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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXW11-STK10 (FusionGDB2 ID:29890)

Fusion Gene Summary for FBXW11-STK10

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW11-STK10
Fusion gene ID: 29890
HgeneTgene
Gene symbol

FBXW11

STK10

Gene ID

23291

6793

Gene nameF-box and WD repeat domain containing 11serine/threonine kinase 10
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|HosLOK|PRO2729
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homologserine/threonine-protein kinase 10lymphocyte-oriented kinase
Modification date2020032920200313
UniProtAcc

Q9UKB1

.
Ensembl transtripts involved in fusion geneENST00000265094, ENST00000296933, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 		ENST00000517775, 
ENST00000176763, 
Fusion gene scores* DoF score13 X 6 X 9=70216 X 15 X 7=1680
# samples 1317
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1680*10)=-3.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXW11 [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXW11(171433462)-STK10(171554425), # samples:1
FBXW11(171423894)-STK10(171554425), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneSTK10

GO:0046777

protein autophosphorylation

12639966|18239682


check buttonFusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STK10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2000-01AFBXW11chr5

171423894

-STK10chr5

171554425

-
ChimerDB4OVTCGA-61-2000-01AFBXW11chr5

171433462

-STK10chr5

171554425

-


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Fusion Gene ORF analysis for FBXW11-STK10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265094ENST00000517775FBXW11chr5

171433462

-STK10chr5

171554425

-
5CDS-intronENST00000296933ENST00000517775FBXW11chr5

171433462

-STK10chr5

171554425

-
5CDS-intronENST00000393802ENST00000517775FBXW11chr5

171433462

-STK10chr5

171554425

-
5UTR-3CDSENST00000425623ENST00000176763FBXW11chr5

171423894

-STK10chr5

171554425

-
5UTR-intronENST00000425623ENST00000517775FBXW11chr5

171423894

-STK10chr5

171554425

-
In-frameENST00000265094ENST00000176763FBXW11chr5

171433462

-STK10chr5

171554425

-
In-frameENST00000296933ENST00000176763FBXW11chr5

171433462

-STK10chr5

171554425

-
In-frameENST00000393802ENST00000176763FBXW11chr5

171433462

-STK10chr5

171554425

-
intron-3CDSENST00000265094ENST00000176763FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-3CDSENST00000296933ENST00000176763FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-3CDSENST00000393802ENST00000176763FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-3CDSENST00000425623ENST00000176763FBXW11chr5

171433462

-STK10chr5

171554425

-
intron-3CDSENST00000522891ENST00000176763FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-3CDSENST00000522891ENST00000176763FBXW11chr5

171433462

-STK10chr5

171554425

-
intron-intronENST00000265094ENST00000517775FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-intronENST00000296933ENST00000517775FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-intronENST00000393802ENST00000517775FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-intronENST00000425623ENST00000517775FBXW11chr5

171433462

-STK10chr5

171554425

-
intron-intronENST00000522891ENST00000517775FBXW11chr5

171423894

-STK10chr5

171554425

-
intron-intronENST00000522891ENST00000517775FBXW11chr5

171433462

-STK10chr5

171554425

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296933FBXW11chr5171433462-ENST00000176763STK10chr5171554425-58114162903001903
ENST00000265094FBXW11chr5171433462-ENST00000176763STK10chr5171554425-5578183572768903
ENST00000393802FBXW11chr5171433462-ENST00000176763STK10chr5171554425-5588193672778903

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296933ENST00000176763FBXW11chr5171433462-STK10chr5171554425-0.0078122850.99218774
ENST00000265094ENST00000176763FBXW11chr5171433462-STK10chr5171554425-0.0080227410.9919773
ENST00000393802ENST00000176763FBXW11chr5171433462-STK10chr5171554425-0.0080252120.9919748

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Fusion Genomic Features for FBXW11-STK10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXW11-STK10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171433462/chr5:171554425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW11

Q9UKB1

.
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:19730691}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTK10chr5:171433462chr5:171554425ENST00000176763119573_947107969.0Coiled coilOntology_term=ECO:0000255
TgeneSTK10chr5:171433462chr5:171554425ENST00000176763119750_884107969.0Compositional biasNote=Gln-rich
TgeneSTK10chr5:171433462chr5:171554425ENST00000176763119175_224107969.0RegionNote=Activation segment

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113129_167151360.3333333333333DomainF-box
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113129_167151283.6666666666667DomainF-box
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112129_16715592.0DomainF-box
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-11367_116151360.3333333333333RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-11367_116151283.6666666666667RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-11267_11615592.0RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113238_275151360.3333333333333RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113278_315151360.3333333333333RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113318_355151360.3333333333333RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113361_398151360.3333333333333RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113401_440151360.3333333333333RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113442_478151360.3333333333333RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr5:171554425ENST00000265094-113490_527151360.3333333333333RepeatNote=WD 7
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113238_275151283.6666666666667RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113278_315151283.6666666666667RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113318_355151283.6666666666667RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113361_398151283.6666666666667RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113401_440151283.6666666666667RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113442_478151283.6666666666667RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr5:171554425ENST00000296933-113490_527151283.6666666666667RepeatNote=WD 7
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112238_27515592.0RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112278_31515592.0RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112318_35515592.0RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112361_39815592.0RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112401_44015592.0RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112442_47815592.0RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr5:171554425ENST00000393802-112490_52715592.0RepeatNote=WD 7
TgeneSTK10chr5:171433462chr5:171554425ENST0000017676311936_294107969.0DomainProtein kinase
TgeneSTK10chr5:171433462chr5:171554425ENST0000017676311942_50107969.0Nucleotide bindingATP


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Fusion Gene Sequence for FBXW11-STK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29890_29890_1_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000265094_STK10_chr5_171554425_ENST00000176763_length(transcript)=5578nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCAGATACAGGTG
GTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGTGCTGATGACC
CTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCATCGGCACGCCT
TACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACTACAAAGCCGACATCTGGTCCCTGGGCATCACG
CTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGACCCTCCCACG
CTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACCCAGTGCCGCG
CAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGAGGTGATGGAA
GAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAACTCCTCTGAG
GTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGACAGTGTGAAT
GAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGGCCTGGCAGTG
CCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCAGGGTGGGGAC
CTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGAGAAGCTGGCC
AATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTCTGAGAGCATG
GACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTACAAAAAAACC
CTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAAGAAGGATGAG
GAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCTGAGTAACAAG
CATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATTAGAGAACCTG
GAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCGCCTGGAGCAG
GATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGTGAAGAACGAGGTGGAGAAGCTCCCCCGACAGCAGCGG
AAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAGAAGGAGGACCTG
GAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAGCAGGAGCTCCTT
CGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTCAAAGACCAGTAC
TTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATAGAGCAGCTGAAG
GTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAGAAGAGCCTCCAC
ATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAGTCGGAGCGGCTG
CAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAGCTGCAGAATGAA
AAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAATGGCGGGACAAG
CTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGCGAGGAGGCGGAG
TGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCCCGGGGCTGTGGCT
GGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCGTCTGTGCCAGCTC
AAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCCTGTGGAGGGTGAG
GTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGCTGTTGGTGGGGTC
AGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGGGACAAAGCACTGC
TGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATCAAGTCCCTCACAG
CCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTTTGCTTTCCACTTA
AGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTGTTTCATGCCATCT
CGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCCTCTTCTGCCCAGG
TGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGGGTGTTGGCACCGG
AGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGACTGATTCCTCAGCA
CACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTTGCCTCTGCCCCAT
CCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAGAAAAAGCATCAGG
GGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCTTCGGGGTCTCAGT
TGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGCGGGTTTACTTACA
AGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATATCTGCTTTTTAAA
ACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGTTTCGCTGGTGGTA
GAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGGCATGGTGACTCAC
CTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAGGCGTGGTGGTGCA
TGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAGGTCACACCAC
TGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTCTCTAATATGTTGC
CCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCTACTGCACCCAGCT
AGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGCTTGGGAAGGGAGG
GGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGTTCTCAGGTTAGTG
AGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAAACAATTGTCTCCT
TTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCTACCAGGCCAGGCC
AGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAAGTATTAGGTGAAA
TGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCAAGGAGTTGCCGCG
TCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCTCACCGTGGAGCCA
CCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAGACAGAACTGGGTT
TTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTATGTAGTTTCCAGAC

>29890_29890_1_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000265094_STK10_chr5_171554425_ENST00000176763_length(amino acids)=903AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH
RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV
LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS
TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVA
QEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSL
SIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAK
KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLD
RDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQ
RYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES
NMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSA

--------------------------------------------------------------
>29890_29890_2_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000296933_STK10_chr5_171554425_ENST00000176763_length(transcript)=5811nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGG
ACGCCATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGC
ACAGCAAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGT
CTGCCAAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCA
TGAAAGACACGCCCTACGACTACAAAGCCGACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACG
AGCTCAACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTG
ACTTCCTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCA
GTAACAAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGG
ACGCCGTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCG
AGGAGTCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCC
AAACCACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGG
ATGCCAGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCC
AGAGCCGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAG
GGCCTTCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGA
ACAAAGAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGG
AGGTGAGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGC
TTCGGCTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTG
AACAGGAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGC
AAGACCATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAAC
TGATGAAGAAAGAGGTGAAGAACGAGGTGGAGAAGCTCCCCCGACAGCAGCGGAAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGC
AGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAGAAGGAGGACCTGGAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGC
GGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAGCAGGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGC
ACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTCAAAGACCAGTACTTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGA
AGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATAGAGCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGA
TCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAGAAGAGCCTCCACATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGA
AGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAGTCGGAGCGGCTGCAGCAACAGCAGAAACACGAGAACCAGATGCGGGACA
TGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAGCTGCAGAATGAAAAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAAC
TGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAATGGCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGA
ACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGCGAGGAGGCGGAGTGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGT
TCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCCCGGGGCTGTGGCTGGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTC
TCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCGTCTGTGCCAGCTCAAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGC
CTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCCTGTGGAGGGTGAGGTGTAATTATTTGTCACCTGAACCTAATGTATATTCT
CCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGCTGTTGGTGGGGTCAGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGT
CCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGGGACAAAGCACTGCTGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTC
TTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATCAAGTCCCTCACAGCCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGG
CTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTTTGCTTTCCACTTAAGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGG
GAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTGTTTCATGCCATCTCGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACAC
ACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCCTCTTCTGCCCAGGTGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCAC
TGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGGGTGTTGGCACCGGAGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCG
ATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGACTGATTCCTCAGCACACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACT
CTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTTGCCTCTGCCCCATCCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTC
AGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAGAAAAAGCATCAGGGGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGA
AGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCTTCGGGGTCTCAGTTGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAAT
GTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGCGGGTTTACTTACAAGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTA
TTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATATCTGCTTTTTAAAACAACAAACAAGAACAACAACACAAAACTGGTAATGA
TTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGTTTCGCTGGTGGTAGAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCT
TCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGGCATGGTGACTCACCTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATG
GCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAGGCGTGGTGGTGCATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGG
AGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAGGTCACACCACTGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCT
CTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTCTCTAATATGTTGCCCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTC
CCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCTACTGCACCCAGCTAGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAA
TTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGCTTGGGAAGGGAGGGGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATC
TTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGTTCTCAGGTTAGTGAGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGAT
GGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAAACAATTGTCTCCTTTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATG
AACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCTACCAGGCCAGGCCAGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTT
TGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAAGTATTAGGTGAAATGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCAT
TCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCAAGGAGTTGCCGCGTCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCC
TGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCTCACCGTGGAGCCACCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTAT
TCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAGACAGAACTGGGTTTTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAA
CTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTATGTAGTTTCCAGACTTTATACAAAATTTTTGTAAAATGTTCTCTGGAAAGT

>29890_29890_2_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000296933_STK10_chr5_171554425_ENST00000176763_length(amino acids)=903AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH
RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV
LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS
TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVA
QEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSL
SIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAK
KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLD
RDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQ
RYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES
NMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSA

--------------------------------------------------------------
>29890_29890_3_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000393802_STK10_chr5_171554425_ENST00000176763_length(transcript)=5588nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCA
GATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGT
GCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCAT
CGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACTACAAAGCCGACATCTGGTCCCT
GGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGA
CCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACC
CAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGA
GGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAA
CTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGA
CAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGG
CCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCA
GGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGA
GAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTC
TGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTA
CAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAA
GAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCT
GAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATT
AGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCG
CCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGTGAAGAACGAGGTGGAGAAGCTCCCCCG
ACAGCAGCGGAAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAGAA
GGAGGACCTGGAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAGCA
GGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTCAA
AGACCAGTACTTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATAGA
GCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAGAA
GAGCCTCCACATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAGTC
GGAGCGGCTGCAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAGCT
GCAGAATGAAAAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAATG
GCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGCGA
GGAGGCGGAGTGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCCCGG
GGCTGTGGCTGGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCGTCT
GTGCCAGCTCAAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCCTGT
GGAGGGTGAGGTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGCTGT
TGGTGGGGTCAGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGGGAC
AAAGCACTGCTGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATCAAG
TCCCTCACAGCCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTTTGC
TTTCCACTTAAGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTGTTT
CATGCCATCTCGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCCTCT
TCTGCCCAGGTGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGGGTG
TTGGCACCGGAGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGACTGA
TTCCTCAGCACACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTTGCC
TCTGCCCCATCCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAGAAA
AAGCATCAGGGGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCTTCG
GGGTCTCAGTTGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGCGGG
TTTACTTACAAGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATATCT
GCTTTTTAAAACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGTTTC
GCTGGTGGTAGAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGGCAT
GGTGACTCACCTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAGGCG
TGGTGGTGCATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAG
GTCACACCACTGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTCTCT
AATATGTTGCCCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCTACT
GCACCCAGCTAGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGCTTG
GGAAGGGAGGGGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGTTCT
CAGGTTAGTGAGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAAACA
ATTGTCTCCTTTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCTACC
AGGCCAGGCCAGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAAGTA
TTAGGTGAAATGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCAAGG
AGTTGCCGCGTCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCTCAC
CGTGGAGCCACCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAGACA
GAACTGGGTTTTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTATGTA
GTTTCCAGACTTTATACAAAATTTTTGTAAAATGTTCTCTGGAAAGTTAACTACAAGAATGTAAATATGCTTCTAATAAAATAACAAGGT

>29890_29890_3_FBXW11-STK10_FBXW11_chr5_171433462_ENST00000393802_STK10_chr5_171554425_ENST00000176763_length(amino acids)=903AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH
RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV
LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS
TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVA
QEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSL
SIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAK
KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLD
RDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQ
RYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCES
NMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXW11-STK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXW11-STK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXW11-STK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource