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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FCGRT-ALCAM (FusionGDB2 ID:29961) |
Fusion Gene Summary for FCGRT-ALCAM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FCGRT-ALCAM | Fusion gene ID: 29961 | Hgene | Tgene | Gene symbol | FCGRT | ALCAM | Gene ID | 2217 | 214 |
| Gene name | Fc fragment of IgG receptor and transporter | activated leukocyte cell adhesion molecule | |
| Synonyms | FCRN|alpha-chain | CD166|MEMD | |
| Cytomap | 19q13.33 | 3q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | IgG receptor FcRn large subunit p51Fc fragment of IgG, receptor, transporter, alphaFcRn alpha chainIgG Fc fragment receptor transporter alpha chainheavy chain of the major histocompatibility complex class I-like Fc receptorimmunoglobulin receptor, in | CD166 antigen | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | P55899 | Q13740 | |
| Ensembl transtripts involved in fusion gene | ENST00000221466, ENST00000426395, ENST00000596975, ENST00000599988, ENST00000594823, | ENST00000306107, ENST00000389927, ENST00000472644, ENST00000481337, ENST00000486979, | |
| Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 11 X 11 X 6=726 |
| # samples | 7 | 12 | |
| ** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/726*10)=-2.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FCGRT [Title/Abstract] AND ALCAM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FCGRT(50029419)-ALCAM(105181722), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FCGRT (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ALCAM (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BE940440 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
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Fusion Gene ORF analysis for FCGRT-ALCAM |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000221466 | ENST00000306107 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000221466 | ENST00000389927 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000221466 | ENST00000472644 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000221466 | ENST00000481337 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000221466 | ENST00000486979 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000426395 | ENST00000306107 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000426395 | ENST00000389927 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000426395 | ENST00000472644 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000426395 | ENST00000481337 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000426395 | ENST00000486979 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000596975 | ENST00000306107 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000596975 | ENST00000389927 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000596975 | ENST00000472644 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000596975 | ENST00000481337 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000596975 | ENST00000486979 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000599988 | ENST00000306107 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000599988 | ENST00000389927 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000599988 | ENST00000472644 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000599988 | ENST00000481337 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| 3UTR-intron | ENST00000599988 | ENST00000486979 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| intron-intron | ENST00000594823 | ENST00000306107 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| intron-intron | ENST00000594823 | ENST00000389927 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| intron-intron | ENST00000594823 | ENST00000472644 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| intron-intron | ENST00000594823 | ENST00000481337 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| intron-intron | ENST00000594823 | ENST00000486979 | FCGRT | chr19 | 50029419 | - | ALCAM | chr3 | 105181722 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FCGRT-ALCAM |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FCGRT-ALCAM |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50029419/:105181722) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FCGRT | ALCAM |
| FUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:10998088, ECO:0000269|PubMed:24469444, ECO:0000269|PubMed:28330995, ECO:0000269|PubMed:7964511}.; FUNCTION: (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. {ECO:0000269|PubMed:30808762, ECO:0000269|PubMed:31104841}. | FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}.; FUNCTION: [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FCGRT-ALCAM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for FCGRT-ALCAM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FCGRT-ALCAM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FCGRT-ALCAM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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