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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXO9-CD74 (FusionGDB2 ID:29875)

Fusion Gene Summary for FBXO9-CD74

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO9-CD74
Fusion gene ID: 29875
HgeneTgene
Gene symbol

FBXO9

CD74

Gene ID

26268

972

Gene nameF-box protein 9CD74 molecule
SynonymsFBX9|NY-REN-57|VCIA1|dJ341E18.2DHLAG|HLADG|II|Ia-GAMMA|p33
Cytomap

6p12.1

5q33.1

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 9F-box protein Fbx9cross-immune reaction antigen 1renal carcinoma antigen NY-REN-57HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated
Modification date2020031320200313
UniProtAcc

Q9UK97

P04233

Ensembl transtripts involved in fusion geneENST00000244426, ENST00000323557, 
ENST00000370939, ENST00000461222, 
ENST00000009530, ENST00000524315, 
ENST00000353334, ENST00000377795, 
Fusion gene scores* DoF score6 X 7 X 3=12631 X 31 X 11=10571
# samples 739
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/10571*10)=-4.76049392566144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO9 [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXO9(52960462)-CD74(149782188), # samples:2
Anticipated loss of major functional domain due to fusion event.FBXO9-CD74 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FBXO9-CD74 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO9

GO:0016567

protein ubiquitination

23263282

HgeneFBXO9

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

23263282

TgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

TgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

TgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

TgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

TgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

TgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

TgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

TgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

TgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

TgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

TgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

TgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

TgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581


check buttonFusion gene breakpoints across FBXO9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD74 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-64-1680-01AFBXO9chr6

52960462

+CD74chr5

149782188

-


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Fusion Gene ORF analysis for FBXO9-CD74

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000244426ENST00000009530FBXO9chr6

52960462

+CD74chr5

149782188

-
5CDS-intronENST00000244426ENST00000524315FBXO9chr6

52960462

+CD74chr5

149782188

-
5CDS-intronENST00000323557ENST00000009530FBXO9chr6

52960462

+CD74chr5

149782188

-
5CDS-intronENST00000323557ENST00000524315FBXO9chr6

52960462

+CD74chr5

149782188

-
5CDS-intronENST00000370939ENST00000009530FBXO9chr6

52960462

+CD74chr5

149782188

-
5CDS-intronENST00000370939ENST00000524315FBXO9chr6

52960462

+CD74chr5

149782188

-
Frame-shiftENST00000244426ENST00000353334FBXO9chr6

52960462

+CD74chr5

149782188

-
Frame-shiftENST00000323557ENST00000353334FBXO9chr6

52960462

+CD74chr5

149782188

-
Frame-shiftENST00000370939ENST00000353334FBXO9chr6

52960462

+CD74chr5

149782188

-
In-frameENST00000244426ENST00000377795FBXO9chr6

52960462

+CD74chr5

149782188

-
In-frameENST00000323557ENST00000377795FBXO9chr6

52960462

+CD74chr5

149782188

-
In-frameENST00000370939ENST00000377795FBXO9chr6

52960462

+CD74chr5

149782188

-
intron-3CDSENST00000461222ENST00000353334FBXO9chr6

52960462

+CD74chr5

149782188

-
intron-3CDSENST00000461222ENST00000377795FBXO9chr6

52960462

+CD74chr5

149782188

-
intron-intronENST00000461222ENST00000009530FBXO9chr6

52960462

+CD74chr5

149782188

-
intron-intronENST00000461222ENST00000524315FBXO9chr6

52960462

+CD74chr5

149782188

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370939FBXO9chr652960462+ENST00000377795CD74chr5149782188-209014132921662456
ENST00000323557FBXO9chr652960462+ENST00000377795CD74chr5149782188-221315361301785551
ENST00000244426FBXO9chr652960462+ENST00000377795CD74chr5149782188-208414071721656494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370939ENST00000377795FBXO9chr652960462+CD74chr5149782188-0.0030236840.9969764
ENST00000323557ENST00000377795FBXO9chr652960462+CD74chr5149782188-0.0084271870.99157286
ENST00000244426ENST00000377795FBXO9chr652960462+CD74chr5149782188-0.0036101290.9963898

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Fusion Genomic Features for FBXO9-CD74


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXO9-CD74


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:52960462/chr5:149782188)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO9

Q9UK97

CD74

P04233

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269|PubMed:23263282}.FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXO9chr6:52960462chr5:149782188ENST00000244426+1112185_236411448.0DomainF-box
HgeneFBXO9chr6:52960462chr5:149782188ENST00000323557+1213185_236401438.0DomainF-box
HgeneFBXO9chr6:52960462chr5:149782188ENST00000370939+1213185_236367404.0DomainF-box
HgeneFBXO9chr6:52960462chr5:149782188ENST00000244426+111294_127411448.0RepeatNote=TPR
HgeneFBXO9chr6:52960462chr5:149782188ENST00000323557+121394_127401438.0RepeatNote=TPR
HgeneFBXO9chr6:52960462chr5:149782188ENST00000370939+121394_127367404.0RepeatNote=TPR
TgeneCD74chr6:52960462chr5:149782188ENST0000035333458210_271208233.0DomainThyroglobulin type-1
TgeneCD74chr6:52960462chr5:149782188ENST0000037779536210_271147280.6666666666667DomainThyroglobulin type-1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD74chr6:52960462chr5:149782188ENST0000000953069210_271272297.0DomainThyroglobulin type-1
TgeneCD74chr6:52960462chr5:149782188ENST00000009530691_46272297.0Topological domainCytoplasmic
TgeneCD74chr6:52960462chr5:149782188ENST000000095306973_296272297.0Topological domainExtracellular
TgeneCD74chr6:52960462chr5:149782188ENST00000353334581_46208233.0Topological domainCytoplasmic
TgeneCD74chr6:52960462chr5:149782188ENST000003533345873_296208233.0Topological domainExtracellular
TgeneCD74chr6:52960462chr5:149782188ENST00000377795361_46147280.6666666666667Topological domainCytoplasmic
TgeneCD74chr6:52960462chr5:149782188ENST000003777953673_296147280.6666666666667Topological domainExtracellular
TgeneCD74chr6:52960462chr5:149782188ENST000000095306947_72272297.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCD74chr6:52960462chr5:149782188ENST000003533345847_72208233.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCD74chr6:52960462chr5:149782188ENST000003777953647_72147280.6666666666667TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for FBXO9-CD74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29875_29875_1_FBXO9-CD74_FBXO9_chr6_52960462_ENST00000244426_CD74_chr5_149782188_ENST00000377795_length(transcript)=2084nt_BP=1407nt
AGAGAATATGCTTTTCAGACTCATTTTCCTTTGGAAATTAATAGTAAGGTCTCAAGTGCCCCCTACAGCCTTGCTACTCAAAGTGGGTTC
CACAAAGTGTTGACAGTATGGTACTAAATAGAAAGTGGCTGAATGAGAAATGTAGATTGCAGAGGGCAACTGGTGTGTTTATATGCCTGA
CATTATTTGGGTTTTCCCCCCTCAGGCAGAAGCTGAGGAAGATTGTCATTCTGATACTGTCAGAGCAGATGATGATGAAGAAAATGAAAG
TCCTGCTGAAACAGATCTGCAGGCACAACTCCAGATGTTCCGAGCTCAGTGGATGTTTGAACTTGCTCCAGGTGTAAGCTCTAGCAATTT
AGAAAATCGACCTTGCAGAGCAGCAAGAGGCTCTCTCCAGAAAACATCGGCAGATACCAAAGGAAAACAAGAACAGGCAAAAGAAGAAAA
GGCTCGAGAACTCTTCCTAAAAGCAGTAGAAGAAGAACAAAATGGAGCTCTCTATGAAGCCATCAAGTTTTATCGTAGGGCTATGCAACT
TGTACCTGATATAGAGTTCAAGATTACTTATACCCGGTCTCCAGATGGTGATGGCGTTGGAAACAGCTACATTGAAGATAATGATGATGA
CAGCAAAATGGCAGATCTCTTGTCCTACTTCCAGCAGCAACTCACATTTCAGGAGTCTGTGCTTAAACTGTGTCAGCCTGAGCTTGAGAG
CAGTCAGATTCACATATCAGTGCTGCCAATGGAGGTCCTGATGTACATCTTCCGATGGGTGGTGTCTAGTGACTTGGACCTCAGATCATT
GGAGCAGTTGTCGCTGGTGTGCAGAGGATTCTACATCTGTGCCAGAGACCCTGAAATATGGCGTCTGGCCTGCTTGAAAGTTTGGGGCAG
AAGCTGTATTAAACTTGTTCCGTACACGTCCTGGAGAGAGATGTTTTTAGAACGGCCTCGTGTTCGGTTTGATGGCGTGTATATCAGTAA
AACCACATATATTCGTCAAGGGGAACAGTCTCTTGATGGTTTCTATAGAGCCTGGCACCAAGTGGAATATTACAGGTACATAAGATTCTT
TCCTGATGGCCATGTGATGATGTTGACAACCCCTGAAGAGCCTCAGTCCATTGTTCCACGTTTAAGAACTAGGAATACCAGGACTGATGC
AATTCTACTGGGTCACTATCGCTTGTCACAAGACACAGACAATCAGACCAAAGTATTTGCTGTAATAACTAAGAAAAAAGAAGAAAAACC
ACTTGACTATAAATACAGATATTTTCGTCGTGTCCCTGTACAAGAAGCAGATCAGAGTTTTCATGTGGGGCTACAGCTATGTTCCAGTGG
TCACCAGAGGTTCAACAAACTCATCTGGATACATCATTCTTGTCACATTACTTACAAAGTCACTGGAACTGGAGGACCCGTCTTCTGGGC
TGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCAGCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAG
CTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCCTGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCAC
CCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGG
TCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACAGCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGAC
GAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCCCAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCC
TTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCCCTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCAC
CCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTTATCAGCTTTCAGGGCCATGGTTCACATTAGAATAAAAGG

>29875_29875_1_FBXO9-CD74_FBXO9_chr6_52960462_ENST00000244426_CD74_chr5_149782188_ENST00000377795_length(amino acids)=494AA_BP=412
MPDIIWVFPPQAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAK
EEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPE
LESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVY
ISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKE
EKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKVTGTGGPVFWAGCDQAGSGPSPHVRAAEAVFNILPAPH

--------------------------------------------------------------
>29875_29875_2_FBXO9-CD74_FBXO9_chr6_52960462_ENST00000323557_CD74_chr5_149782188_ENST00000377795_length(transcript)=2213nt_BP=1536nt
GTCCGGGGTCTCCAGTAGGGCTGACGCTCCGGTGCTCGCACAATCCCCCGCCTCGGCTGGCAACGGGCGTCCCTCCACTCCCCGAGTCCC
CGGCAGCCGCCGCCACCCCAGCGCGCCCCGATCTGGCCCCCTGCCCCGCGAAGATGGCTGCCGTACGCCGGGCCCGCAGTTATTGCCGCT
GCCTGGTGCGCTTCTCCGACCGAGAACTCTGCTAAGCTCCGCTGCAGAGACAGGCAGGAGTAGACACCCGGACACCCAGCACCCCTCCTC
CGGGGGGCGGTGCAGAGGGGGCACGGAGAGCCCCTCGAGCGCAGCAGGCCGCCCCGCCAGCATGGCAGAAGCTGAGGAAGATTGTCATTC
TGATACTGTCAGAGCAGATGATGATGAAGAAAATGAAAGTCCTGCTGAAACAGATCTGCAGGCACAACTCCAGATGTTCCGAGCTCAGTG
GATGTTTGAACTTGCTCCAGGTGTAAGCTCTAGCAATTTAGAAAATCGACCTTGCAGAGCAGCAAGAGGCTCTCTCCAGAAAACATCGGC
AGATACCAAAGGAAAACAAGAACAGGCAAAAGAAGAAAAGGCTCGAGAACTCTTCCTAAAAGCAGTAGAAGAAGAACAAAATGGAGCTCT
CTATGAAGCCATCAAGTTTTATCGTAGGGCTATGCAACTTGTACCTGATATAGAGTTCAAGATTACTTATACCCGGTCTCCAGATGGTGA
TGGCGTTGGAAACAGCTACATTGAAGATAATGATGATGACAGCAAAATGGCAGATCTCTTGTCCTACTTCCAGCAGCAACTCACATTTCA
GGAGTCTGTGCTTAAACTGTGTCAGCCTGAGCTTGAGAGCAGTCAGATTCACATATCAGTGCTGCCAATGGAGGTCCTGATGTACATCTT
CCGATGGGTGGTGTCTAGTGACTTGGACCTCAGATCATTGGAGCAGTTGTCGCTGGTGTGCAGAGGATTCTACATCTGTGCCAGAGACCC
TGAAATATGGCGTCTGGCCTGCTTGAAAGTTTGGGGCAGAAGCTGTATTAAACTTGTTCCGTACACGTCCTGGAGAGAGATGTTTTTAGA
ACGGCCTCGTGTTCGGTTTGATGGCGTGTATATCAGTAAAACCACATATATTCGTCAAGGGGAACAGTCTCTTGATGGTTTCTATAGAGC
CTGGCACCAAGTGGAATATTACAGGTACATAAGATTCTTTCCTGATGGCCATGTGATGATGTTGACAACCCCTGAAGAGCCTCAGTCCAT
TGTTCCACGTTTAAGAACTAGGAATACCAGGACTGATGCAATTCTACTGGGTCACTATCGCTTGTCACAAGACACAGACAATCAGACCAA
AGTATTTGCTGTAATAACTAAGAAAAAAGAAGAAAAACCACTTGACTATAAATACAGATATTTTCGTCGTGTCCCTGTACAAGAAGCAGA
TCAGAGTTTTCATGTGGGGCTACAGCTATGTTCCAGTGGTCACCAGAGGTTCAACAAACTCATCTGGATACATCATTCTTGTCACATTAC
TTACAAAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCAGCAGA
GGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCCTGTAC
CTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGC
CCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACAGC
AGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCCCAGGC
TGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCCCTTTC
CCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTT

>29875_29875_2_FBXO9-CD74_FBXO9_chr6_52960462_ENST00000323557_CD74_chr5_149782188_ENST00000377795_length(amino acids)=551AA_BP=469
MPREDGCRTPGPQLLPLPGALLRPRTLLSSAAETGRSRHPDTQHPSSGGRCRGGTESPSSAAGRPASMAEAEEDCHSDTVRADDDEENES
PAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQL
VPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSL
EQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFF
PDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSG
HQRFNKLIWIHHSCHITYKVTGTGGPVFWAGCDQAGSGPSPHVRAAEAVFNILPAPHSYSFLAPFSPQPLPHLPPCTSSHETLVPGSFVT

--------------------------------------------------------------
>29875_29875_3_FBXO9-CD74_FBXO9_chr6_52960462_ENST00000370939_CD74_chr5_149782188_ENST00000377795_length(transcript)=2090nt_BP=1413nt
CTCCAGTCTGTCTGTGCTCTCAAAAACTTTAGTCGTTATAACAACTGTGACTGTTGAGAAATTTCACTGTTTTCCTGCATTCCTGGCGCG
GGACTCTAGCCAGAGGCTCCGAGGACTTTGTAGCGACTGTCCCAAGCGTCCAGTTCGATGCTTCTCAGGGCGGCTTGCTTTAAGGGCCCA
CCCCTAAATTTGGGTTGTAAAAATTTTTGAGGCAGAAGCTGAGGAAGATTGTCATTCTGATACTGTCAGAGCAGATGATGATGAAGAAAA
TGAAAGTCCTGCTGAAACAGATCTGCAGGCACAACTCCAGATGTTCCGAGCTCAGTGGATGTTTGAACTTGCTCCAGGTGTAAGCTCTAG
CAATTTAGAAAATCGACCTTGCAGAGCAGCAAGAGGCTCTCTCCAGAAAACATCGGCAGATACCAAAGGAAAACAAGAACAGGCAAAAGA
AGAAAAGGCTCGAGAACTCTTCCTAAAAGCAGTAGAAGAAGAACAAAATGGAGCTCTCTATGAAGCCATCAAGTTTTATCGTAGGGCTAT
GCAACTTGTACCTGATATAGAGTTCAAGATTACTTATACCCGGTCTCCAGATGGTGATGGCGTTGGAAACAGCTACATTGAAGATAATGA
TGATGACAGCAAAATGGCAGATCTCTTGTCCTACTTCCAGCAGCAACTCACATTTCAGGAGTCTGTGCTTAAACTGTGTCAGCCTGAGCT
TGAGAGCAGTCAGATTCACATATCAGTGCTGCCAATGGAGGTCCTGATGTACATCTTCCGATGGGTGGTGTCTAGTGACTTGGACCTCAG
ATCATTGGAGCAGTTGTCGCTGGTGTGCAGAGGATTCTACATCTGTGCCAGAGACCCTGAAATATGGCGTCTGGCCTGCTTGAAAGTTTG
GGGCAGAAGCTGTATTAAACTTGTTCCGTACACGTCCTGGAGAGAGATGTTTTTAGAACGGCCTCGTGTTCGGTTTGATGGCGTGTATAT
CAGTAAAACCACATATATTCGTCAAGGGGAACAGTCTCTTGATGGTTTCTATAGAGCCTGGCACCAAGTGGAATATTACAGGTACATAAG
ATTCTTTCCTGATGGCCATGTGATGATGTTGACAACCCCTGAAGAGCCTCAGTCCATTGTTCCACGTTTAAGAACTAGGAATACCAGGAC
TGATGCAATTCTACTGGGTCACTATCGCTTGTCACAAGACACAGACAATCAGACCAAAGTATTTGCTGTAATAACTAAGAAAAAAGAAGA
AAAACCACTTGACTATAAATACAGATATTTTCGTCGTGTCCCTGTACAAGAAGCAGATCAGAGTTTTCATGTGGGGCTACAGCTATGTTC
CAGTGGTCACCAGAGGTTCAACAAACTCATCTGGATACATCATTCTTGTCACATTACTTACAAAGTCACTGGAACTGGAGGACCCGTCTT
CTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCAGCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAG
CTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCCTGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTT
CGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGC
GTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACAGCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTC
ATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCCCAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCT
TTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCCCTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTT
TTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTTATCAGCTTTCAGGGCCATGGTTCACATTAGAAT

>29875_29875_3_FBXO9-CD74_FBXO9_chr6_52960462_ENST00000370939_CD74_chr5_149782188_ENST00000377795_length(amino acids)=456AA_BP=374
MQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIE
FKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSL
VCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHV
MMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFN
KLIWIHHSCHITYKVTGTGGPVFWAGCDQAGSGPSPHVRAAEAVFNILPAPHSYSFLAPFSPQPLPHLPPCTSSHETLVPGSFVTLGQDK

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Fusion Gene PPI Analysis for FBXO9-CD74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXO9-CD74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXO9-CD74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource