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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXO44-AGTRAP (FusionGDB2 ID:29844)

Fusion Gene Summary for FBXO44-AGTRAP

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO44-AGTRAP
Fusion gene ID: 29844
HgeneTgene
Gene symbol

FBXO44

AGTRAP

Gene ID

93611

57085

Gene nameF-box protein 44angiotensin II receptor associated protein
SynonymsFBG3|FBX30|FBX6A|Fbx44|Fbxo6aATRAP
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 44F-box gene 3F-box protein FBX30F-box/G-domain protein 3type-1 angiotensin II receptor-associated proteinAT1 receptor-associated proteinATI receptor-associated proteinangiotensin II, type I receptor-associated protein
Modification date2020031320200327
UniProtAcc

Q9H4M3

Q6RW13

Ensembl transtripts involved in fusion geneENST00000251546, ENST00000251547, 
ENST00000376760, ENST00000376762, 
ENST00000376768, ENST00000376770, 
ENST00000314340, ENST00000376627, 
ENST00000376629, ENST00000452018, 
ENST00000491346, ENST00000510878, 
ENST00000376637, ENST00000400895, 
Fusion gene scores* DoF score4 X 3 X 3=367 X 5 X 5=175
# samples 37
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO44 [Title/Abstract] AND AGTRAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXO44(11718928)-AGTRAP(11807496), # samples:2
Anticipated loss of major functional domain due to fusion event.FBXO44-AGTRAP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO44

GO:0010498

proteasomal protein catabolic process

25970626


check buttonFusion gene breakpoints across FBXO44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AGTRAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YBFBXO44chr1

11718928

+AGTRAPchr1

11807496

+


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Fusion Gene ORF analysis for FBXO44-AGTRAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000251546ENST00000314340FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251546ENST00000376627FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251546ENST00000376629FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251546ENST00000452018FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251546ENST00000491346FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251547ENST00000314340FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251547ENST00000376627FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251547ENST00000376629FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251547ENST00000452018FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000251547ENST00000491346FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376760ENST00000314340FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376760ENST00000376627FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376760ENST00000376629FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376760ENST00000452018FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376760ENST00000491346FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376762ENST00000314340FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376762ENST00000376627FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376762ENST00000376629FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376762ENST00000452018FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376762ENST00000491346FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376768ENST00000314340FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376768ENST00000376627FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376768ENST00000376629FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376768ENST00000452018FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376768ENST00000491346FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376770ENST00000314340FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376770ENST00000376627FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376770ENST00000376629FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376770ENST00000452018FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-3UTRENST00000376770ENST00000491346FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-intronENST00000251546ENST00000510878FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-intronENST00000251547ENST00000510878FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-intronENST00000376760ENST00000510878FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-intronENST00000376762ENST00000510878FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-intronENST00000376768ENST00000510878FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
5CDS-intronENST00000376770ENST00000510878FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000251546ENST00000376637FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000251546ENST00000400895FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000376760ENST00000376637FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000376760ENST00000400895FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000376762ENST00000376637FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000376762ENST00000400895FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000376768ENST00000376637FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
Frame-shiftENST00000376768ENST00000400895FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
In-frameENST00000251547ENST00000376637FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
In-frameENST00000251547ENST00000400895FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
In-frameENST00000376770ENST00000376637FBXO44chr1

11718928

+AGTRAPchr1

11807496

+
In-frameENST00000376770ENST00000400895FBXO44chr1

11718928

+AGTRAPchr1

11807496

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FBXO44-AGTRAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXO44chr111718928+AGTRAPchr111807496+2.23E-060.99999774
FBXO44chr111718928+AGTRAPchr111807496+2.23E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXO44-AGTRAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:11718928/chr1:11807496)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO44

Q9H4M3

AGTRAP

Q6RW13

FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXO44chr1:11718928chr1:11807496ENST00000251546+453_50166225.0DomainF-box
HgeneFBXO44chr1:11718928chr1:11807496ENST00000251547+563_50208256.0DomainF-box
HgeneFBXO44chr1:11718928chr1:11807496ENST00000376760+563_50166225.0DomainF-box
HgeneFBXO44chr1:11718928chr1:11807496ENST00000376762+453_50166225.0DomainF-box
HgeneFBXO44chr1:11718928chr1:11807496ENST00000376770+673_50208256.0DomainF-box
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000031434015108_15920160.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003143401545_5520160.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003143401577_8620160.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000037662915108_15920153.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766291545_5520153.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766291577_8620153.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000037663704108_1599112.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766370445_559112.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766370477_869112.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000040089526108_15953190.66666666666666Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004008952677_8653190.66666666666666Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000045201826108_15953156.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004520182677_8653156.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003143401524_4420160.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003143401556_7620160.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003143401587_10720160.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766291524_4420153.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766291556_7620153.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766291587_10720153.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766370424_449112.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766370456_769112.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000003766370487_1079112.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004008952656_7653190.66666666666666TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004008952687_10753190.66666666666666TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004520182656_7653156.0TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004520182687_10753156.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXO44chr1:11718928chr1:11807496ENST00000251546+4571_252166225.0DomainFBA
HgeneFBXO44chr1:11718928chr1:11807496ENST00000251547+5671_252208256.0DomainFBA
HgeneFBXO44chr1:11718928chr1:11807496ENST00000376760+5671_252166225.0DomainFBA
HgeneFBXO44chr1:11718928chr1:11807496ENST00000376762+4571_252166225.0DomainFBA
HgeneFBXO44chr1:11718928chr1:11807496ENST00000376770+6771_252208256.0DomainFBA
TgeneAGTRAPchr1:11718928chr1:11807496ENST00000314340151_2320160.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST00000376629151_2320153.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST00000376637041_239112.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST00000400895261_2353190.66666666666666Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004008952645_5553190.66666666666666Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST00000452018261_2353156.0Topological domainExtracellular
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004520182645_5553156.0Topological domainCytoplasmic
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004008952624_4453190.66666666666666TransmembraneHelical
TgeneAGTRAPchr1:11718928chr1:11807496ENST000004520182624_4453156.0TransmembraneHelical


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Fusion Gene Sequence for FBXO44-AGTRAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FBXO44-AGTRAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000031434015110_12220.666666666666668160.0AGTR1
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000037662915110_12220.666666666666668153.0AGTR1
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000037663704110_1229.0112.0AGTR1
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000040089526110_12253.0190.66666666666666AGTR1
TgeneAGTRAPchr1:11718928chr1:11807496ENST0000045201826110_12253.0156.0AGTR1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXO44-AGTRAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXO44-AGTRAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource