITGA8chr1015648421-0.0003997530.99960023

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Fusion Genomic Features for FBXO18-ITGA8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXO18-ITGA8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:5960441/chr10:15648421)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA8

P53708

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXO18chr10:5960441chr10:15648421ENST00000362091+1321138_1847001044.0DomainF-box
HgeneFBXO18chr10:5960441chr10:15648421ENST00000379999+1422138_1847511095.0DomainF-box
HgeneFBXO18chr10:5960441chr10:15648421ENST00000379999+1422442_7057511095.0DomainUvrD-like helicase ATP-binding
HgeneFBXO18chr10:5960441chr10:15648421ENST00000362091+132157_647001044.0MotifPIP-box
HgeneFBXO18chr10:5960441chr10:15648421ENST00000379999+142257_647511095.0MotifPIP-box
HgeneFBXO18chr10:5960441chr10:15648421ENST00000362091+1321463_4707001044.0Nucleotide bindingATP
HgeneFBXO18chr10:5960441chr10:15648421ENST00000379999+1422463_4707511095.0Nucleotide bindingATP
TgeneITGA8chr10:5960441chr10:15648421ENST0000037807616301034_10635881064.0Topological domainCytoplasmic
TgeneITGA8chr10:5960441chr10:15648421ENST0000037807616301013_10335881064.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXO18chr10:5960441chr10:15648421ENST00000362091+1321442_7057001044.0DomainUvrD-like helicase ATP-binding
HgeneFBXO18chr10:5960441chr10:15648421ENST00000362091+1321807_8117001044.0MotifAPIM motif
HgeneFBXO18chr10:5960441chr10:15648421ENST00000379999+1422807_8117511095.0MotifAPIM motif
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630329_3375881064.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630395_4035881064.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630459_4675881064.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630455_4575881064.0MotifCell attachment site
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630122_1835881064.0RepeatFG-GAP 2
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630188_2405881064.0RepeatFG-GAP 3
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630253_3065881064.0RepeatFG-GAP 4
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630307_3725881064.0RepeatFG-GAP 5
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630373_4315881064.0RepeatFG-GAP 6
TgeneITGA8chr10:5960441chr10:15648421ENST000003780761630435_4985881064.0RepeatFG-GAP 7
TgeneITGA8chr10:5960441chr10:15648421ENST00000378076163044_1055881064.0RepeatFG-GAP 1
TgeneITGA8chr10:5960441chr10:15648421ENST00000378076163039_10125881064.0Topological domainExtracellular


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Fusion Gene Sequence for FBXO18-ITGA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29765_29765_1_FBXO18-ITGA8_FBXO18_chr10_5960441_ENST00000362091_ITGA8_chr10_15648421_ENST00000378076_length(transcript)=6852nt_BP=2215nt
CTCGGGCTCCAGGTCCCGGCCAGAGGAGGAGCTCGCTGCCGGGGGACGCTGGGCTGAGCGGCCGGCGGCGCGGGCCCGGCGGCGGCGGCA
GCGGGGTCCGGGTCCGGAGCGCCACATGAGACGGTTTAAGCGGAAGCATCTTACTGCCATTGACTGCCAGCATTTGGCTCGGAGTCACTT
GGCTGTGACCCAGCCCTTCGGTCAAAGATGGACAAACAGAGATCCGAACCATGGTCTCTATCCTAAACCGAGAACAAAAAGAGGGAGTAG
GGGTCAGGGAAGTCAAAGATGCATCCCTGAGTTCTTCCTAGCAGGCAAGCAGCCGTGCACCAATGACATGGCCAAAAGCAATTCTGTTGG
CCAGGACAGCTGTCAGGACTCTGAGGGTGACATGATCTTTCCTGCAGAGAGCAGCTGTGCACTGCCTCAGGAAGGCAGTGCAGGGCCGGG
CTCACCAGGGTCTGCCCCGCCCTCCAGGAAGCGGTCTTGGTCCTCTGAGGAAGAGAGTAACCAGGCTACCGGGACCAGCCGGTGGGATGG
AGTTTCTAAGAAAGCTCCACGGCACCATTTGTCTGTGCCATGCACAAGGCCTAGGGAGGCCAGGCAAGAAGCAGAGGACAGTACGTCTCG
GCTCTCTGCGGAGTCTGGTGAAACCGACCAAGATGCTGGGGACGTGGGTCCTGATCCCATTCCTGACTCATACTATGGGCTTCTTGGGAC
CTTGCCCTGCCAGGAAGCACTGAGCCACATTTGCAGCCTGCCTAGTGAGGTCCTGAGGCACGTGTTTGCCTTCCTCCCGGTGGAAGACCT
CTATTGGAACCTGAGCTTGGTGTGCCACTTGTGGAGGGAGATCATCAGTGACCCGCTGTTCATTCCTTGGAAGAAGCTGTACCATCGATA
CCTGATGAATGAAGAGCAAGCTGTCAGCAAAGTGGACGGCATCCTGTCTAACTGTGGCATAGAAAAGGAGTCAGACCTGTGTGTGCTGAA
CCTCATACGATACACAGCCACCACTAAGTGCTCTCCGAGTGTGGATCCCGAGAGGGTGCTGTGGAGTCTGAGGGACCACCCCCTCCTCCC
CGAGGCTGAGGCGTGTGTGCGGCAACACCTCCCCGACCTCTACGCTGCTGCCGGGGGTGTCAACATCTGGGCCCTGGTGGCGGCTGTGGT
GCTCCTCTCCAGCAGTGTGAATGACATCCAGCGACTGCTCTTCTGCCTCCGGAGACCCAGCTCCACGGTGACCATGCCAGATGTCACCGA
GACCCTGTACTGCATAGCCGTGCTTCTCTACGCCATGAGGGAGAAGGGGATTAACATCAGCAATAGGATTCACTACAACATTTTCTATTG
CCTATATCTTCAGGAGAATTCCTGCACTCAGGCCACAAAAGTTAAAGAGGAGCCATCTGTCTGGCCAGGCAAGAAAACCATCCAACTTAC
ACATGAACAACAGCTGATTCTGAATCACAAGATGGAACCTCTCCAGGTGGTGAAAATTATGGCCTTTGCCGGCACTGGGAAGACCTCAAC
GCTGGTCAAGTATGCAGAGAAGTGGTCTCAGAGCAGGTTTCTGTATGTGACATTCAACAAGAGCATCGCAAAGCAGGCCGAACGCGTCTT
CCCCAGCAACGTCATCTGCAAAACCTTCCACTCCATGGCCTACGGGCACATAGGGCGGAAGTACCAGTCAAAGAAGAAGTTGAATCTCTT
CAAGTTAACACCCTTCATGGTCAACTCCGTCCTTGCTGAAGGGAAGGGTGGATTCATAAGAGCCAAGCTTGTGTGTAAGACTCTAGAAAA
CTTCTTTGCCTCGGCTGACGAAGAGCTGACCATTGATCACGTGCCTATTTGGTGTAAGAACAGCCAAGGACAGAGAGTCATGGTTGAGCA
GAGTGAAAAACTGAATGGTGTCCTTGAAGCGAGCCGCCTCTGGGATAACATGCGGAAGCTGGGGGAGTGCACAGAAGAGGCGCACCAGAT
GACTCATGACGGCTACTTGAAACTCTGGCAGCTGAGCAAGCCTTCGCTGGCCTCTTTTGACGCCATCTTTGTGGATGAGGCCCAGGACTG
CACACCAGCTATCATGAACATAGTTCTGTCTCAGCCATGTGGGAAAATCTTTGTAGGGGACCCGCACCAGCAGATCTATACCTTCCGGGG
TGCGGTCAACGCCCTGTTCACAGTGCCCCACACCCACGTCTTCTATCTCACGCAGGATGAAACTGAATTCCGAGATAAATTATCTCCAAT
CAACATTAGTTTGAATTACAGTTTGGACGAATCCACCTTTAAAGAAGGCCTGGAAGTGAAACCAATATTGAACTACTACAGAGAAAACAT
TGTTAGTGAACAGGCTCACATTCTGGTGGACTGTGGAGAAGACAATCTGTGTGTTCCTGACTTGAAGCTGTCGGCTAGACCAGATAAGCA
TCAGGTAATCATTGGAGATGAAAATCACCTTATGCTCATAATAAATGCAAGAAATGAAGGGGAAGGAGCATATGAAGCTGAACTCTTTGT
AATGATACCAGAAGAGGCAGATTATGTTGGAATCGAACGCAACAACAAGGGATTTCGACCACTGAGCTGTGAGTACAAGATGGAAAATGT
AACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGGTGTCTGGAACAAATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGA
GAAAACAAACATGAGCATTAACTTCGATCTCCAAATCAGAAGTTCCAACAAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAA
CATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGTGTCACACCCTCCGCAGATTGTTCTGCCCATTCATAACTGGGAACCAGAAGAGGA
GCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAACATATTTATGAGCTGCACAATATTGGACCAAGTACCATCAGTGACACCATCCT
GGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATTTCTTCTCTATATTTTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAA
TCCTAATATCAATCCACAGGATATAAAGCCTGCTGCCTCCCCAGAGGACACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCTACTATTCC
TCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAATTCCACAGACAGAGCCCTGCAAAAATACTGAATTGTACAAATATCGAGTGTTT
ACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAGAAAGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCTCCA
GAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGTGTCCTTTGAAGTTAAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCAGA
AGGAAGCATAGTAATTAAGACATCAGTTATTTGGGCAACTCCGAATGTTTCCTTCTCAATCCCATTATGGGTAATAATACTAGCAATACT
TCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTTTATGGAAGTGTGGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGAC
CGACAGGGAACAGCTGACAAATGACAAGACCCCTGAGGCATGACAAGAAAAAAAAAGAAGACCAAAGACCTCAAACACTGGTCCTGTTCA
AAGAAAAAGAAAGAACATGAGGGTTAAAAATCAAAGCTTTCTGATACCTGACAGTGACCCAGGAAATGGAGGGGACCCTGGAAACATCAC
CTCATCTACACCGCACTTTGGAGAAATTGTCCTGGGTGCCCAGTGAGCCCTGTTGGAAAAGGAAACACCAAAGCTGGAGAAGCCATCAGC
AATTGTGGAAGATTTTCTTTTGCTTTAATCGTTCTGTACTTGGCAGACACTTTGAAATGCGTATGGGAACGTAAGTTGCAGTCCAGATCA
ATCCAGCATAAGTTGCAGAGATGAAATGTCTGAATCACTATAGAATTTACAAGGTGAACTAAGGTGAAATGACTGATTTACTATAGAACT
TAGAACTAAGACCACACCATCCAACACTACTGTATCCAATGGAACATTTGACACCTCCCTATGGAAAAGAAACATTTCTAAGGACATTAT
GGCTCAGGGAGACAAGCAATATGTTGTTGGTACTGTGAAAGTACTTTTGAAAGGACAAAAATAATCTTGTGAGTGAGGGTGAGAGTTTAT
TTATTTATTTTCCATGTCTCTAGGTTGAGAATCTGTCATCTAGAGAATTTGGAAATTAAGATTTGGTTAGCTAGTTTTCAAAATCACTCA
CTCAGTTTCCTCCTAAGAACCACTGTGTGCAGATAACTCATTTAGCAGAGCTTCTTCAGAATTTAGACAGTGCTAAGGAAAGGAAGATTG
GCATTAGGAATCAGTTCTATTTAATACCTTGCTGCCTTCCATCTGAAATTCCTTTCACTCACATTATCCAGGGACTCACATCTGCTTAAT
TTAGCTTTGCAAGATGTTGCATTTATATTTCCTTGTATATCTTTCCATTGACTTAGTTAATACATGAATTTCGAGGTACTCTCTACCTTT
GGAGTGTTTAAAAGTCATGGTAAAATGTCTAGAGTTCATTAATTAAAAAGCAATTTAACATTATGGGTAAACATTATTTTTAATATCTAT
AAGAAGCAACACTTCTTATAGATATTTAGCTTGGGATTAAATACCCGTTTTTCCTGCTATGCCTTGTACTTGTATACACAGAGAAAACAT
GTTGAATATAACTTAGACAAAAACATAAAATTATACAGGCATGAGCCAAACTGGGAAAACTGATTCCTAAAGATTTTTATTTAAAATTGC
TTATTCCAACTTTATTACTTATTTTTACTGCTAATCTTTATAATATGTAACTTTGGAGAATAATCTTTTATTTAAGCTATTTTCCCATCA
TCTTGAATTTAACCATCACAAATTTTTTATGTTTAAAACTCTTGTAAATAATTCATAATCTTGTAATATTATCATTTTTGAAGTAAAATT
GACCAGCCAAATTTATAGGTAGTCTGCACAATTTTGTATCCTTTTTTAATAATGAAAAATTACTATGAAGAAATACTGAACAAATTTTTA
TGTGCAATATTTTATAGACCTATGTATCTGAAGCATGTTTACACTGGCGTTTTTTTTTTTAATTAATTTCCTAAATGTTAAGTATGATAG
AACAAGCTGACCCAAATCCTTAAGTTTACAAAGCTGTTGGAAAACTTTGTGTCCTGATTTCAACAATCACGCTTTGTTTGAAAGATGAGC
CAAGCTCACAGACACTAAATTTTATGTCATGCCATAAGCTGGAGAGGAGCCATTTGGCTACAGCTGCGGAACTTCATTGAGGAGCAAATG
AAAGGCACATGGACGAGCACGCTGGTGCAGTTCATGTTCTTCCTGCCTGTGAATTGAATACTGTCCTGGTAGCAGTTTCGGGTCGGTCAG
GAGCTCAAGGCTGGTTTGTGTGGCTGACTACGGATGAGCACTGAAGTTGCCTCAAAGAATTAAGGGGTGTCCACACCAGCCTCTGGGGGT
CTTTGGTGTTAGTCTTCCAGGTAGAGCTGGTTTTACAAGTAGGTGGCCATCTACAGGATGTGATGTGAGCGATGCCAGACAGCTCTCTCT
GACCCCAGGTAATGCCCTGAATCTGGTGATCCTGGCTGATCTGTGACCAATAGAGATTAGCTCCTTGGGATTTGGGGTCCTAAAAGGTCC
CTGAAAAAATGCACCCCTTGTCTTTAAGCCAACATTGGTGAAGGAACTGAGAACTCTTAGGGTTACATAAAAAAAGACCCCTGTTGAGAT
AGTTTATGCAGATACCTGGAAGGAACTAGAGATGCCAGGAGGAAGACTGAGACCCAGAATGAAGCAAGGCATGAGGGCTCCAAAGTGAAC
TGCACCATCCCAGAGTCTCAGCCAAGATGGCCCTTTCCTAGAGGGACGGGCACCTTCCACCTGCCCACAGGCACTGCTACCTATGGGAAT
TGCAGAAGGCCGTTGTACACACGCGCATGCACGCAGTGGCCCTCTGCCCTTTAGAATATGGAAGCAAAGTCTGGGTGCAGTGACTCACAC
TTGTAATCCCAACACTTTGGGAGGCCGAGACGGGCAGATCACCTGAGTTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGCAAAACCCCA
TCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGTCTCCTGTAATCCCAGCTACCTAGGAGGCTGAGGCAGAGAGAGAATCGC
TTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCGCGACTGCACTCCAGCCTGGGCGACAGAGGGAAACTCTGTCTCAACAAAA
AAATAAATAAAATAAAAAATAAAAAAAGAATATGGAAGCAAATGGAGAAAGGGAGGAAACTGAGGTCAGGCAAACCTTCCAGCAATCCGT
TCTGCCCAGAGAACATACTGACGACAGAGAACACACTGAGCGTTATCTGCTTCTAGTTAGAGCATTGCCGATTGCCTTCATAATTCATAA
TGTGCTGTGCTCCTCTGAGGGTCTATCTGTATTTCTCTTCAAAGAATTCCCTTTTTAAATTCTTGCAGCTGGGTTTTAAGACACAATAAT
GGGGCAAATTAAGTTTTATAAACTTGGAGATTTTTATACAGTAAATAAAAAAATAATATGTACTAGTCACCCCTGAAACTGCATTCTTAG
AACTCGACTCTTGTTTTATTTAAATACGTGCGTAGATATCTGTGAAGATTTTCATGTACCTATTTACCTTGTCACTAATAAAATTAAAAC

>29765_29765_1_FBXO18-ITGA8_FBXO18_chr10_5960441_ENST00000362091_ITGA8_chr10_15648421_ENST00000378076_length(amino acids)=1175AA_BP=700
MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSE
GDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGET
DQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAV
SKVDGILSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVND
IQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILN
HKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVN
SVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKL
WQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQDETEFRDKLSPINISLNYSL
DESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADY
VGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVE
IRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDI
KPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYAL
ASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTND

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>29765_29765_2_FBXO18-ITGA8_FBXO18_chr10_5960441_ENST00000379999_ITGA8_chr10_15648421_ENST00000378076_length(transcript)=6994nt_BP=2357nt
CTGCTTTCAAGGTGTCTAGATACAGAGTGAAGAATGTCACAGTAGGAAGTGCACTGGACTAGGGGAGTCAGGAGACCCGGGTTCTTGTGT
TGGCACCATCACTCATGAGCTACGAGGTGACTTCAGGCTGCCATTGGACCTGTCAAGTGCCTGAGTCATGTGATAATGGGCTACATTGCG
CAGGGCCCCTGGGCCATCTCCACAGGAGATGCCAGAGGACGAGTGCCCACTTGCTGGTCTTCACAGAGCACGCTGAAATGAGACGGTTTA
AGCGGAAGCATCTTACTGCCATTGACTGCCAGCATTTGGCTCGGAGTCACTTGGCTGTGACCCAGCCCTTCGGTCAAAGATGGACAAACA
GAGATCCGAACCATGGTCTCTATCCTAAACCGAGAACAAAAAGAGGGAGTAGGGGTCAGGGAAGTCAAAGATGCATCCCTGAGTTCTTCC
TAGCAGGCAAGCAGCCGTGCACCAATGACATGGCCAAAAGCAATTCTGTTGGCCAGGACAGCTGTCAGGACTCTGAGGGTGACATGATCT
TTCCTGCAGAGAGCAGCTGTGCACTGCCTCAGGAAGGCAGTGCAGGGCCGGGCTCACCAGGGTCTGCCCCGCCCTCCAGGAAGCGGTCTT
GGTCCTCTGAGGAAGAGAGTAACCAGGCTACCGGGACCAGCCGGTGGGATGGAGTTTCTAAGAAAGCTCCACGGCACCATTTGTCTGTGC
CATGCACAAGGCCTAGGGAGGCCAGGCAAGAAGCAGAGGACAGTACGTCTCGGCTCTCTGCGGAGTCTGGTGAAACCGACCAAGATGCTG
GGGACGTGGGTCCTGATCCCATTCCTGACTCATACTATGGGCTTCTTGGGACCTTGCCCTGCCAGGAAGCACTGAGCCACATTTGCAGCC
TGCCTAGTGAGGTCCTGAGGCACGTGTTTGCCTTCCTCCCGGTGGAAGACCTCTATTGGAACCTGAGCTTGGTGTGCCACTTGTGGAGGG
AGATCATCAGTGACCCGCTGTTCATTCCTTGGAAGAAGCTGTACCATCGATACCTGATGAATGAAGAGCAAGCTGTCAGCAAAGTGGACG
GCATCCTGTCTAACTGTGGCATAGAAAAGGAGTCAGACCTGTGTGTGCTGAACCTCATACGATACACAGCCACCACTAAGTGCTCTCCGA
GTGTGGATCCCGAGAGGGTGCTGTGGAGTCTGAGGGACCACCCCCTCCTCCCCGAGGCTGAGGCGTGTGTGCGGCAACACCTCCCCGACC
TCTACGCTGCTGCCGGGGGTGTCAACATCTGGGCCCTGGTGGCGGCTGTGGTGCTCCTCTCCAGCAGTGTGAATGACATCCAGCGACTGC
TCTTCTGCCTCCGGAGACCCAGCTCCACGGTGACCATGCCAGATGTCACCGAGACCCTGTACTGCATAGCCGTGCTTCTCTACGCCATGA
GGGAGAAGGGGATTAACATCAGCAATAGGATTCACTACAACATTTTCTATTGCCTATATCTTCAGGAGAATTCCTGCACTCAGGCCACAA
AAGTTAAAGAGGAGCCATCTGTCTGGCCAGGCAAGAAAACCATCCAACTTACACATGAACAACAGCTGATTCTGAATCACAAGATGGAAC
CTCTCCAGGTGGTGAAAATTATGGCCTTTGCCGGCACTGGGAAGACCTCAACGCTGGTCAAGTATGCAGAGAAGTGGTCTCAGAGCAGGT
TTCTGTATGTGACATTCAACAAGAGCATCGCAAAGCAGGCCGAACGCGTCTTCCCCAGCAACGTCATCTGCAAAACCTTCCACTCCATGG
CCTACGGGCACATAGGGCGGAAGTACCAGTCAAAGAAGAAGTTGAATCTCTTCAAGTTAACACCCTTCATGGTCAACTCCGTCCTTGCTG
AAGGGAAGGGTGGATTCATAAGAGCCAAGCTTGTGTGTAAGACTCTAGAAAACTTCTTTGCCTCGGCTGACGAAGAGCTGACCATTGATC
ACGTGCCTATTTGGTGTAAGAACAGCCAAGGACAGAGAGTCATGGTTGAGCAGAGTGAAAAACTGAATGGTGTCCTTGAAGCGAGCCGCC
TCTGGGATAACATGCGGAAGCTGGGGGAGTGCACAGAAGAGGCGCACCAGATGACTCATGACGGCTACTTGAAACTCTGGCAGCTGAGCA
AGCCTTCGCTGGCCTCTTTTGACGCCATCTTTGTGGATGAGGCCCAGGACTGCACACCAGCTATCATGAACATAGTTCTGTCTCAGCCAT
GTGGGAAAATCTTTGTAGGGGACCCGCACCAGCAGATCTATACCTTCCGGGGTGCGGTCAACGCCCTGTTCACAGTGCCCCACACCCACG
TCTTCTATCTCACGCAGGATGAAACTGAATTCCGAGATAAATTATCTCCAATCAACATTAGTTTGAATTACAGTTTGGACGAATCCACCT
TTAAAGAAGGCCTGGAAGTGAAACCAATATTGAACTACTACAGAGAAAACATTGTTAGTGAACAGGCTCACATTCTGGTGGACTGTGGAG
AAGACAATCTGTGTGTTCCTGACTTGAAGCTGTCGGCTAGACCAGATAAGCATCAGGTAATCATTGGAGATGAAAATCACCTTATGCTCA
TAATAAATGCAAGAAATGAAGGGGAAGGAGCATATGAAGCTGAACTCTTTGTAATGATACCAGAAGAGGCAGATTATGTTGGAATCGAAC
GCAACAACAAGGGATTTCGACCACTGAGCTGTGAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGG
TGTCTGGAACAAATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGATCTCCAAATCA
GAAGTTCCAACAAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGTGT
CACACCCTCCGCAGATTGTTCTGCCCATTCATAACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAAC
ATATTTATGAGCTGCACAATATTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATTTC
TTCTCTATATTTTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGGATATAAAGCCTGCTGCCT
CCCCAGAGGACACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAAT
TCCACAGACAGAGCCCTGCAAAAATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAG
AAAGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGTGT
CCTTTGAAGTTAAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGACATCAGTTATTTGGGCAA
CTCCGAATGTTTCCTTCTCAATCCCATTATGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTT
TATGGAAGTGTGGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGACAAGACCCCTGAGG
CATGACAAGAAAAAAAAAGAAGACCAAAGACCTCAAACACTGGTCCTGTTCAAAGAAAAAGAAAGAACATGAGGGTTAAAAATCAAAGCT
TTCTGATACCTGACAGTGACCCAGGAAATGGAGGGGACCCTGGAAACATCACCTCATCTACACCGCACTTTGGAGAAATTGTCCTGGGTG
CCCAGTGAGCCCTGTTGGAAAAGGAAACACCAAAGCTGGAGAAGCCATCAGCAATTGTGGAAGATTTTCTTTTGCTTTAATCGTTCTGTA
CTTGGCAGACACTTTGAAATGCGTATGGGAACGTAAGTTGCAGTCCAGATCAATCCAGCATAAGTTGCAGAGATGAAATGTCTGAATCAC
TATAGAATTTACAAGGTGAACTAAGGTGAAATGACTGATTTACTATAGAACTTAGAACTAAGACCACACCATCCAACACTACTGTATCCA
ATGGAACATTTGACACCTCCCTATGGAAAAGAAACATTTCTAAGGACATTATGGCTCAGGGAGACAAGCAATATGTTGTTGGTACTGTGA
AAGTACTTTTGAAAGGACAAAAATAATCTTGTGAGTGAGGGTGAGAGTTTATTTATTTATTTTCCATGTCTCTAGGTTGAGAATCTGTCA
TCTAGAGAATTTGGAAATTAAGATTTGGTTAGCTAGTTTTCAAAATCACTCACTCAGTTTCCTCCTAAGAACCACTGTGTGCAGATAACT
CATTTAGCAGAGCTTCTTCAGAATTTAGACAGTGCTAAGGAAAGGAAGATTGGCATTAGGAATCAGTTCTATTTAATACCTTGCTGCCTT
CCATCTGAAATTCCTTTCACTCACATTATCCAGGGACTCACATCTGCTTAATTTAGCTTTGCAAGATGTTGCATTTATATTTCCTTGTAT
ATCTTTCCATTGACTTAGTTAATACATGAATTTCGAGGTACTCTCTACCTTTGGAGTGTTTAAAAGTCATGGTAAAATGTCTAGAGTTCA
TTAATTAAAAAGCAATTTAACATTATGGGTAAACATTATTTTTAATATCTATAAGAAGCAACACTTCTTATAGATATTTAGCTTGGGATT
AAATACCCGTTTTTCCTGCTATGCCTTGTACTTGTATACACAGAGAAAACATGTTGAATATAACTTAGACAAAAACATAAAATTATACAG
GCATGAGCCAAACTGGGAAAACTGATTCCTAAAGATTTTTATTTAAAATTGCTTATTCCAACTTTATTACTTATTTTTACTGCTAATCTT
TATAATATGTAACTTTGGAGAATAATCTTTTATTTAAGCTATTTTCCCATCATCTTGAATTTAACCATCACAAATTTTTTATGTTTAAAA
CTCTTGTAAATAATTCATAATCTTGTAATATTATCATTTTTGAAGTAAAATTGACCAGCCAAATTTATAGGTAGTCTGCACAATTTTGTA
TCCTTTTTTAATAATGAAAAATTACTATGAAGAAATACTGAACAAATTTTTATGTGCAATATTTTATAGACCTATGTATCTGAAGCATGT
TTACACTGGCGTTTTTTTTTTTAATTAATTTCCTAAATGTTAAGTATGATAGAACAAGCTGACCCAAATCCTTAAGTTTACAAAGCTGTT
GGAAAACTTTGTGTCCTGATTTCAACAATCACGCTTTGTTTGAAAGATGAGCCAAGCTCACAGACACTAAATTTTATGTCATGCCATAAG
CTGGAGAGGAGCCATTTGGCTACAGCTGCGGAACTTCATTGAGGAGCAAATGAAAGGCACATGGACGAGCACGCTGGTGCAGTTCATGTT
CTTCCTGCCTGTGAATTGAATACTGTCCTGGTAGCAGTTTCGGGTCGGTCAGGAGCTCAAGGCTGGTTTGTGTGGCTGACTACGGATGAG
CACTGAAGTTGCCTCAAAGAATTAAGGGGTGTCCACACCAGCCTCTGGGGGTCTTTGGTGTTAGTCTTCCAGGTAGAGCTGGTTTTACAA
GTAGGTGGCCATCTACAGGATGTGATGTGAGCGATGCCAGACAGCTCTCTCTGACCCCAGGTAATGCCCTGAATCTGGTGATCCTGGCTG
ATCTGTGACCAATAGAGATTAGCTCCTTGGGATTTGGGGTCCTAAAAGGTCCCTGAAAAAATGCACCCCTTGTCTTTAAGCCAACATTGG
TGAAGGAACTGAGAACTCTTAGGGTTACATAAAAAAAGACCCCTGTTGAGATAGTTTATGCAGATACCTGGAAGGAACTAGAGATGCCAG
GAGGAAGACTGAGACCCAGAATGAAGCAAGGCATGAGGGCTCCAAAGTGAACTGCACCATCCCAGAGTCTCAGCCAAGATGGCCCTTTCC
TAGAGGGACGGGCACCTTCCACCTGCCCACAGGCACTGCTACCTATGGGAATTGCAGAAGGCCGTTGTACACACGCGCATGCACGCAGTG
GCCCTCTGCCCTTTAGAATATGGAAGCAAAGTCTGGGTGCAGTGACTCACACTTGTAATCCCAACACTTTGGGAGGCCGAGACGGGCAGA
TCACCTGAGTTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGG
CAGTCTCCTGTAATCCCAGCTACCTAGGAGGCTGAGGCAGAGAGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATC
GCGCGACTGCACTCCAGCCTGGGCGACAGAGGGAAACTCTGTCTCAACAAAAAAATAAATAAAATAAAAAATAAAAAAAGAATATGGAAG
CAAATGGAGAAAGGGAGGAAACTGAGGTCAGGCAAACCTTCCAGCAATCCGTTCTGCCCAGAGAACATACTGACGACAGAGAACACACTG
AGCGTTATCTGCTTCTAGTTAGAGCATTGCCGATTGCCTTCATAATTCATAATGTGCTGTGCTCCTCTGAGGGTCTATCTGTATTTCTCT
TCAAAGAATTCCCTTTTTAAATTCTTGCAGCTGGGTTTTAAGACACAATAATGGGGCAAATTAAGTTTTATAAACTTGGAGATTTTTATA
CAGTAAATAAAAAAATAATATGTACTAGTCACCCCTGAAACTGCATTCTTAGAACTCGACTCTTGTTTTATTTAAATACGTGCGTAGATA

>29765_29765_2_FBXO18-ITGA8_FBXO18_chr10_5960441_ENST00000379999_ITGA8_chr10_15648421_ENST00000378076_length(amino acids)=1231AA_BP=756
MAPSLMSYEVTSGCHWTCQVPESCDNGLHCAGPLGHLHRRCQRTSAHLLVFTEHAEMRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTN
RDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRS
WSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGETDQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICS
LPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGILSNCGIEKESDLCVLNLIRYTATTKCSP
SVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVNDIQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAM
REKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSR
FLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASADEELTID
HVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQP
CGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCG
EDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPM
VSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVE
HIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVE
FHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWA

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>29765_29765_3_FBXO18-ITGA8_FBXO18_chr10_5960441_ENST00000397269_ITGA8_chr10_15648421_ENST00000378076_length(transcript)=6906nt_BP=2269nt
ACAGCCCCGGCCTGCCCCGCGTGGGAGAAGCCGCGGTTCCGGGCACGGGGCGGTTTTTCCTCAGGGACGGAGCGGTCCGGGATGAGCACG
GAGGGGCCTGGGGATCCGAGAGCGCTGGCGTCCGCCGTCCTGGAGCTGCAGCGGCCCGTACGTGATTCGGGACTGAACACTGAGACGGTT
TAAGCGGAAGCATCTTACTGCCATTGACTGCCAGCATTTGGCTCGGAGTCACTTGGCTGTGACCCAGCCCTTCGGTCAAAGATGGACAAA
CAGAGATCCGAACCATGGTCTCTATCCTAAACCGAGAACAAAAAGAGGGAGTAGGGGTCAGGGAAGTCAAAGATGCATCCCTGAGTTCTT
CCTAGCAGGCAAGCAGCCGTGCACCAATGACATGGCCAAAAGCAATTCTGTTGGCCAGGACAGCTGTCAGGACTCTGAGGGTGACATGAT
CTTTCCTGCAGAGAGCAGCTGTGCACTGCCTCAGGAAGGCAGTGCAGGGCCGGGCTCACCAGGGTCTGCCCCGCCCTCCAGGAAGCGGTC
TTGGTCCTCTGAGGAAGAGAGTAACCAGGCTACCGGGACCAGCCGGTGGGATGGAGTTTCTAAGAAAGCTCCACGGCACCATTTGTCTGT
GCCATGCACAAGGCCTAGGGAGGCCAGGCAAGAAGCAGAGGACAGTACGTCTCGGCTCTCTGCGGAGTCTGGTGAAACCGACCAAGATGC
TGGGGACGTGGGTCCTGATCCCATTCCTGACTCATACTATGGGCTTCTTGGGACCTTGCCCTGCCAGGAAGCACTGAGCCACATTTGCAG
CCTGCCTAGTGAGGTCCTGAGGCACGTGTTTGCCTTCCTCCCGGTGGAAGACCTCTATTGGAACCTGAGCTTGGTGTGCCACTTGTGGAG
GGAGATCATCAGTGACCCGCTGTTCATTCCTTGGAAGAAGCTGTACCATCGATACCTGATGAATGAAGAGCAAGCTGTCAGCAAAGTGGA
CGGCATCCTGTCTAACTGTGGCATAGAAAAGGAGTCAGACCTGTGTGTGCTGAACCTCATACGATACACAGCCACCACTAAGTGCTCTCC
GAGTGTGGATCCCGAGAGGGTGCTGTGGAGTCTGAGGGACCACCCCCTCCTCCCCGAGGCTGAGGCGTGTGTGCGGCAACACCTCCCCGA
CCTCTACGCTGCTGCCGGGGGTGTCAACATCTGGGCCCTGGTGGCGGCTGTGGTGCTCCTCTCCAGCAGTGTGAATGACATCCAGCGACT
GCTCTTCTGCCTCCGGAGACCCAGCTCCACGGTGACCATGCCAGATGTCACCGAGACCCTGTACTGCATAGCCGTGCTTCTCTACGCCAT
GAGGGAGAAGGGGATTAACATCAGCAATAGGATTCACTACAACATTTTCTATTGCCTATATCTTCAGGAGAATTCCTGCACTCAGGCCAC
AAAAGTTAAAGAGGAGCCATCTGTCTGGCCAGGCAAGAAAACCATCCAACTTACACATGAACAACAGCTGATTCTGAATCACAAGATGGA
ACCTCTCCAGGTGGTGAAAATTATGGCCTTTGCCGGCACTGGGAAGACCTCAACGCTGGTCAAGTATGCAGAGAAGTGGTCTCAGAGCAG
GTTTCTGTATGTGACATTCAACAAGAGCATCGCAAAGCAGGCCGAACGCGTCTTCCCCAGCAACGTCATCTGCAAAACCTTCCACTCCAT
GGCCTACGGGCACATAGGGCGGAAGTACCAGTCAAAGAAGAAGTTGAATCTCTTCAAGTTAACACCCTTCATGGTCAACTCCGTCCTTGC
TGAAGGGAAGGGTGGATTCATAAGAGCCAAGCTTGTGTGTAAGACTCTAGAAAACTTCTTTGCCTCGGCTGACGAAGAGCTGACCATTGA
TCACGTGCCTATTTGGTGTAAGAACAGCCAAGGACAGAGAGTCATGGTTGAGCAGAGTGAAAAACTGAATGGTGTCCTTGAAGCGAGCCG
CCTCTGGGATAACATGCGGAAGCTGGGGGAGTGCACAGAAGAGGCGCACCAGATGACTCATGACGGCTACTTGAAACTCTGGCAGCTGAG
CAAGCCTTCGCTGGCCTCTTTTGACGCCATCTTTGTGGATGAGGCCCAGGACTGCACACCAGCTATCATGAACATAGTTCTGTCTCAGCC
ATGTGGGAAAATCTTTGTAGGGGACCCGCACCAGCAGATCTATACCTTCCGGGGTGCGGTCAACGCCCTGTTCACAGTGCCCCACACCCA
CGTCTTCTATCTCACGCAGGATGAAACTGAATTCCGAGATAAATTATCTCCAATCAACATTAGTTTGAATTACAGTTTGGACGAATCCAC
CTTTAAAGAAGGCCTGGAAGTGAAACCAATATTGAACTACTACAGAGAAAACATTGTTAGTGAACAGGCTCACATTCTGGTGGACTGTGG
AGAAGACAATCTGTGTGTTCCTGACTTGAAGCTGTCGGCTAGACCAGATAAGCATCAGGTAATCATTGGAGATGAAAATCACCTTATGCT
CATAATAAATGCAAGAAATGAAGGGGAAGGAGCATATGAAGCTGAACTCTTTGTAATGATACCAGAAGAGGCAGATTATGTTGGAATCGA
ACGCAACAACAAGGGATTTCGACCACTGAGCTGTGAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTAT
GGTGTCTGGAACAAATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGATCTCCAAAT
CAGAAGTTCCAACAAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGT
GTCACACCCTCCGCAGATTGTTCTGCCCATTCATAACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGA
ACATATTTATGAGCTGCACAATATTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATT
TCTTCTCTATATTTTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGGATATAAAGCCTGCTGC
CTCCCCAGAGGACACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGA
ATTCCACAGACAGAGCCCTGCAAAAATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGG
AGAAAGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGT
GTCCTTTGAAGTTAAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGACATCAGTTATTTGGGC
AACTCCGAATGTTTCCTTCTCAATCCCATTATGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGC
TTTATGGAAGTGTGGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGACAAGACCCCTGA
GGCATGACAAGAAAAAAAAAGAAGACCAAAGACCTCAAACACTGGTCCTGTTCAAAGAAAAAGAAAGAACATGAGGGTTAAAAATCAAAG
CTTTCTGATACCTGACAGTGACCCAGGAAATGGAGGGGACCCTGGAAACATCACCTCATCTACACCGCACTTTGGAGAAATTGTCCTGGG
TGCCCAGTGAGCCCTGTTGGAAAAGGAAACACCAAAGCTGGAGAAGCCATCAGCAATTGTGGAAGATTTTCTTTTGCTTTAATCGTTCTG
TACTTGGCAGACACTTTGAAATGCGTATGGGAACGTAAGTTGCAGTCCAGATCAATCCAGCATAAGTTGCAGAGATGAAATGTCTGAATC
ACTATAGAATTTACAAGGTGAACTAAGGTGAAATGACTGATTTACTATAGAACTTAGAACTAAGACCACACCATCCAACACTACTGTATC
CAATGGAACATTTGACACCTCCCTATGGAAAAGAAACATTTCTAAGGACATTATGGCTCAGGGAGACAAGCAATATGTTGTTGGTACTGT
GAAAGTACTTTTGAAAGGACAAAAATAATCTTGTGAGTGAGGGTGAGAGTTTATTTATTTATTTTCCATGTCTCTAGGTTGAGAATCTGT
CATCTAGAGAATTTGGAAATTAAGATTTGGTTAGCTAGTTTTCAAAATCACTCACTCAGTTTCCTCCTAAGAACCACTGTGTGCAGATAA
CTCATTTAGCAGAGCTTCTTCAGAATTTAGACAGTGCTAAGGAAAGGAAGATTGGCATTAGGAATCAGTTCTATTTAATACCTTGCTGCC
TTCCATCTGAAATTCCTTTCACTCACATTATCCAGGGACTCACATCTGCTTAATTTAGCTTTGCAAGATGTTGCATTTATATTTCCTTGT
ATATCTTTCCATTGACTTAGTTAATACATGAATTTCGAGGTACTCTCTACCTTTGGAGTGTTTAAAAGTCATGGTAAAATGTCTAGAGTT
CATTAATTAAAAAGCAATTTAACATTATGGGTAAACATTATTTTTAATATCTATAAGAAGCAACACTTCTTATAGATATTTAGCTTGGGA
TTAAATACCCGTTTTTCCTGCTATGCCTTGTACTTGTATACACAGAGAAAACATGTTGAATATAACTTAGACAAAAACATAAAATTATAC
AGGCATGAGCCAAACTGGGAAAACTGATTCCTAAAGATTTTTATTTAAAATTGCTTATTCCAACTTTATTACTTATTTTTACTGCTAATC
TTTATAATATGTAACTTTGGAGAATAATCTTTTATTTAAGCTATTTTCCCATCATCTTGAATTTAACCATCACAAATTTTTTATGTTTAA
AACTCTTGTAAATAATTCATAATCTTGTAATATTATCATTTTTGAAGTAAAATTGACCAGCCAAATTTATAGGTAGTCTGCACAATTTTG
TATCCTTTTTTAATAATGAAAAATTACTATGAAGAAATACTGAACAAATTTTTATGTGCAATATTTTATAGACCTATGTATCTGAAGCAT
GTTTACACTGGCGTTTTTTTTTTTAATTAATTTCCTAAATGTTAAGTATGATAGAACAAGCTGACCCAAATCCTTAAGTTTACAAAGCTG
TTGGAAAACTTTGTGTCCTGATTTCAACAATCACGCTTTGTTTGAAAGATGAGCCAAGCTCACAGACACTAAATTTTATGTCATGCCATA
AGCTGGAGAGGAGCCATTTGGCTACAGCTGCGGAACTTCATTGAGGAGCAAATGAAAGGCACATGGACGAGCACGCTGGTGCAGTTCATG
TTCTTCCTGCCTGTGAATTGAATACTGTCCTGGTAGCAGTTTCGGGTCGGTCAGGAGCTCAAGGCTGGTTTGTGTGGCTGACTACGGATG
AGCACTGAAGTTGCCTCAAAGAATTAAGGGGTGTCCACACCAGCCTCTGGGGGTCTTTGGTGTTAGTCTTCCAGGTAGAGCTGGTTTTAC
AAGTAGGTGGCCATCTACAGGATGTGATGTGAGCGATGCCAGACAGCTCTCTCTGACCCCAGGTAATGCCCTGAATCTGGTGATCCTGGC
TGATCTGTGACCAATAGAGATTAGCTCCTTGGGATTTGGGGTCCTAAAAGGTCCCTGAAAAAATGCACCCCTTGTCTTTAAGCCAACATT
GGTGAAGGAACTGAGAACTCTTAGGGTTACATAAAAAAAGACCCCTGTTGAGATAGTTTATGCAGATACCTGGAAGGAACTAGAGATGCC
AGGAGGAAGACTGAGACCCAGAATGAAGCAAGGCATGAGGGCTCCAAAGTGAACTGCACCATCCCAGAGTCTCAGCCAAGATGGCCCTTT
CCTAGAGGGACGGGCACCTTCCACCTGCCCACAGGCACTGCTACCTATGGGAATTGCAGAAGGCCGTTGTACACACGCGCATGCACGCAG
TGGCCCTCTGCCCTTTAGAATATGGAAGCAAAGTCTGGGTGCAGTGACTCACACTTGTAATCCCAACACTTTGGGAGGCCGAGACGGGCA
GATCACCTGAGTTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGT
GGCAGTCTCCTGTAATCCCAGCTACCTAGGAGGCTGAGGCAGAGAGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGA
TCGCGCGACTGCACTCCAGCCTGGGCGACAGAGGGAAACTCTGTCTCAACAAAAAAATAAATAAAATAAAAAATAAAAAAAGAATATGGA
AGCAAATGGAGAAAGGGAGGAAACTGAGGTCAGGCAAACCTTCCAGCAATCCGTTCTGCCCAGAGAACATACTGACGACAGAGAACACAC
TGAGCGTTATCTGCTTCTAGTTAGAGCATTGCCGATTGCCTTCATAATTCATAATGTGCTGTGCTCCTCTGAGGGTCTATCTGTATTTCT
CTTCAAAGAATTCCCTTTTTAAATTCTTGCAGCTGGGTTTTAAGACACAATAATGGGGCAAATTAAGTTTTATAAACTTGGAGATTTTTA
TACAGTAAATAAAAAAATAATATGTACTAGTCACCCCTGAAACTGCATTCTTAGAACTCGACTCTTGTTTTATTTAAATACGTGCGTAGA

>29765_29765_3_FBXO18-ITGA8_FBXO18_chr10_5960441_ENST00000397269_ITGA8_chr10_15648421_ENST00000378076_length(amino acids)=1175AA_BP=700
MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSE
GDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGET
DQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAV
SKVDGILSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVND
IQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILN
HKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVN
SVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKL
WQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQDETEFRDKLSPINISLNYSL
DESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADY
VGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVE
IRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDI
KPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYAL
ASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTND

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Fusion Gene PPI Analysis for FBXO18-ITGA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXO18-ITGA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXO18-ITGA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource