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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXO31-ZNRF1 (FusionGDB2 ID:29795)

Fusion Gene Summary for FBXO31-ZNRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO31-ZNRF1
Fusion gene ID: 29795
HgeneTgene
Gene symbol

FBXO31

ZNRF1

Gene ID

79791

84937

Gene nameF-box protein 31zinc and ring finger 1
SynonymsFBX14|FBXO14|Fbx31|MRT45|pp2386NIN283
Cytomap

16q24.2

16q23.1

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 31SCF ubiquitin ligase specificity factorputative breast cancer tumor-suppressorE3 ubiquitin-protein ligase ZNRF1RING-type E3 ubiquitin transferase ZNRF1nerve injury gene 283nerve injury-induced gene 283 proteinzinc and ring finger 1, E3 ubiquitin protein ligasezinc and ring finger protein 1zinc/RING finger protein 1
Modification date2020031320200313
UniProtAcc

Q5XUX0

.
Ensembl transtripts involved in fusion geneENST00000311635, ENST00000563956, 
ENST00000564320, ENST00000320619, 
ENST00000335325, ENST00000566250, 
ENST00000567962, 
Fusion gene scores* DoF score4 X 4 X 4=647 X 7 X 6=294
# samples 69
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO31 [Title/Abstract] AND ZNRF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXO31(87393901)-ZNRF1(75127470), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO31

GO:0006974

cellular response to DNA damage stimulus

19412162

HgeneFBXO31

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

19412162


check buttonFusion gene breakpoints across FBXO31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNRF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E5-A4TZ-01AFBXO31chr16

87393901

-ZNRF1chr16

75127470

+
ChimerDB4BLCATCGA-E5-A4TZFBXO31chr16

87393900

-ZNRF1chr16

75127469

+


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Fusion Gene ORF analysis for FBXO31-ZNRF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000311635ENST00000564320FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
5CDS-3UTRENST00000311635ENST00000564320FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
In-frameENST00000311635ENST00000320619FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
In-frameENST00000311635ENST00000320619FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
In-frameENST00000311635ENST00000335325FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
In-frameENST00000311635ENST00000335325FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
In-frameENST00000311635ENST00000566250FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
In-frameENST00000311635ENST00000566250FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
In-frameENST00000311635ENST00000567962FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
In-frameENST00000311635ENST00000567962FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
intron-3CDSENST00000563956ENST00000320619FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
intron-3CDSENST00000563956ENST00000320619FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
intron-3CDSENST00000563956ENST00000335325FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
intron-3CDSENST00000563956ENST00000335325FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
intron-3CDSENST00000563956ENST00000566250FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
intron-3CDSENST00000563956ENST00000566250FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
intron-3CDSENST00000563956ENST00000567962FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
intron-3CDSENST00000563956ENST00000567962FBXO31chr16

87393900

-ZNRF1chr16

75127469

+
intron-3UTRENST00000563956ENST00000564320FBXO31chr16

87393901

-ZNRF1chr16

75127470

+
intron-3UTRENST00000563956ENST00000564320FBXO31chr16

87393900

-ZNRF1chr16

75127469

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311635FBXO31chr1687393901-ENST00000335325ZNRF1chr1675127470+39794254684226
ENST00000311635FBXO31chr1687393901-ENST00000320619ZNRF1chr1675127470+18454254837277
ENST00000311635FBXO31chr1687393901-ENST00000566250ZNRF1chr1675127470+7434254630208
ENST00000311635FBXO31chr1687393901-ENST00000567962ZNRF1chr1675127470+9084254684226
ENST00000311635FBXO31chr1687393900-ENST00000335325ZNRF1chr1675127469+39794254684226
ENST00000311635FBXO31chr1687393900-ENST00000320619ZNRF1chr1675127469+18454254837277
ENST00000311635FBXO31chr1687393900-ENST00000566250ZNRF1chr1675127469+7434254630208
ENST00000311635FBXO31chr1687393900-ENST00000567962ZNRF1chr1675127469+9084254684226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311635ENST00000335325FBXO31chr1687393901-ZNRF1chr1675127470+0.04911720.9508828
ENST00000311635ENST00000320619FBXO31chr1687393901-ZNRF1chr1675127470+0.096077430.9039226
ENST00000311635ENST00000566250FBXO31chr1687393901-ZNRF1chr1675127470+0.0297495560.9702505
ENST00000311635ENST00000567962FBXO31chr1687393901-ZNRF1chr1675127470+0.0250096060.9749904
ENST00000311635ENST00000335325FBXO31chr1687393900-ZNRF1chr1675127469+0.04911720.9508828
ENST00000311635ENST00000320619FBXO31chr1687393900-ZNRF1chr1675127469+0.096077430.9039226
ENST00000311635ENST00000566250FBXO31chr1687393900-ZNRF1chr1675127469+0.0297495560.9702505
ENST00000311635ENST00000567962FBXO31chr1687393900-ZNRF1chr1675127469+0.0250096060.9749904

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Fusion Genomic Features for FBXO31-ZNRF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXO31chr1687393900-ZNRF1chr1675127469+5.43E-091
FBXO31chr1687393900-ZNRF1chr1675127469+5.43E-091
FBXO31chr1687393900-ZNRF1chr1675127469+5.43E-091
FBXO31chr1687393900-ZNRF1chr1675127469+5.43E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXO31-ZNRF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:87393901/chr16:75127470)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO31

Q5XUX0

.
FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. {ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXO31chr16:87393900chr16:75127469ENST00000311635-2958_63137540.0Compositional biasNote=Poly-Pro
HgeneFBXO31chr16:87393901chr16:75127470ENST00000311635-2958_63137540.0Compositional biasNote=Poly-Pro
HgeneFBXO31chr16:87393900chr16:75127469ENST00000311635-2964_110137540.0DomainF-box
HgeneFBXO31chr16:87393901chr16:75127470ENST00000311635-2964_110137540.0DomainF-box
TgeneZNRF1chr16:87393900chr16:75127469ENST0000032061906184_225141251.0Zinc fingerRING-type%3B atypical
TgeneZNRF1chr16:87393900chr16:75127469ENST0000033532505184_225141960.0Zinc fingerRING-type%3B atypical
TgeneZNRF1chr16:87393900chr16:75127469ENST0000056796205184_22514141.333333333333336Zinc fingerRING-type%3B atypical
TgeneZNRF1chr16:87393901chr16:75127470ENST0000032061906184_225141251.0Zinc fingerRING-type%3B atypical
TgeneZNRF1chr16:87393901chr16:75127470ENST0000033532505184_225141960.0Zinc fingerRING-type%3B atypical
TgeneZNRF1chr16:87393901chr16:75127470ENST0000056796205184_22514141.333333333333336Zinc fingerRING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNRF1chr16:87393900chr16:75127469ENST00000320619062_10141251.0RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr16:87393900chr16:75127469ENST00000335325052_10141960.0RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr16:87393900chr16:75127469ENST00000567962052_1014141.333333333333336RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr16:87393901chr16:75127470ENST00000320619062_10141251.0RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr16:87393901chr16:75127470ENST00000335325052_10141960.0RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr16:87393901chr16:75127470ENST00000567962052_1014141.333333333333336RegionNote=Required for endosomal and lysosomal localization and myristoylation


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Fusion Gene Sequence for FBXO31-ZNRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29795_29795_1_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000320619_length(transcript)=1845nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGGAAGAATACAAAGAAGCCT
CAGAGGGGCTCAGCCTGAGAAAACCTGGCTCTCAGGAAGAACTTTGCAAGAGCAGCCGTGGAGGACAGAGTGCTCTTGGGCCCCCATGGC
CCAAATGCAGAGTTACCCCCACTGCCCTGTGGAGAACCGGGAAGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGATCTGCCTGGA
GGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGAAGTGAACAG
ATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGACAGAGCGCCCCTGCTCCAGGGAGGAGG
CTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGCACTGACTTCCAGATCATGGTTCTCCCT
TCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCCTCAGCCCAGGAG
GGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATAAAAAAAAAGTCT
AGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACCCACTCAGTGACAGACGAACACAGCTAA
GGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGCCCTCTCCACCACCAACTTCTCTACTTT
GGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAGACCCTAATATCTTGACTTCATTGCCAA
AAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGGTTCCGGTCAGTTCAGAGGATTTAACAA
TCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCAGAAAACTTAAACAAAAAAAGACTTACT
AAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGATGTTCACACGTGGCATCAGCCCATGCAA
GATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATGTTCAAAGCTTGGGAGAAAAGCTTTCTT

>29795_29795_1_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000320619_length(amino acids)=277AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNGRIQRSLR
GAQPEKTWLSGRTLQEQPWRTECSWAPMAQMQSYPHCPVENREDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRS

--------------------------------------------------------------
>29795_29795_2_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000335325_length(transcript)=3979nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGA
CGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTG
CATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGA
CAGAGCGCCCCTGCTCCAGGGAGGAGGCTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGC
ACTGACTTCCAGATCATGGTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTAT
CCTTCCCCTCACCCCTCAGCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACA
AAAAAAAATTATATAAAAAAAAAGTCTAGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACC
CACTCAGTGACAGACGAACACAGCTAAGGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGC
CCTCTCCACCACCAACTTCTCTACTTTGGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAG
ACCCTAATATCTTGACTTCATTGCCAAAAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGG
TTCCGGTCAGTTCAGAGGATTTAACAATCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCA
GAAAACTTAAACAAAAAAAGACTTACTAAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGAT
GTTCACACGTGGCATCAGCCCATGCAAGATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATG
TTCAAAGCTTGGGAGAAAAGCTTTCTTCATTAGTCAAGGTGTTTTGATATGGTATTAAAATGTCTAATAAAAGATGGCACTGCGTGATTT
TATTTTAATGAAGTGTTATACAATCAAGAAATGGGGGCAAGGGCCTGCCCCCCACTCCCTCACCTACCTCCTTAGCATTCCTTCAGGCTG
CTACTCGGGGCTCCAGGTGTGTGAATTGGTCCTCAGATAGTCAGGCCTGGGTGGAGGGAGTGGCAAGTCAGGCGTGCCTCCTACAAGCTT
CCTAACCTCTTAAGCATCATGGAACCAGTCAGCCCTCTGTGGAGTCATTGTGCTGGACCTCTGAAAAGATCTGCAGGGGCCAAGATGTTG
CAGCCACCGGAGGCTGCAAGGATGTGGGTTCTTCCAGGTGTGGGCCCAGCCCCCCTCCTTCCAGCCTTTGCTCCCCATCCCACGTTCCAC
TCGCCCTGCCTGTTGTTCAGTTTGCGTCTCAGTGCTGACTCACGGGCATGCTTCATTGAGGCCCAGGAAGAGGCCCTGGTTTGGGGCTGT
GCCAGCTCAGAGCCCTTGAACCAGAACCAACTGCTCAGGCTCACAAAAGTTGGCAAAATGCGGGCTGGGCAGGCAGCTCGGGGCAGGGAG
CAGCAGTGCAGGCCTGGCCTGTGTCCCCGTGCCCAGCGGGCTCCCGGAGCAGCATTCCAGAGCCTCCTGCAGAGCCAGCGAAGGAAAGCT
CTAGAGGGAGACGACTCCACCGCCTCTCTGCTCTGACCCTTCTCAGGCCCGCCTGATGTGCTGGACCATCCCCCTGCTGCCACGGCCCCT
GGCTCCGCAGTCACCCTCCATCAGATGCTTCCAGAAGCACCTACTCTGTGCAAGGGCATTCACAACAGGCCAGTGGGCAAACGTGAGCCA
GGGCCAGCGGAGAAACACTAAAGAAGACTCGGTGGTTCAGAGCCTGGGTCTCAGCGCGGGACCCGTCTGGGGTGAAGACCTTGGGGCTGT
TGTGAGTCGGTGGCAGGAACGTGGGCTCTAGACTGTGCATTCAGGCTCTCCTACTTGGCAGAATGATCTTGGGGAAACGACTTCATCTGA
ACTTCAGATATTTCACATGTGAAGCGGGGACAAAACCATGCAGCTCAGAGGTCCCTGTGGGGGCTGGGGGAGCTGCCCTGCAGGTCTTGG
CACATGCACAGCAGGCTCCCCATAGCTTTGTCACCACAAAGGGCACTGTTCTATTCACAGCACCTCCTGCTTCTGCCTGGCAACTGTGTC
TCCCTGTGCTATATTTAATTCCACCAGCAAAGCTGGCGAGGCAGGGCCCAGCCCTGAAGGAGATCTCCTTGCCTGACCCCTGGACCTGGA
AATGGAGGCTTCATGTGCCCGCCTTGGCGGCTTAAGCCTGCTGCTTTGGCAGTGCCATGGGTGAGCCGAGCAGCTGTGAGGTGGGTGGGG
CAGGGCTGTAGCCCACGCCGGGTGCTATTCCAGGCTCTAGGGGCTGGTGCTCATCCCCACCCCCAGCGACTTCCGTCCTACCTGGCATGC
TGCAGCCCTCTGCCGGCTGTGGTGTCCTCTGAATTTGGACCCAGGTTGCCTGCTCTTGTTGTGGGGGTGGGATTGGGGCTGTCTGTGTTT
CCCAGGTGGAGCTCATGTTTGTGATCCTCTATCTGGACAGCTCTCCAGAATCCTGTGTTGCCCCTGTTCTGCCTTTCTGGGATGGGAGAG
AAGGTGAGGGAGCCGGCGAGCAGGTTCTACCCTCTCTGCTAAGGGCCTAGCACACTTTGATGAGGTTCCTGGACGTGAGACCCTCACAAA
GACCAACCATTCCTCTAATAGCCATTTAACGGTACTGCAGTTCATGGGAAAATGTCCTCATTCTTAGGAGATAGATGCTGGATTATATAG
GTGAATGCCTTCAAGAAATGTGTAATTTAATTCCAAATAGTTCCCCCCAAAATACACAAAGCAAATAAGGCCAAAATGTTCATTGTTGAA
TCTGCAGTGGCTGGTATTTCAGTGAACAGTGTACTTGTTCTTTCAACTTTTCTGTATGTTTGGAATTTTTCTTAATAAAAGATTGTGGGA
AATGGTCATTTGCTGAGCGCCTCCTAGTTGCCAGGCACTGGAGGGCGCATCAAAGAAGAGTCCTACCCAGGAGGGAGAGCGCAGCTGCTG
CAGGATTCTCGCCTGGAAGAGTGGGTGGCTGGCTGGCTGGCTGGAAGGGGAGGGGCGAGAGGGCTGTCTCGGTGATGAGCACACGCGTGC
TGGGGTGGTTTGGGGAGAGGGCTGAGATTTGTCACCAGTGAGCCCTTGGCACGGTCTCTGCTCCCCACCAGGGCAGCACGGGACAGAAAC

>29795_29795_2_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000335325_length(amino acids)=226AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA

--------------------------------------------------------------
>29795_29795_3_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000566250_length(transcript)=743nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGA
CGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGGTA
GGAGGGGTTGGCAAGGTAGCTTAGTGCACCCCACCTCCCAGAGGGGCGGACCCCCATCTCCAGCCATTCTGTCTCCTTTGGTTATGGGAT

>29795_29795_3_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000566250_length(amino acids)=208AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA

--------------------------------------------------------------
>29795_29795_4_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000567962_length(transcript)=908nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGA
CGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTG
CATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGATC
ATGGTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCC
TCAGCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATA

>29795_29795_4_FBXO31-ZNRF1_FBXO31_chr16_87393900_ENST00000311635_ZNRF1_chr16_75127469_ENST00000567962_length(amino acids)=226AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA

--------------------------------------------------------------
>29795_29795_5_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000320619_length(transcript)=1845nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGGAAGAATACAAAGAAGCCT
CAGAGGGGCTCAGCCTGAGAAAACCTGGCTCTCAGGAAGAACTTTGCAAGAGCAGCCGTGGAGGACAGAGTGCTCTTGGGCCCCCATGGC
CCAAATGCAGAGTTACCCCCACTGCCCTGTGGAGAACCGGGAAGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGATCTGCCTGGA
GGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGAAGTGAACAG
ATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGACAGAGCGCCCCTGCTCCAGGGAGGAGG
CTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGCACTGACTTCCAGATCATGGTTCTCCCT
TCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCCTCAGCCCAGGAG
GGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATAAAAAAAAAGTCT
AGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACCCACTCAGTGACAGACGAACACAGCTAA
GGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGCCCTCTCCACCACCAACTTCTCTACTTT
GGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAGACCCTAATATCTTGACTTCATTGCCAA
AAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGGTTCCGGTCAGTTCAGAGGATTTAACAA
TCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCAGAAAACTTAAACAAAAAAAGACTTACT
AAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGATGTTCACACGTGGCATCAGCCCATGCAA
GATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATGTTCAAAGCTTGGGAGAAAAGCTTTCTT

>29795_29795_5_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000320619_length(amino acids)=277AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNGRIQRSLR
GAQPEKTWLSGRTLQEQPWRTECSWAPMAQMQSYPHCPVENREDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRS

--------------------------------------------------------------
>29795_29795_6_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000335325_length(transcript)=3979nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGA
CGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTG
CATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGA
CAGAGCGCCCCTGCTCCAGGGAGGAGGCTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGC
ACTGACTTCCAGATCATGGTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTAT
CCTTCCCCTCACCCCTCAGCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACA
AAAAAAAATTATATAAAAAAAAAGTCTAGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACC
CACTCAGTGACAGACGAACACAGCTAAGGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGC
CCTCTCCACCACCAACTTCTCTACTTTGGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAG
ACCCTAATATCTTGACTTCATTGCCAAAAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGG
TTCCGGTCAGTTCAGAGGATTTAACAATCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCA
GAAAACTTAAACAAAAAAAGACTTACTAAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGAT
GTTCACACGTGGCATCAGCCCATGCAAGATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATG
TTCAAAGCTTGGGAGAAAAGCTTTCTTCATTAGTCAAGGTGTTTTGATATGGTATTAAAATGTCTAATAAAAGATGGCACTGCGTGATTT
TATTTTAATGAAGTGTTATACAATCAAGAAATGGGGGCAAGGGCCTGCCCCCCACTCCCTCACCTACCTCCTTAGCATTCCTTCAGGCTG
CTACTCGGGGCTCCAGGTGTGTGAATTGGTCCTCAGATAGTCAGGCCTGGGTGGAGGGAGTGGCAAGTCAGGCGTGCCTCCTACAAGCTT
CCTAACCTCTTAAGCATCATGGAACCAGTCAGCCCTCTGTGGAGTCATTGTGCTGGACCTCTGAAAAGATCTGCAGGGGCCAAGATGTTG
CAGCCACCGGAGGCTGCAAGGATGTGGGTTCTTCCAGGTGTGGGCCCAGCCCCCCTCCTTCCAGCCTTTGCTCCCCATCCCACGTTCCAC
TCGCCCTGCCTGTTGTTCAGTTTGCGTCTCAGTGCTGACTCACGGGCATGCTTCATTGAGGCCCAGGAAGAGGCCCTGGTTTGGGGCTGT
GCCAGCTCAGAGCCCTTGAACCAGAACCAACTGCTCAGGCTCACAAAAGTTGGCAAAATGCGGGCTGGGCAGGCAGCTCGGGGCAGGGAG
CAGCAGTGCAGGCCTGGCCTGTGTCCCCGTGCCCAGCGGGCTCCCGGAGCAGCATTCCAGAGCCTCCTGCAGAGCCAGCGAAGGAAAGCT
CTAGAGGGAGACGACTCCACCGCCTCTCTGCTCTGACCCTTCTCAGGCCCGCCTGATGTGCTGGACCATCCCCCTGCTGCCACGGCCCCT
GGCTCCGCAGTCACCCTCCATCAGATGCTTCCAGAAGCACCTACTCTGTGCAAGGGCATTCACAACAGGCCAGTGGGCAAACGTGAGCCA
GGGCCAGCGGAGAAACACTAAAGAAGACTCGGTGGTTCAGAGCCTGGGTCTCAGCGCGGGACCCGTCTGGGGTGAAGACCTTGGGGCTGT
TGTGAGTCGGTGGCAGGAACGTGGGCTCTAGACTGTGCATTCAGGCTCTCCTACTTGGCAGAATGATCTTGGGGAAACGACTTCATCTGA
ACTTCAGATATTTCACATGTGAAGCGGGGACAAAACCATGCAGCTCAGAGGTCCCTGTGGGGGCTGGGGGAGCTGCCCTGCAGGTCTTGG
CACATGCACAGCAGGCTCCCCATAGCTTTGTCACCACAAAGGGCACTGTTCTATTCACAGCACCTCCTGCTTCTGCCTGGCAACTGTGTC
TCCCTGTGCTATATTTAATTCCACCAGCAAAGCTGGCGAGGCAGGGCCCAGCCCTGAAGGAGATCTCCTTGCCTGACCCCTGGACCTGGA
AATGGAGGCTTCATGTGCCCGCCTTGGCGGCTTAAGCCTGCTGCTTTGGCAGTGCCATGGGTGAGCCGAGCAGCTGTGAGGTGGGTGGGG
CAGGGCTGTAGCCCACGCCGGGTGCTATTCCAGGCTCTAGGGGCTGGTGCTCATCCCCACCCCCAGCGACTTCCGTCCTACCTGGCATGC
TGCAGCCCTCTGCCGGCTGTGGTGTCCTCTGAATTTGGACCCAGGTTGCCTGCTCTTGTTGTGGGGGTGGGATTGGGGCTGTCTGTGTTT
CCCAGGTGGAGCTCATGTTTGTGATCCTCTATCTGGACAGCTCTCCAGAATCCTGTGTTGCCCCTGTTCTGCCTTTCTGGGATGGGAGAG
AAGGTGAGGGAGCCGGCGAGCAGGTTCTACCCTCTCTGCTAAGGGCCTAGCACACTTTGATGAGGTTCCTGGACGTGAGACCCTCACAAA
GACCAACCATTCCTCTAATAGCCATTTAACGGTACTGCAGTTCATGGGAAAATGTCCTCATTCTTAGGAGATAGATGCTGGATTATATAG
GTGAATGCCTTCAAGAAATGTGTAATTTAATTCCAAATAGTTCCCCCCAAAATACACAAAGCAAATAAGGCCAAAATGTTCATTGTTGAA
TCTGCAGTGGCTGGTATTTCAGTGAACAGTGTACTTGTTCTTTCAACTTTTCTGTATGTTTGGAATTTTTCTTAATAAAAGATTGTGGGA
AATGGTCATTTGCTGAGCGCCTCCTAGTTGCCAGGCACTGGAGGGCGCATCAAAGAAGAGTCCTACCCAGGAGGGAGAGCGCAGCTGCTG
CAGGATTCTCGCCTGGAAGAGTGGGTGGCTGGCTGGCTGGCTGGAAGGGGAGGGGCGAGAGGGCTGTCTCGGTGATGAGCACACGCGTGC
TGGGGTGGTTTGGGGAGAGGGCTGAGATTTGTCACCAGTGAGCCCTTGGCACGGTCTCTGCTCCCCACCAGGGCAGCACGGGACAGAAAC

>29795_29795_6_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000335325_length(amino acids)=226AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA

--------------------------------------------------------------
>29795_29795_7_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000566250_length(transcript)=743nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGA
CGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGGTA
GGAGGGGTTGGCAAGGTAGCTTAGTGCACCCCACCTCCCAGAGGGGCGGACCCCCATCTCCAGCCATTCTGTCTCCTTTGGTTATGGGAT

>29795_29795_7_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000566250_length(amino acids)=208AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA

--------------------------------------------------------------
>29795_29795_8_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000567962_length(transcript)=908nt_BP=425nt
GTCACTGGGCGGCATGGCGGTGTGTGCTCGCCTTTGCGGCGTGGGCCCGTCGCGCGGATGTCGGCGCCGCCAGCAGCGCCGGGGCCCGGC
CGAGACGGCGGCGGCCGACAGCGAGCCGGACACAGACCCCGAGGAGGAGCGCATCGAGGCTAGCGCCGGGGTCGGGGGCGGCTTGTGCGC
GGGCCCCTCGCCGCCGCCCCCGCGCTGCTCGCTGCTGGAGCTGCCGCCCGAGCTGCTGGTGGAGATCTTCGCGTCGCTGCCGGGCACGGA
CCTACCCAGCTTGGCCCAGGTCTGCACGAAGTTCCGGCGCATCCTCCACACCGACACCATCTGGAGGAGGCGTTGCCGTGAGGAGTATGG
TGTTTGCGAAAACTTGCGGAAGCTGGAGATCACAGGCGTGTCTTGTCGGGACGTCTATGCGAAGCGTTTCAAGTGCCCCATTTGCTCCAA
GTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGA
CGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTG
CATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGATC
ATGGTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCC
TCAGCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATA

>29795_29795_8_FBXO31-ZNRF1_FBXO31_chr16_87393901_ENST00000311635_ZNRF1_chr16_75127470_ENST00000567962_length(amino acids)=226AA_BP=141
MGGMAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDL
PSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKRFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKDA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXO31-ZNRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXO31-ZNRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXO31-ZNRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource