FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FBXW11-NPM1 (FusionGDB2 ID:29884)

Fusion Gene Summary for FBXW11-NPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW11-NPM1
Fusion gene ID: 29884
HgeneTgene
Gene symbol

FBXW11

NPM1

Gene ID

23291

4869

Gene nameF-box and WD repeat domain containing 11nucleophosmin 1
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|HosB23|NPM
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homolognucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128
Modification date2020032920200329
UniProtAcc

Q9UKB1

P06748

Ensembl transtripts involved in fusion geneENST00000265094, ENST00000296933, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 		ENST00000296930, 
ENST00000351986, ENST00000393820, 
ENST00000517671, 
Fusion gene scores* DoF score13 X 6 X 9=70210 X 9 X 3=270
# samples 1311
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXW11 [Title/Abstract] AND NPM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXW11(171433461)-NPM1(170832305), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneNPM1

GO:0006281

DNA repair

19188445

TgeneNPM1

GO:0006334

nucleosome assembly

11602260

TgeneNPM1

GO:0006913

nucleocytoplasmic transport

16041368

TgeneNPM1

GO:0008104

protein localization

18420587

TgeneNPM1

GO:0008284

positive regulation of cell proliferation

22528486

TgeneNPM1

GO:0032071

regulation of endodeoxyribonuclease activity

19188445

TgeneNPM1

GO:0034644

cellular response to UV

19160485

TgeneNPM1

GO:0043066

negative regulation of apoptotic process

12882984

TgeneNPM1

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

12882984

TgeneNPM1

GO:0045727

positive regulation of translation

12882984

TgeneNPM1

GO:0045893

positive regulation of transcription, DNA-templated

22528486

TgeneNPM1

GO:0045944

positive regulation of transcription by RNA polymerase II

19160485

TgeneNPM1

GO:0060699

regulation of endoribonuclease activity

19188445

TgeneNPM1

GO:0060735

regulation of eIF2 alpha phosphorylation by dsRNA

12882984

TgeneNPM1

GO:1902751

positive regulation of cell cycle G2/M phase transition

22528486


check buttonFusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NPM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1563FBXW11chr5

171433461

-NPM1chr5

170832305

+


Top

Fusion Gene ORF analysis for FBXW11-NPM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265094ENST00000296930FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000265094ENST00000351986FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000265094ENST00000393820FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000265094ENST00000517671FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000296933ENST00000296930FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000296933ENST00000351986FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000296933ENST00000393820FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000296933ENST00000517671FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000393802ENST00000296930FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000393802ENST00000351986FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000393802ENST00000393820FBXW11chr5

171433461

-NPM1chr5

170832305

+
In-frameENST00000393802ENST00000517671FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000425623ENST00000296930FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000425623ENST00000351986FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000425623ENST00000393820FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000425623ENST00000517671FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000522891ENST00000296930FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000522891ENST00000351986FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000522891ENST00000393820FBXW11chr5

171433461

-NPM1chr5

170832305

+
intron-3CDSENST00000522891ENST00000517671FBXW11chr5

171433461

-NPM1chr5

170832305

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296933FBXW11chr5171433461-ENST00000517671NPM1chr5170832305+950416555100151
ENST00000296933FBXW11chr5171433461-ENST00000296930NPM1chr5170832305+1204416555100151
ENST00000296933FBXW11chr5171433461-ENST00000351986NPM1chr5170832305+95141628393121
ENST00000296933FBXW11chr5171433461-ENST00000393820NPM1chr5170832305+1247416618100172
ENST00000265094FBXW11chr5171433461-ENST00000517671NPM1chr5170832305+71718338027117
ENST00000265094FBXW11chr5171433461-ENST00000296930NPM1chr5170832305+97118357398113
ENST00000265094FBXW11chr5171433461-ENST00000351986NPM1chr5170832305+71818338027117
ENST00000265094FBXW11chr5171433461-ENST00000393820NPM1chr5170832305+10141833852128
ENST00000393802FBXW11chr5171433461-ENST00000517671NPM1chr5170832305+72719339037117
ENST00000393802FBXW11chr5171433461-ENST00000296930NPM1chr5170832305+98119367408113
ENST00000393802FBXW11chr5171433461-ENST00000351986NPM1chr5170832305+72819339037117
ENST00000393802FBXW11chr5171433461-ENST00000393820NPM1chr5170832305+10241933950132

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296933ENST00000517671FBXW11chr5171433461-NPM1chr5170832305+0.78167280.21832721
ENST00000296933ENST00000296930FBXW11chr5171433461-NPM1chr5170832305+0.799860240.2001397
ENST00000296933ENST00000351986FBXW11chr5171433461-NPM1chr5170832305+0.779715360.22028461
ENST00000296933ENST00000393820FBXW11chr5171433461-NPM1chr5170832305+0.7366550.26334497
ENST00000265094ENST00000517671FBXW11chr5171433461-NPM1chr5170832305+0.0233491420.9766509
ENST00000265094ENST00000296930FBXW11chr5171433461-NPM1chr5170832305+0.020660220.9793397
ENST00000265094ENST00000351986FBXW11chr5171433461-NPM1chr5170832305+0.0235423240.97645766
ENST00000265094ENST00000393820FBXW11chr5171433461-NPM1chr5170832305+0.181839780.8181602
ENST00000393802ENST00000517671FBXW11chr5171433461-NPM1chr5170832305+0.0330445580.9669554
ENST00000393802ENST00000296930FBXW11chr5171433461-NPM1chr5170832305+0.0337043630.96629566
ENST00000393802ENST00000351986FBXW11chr5171433461-NPM1chr5170832305+0.0330405650.9669594
ENST00000393802ENST00000393820FBXW11chr5171433461-NPM1chr5170832305+0.255563470.74443656

Top

Fusion Genomic Features for FBXW11-NPM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXW11chr5171433461-NPM1chr5170832305+9.70E-091
FBXW11chr5171433461-NPM1chr5170832305+9.70E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FBXW11-NPM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171433461/chr5:170832305)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW11

Q9UKB1

NPM1

P06748

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:19730691}.FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). {ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610191_197194266.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711243_294223295.0RegionNote=Required for nucleolar localization
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610243_294194266.0RegionNote=Required for nucleolar localization
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710243_294223260.0RegionNote=Required for nucleolar localization
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812243_294223295.0RegionNote=Required for nucleolar localization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113129_167151360.3333333333333DomainF-box
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113129_167151283.6666666666667DomainF-box
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112129_16715592.0DomainF-box
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-11367_116151360.3333333333333RegionHomodimerization domain D
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-11367_116151283.6666666666667RegionHomodimerization domain D
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-11267_11615592.0RegionHomodimerization domain D
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113238_275151360.3333333333333RepeatNote=WD 1
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113278_315151360.3333333333333RepeatNote=WD 2
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113318_355151360.3333333333333RepeatNote=WD 3
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113361_398151360.3333333333333RepeatNote=WD 4
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113401_440151360.3333333333333RepeatNote=WD 5
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113442_478151360.3333333333333RepeatNote=WD 6
HgeneFBXW11chr5:171433461chr5:170832305ENST00000265094-113490_527151360.3333333333333RepeatNote=WD 7
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113238_275151283.6666666666667RepeatNote=WD 1
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113278_315151283.6666666666667RepeatNote=WD 2
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113318_355151283.6666666666667RepeatNote=WD 3
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113361_398151283.6666666666667RepeatNote=WD 4
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113401_440151283.6666666666667RepeatNote=WD 5
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113442_478151283.6666666666667RepeatNote=WD 6
HgeneFBXW11chr5:171433461chr5:170832305ENST00000296933-113490_527151283.6666666666667RepeatNote=WD 7
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112238_27515592.0RepeatNote=WD 1
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112278_31515592.0RepeatNote=WD 2
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112318_35515592.0RepeatNote=WD 3
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112361_39815592.0RepeatNote=WD 4
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112401_44015592.0RepeatNote=WD 5
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112442_47815592.0RepeatNote=WD 6
HgeneFBXW11chr5:171433461chr5:170832305ENST00000393802-112490_52715592.0RepeatNote=WD 7
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711120_132223295.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711161_188223295.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000002969307111_9223295.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610120_132194266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610161_188194266.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000003519866101_9194266.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710120_132223260.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710161_188223260.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000003938207101_9223260.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812120_132223295.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812161_188223295.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneNPM1chr5:171433461chr5:170832305ENST000005176718121_9223295.0Compositional biasNote=Met-rich
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711152_157223295.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000296930711191_197223295.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000351986610152_157194266.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710152_157223260.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000393820710191_197223260.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812152_157223295.0MotifNuclear localization signal
TgeneNPM1chr5:171433461chr5:170832305ENST00000517671812191_197223295.0MotifNuclear localization signal


Top

Fusion Gene Sequence for FBXW11-NPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29884_29884_1_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000296930_length(transcript)=971nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAA
GCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAG
GCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTATTTCATTTCT
GTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGGTTCTATTGCC
AAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATA
GGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGTGGGGAGACAAAAATATACATGTGAAATAAAACTCAGTATTTTAATAAAGTAGC
ACGGTTTCTATTGACTTATTTAACTGCTTTATACTTTGTCAAAGAAATAATTAATGTAGTTAGGAATGGCAAATAGTCTTGTAAAATTCT
ATGAGAATGTCCCTGCCCTCCCCTTCAATATTCTCTCTGGAGCTAACCACTTTTTCATCATAAGGATTTAGTGCTGTGTTCCCACCTCCT

>29884_29884_1_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000296930_length(amino acids)=113AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINY

--------------------------------------------------------------
>29884_29884_2_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000351986_length(transcript)=718nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAA
GCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAG
GCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTATTTCATTTCT
GTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGGTTCTATTGCC
AAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATA

>29884_29884_2_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000351986_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------
>29884_29884_3_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000393820_length(transcript)=1014nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAA
GCAAGTATAGAAAAAGCGCATTGAACAGTCCTGGGCACTACATGTAAATTAAGCCCAAAGATGGGGAGAAAGGAAAAGGAGAGACAAATA
TAGTCCATACTGAGTGTCATCAACAATCCAGACTGAAGTCTTCTATTTTAATCTCAATCCCCTTTTCTGATTTGCCACCCATGCCTCTTC
AGGCTGGAAACAATCTCTTGGTTCCCTAAAGCACTTTCTTCTGACTGCTGTGATTCAGTGAACCTTGCCCTTTGCTTTCTATTACTTGTG
CATTTGCCTCACCTGACAATGTTTTAAATCGCCTTTGTATCTCCTTAGCTGCTCAATAAATATTTGAATGCATCAATTAAGAATGTATGT
GACAATAATTTTGAAATGGAAATTGTGAGGTTTATTTTACTAGGTTATTGGAGGCAGTTAAGTTTCTTAATGCTATACCTGATTCTGCCA
AAGTCCCTTGGACATTTGAAAACCTTTTCAATCTTTTAAAAATGCATAAAAGATACTTAGAGGGAAAGGTATTAATTAAATTTAGTAAAA
ACAAATATATTCAATGCTTTAAATTCCAAAGTAGTGATAAATACAAACATTTCAAGATATTTGCAATAGTAATGTTTTGAAATTTTGGTT
ACAAAGTCACAGGTCTTGCCAATACTGTTGTAGTTTCTTGCCTATATCCGTAATTTGAAGGAAATGGTGAGAGTGATTAGAGAAGTGTAA

>29884_29884_3_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000393820_length(amino acids)=128AA_BP=1
MLMTLSMDYICLSFSFLPIFGLNLHVVPRTVQCAFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPP

--------------------------------------------------------------
>29884_29884_4_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000517671_length(transcript)=717nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAA
GCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAG
GCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTATTTCATTTCT
GTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGGTTCTATTGCC
AAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATA

>29884_29884_4_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000265094_NPM1_chr5_170832305_ENST00000517671_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------
>29884_29884_5_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000296930_length(transcript)=1204nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTC
CTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGG
AAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTT
AAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTATTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCA
GAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGGTTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAA
AGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGT
GGGGAGACAAAAATATACATGTGAAATAAAACTCAGTATTTTAATAAAGTAGCACGGTTTCTATTGACTTATTTAACTGCTTTATACTTT
GTCAAAGAAATAATTAATGTAGTTAGGAATGGCAAATAGTCTTGTAAAATTCTATGAGAATGTCCCTGCCCTCCCCTTCAATATTCTCTC
TGGAGCTAACCACTTTTTCATCATAAGGATTTAGTGCTGTGTTCCCACCTCCTGATGATAGTTAACAATTATTATAACTATGCAACATGT

>29884_29884_5_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000296930_length(amino acids)=151AA_BP=1
MMNLASTLGREPPFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPPRSPRAAANGPGGGGDGGGGRG

--------------------------------------------------------------
>29884_29884_6_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000351986_length(transcript)=951nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTC
CTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGG
AAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTT
AAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTATTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCA
GAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGGTTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAA
AGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGT

>29884_29884_6_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000351986_length(amino acids)=121AA_BP=
MSKLLTLQVCTSYAHRPVLLSARSSASGCQEPATWCQRLGPTTLCGPRRLLGGVVPDLRTAFAEGEGGAAGGPGGLAARVGAIAASASAA

--------------------------------------------------------------
>29884_29884_7_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000393820_length(transcript)=1247nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTC
CTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGCGCATTGAACAGTCCTGGGCA
CTACATGTAAATTAAGCCCAAAGATGGGGAGAAAGGAAAAGGAGAGACAAATATAGTCCATACTGAGTGTCATCAACAATCCAGACTGAA
GTCTTCTATTTTAATCTCAATCCCCTTTTCTGATTTGCCACCCATGCCTCTTCAGGCTGGAAACAATCTCTTGGTTCCCTAAAGCACTTT
CTTCTGACTGCTGTGATTCAGTGAACCTTGCCCTTTGCTTTCTATTACTTGTGCATTTGCCTCACCTGACAATGTTTTAAATCGCCTTTG
TATCTCCTTAGCTGCTCAATAAATATTTGAATGCATCAATTAAGAATGTATGTGACAATAATTTTGAAATGGAAATTGTGAGGTTTATTT
TACTAGGTTATTGGAGGCAGTTAAGTTTCTTAATGCTATACCTGATTCTGCCAAAGTCCCTTGGACATTTGAAAACCTTTTCAATCTTTT
AAAAATGCATAAAAGATACTTAGAGGGAAAGGTATTAATTAAATTTAGTAAAAACAAATATATTCAATGCTTTAAATTCCAAAGTAGTGA
TAAATACAAACATTTCAAGATATTTGCAATAGTAATGTTTTGAAATTTTGGTTACAAAGTCACAGGTCTTGCCAATACTGTTGTAGTTTC

>29884_29884_7_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000393820_length(amino acids)=172AA_BP=1
MLMTLSMDYICLSFSFLPIFGLNLHVVPRTVQCAFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPP

--------------------------------------------------------------
>29884_29884_8_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000517671_length(transcript)=950nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTC
CTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGG
AAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTT
AAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTATTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCA
GAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGGTTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAA
AGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAATGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGT

>29884_29884_8_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000296933_NPM1_chr5_170832305_ENST00000517671_length(amino acids)=151AA_BP=1
MMNLASTLGREPPFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPPRSPRAAANGPGGGGDGGGGRG

--------------------------------------------------------------
>29884_29884_9_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000296930_length(transcript)=981nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGC
AAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGAC
TGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTA
TTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGG
TTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAA
TGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGTGGGGAGACAAAAATATACATGTGAAATAAAACTCAGTATTTTA
ATAAAGTAGCACGGTTTCTATTGACTTATTTAACTGCTTTATACTTTGTCAAAGAAATAATTAATGTAGTTAGGAATGGCAAATAGTCTT
GTAAAATTCTATGAGAATGTCCCTGCCCTCCCCTTCAATATTCTCTCTGGAGCTAACCACTTTTTCATCATAAGGATTTAGTGCTGTGTT

>29884_29884_9_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000296930_length(amino acids)=113AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINY

--------------------------------------------------------------
>29884_29884_10_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000351986_length(transcript)=728nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGC
AAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGAC
TGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTA
TTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGG
TTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAA
TGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGTGGGGAGACAAAAATATACATGTGAAATAAAACTCAGTATTTTA

>29884_29884_10_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000351986_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------
>29884_29884_11_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000393820_length(transcript)=1024nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGC
AAAAATGCAAGCAAGTATAGAAAAAGCGCATTGAACAGTCCTGGGCACTACATGTAAATTAAGCCCAAAGATGGGGAGAAAGGAAAAGGA
GAGACAAATATAGTCCATACTGAGTGTCATCAACAATCCAGACTGAAGTCTTCTATTTTAATCTCAATCCCCTTTTCTGATTTGCCACCC
ATGCCTCTTCAGGCTGGAAACAATCTCTTGGTTCCCTAAAGCACTTTCTTCTGACTGCTGTGATTCAGTGAACCTTGCCCTTTGCTTTCT
ATTACTTGTGCATTTGCCTCACCTGACAATGTTTTAAATCGCCTTTGTATCTCCTTAGCTGCTCAATAAATATTTGAATGCATCAATTAA
GAATGTATGTGACAATAATTTTGAAATGGAAATTGTGAGGTTTATTTTACTAGGTTATTGGAGGCAGTTAAGTTTCTTAATGCTATACCT
GATTCTGCCAAAGTCCCTTGGACATTTGAAAACCTTTTCAATCTTTTAAAAATGCATAAAAGATACTTAGAGGGAAAGGTATTAATTAAA
TTTAGTAAAAACAAATATATTCAATGCTTTAAATTCCAAAGTAGTGATAAATACAAACATTTCAAGATATTTGCAATAGTAATGTTTTGA
AATTTTGGTTACAAAGTCACAGGTCTTGCCAATACTGTTGTAGTTTCTTGCCTATATCCGTAATTTGAAGGAAATGGTGAGAGTGATTAG

>29884_29884_11_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000393820_length(amino acids)=132AA_BP=1
MLMTLSMDYICLSFSFLPIFGLNLHVVPRTVQCAFSILACIFALMSSTELGPFGVLGVFSCFLKDSCPMSSMVLSSITESGSMAAPAAPP

--------------------------------------------------------------
>29884_29884_12_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000517671_length(transcript)=727nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGACCTAGTTCTGTAGAAGACATTAAAGC
AAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCTCTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGAC
TGACCAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAAGAAAATAGTTTAAACAATTTGTTAAAAAATTTTCCGTCTTA
TTTCATTTCTGTAACAGTTGATATCTGGCTGTCCTTTTTATAATGCAGAGTGAGAACTTTCCCTACCGTGTTTGATAAATGTTGTCCAGG
TTCTATTGCCAAGAATGTGTTGTCCAAAATGCCTGTTTAGTTTTTAAAGATGGAACTCCACCCTTTGCTTGGTTTTAAGTATGTATGGAA
TGTTATGATAGGACATAGTAGTAGCGGTGGTCAGACATGGAAATGGTGGGGAGACAAAAATATACATGTGAAATAAAACTCAGTATTTTA

>29884_29884_12_FBXW11-NPM1_FBXW11_chr5_171433461_ENST00000393802_NPM1_chr5_170832305_ENST00000517671_length(amino acids)=117AA_BP=7
MPEILNSLLVSHPEAILHIIDEFGFHFGKRTTFFYTCLHFCFNVFYRTRSFWCFRSFFLFLEGFLSHELDGLVLNHRVGLHGGPGGPASL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FBXW11-NPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FBXW11-NPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FBXW11-NPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource