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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FBXW8-CHST11 (FusionGDB2 ID:29931) |
Fusion Gene Summary for FBXW8-CHST11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXW8-CHST11 | Fusion gene ID: 29931 | Hgene | Tgene | Gene symbol | FBXW8 | CHST11 | Gene ID | 26259 | 50515 |
| Gene name | F-box and WD repeat domain containing 8 | carbohydrate sulfotransferase 11 | |
| Synonyms | FBW6|FBW8|FBX29|FBXO29|FBXW6 | C4ST|C4ST-1|C4ST1|HSA269537|OCBMD | |
| Cytomap | 12q24.22 | 12q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/WD repeat-containing protein 8F-box and WD-40 domain protein 8F-box and WD-40 domain-containing protein 8F-box only protein 29 | carbohydrate sulfotransferase 11C4S-1IgH/CHST11 fusioncarbohydrate (chondroitin 4) sulfotransferase 11chondroitin 4-O-sulfotransferase 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8N3Y1 | Q9NPF2 | |
| Ensembl transtripts involved in fusion gene | ENST00000309909, ENST00000455858, ENST00000551773, | ENST00000550711, ENST00000303694, ENST00000549260, ENST00000546689, ENST00000547956, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 14 X 13 X 7=1274 |
| # samples | 8 | 16 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1274*10)=-2.99322146736894 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXW8 [Title/Abstract] AND CHST11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FBXW8(117426674)-CHST11(104995684), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FBXW8-CHST11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FBXW8-CHST11 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. FBXW8-CHST11 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. FBXW8-CHST11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBXW8 | GO:0008283 | cell proliferation | 24362026 |
| Hgene | FBXW8 | GO:0016567 | protein ubiquitination | 18498745|24362026 |
| Hgene | FBXW8 | GO:0050775 | positive regulation of dendrite morphogenesis | 21572988 |
| Tgene | CHST11 | GO:0030206 | chondroitin sulfate biosynthetic process | 11056388 |
| Fusion gene breakpoints across FBXW8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CHST11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-B6-A0RH-01A | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
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Fusion Gene ORF analysis for FBXW8-CHST11 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000309909 | ENST00000550711 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| 5CDS-intron | ENST00000455858 | ENST00000550711 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| Frame-shift | ENST00000309909 | ENST00000303694 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| Frame-shift | ENST00000309909 | ENST00000549260 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| Frame-shift | ENST00000455858 | ENST00000303694 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| Frame-shift | ENST00000455858 | ENST00000549260 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| In-frame | ENST00000309909 | ENST00000546689 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| In-frame | ENST00000309909 | ENST00000547956 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| In-frame | ENST00000455858 | ENST00000546689 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| In-frame | ENST00000455858 | ENST00000547956 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| intron-3CDS | ENST00000551773 | ENST00000303694 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| intron-3CDS | ENST00000551773 | ENST00000546689 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| intron-3CDS | ENST00000551773 | ENST00000547956 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| intron-3CDS | ENST00000551773 | ENST00000549260 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| intron-intron | ENST00000551773 | ENST00000550711 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000309909 | FBXW8 | chr12 | 117426674 | - | ENST00000547956 | CHST11 | chr12 | 104995684 | + | 1695 | 1321 | 25 | 1410 | 461 |
| ENST00000309909 | FBXW8 | chr12 | 117426674 | - | ENST00000546689 | CHST11 | chr12 | 104995684 | + | 1563 | 1321 | 25 | 1410 | 461 |
| ENST00000455858 | FBXW8 | chr12 | 117426674 | - | ENST00000547956 | CHST11 | chr12 | 104995684 | + | 1488 | 1114 | 16 | 1203 | 395 |
| ENST00000455858 | FBXW8 | chr12 | 117426674 | - | ENST00000546689 | CHST11 | chr12 | 104995684 | + | 1356 | 1114 | 16 | 1203 | 395 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000309909 | ENST00000547956 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + | 0.001479143 | 0.9985209 |
| ENST00000309909 | ENST00000546689 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + | 0.001241591 | 0.99875844 |
| ENST00000455858 | ENST00000547956 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + | 0.002136143 | 0.9978638 |
| ENST00000455858 | ENST00000546689 | FBXW8 | chr12 | 117426674 | - | CHST11 | chr12 | 104995684 | + | 0.00179717 | 0.9982028 |
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Fusion Genomic Features for FBXW8-CHST11 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FBXW8-CHST11 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:117426674/chr12:104995684) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXW8 | CHST11 |
| FUNCTION: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695}. | FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000309909 | - | 7 | 11 | 113_159 | 413 | 599.0 | Domain | F-box |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000455858 | - | 7 | 11 | 113_159 | 347 | 533.0 | Domain | F-box |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000309909 | - | 7 | 11 | 197_245 | 413 | 599.0 | Repeat | Note=WD 1 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000309909 | - | 7 | 11 | 254_294 | 413 | 599.0 | Repeat | Note=WD 2 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000309909 | - | 7 | 11 | 297_336 | 413 | 599.0 | Repeat | Note=WD 3 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000455858 | - | 7 | 11 | 197_245 | 347 | 533.0 | Repeat | Note=WD 1 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000455858 | - | 7 | 11 | 254_294 | 347 | 533.0 | Repeat | Note=WD 2 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000455858 | - | 7 | 11 | 297_336 | 347 | 533.0 | Repeat | Note=WD 3 |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000303694 | 0 | 3 | 124_130 | 39 | 353.0 | Nucleotide binding | PAPS | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000303694 | 0 | 3 | 186_194 | 39 | 353.0 | Nucleotide binding | PAPS | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000549260 | 0 | 3 | 124_130 | 34 | 348.0 | Nucleotide binding | PAPS | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000549260 | 0 | 3 | 186_194 | 34 | 348.0 | Nucleotide binding | PAPS | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000303694 | 0 | 3 | 38_352 | 39 | 353.0 | Topological domain | Lumenal | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000549260 | 0 | 3 | 38_352 | 34 | 348.0 | Topological domain | Lumenal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000309909 | - | 7 | 11 | 430_470 | 413 | 599.0 | Repeat | Note=WD 4 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000309909 | - | 7 | 11 | 473_510 | 413 | 599.0 | Repeat | Note=WD 5 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000455858 | - | 7 | 11 | 430_470 | 347 | 533.0 | Repeat | Note=WD 4 |
| Hgene | FBXW8 | chr12:117426674 | chr12:104995684 | ENST00000455858 | - | 7 | 11 | 473_510 | 347 | 533.0 | Repeat | Note=WD 5 |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000303694 | 0 | 3 | 1_16 | 39 | 353.0 | Topological domain | Cytoplasmic | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000549260 | 0 | 3 | 1_16 | 34 | 348.0 | Topological domain | Cytoplasmic | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000303694 | 0 | 3 | 17_37 | 39 | 353.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein | |
| Tgene | CHST11 | chr12:117426674 | chr12:104995684 | ENST00000549260 | 0 | 3 | 17_37 | 34 | 348.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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Fusion Gene Sequence for FBXW8-CHST11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >29931_29931_1_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000309909_CHST11_chr12_104995684_ENST00000546689_length(transcript)=1563nt_BP=1321nt GCGGCGGACACTTCCCTGGGCGGGACTGTCTCGTGGCACCCGGTGGAACCGAGGAGAACGTGGAGCGCCGGGAGCGGCGAATATGGACGA CTACAGCCTGGATGAGTTCCGTCGGCGCTGGCAGGAGGAGCTGGCGCAGGCCCAGGCGCCGAAGAAGCGGCGACGGCCCGAGGCTGCCGA GAGGCGGGCTCGGCGGCCGGAGGTGGGCTCCGGGCGCGGCGAACAGGCCTCGGGGGACCCGGCGCTGGCCCAGCGTCTCCTGGAGGGCGC GGGGAGGCCCCCGGCGGCGCGGGCGACTCGGGCCGAGGGGCAGGACGTAGCGAGCCGCTCACGTTCTCCTCTGGCCCGCGAGGGCGCCGG GGGCGGGGAGCAGCTGGTGGACCAGCTCATCCGCGACCTGAATGAAATGAATGATGTGCCTTTCTTTGATATCCAACTGCCTTACGAATT GGCAATCAATATATTTCAGTATCTGGACAGGAAAGAACTAGGAAGATGTGCACAGGTGAGCAAGACGTGGAAGGTGATTGCAGAGGATGA GGTGCTGTGGTACAGGCTGTGCCAGCAGGAAGGGCACCTTCCGGATAGCAGCATCTCTGACTATTCTTGCTGGAAGCTCATCTTCCAAGA GTGCCGAGCCAAGGAACACATGTTACGAACCAACTGGAAGAATCGCAAAGGTGCCGTGAGCGAGCTGGAGCATGTTCCTGACACAGTTTT GTGTGATGTGCATTCTCACGATGGTGTGGTCATTGCGGGATATACATCAGGGGATGTGAGAGTGTGGGACACCCGCACCTGGGACTACGT AGCCCCCTTCCTGGAATCAGAGGACGAGGAGGATGAGCCTGGAATGCAGCCAAATGTCTCCTTTGTGAGGATAAACAGCTCGTTGGCAGT AGCAGCTTATGAGGATGGGTTTCTTAATATTTGGGATTTAAGGACCGGAAAGTACCCTGTTCATCGTTTTGAGCACGATGCAAGAATACA GGCACTAGCCCTCAGCCAGGACGATGCAACCGTGGCCACAGCTTCTGCTTTTGATGTCGTGATGTTATCCCCCAATGAGGAGGGGTACTG GCAGATAGCTGCGGAATTTGAAGTTCCGAAACTGGTTCAGTACCTTGAAATAGTTCCAGAAACCAGAAGGTACCCTGTGGCAGTAGCCGC TGCTGGAGATCTGATGTACCTGCTCAAAGCCGAAGACTCCGCCAGAACCCTCCTTTACGCCCACGGCCCGCCTGTCACATGTCTAGACGT CTCGGCCAACCAAGTTGCTTTTGGTGTACAGGGTCTGGGATGGGTGTACGAAGGAAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGAC ATCTGCTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATT TTTTTTTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCT >29931_29931_1_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000309909_CHST11_chr12_104995684_ENST00000546689_length(amino acids)=461AA_BP=432 MSRGTRWNRGERGAPGAANMDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLLEGAGRPPAARA TRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQ QEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESED EEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEV PKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKSCGGIPLVWTSAAGRGPE -------------------------------------------------------------- >29931_29931_2_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000309909_CHST11_chr12_104995684_ENST00000547956_length(transcript)=1695nt_BP=1321nt GCGGCGGACACTTCCCTGGGCGGGACTGTCTCGTGGCACCCGGTGGAACCGAGGAGAACGTGGAGCGCCGGGAGCGGCGAATATGGACGA CTACAGCCTGGATGAGTTCCGTCGGCGCTGGCAGGAGGAGCTGGCGCAGGCCCAGGCGCCGAAGAAGCGGCGACGGCCCGAGGCTGCCGA GAGGCGGGCTCGGCGGCCGGAGGTGGGCTCCGGGCGCGGCGAACAGGCCTCGGGGGACCCGGCGCTGGCCCAGCGTCTCCTGGAGGGCGC GGGGAGGCCCCCGGCGGCGCGGGCGACTCGGGCCGAGGGGCAGGACGTAGCGAGCCGCTCACGTTCTCCTCTGGCCCGCGAGGGCGCCGG GGGCGGGGAGCAGCTGGTGGACCAGCTCATCCGCGACCTGAATGAAATGAATGATGTGCCTTTCTTTGATATCCAACTGCCTTACGAATT GGCAATCAATATATTTCAGTATCTGGACAGGAAAGAACTAGGAAGATGTGCACAGGTGAGCAAGACGTGGAAGGTGATTGCAGAGGATGA GGTGCTGTGGTACAGGCTGTGCCAGCAGGAAGGGCACCTTCCGGATAGCAGCATCTCTGACTATTCTTGCTGGAAGCTCATCTTCCAAGA GTGCCGAGCCAAGGAACACATGTTACGAACCAACTGGAAGAATCGCAAAGGTGCCGTGAGCGAGCTGGAGCATGTTCCTGACACAGTTTT GTGTGATGTGCATTCTCACGATGGTGTGGTCATTGCGGGATATACATCAGGGGATGTGAGAGTGTGGGACACCCGCACCTGGGACTACGT AGCCCCCTTCCTGGAATCAGAGGACGAGGAGGATGAGCCTGGAATGCAGCCAAATGTCTCCTTTGTGAGGATAAACAGCTCGTTGGCAGT AGCAGCTTATGAGGATGGGTTTCTTAATATTTGGGATTTAAGGACCGGAAAGTACCCTGTTCATCGTTTTGAGCACGATGCAAGAATACA GGCACTAGCCCTCAGCCAGGACGATGCAACCGTGGCCACAGCTTCTGCTTTTGATGTCGTGATGTTATCCCCCAATGAGGAGGGGTACTG GCAGATAGCTGCGGAATTTGAAGTTCCGAAACTGGTTCAGTACCTTGAAATAGTTCCAGAAACCAGAAGGTACCCTGTGGCAGTAGCCGC TGCTGGAGATCTGATGTACCTGCTCAAAGCCGAAGACTCCGCCAGAACCCTCCTTTACGCCCACGGCCCGCCTGTCACATGTCTAGACGT CTCGGCCAACCAAGTTGCTTTTGGTGTACAGGGTCTGGGATGGGTGTACGAAGGAAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGAC ATCTGCTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATT TTTTTTTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCT TCAGTGGTTGCTTTCTCCGTCACCCTTTTTCTATGTAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGT >29931_29931_2_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000309909_CHST11_chr12_104995684_ENST00000547956_length(amino acids)=461AA_BP=432 MSRGTRWNRGERGAPGAANMDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLLEGAGRPPAARA TRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQ QEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESED EEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEV PKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKSCGGIPLVWTSAAGRGPE -------------------------------------------------------------- >29931_29931_3_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000455858_CHST11_chr12_104995684_ENST00000546689_length(transcript)=1356nt_BP=1114nt ACTTCCCTGGGCGGGACTGTCTCGTGGCACCCGGTGGAACCGAGGAGAACGTGGAGCGCCGGGAGCGGCGAATATGGACGACTACAGCCT GGATGAGTTCCGTCGGCGCTGGCAGGAGGAGCTGGCGCAGGCCCAGGCGCCGAAGAAGCGGCGACGGCCCGAGGCTGCCGAGAGGCGGGC TCGGCGGCCGGAGAATGAAATGAATGATGTGCCTTTCTTTGATATCCAACTGCCTTACGAATTGGCAATCAATATATTTCAGTATCTGGA CAGGAAAGAACTAGGAAGATGTGCACAGGTGAGCAAGACGTGGAAGGTGATTGCAGAGGATGAGGTGCTGTGGTACAGGCTGTGCCAGCA GGAAGGGCACCTTCCGGATAGCAGCATCTCTGACTATTCTTGCTGGAAGCTCATCTTCCAAGAGTGCCGAGCCAAGGAACACATGTTACG AACCAACTGGAAGAATCGCAAAGGTGCCGTGAGCGAGCTGGAGCATGTTCCTGACACAGTTTTGTGTGATGTGCATTCTCACGATGGTGT GGTCATTGCGGGATATACATCAGGGGATGTGAGAGTGTGGGACACCCGCACCTGGGACTACGTAGCCCCCTTCCTGGAATCAGAGGACGA GGAGGATGAGCCTGGAATGCAGCCAAATGTCTCCTTTGTGAGGATAAACAGCTCGTTGGCAGTAGCAGCTTATGAGGATGGGTTTCTTAA TATTTGGGATTTAAGGACCGGAAAGTACCCTGTTCATCGTTTTGAGCACGATGCAAGAATACAGGCACTAGCCCTCAGCCAGGACGATGC AACCGTGGCCACAGCTTCTGCTTTTGATGTCGTGATGTTATCCCCCAATGAGGAGGGGTACTGGCAGATAGCTGCGGAATTTGAAGTTCC GAAACTGGTTCAGTACCTTGAAATAGTTCCAGAAACCAGAAGGTACCCTGTGGCAGTAGCCGCTGCTGGAGATCTGATGTACCTGCTCAA AGCCGAAGACTCCGCCAGAACCCTCCTTTACGCCCACGGCCCGCCTGTCACATGTCTAGACGTCTCGGCCAACCAAGTTGCTTTTGGTGT ACAGGGTCTGGGATGGGTGTACGAAGGAAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTGCTGCCGGAAGGGGTCCCGAAGC CCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTTTTTTTGTAGGTATGGATACTAA AAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGTGGTTGCTTTCTCCGTCACCCTT >29931_29931_3_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000455858_CHST11_chr12_104995684_ENST00000546689_length(amino acids)=395AA_BP=366 MSRGTRWNRGERGAPGAANMDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKELG RCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGY TSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATA SAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGW -------------------------------------------------------------- >29931_29931_4_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000455858_CHST11_chr12_104995684_ENST00000547956_length(transcript)=1488nt_BP=1114nt ACTTCCCTGGGCGGGACTGTCTCGTGGCACCCGGTGGAACCGAGGAGAACGTGGAGCGCCGGGAGCGGCGAATATGGACGACTACAGCCT GGATGAGTTCCGTCGGCGCTGGCAGGAGGAGCTGGCGCAGGCCCAGGCGCCGAAGAAGCGGCGACGGCCCGAGGCTGCCGAGAGGCGGGC TCGGCGGCCGGAGAATGAAATGAATGATGTGCCTTTCTTTGATATCCAACTGCCTTACGAATTGGCAATCAATATATTTCAGTATCTGGA CAGGAAAGAACTAGGAAGATGTGCACAGGTGAGCAAGACGTGGAAGGTGATTGCAGAGGATGAGGTGCTGTGGTACAGGCTGTGCCAGCA GGAAGGGCACCTTCCGGATAGCAGCATCTCTGACTATTCTTGCTGGAAGCTCATCTTCCAAGAGTGCCGAGCCAAGGAACACATGTTACG AACCAACTGGAAGAATCGCAAAGGTGCCGTGAGCGAGCTGGAGCATGTTCCTGACACAGTTTTGTGTGATGTGCATTCTCACGATGGTGT GGTCATTGCGGGATATACATCAGGGGATGTGAGAGTGTGGGACACCCGCACCTGGGACTACGTAGCCCCCTTCCTGGAATCAGAGGACGA GGAGGATGAGCCTGGAATGCAGCCAAATGTCTCCTTTGTGAGGATAAACAGCTCGTTGGCAGTAGCAGCTTATGAGGATGGGTTTCTTAA TATTTGGGATTTAAGGACCGGAAAGTACCCTGTTCATCGTTTTGAGCACGATGCAAGAATACAGGCACTAGCCCTCAGCCAGGACGATGC AACCGTGGCCACAGCTTCTGCTTTTGATGTCGTGATGTTATCCCCCAATGAGGAGGGGTACTGGCAGATAGCTGCGGAATTTGAAGTTCC GAAACTGGTTCAGTACCTTGAAATAGTTCCAGAAACCAGAAGGTACCCTGTGGCAGTAGCCGCTGCTGGAGATCTGATGTACCTGCTCAA AGCCGAAGACTCCGCCAGAACCCTCCTTTACGCCCACGGCCCGCCTGTCACATGTCTAGACGTCTCGGCCAACCAAGTTGCTTTTGGTGT ACAGGGTCTGGGATGGGTGTACGAAGGAAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTGCTGCCGGAAGGGGTCCCGAAGC CCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTTTTTTTGTAGGTATGGATACTAA AAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGTGGTTGCTTTCTCCGTCACCCTT TTTCTATGTAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGTTTAGTGCTAAGCATTCAGACCTGCCCA >29931_29931_4_FBXW8-CHST11_FBXW8_chr12_117426674_ENST00000455858_CHST11_chr12_104995684_ENST00000547956_length(amino acids)=395AA_BP=366 MSRGTRWNRGERGAPGAANMDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKELG RCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGY TSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATA SAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FBXW8-CHST11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FBXW8-CHST11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FBXW8-CHST11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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