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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXW7-ARFIP1 (FusionGDB2 ID:29912)

Fusion Gene Summary for FBXW7-ARFIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW7-ARFIP1
Fusion gene ID: 29912
HgeneTgene
Gene symbol

FBXW7

ARFIP1

Gene ID

55294

27236

Gene nameF-box and WD repeat domain containing 7ADP ribosylation factor interacting protein 1
SynonymsAGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4HSU52521
Cytomap

4q31.3

4q31.3

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog ofarfaptin-1
Modification date2020032720200313
UniProtAcc

Q969H0

P53367

Ensembl transtripts involved in fusion geneENST00000263981, ENST00000281708, 
ENST00000296555, ENST00000393956, 
ENST00000603548, ENST00000603841, 
ENST00000604095, ENST00000604872, 
ENST00000511289, ENST00000353617, 
ENST00000356064, ENST00000405727, 
ENST00000451320, ENST00000429148, 
Fusion gene scores* DoF score15 X 9 X 10=135010 X 10 X 11=1100
# samples 1719
** MAII scorelog2(17/1350*10)=-2.98935275580049
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1100*10)=-2.53343220008107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXW7 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFIP1(153701378)-FBXW7(153271276), # samples:1
FBXW7(153268082)-ARFIP1(153831216), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FBXW7-ARFIP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW7

GO:0016567

protein ubiquitination

12354302|15103331

HgeneFBXW7

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

15103331|17434132

HgeneFBXW7

GO:0031398

positive regulation of protein ubiquitination

12628165

HgeneFBXW7

GO:0045741

positive regulation of epidermal growth factor-activated receptor activity

20208556

HgeneFBXW7

GO:0050821

protein stabilization

20208556

HgeneFBXW7

GO:0051443

positive regulation of ubiquitin-protein transferase activity

12628165

HgeneFBXW7

GO:1901800

positive regulation of proteasomal protein catabolic process

23858059

HgeneFBXW7

GO:1903378

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

23858059

HgeneFBXW7

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

20208556

TgeneARFIP1

GO:0006886

intracellular protein transport

12606037

TgeneARFIP1

GO:0050708

regulation of protein secretion

12606037


check buttonFusion gene breakpoints across FBXW7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARFIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315398FBXW7chr4

153268082

-ARFIP1chr4

153831216

+


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Fusion Gene ORF analysis for FBXW7-ARFIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263981ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
5CDS-intronENST00000281708ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
5CDS-intronENST00000296555ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
5CDS-intronENST00000393956ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
5CDS-intronENST00000603548ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
5CDS-intronENST00000603841ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000263981ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000263981ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000263981ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000263981ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000281708ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000281708ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000281708ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000281708ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000296555ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000296555ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000296555ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000296555ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000393956ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000393956ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000393956ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000393956ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603548ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603548ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603548ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603548ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603841ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603841ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603841ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
Frame-shiftENST00000603841ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
In-frameENST00000263981ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
In-frameENST00000281708ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
In-frameENST00000296555ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
In-frameENST00000393956ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
In-frameENST00000603548ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
In-frameENST00000603841ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604095ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604095ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604095ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604095ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604095ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604872ENST00000353617FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604872ENST00000356064FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604872ENST00000405727FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604872ENST00000429148FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-3CDSENST00000604872ENST00000451320FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-intronENST00000604095ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+
intron-intronENST00000604872ENST00000511289FBXW7chr4

153268082

-ARFIP1chr4

153831216

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281708FBXW7chr4153268082-ENST00000451320ARFIP1chr4153831216+4250195610022111369
ENST00000603548FBXW7chr4153268082-ENST00000429148ARFIP1chr4153831216+1917906811061326
ENST00000296555FBXW7chr4153268082-ENST00000429148ARFIP1chr4153831216+1563552180707175
ENST00000263981FBXW7chr4153268082-ENST00000429148ARFIP1chr4153831216+1738727229882217
ENST00000393956FBXW7chr4153268082-ENST00000429148ARFIP1chr4153831216+128627571430119
ENST00000603841FBXW7chr4153268082-ENST00000429148ARFIP1chr4153831216+18128010956318

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281708ENST00000451320FBXW7chr4153268082-ARFIP1chr4153831216+0.0002401560.99975985
ENST00000603548ENST00000429148FBXW7chr4153268082-ARFIP1chr4153831216+0.0003524830.9996475
ENST00000296555ENST00000429148FBXW7chr4153268082-ARFIP1chr4153831216+0.0216279510.97837204
ENST00000263981ENST00000429148FBXW7chr4153268082-ARFIP1chr4153831216+0.0307879950.96921194
ENST00000393956ENST00000429148FBXW7chr4153268082-ARFIP1chr4153831216+0.128977250.8710227
ENST00000603841ENST00000429148FBXW7chr4153268082-ARFIP1chr4153831216+0.0003880170.99961203

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Fusion Genomic Features for FBXW7-ARFIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXW7chr4153268081-ARFIP1chr4153831215+6.38E-060.9999937
FBXW7chr4153268081-ARFIP1chr4153831215+6.38E-060.9999937

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXW7-ARFIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:153701378/chr4:153271276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW7

Q969H0

ARFIP1

P53367

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}.FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311278_324162628.0DomainF-box
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412278_324242708.0DomainF-box
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311278_324124590.0DomainF-box
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513278_324242708.0DomainF-box
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311278_324242708.0DomainF-box
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311378_418162628.0RepeatNote=WD 1
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311420_456162628.0RepeatNote=WD 2
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311459_498162628.0RepeatNote=WD 3
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311500_536162628.0RepeatNote=WD 4
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311539_578162628.0RepeatNote=WD 5
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311580_618162628.0RepeatNote=WD 6
HgeneFBXW7chr4:153268082chr4:153831216ENST00000263981-311622_659162628.0RepeatNote=WD 7
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412378_418242708.0RepeatNote=WD 1
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412420_456242708.0RepeatNote=WD 2
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412459_498242708.0RepeatNote=WD 3
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412500_536242708.0RepeatNote=WD 4
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412539_578242708.0RepeatNote=WD 5
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412580_618242708.0RepeatNote=WD 6
HgeneFBXW7chr4:153268082chr4:153831216ENST00000281708-412622_659242708.0RepeatNote=WD 7
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311378_418124590.0RepeatNote=WD 1
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311420_456124590.0RepeatNote=WD 2
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311459_498124590.0RepeatNote=WD 3
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311500_536124590.0RepeatNote=WD 4
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311539_578124590.0RepeatNote=WD 5
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311580_618124590.0RepeatNote=WD 6
HgeneFBXW7chr4:153268082chr4:153831216ENST00000296555-311622_659124590.0RepeatNote=WD 7
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513378_418242708.0RepeatNote=WD 1
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513420_456242708.0RepeatNote=WD 2
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513459_498242708.0RepeatNote=WD 3
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513500_536242708.0RepeatNote=WD 4
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513539_578242708.0RepeatNote=WD 5
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513580_618242708.0RepeatNote=WD 6
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603548-513622_659242708.0RepeatNote=WD 7
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311378_418242708.0RepeatNote=WD 1
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311420_456242708.0RepeatNote=WD 2
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311459_498242708.0RepeatNote=WD 3
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311500_536242708.0RepeatNote=WD 4
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311539_578242708.0RepeatNote=WD 5
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311580_618242708.0RepeatNote=WD 6
HgeneFBXW7chr4:153268082chr4:153831216ENST00000603841-311622_659242708.0RepeatNote=WD 7
TgeneARFIP1chr4:153268082chr4:153831216ENST0000035361779153_353322374.0DomainAH
TgeneARFIP1chr4:153268082chr4:153831216ENST0000035606468153_353290342.0DomainAH
TgeneARFIP1chr4:153268082chr4:153831216ENST0000040572768153_353290342.0DomainAH
TgeneARFIP1chr4:153268082chr4:153831216ENST0000045132079153_353322374.0DomainAH


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Fusion Gene Sequence for FBXW7-ARFIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29912_29912_1_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000263981_ARFIP1_chr4_153831216_ENST00000429148_length(transcript)=1738nt_BP=727nt
AGTGCGTTGTGTTCTTACGGGTTCCCTGGAGCGGATCACCATATAATTGATGTGCAGTCTGCATTGCTGAATCCTGGACTGCACCATTCT
GTGTTCAAGGGAAGATGTAATCTGATCCCTCTGCTGCTGAGGGAGGAATCTGTTCAGTCAAGGCTTTGACAGGGCATAGTCTCCTCCAAT
AATCTTCTCCGTTCTCTCTCATTATTCCCTCGAGTTCTTCTCAGTCAAGCTGCATGTATGTATGTGTGTCCCGAGAAGCGGTTTGATACT
GAGCTGCATTTGCCTTTACTGTGGAGTTTTGTTGCCGGTTCTGCTCCCTAATCTTCCTTTTCTGACGTGCCTGAGCATGTCCACATTAGA
ATCTGTGACATACCTACCTGAAAAAGGTTTATATTGTCAGAGACTGCCAAGCAGCCGGACACACGGGGGCACAGAATCACTGAAGGGGAA
AAATACAGAAAATATGGGTTTCTACGGCACATTAAAAATGATTTTTTACAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGCTC
TTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGG
GGACCTCAGAGCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTAAAAAT
GTTTCAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACA
GACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATA
AAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGT
GATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTA
TAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAG
AGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATT
TGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTG
CAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCT
TTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAA
GCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTT
TTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCA

>29912_29912_1_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000263981_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=217AA_BP=165
MHVCMCVPRSGLILSCICLYCGVLLPVLLPNLPFLTCLSMSTLESVTYLPEKGLYCQRLPSSRTHGGTESLKGKNTENMGFYGTLKMIFY
KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKVLHNQLVLFHNA

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>29912_29912_2_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000281708_ARFIP1_chr4_153831216_ENST00000451320_length(transcript)=4250nt_BP=1956nt
CCCGCCCCTCTCTCTGGAGTGAGGCGAGAGCCCCGCACAGAGCGAGGGAGACAGCGAGCTGAGCTCCGGGCGCTGCCGCTGCCGCTGCCG
CCGCCGCCGCCGCTGAGACTGAGAGCGAAGGAGCATCCGAGAGATCCAGTCCCCCTGCACTGGCCGCCGCCGAGACCTTCGCTCTCACCT
GGGCCAGCGGGAGCCGCGGCCGCACTCCTTTCCCCCCCTCACCTTCCCGGCCGGCAGCGGCGGCTGCACACGCCGGAGCCGGAGCCAGAG
CCGGAGCCCGAGCCTGAGCCGGAGCCGGCGGCTTGGGGGGCAGGGAGGCGGCTACCACGGGCCGGGAGTGGGTAGCTGCTCCGCGGTGAG
AGAACGCTGAGGAGGCGCCAGAGCTTCTGCCTCGTCCCGTGGGGCGTGGGGCGAGACCCCCAAGGTGTAGGGAGGGGGGTCCCAGCCGCA
GCGACACATGCGGGAGCCGGGAGCGGGGGCGGCGCCGAGCGGAGCCGGCCGGGTCCCTCGCCTTGCCGCCGACTCGGCCACCCGCCCGGG
GCCGTAGCATCTTGCCCCGGAGTGTATGAACCGGGGCCCCAACCAAGCTCGGCAACCACCCCCCGGCCGGGGGGGCGGGGACCCCGATGT
GAAGCGGCGGCTGGGGCGGCGGAGAGAACAGGACCGACGCCGCCGTCCTTTCCTCACCTTCCCCCTCCCCTCAGCCCCCTCCGGGGGTCT
TCTCCCTTGGCCAGTCGCCGGCCCCCCGGCTCCTTGGCTGGACTCCGGGAGGAGTTCCTAGAGCCCCCCTCCCCCGCCCCAGTCCCGAGG
GCGGCGGGGCCGGGGGGGACCCGGGGGGCCGGCCGCAGCCTCCACCCAGAGGAAACTTTACAAAAACAAAATCCGGAGTCTCCCAAACCT
GACTGTCCCGGGAGAAGTGGCCCTGGACGGGCAGAAGCCGCAGCCTGAAAAGACCCAGGAAGAGGAAAAGAGGAGGTAAGCGGGGCCGCC
GCCTCCCCTCCCCTGGCAGCGCGGAAGAGACCCGGGTTGCCGCCTGGTTTAGCGACACGAGCACCGCTTCTTCCTCAGTACCGCGCCGGA
GCCTTCCGCAGCTGCCGCTTCAGTCCGAAGGAGGAAGGGAACCAACCCACTTTCTCGGCGCCGCGGCTCTTTTCTAAAAGTAATGTGAAA
ACCTTTGCATCTTCTGATAGTCTAGCCAAGGTCCAAGAAGTAGCAAGCTGGCTTTTGGAAATGAATCAGGAACTGCTCTCTGTGGGCAGC
AAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAAGAACAGATGAATCGTGTGGTAGAGGAGGAA
CAGCAACAGCAACTCAGACAACAAGAGGAGGAGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGACCTGGAGGCCAAAAT
GATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGACTCCTCAGGAAACCAAGAAGAACAAGAGGAA
GATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGAGATGGACCAGGAGAGTGACGATTTTGATCAGTCTGATGAT
AGTAGCAGAGAAGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGACCTGCCCGTTCACCAACTCTCCTCCCCA
TTCTATACAAAAACAACAAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGCTCTTTTTCTTTGGGAAAGAAACCATGCAAAGTC
TCAGAATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGGGGACCTCAGAGCAGCCAATGGCCAAGGGCAA
CAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTAAAAATGTTTCAGGTTAAAGTATTGCACAATCAGCTG
GTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAAA
ACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAAC
CAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCC
TTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAG
AAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGG
TTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGAAT
ATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCG
TCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAATTT
TATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTG
GACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATT
CTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTT
TATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTA
CAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCT
TTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGG
GAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAG
TACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTC
AATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGA
AGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAA
TATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAG
AGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCT
TATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATTTG
CGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTT
GAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAG
AATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTACT
TTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATAAA

>29912_29912_2_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000281708_ARFIP1_chr4_153831216_ENST00000451320_length(amino acids)=369AA_BP=317
MAARKRPGLPPGLATRAPLLPQYRAGAFRSCRFSPKEEGNQPTFSAPRLFSKSNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRR
TGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEH
AGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYT
STTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGV

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>29912_29912_3_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000296555_ARFIP1_chr4_153831216_ENST00000429148_length(transcript)=1563nt_BP=552nt
CTCAGACAGGTCAGGACATTTGGTAGGGGAAGGTTGAAAGACAAAAGCAGCAGGCCTTGGGTTCTCAGCCTTTTAAAAACTATTATTAAA
TATATATTTTTAAAATTTAGTGGTTAGAGCTTTTAGTAATGTGCCTGTATTACATGTAGAGAGTATTCGTCAACCAAGAGGAGTTTTAAA
ATGTCAAAACCGGGAAAACCTACTCTAAACCATGGCTTGGTTCCTGTTGATCTTAAAAGTGCAAAAGAGCCTCTACCACATCAAACTGTG
ATGAAGATATTTAGCATTAGCATCATTGCCCAAGGCCTCCCTTTTTGTCGAAGACGGATGAAAAGAAAGTTGGACCATGGTTCTGAGGTC
CGCTCTTTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACT
TTTGGGGACCTCAGAGCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTA
AAAATGTTTCAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTT
GAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGA
AAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATT
ATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGT
TTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCT
AATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACA
TGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTA
TTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAA
TACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCT
TTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAAT
TTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAG

>29912_29912_3_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000296555_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=175AA_BP=123
MSKPGKPTLNHGLVPVDLKSAKEPLPHQTVMKIFSISIIAQGLPFCRRRMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTT

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>29912_29912_4_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000393956_ARFIP1_chr4_153831216_ENST00000429148_length(transcript)=1286nt_BP=275nt
ATTTTGCTTTTCCCTTCTAGTCATGATAAAGTATTTCTTGGATGAGAAATTTGCATTTAATGTTAAACTAACTGTTAATGCTATTTTTTA
AATGTATCAGTCTTCTATTAATATGGCTGATACCAGGACAAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGGGG
ACCTCAGAGCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTAAAAATGT
TTCAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGA
CACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAA
AAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGA
TTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATA
ATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAG
ATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTG
TATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCA
GAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTT
TTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGC
TTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTT
TTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATT

>29912_29912_4_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000393956_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=119AA_BP=67
MLMLFFKCISLLLIWLIPGQSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKVLHNQLVLFHNAIAAYFAGN

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>29912_29912_5_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000603548_ARFIP1_chr4_153831216_ENST00000429148_length(transcript)=1917nt_BP=906nt
CAGTCCGAAGGAGGAAGGGAACCAACCCACTTTCTCGGCGCCGCGGCTCTTTTCTAAAAGTGATTACTTCCTTAGGATAGATTGCCAGAA
GTGGAGTTACTGGGTCAGAGGAATGTGAAAACCTTTGCATCTTCTGATAGTCTAGCCAAGGTCCAAGAAGTAGCAAGCTGGCTTTTGGAA
ATGAATCAGGAACTGCTCTCTGTGGGCAGCAAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAA
GAACAGATGAATCGTGTGGTAGAGGAGGAACAGCAACAGCAACTCAGACAACAAGAGGAGGAGCACACTGCAAGGAATGGTGAAGTTGTT
GGAGTAGAACCTAGACCTGGAGGCCAAAATGATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGAC
TCCTCAGGAAACCAAGAAGAACAAGAGGAAGATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGAGATGGACCAG
GAGAGTGACGATTTTGATCAGTCTGATGATAGTAGCAGAGAAGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTG
GACCTGCCCGTTCACCAACTCTCCTCCCCATTCTATACAAAAACAACAAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGCTCT
TTTTCTTTGGGAAAGAAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGGG
GACCTCAGAGCAGCCAATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTAAAAATG
TTTCAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAG
ACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAA
AAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTG
ATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTAT
AATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGA
GATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTT
GTATCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGC
AGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTT
TTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAG
CTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTT
TTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCAT

>29912_29912_5_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000603548_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=326AA_BP=274
MPEVELLGQRNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNG
EVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSS
SIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEW

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>29912_29912_6_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000603841_ARFIP1_chr4_153831216_ENST00000429148_length(transcript)=1812nt_BP=801nt
CTGCAGAATGTGAAAACCTTTGCATCTTCTGATAGTCTAGCCAAGGTCCAAGAAGTAGCAAGCTGGCTTTTGGAAATGAATCAGGAACTG
CTCTCTGTGGGCAGCAAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAAGAACAGATGAATCGT
GTGGTAGAGGAGGAACAGCAACAGCAACTCAGACAACAAGAGGAGGAGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGA
CCTGGAGGCCAAAATGATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGACTCCTCAGGAAACCAA
GAAGAACAAGAGGAAGATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGAGATGGACCAGGAGAGTGACGATTTT
GATCAGTCTGATGATAGTAGCAGAGAAGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGACCTGCCCGTTCAC
CAACTCTCCTCCCCATTCTATACAAAAACAACAAAAATGAAAAGAAAGTTGGACCATGGTTCTGAGGTCCGCTCTTTTTCTTTGGGAAAG
AAACCATGCAAAGTCTCAGAATATACAAGTACCACTGGGCTTGTACCATGTTCAGCAACACCAACAACTTTTGGGGACCTCAGAGCAGCC
AATGGCCAAGGGCAACAACGACGCCGAATTACATCTGTCCAGCCACCTACAGGCCTCCAGGAATGGCTAAAAATGTTTCAGGTTAAAGTA
TTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTC
CATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTT
GTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACA
GCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATA
ATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAA
GATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGAT
ATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATAT
GGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCT
GTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTT
CACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGAC
GTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAA

>29912_29912_6_FBXW7-ARFIP1_FBXW7_chr4_153268082_ENST00000603841_ARFIP1_chr4_153831216_ENST00000429148_length(amino acids)=318AA_BP=266
LQNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPR
PGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVH
QLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQVKV

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Fusion Gene PPI Analysis for FBXW7-ARFIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXW7-ARFIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXW7-ARFIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource