FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FCHSD1-NCKAP1L (FusionGDB2 ID:29977)

Fusion Gene Summary for FCHSD1-NCKAP1L

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD1-NCKAP1L
Fusion gene ID: 29977
HgeneTgene
Gene symbol

FCHSD1

NCKAP1L

Gene ID

89848

3071

Gene nameFCH and double SH3 domains 1NCK associated protein 1 like
SynonymsNWK2HEM1
Cytomap

5q31.3

12q13.13-q13.2

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 1FCH and double SH3 domains protein 1nervous wreck homolog 2protein nervous wreck 2nck-associated protein 1-likehematopoietic protein 1membrane-associated protein hem-1
Modification date2020031320200313
UniProtAcc

Q86WN1

P55160

Ensembl transtripts involved in fusion geneENST00000435817, ENST00000519800, 
ENST00000522783, ENST00000522126, 
ENST00000523856, 		ENST00000552211, 
ENST00000293373, ENST00000545638, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: FCHSD1 [Title/Abstract] AND NCKAP1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD1(141029926)-NCKAP1L(54936359), # samples:3
Anticipated loss of major functional domain due to fusion event.FCHSD1-NCKAP1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCKAP1L

GO:0006935

chemotaxis

16417406

TgeneNCKAP1L

GO:0030593

neutrophil chemotaxis

16417406


check buttonFusion gene breakpoints across FCHSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCKAP1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A9U7-01AFCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
ChimerDB4CESCTCGA-VS-A9U7FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+


Top

Fusion Gene ORF analysis for FCHSD1-NCKAP1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000435817ENST00000552211FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
5CDS-intronENST00000519800ENST00000552211FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
5CDS-intronENST00000522783ENST00000552211FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
5UTR-3CDSENST00000522126ENST00000293373FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
5UTR-3CDSENST00000522126ENST00000545638FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
5UTR-intronENST00000522126ENST00000552211FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
Frame-shiftENST00000435817ENST00000545638FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
Frame-shiftENST00000519800ENST00000545638FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
Frame-shiftENST00000522783ENST00000545638FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
In-frameENST00000435817ENST00000293373FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
In-frameENST00000519800ENST00000293373FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
In-frameENST00000522783ENST00000293373FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
intron-3CDSENST00000523856ENST00000293373FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
intron-3CDSENST00000523856ENST00000545638FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+
intron-intronENST00000523856ENST00000552211FCHSD1chr5

141029926

-NCKAP1Lchr12

54936359

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435817FCHSD1chr5141029926-ENST00000293373NCKAP1Lchr1254936359+15842165132691
ENST00000522783FCHSD1chr5141029926-ENST00000293373NCKAP1Lchr1254936359+1541173828391
ENST00000519800FCHSD1chr5141029926-ENST00000293373NCKAP1Lchr1254936359+15521841929491

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435817ENST00000293373FCHSD1chr5141029926-NCKAP1Lchr1254936359+0.037244830.96275514
ENST00000522783ENST00000293373FCHSD1chr5141029926-NCKAP1Lchr1254936359+0.0460974350.9539026
ENST00000519800ENST00000293373FCHSD1chr5141029926-NCKAP1Lchr1254936359+0.0418084040.9581916

Top

Fusion Genomic Features for FCHSD1-NCKAP1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FCHSD1chr5141029925-NCKAP1Lchr1254936358+0.0020445850.99795544
FCHSD1chr5141029925-NCKAP1Lchr1254936358+0.0020445850.99795544
FCHSD1chr5141029925-NCKAP1Lchr1254936358+0.0020445850.99795544
FCHSD1chr5141029925-NCKAP1Lchr1254936358+0.0020445850.99795544

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FCHSD1-NCKAP1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:141029926/chr12:54936359)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD1

Q86WN1

NCKAP1L

P55160

FUNCTION: Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}.FUNCTION: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). {ECO:0000250|UniProtKB:Q8K1X4, ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648, ECO:0000303|PubMed:20969869}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000435817-320116_14955691.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000435817-320354_38455691.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000522126-219116_1490615.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000522126-219354_3840615.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000435817-320610_68855691.0Compositional biasNote=Pro-rich
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000522126-219610_6880615.0Compositional biasNote=Pro-rich
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000435817-32012_28255691.0DomainF-BAR
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000435817-320468_52955691.0DomainSH3 1
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000435817-320546_60955691.0DomainSH3 2
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000522126-21912_2820615.0DomainF-BAR
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000522126-219468_5290615.0DomainSH3 1
HgeneFCHSD1chr5:141029926chr12:54936359ENST00000522126-219546_6090615.0DomainSH3 2
TgeneNCKAP1Lchr5:141029926chr12:54936359ENST000002933732931996_101610911128.0TransmembraneHelical
TgeneNCKAP1Lchr5:141029926chr12:54936359ENST000005456382931996_101610411078.0TransmembraneHelical


Top

Fusion Gene Sequence for FCHSD1-NCKAP1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29977_29977_1_FCHSD1-NCKAP1L_FCHSD1_chr5_141029926_ENST00000435817_NCKAP1L_chr12_54936359_ENST00000293373_length(transcript)=1584nt_BP=216nt
GGCTTCCTCCAGTTCCGGAGTCCAGTGGCTGACCGCCTTGCTGGAGCGGAGATGCAGCCGCCGCCCCGAAAAGTGAAGCCGGCCCAGGAG
GTGAAGCTTCGCTTCCTGGAACAGCTGAGCATCCTTCAGACCTGGCAGCAGAGGGAGGCGGATCTGCTGGAGGACATCAGATCCTACAGC
AAGCAGAGGGCAGCCATTGAACGGGAGTATGGGCAGGTGGTGGAGGAGTCATCCTTCCTGACCCTGGACATGCTGGAGTCCTGTTTCCCT
TATGTCCTGCTTCGAAATGCCTATCGGGAGGTGTCTCGGGCCTTCCACCTAAACTGAATGCCTGCCAGTACCCACTGAAGAGCCCTTTGG
ACCTTCCTAAACCCTTGCCATAGTGGAAGCTGTGGTCACTTTCGCAGGGGGTGGGAATGGGGTGGGGTCACTAAGGAGAGAGGGTCAGGA
GCCAGAGTTGATGAGCAGATCTGTGGAAGAACAATCCAGGGCTGAGAAATCGTAGAGCAGTGAGGCAGGCTGGGAGCATGGAGGACAGCT
TATGGAAAAAGTTAGGGCGTGGGGCCACATGTGTGAATTTTACAATGAAAAAAGGAGTAACGTACAAGTATATTTTCTATCTTCTGGTGA
CTTGAGCTTGAGCTCTGACAGGCATGGGCCTCTCCGACCTTCATCACTATTCTTAGGATAATGCTGGCGGGCAGAGATGATCAATCATCA
TATTAAATCATAATGAGCTTATAATCCTCCCACTGGAGCTGCTATTGTCTCCTGCACATTCATTAGGACCATTATCTTCTCTCTTCCTTT
TTCAAATGTGTTCAGCAAACATTCAACCTGCTCCTACTGCAGAGTAGCAGCAAAGGAGCCCCTCTTTTCCTTTGTGGGGCTCTTCGAGGG
GTCATTGGGTCTCTTCCTTTGCCCCCAGCTTGACTGCGTTTCCTACTGGGGCAAGGAGGAAGTGCCCTTCAGAGATGTTCACTGCCCACC
TACTCTACTACATTGTTTGTTACAAGTTCTCTCTTGCTTTAACCCCTCCTGCTTTGATATCTCCACAACCCAGAGCAGAGGGTCAGTTAG
TCTCCGTCAATTCTAGGTTACATGACAACTGATTGGCCCAGACTTAGGTGGGTTTTCCCTCCTGTACCATTTGGGGGTACTCTGCCTTTT
ATTGGGAGGGACTAATTTAACCCCAAATCCTTTTGTCAGCCTGGGTATAGCTGTTGCTCCAGGAAGGGATTTCTCTTCTGGATCTTAAAT
TTCACAGACCTCATTAGGTTGTATGGCCCTGAGAGTGGGTATCCTTGAGGGAGTACAAGCTGTTTCAACTTAGCCCTTTTCTGCGCTAAT
TAGAATTTCAAGCGTCACAGAGCCTGGGGGCTTTCAAGATAGCACTAAACTAGGTTTACTTAACTCCTTGGCAGGAAATAGTGGCCCCCA
TGCATCACTTCTGTGAATCCACTGCCAGGGAGAAGTGGAGAAACAGATCATATATGTCACAGGTCTAGAGTGGTTGGAATTGACAAATAT

>29977_29977_1_FCHSD1-NCKAP1L_FCHSD1_chr5_141029926_ENST00000435817_NCKAP1L_chr12_54936359_ENST00000293373_length(amino acids)=91AA_BP=54
MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQVVEESSFLTLDMLESCFPYVLLRNAYREVSRAFHL

--------------------------------------------------------------
>29977_29977_2_FCHSD1-NCKAP1L_FCHSD1_chr5_141029926_ENST00000519800_NCKAP1L_chr12_54936359_ENST00000293373_length(transcript)=1552nt_BP=184nt
CCGCCTTGCTGGAGCGGAGATGCAGCCGCCGCCCCGAAAAGTGAAGCCGGCCCAGGAGGTGAAGCTTCGCTTCCTGGAACAGCTGAGCAT
CCTTCAGACCTGGCAGCAGAGGGAGGCGGATCTGCTGGAGGACATCAGATCCTACAGCAAGCAGAGGGCAGCCATTGAACGGGAGTATGG
GCAGGTGGTGGAGGAGTCATCCTTCCTGACCCTGGACATGCTGGAGTCCTGTTTCCCTTATGTCCTGCTTCGAAATGCCTATCGGGAGGT
GTCTCGGGCCTTCCACCTAAACTGAATGCCTGCCAGTACCCACTGAAGAGCCCTTTGGACCTTCCTAAACCCTTGCCATAGTGGAAGCTG
TGGTCACTTTCGCAGGGGGTGGGAATGGGGTGGGGTCACTAAGGAGAGAGGGTCAGGAGCCAGAGTTGATGAGCAGATCTGTGGAAGAAC
AATCCAGGGCTGAGAAATCGTAGAGCAGTGAGGCAGGCTGGGAGCATGGAGGACAGCTTATGGAAAAAGTTAGGGCGTGGGGCCACATGT
GTGAATTTTACAATGAAAAAAGGAGTAACGTACAAGTATATTTTCTATCTTCTGGTGACTTGAGCTTGAGCTCTGACAGGCATGGGCCTC
TCCGACCTTCATCACTATTCTTAGGATAATGCTGGCGGGCAGAGATGATCAATCATCATATTAAATCATAATGAGCTTATAATCCTCCCA
CTGGAGCTGCTATTGTCTCCTGCACATTCATTAGGACCATTATCTTCTCTCTTCCTTTTTCAAATGTGTTCAGCAAACATTCAACCTGCT
CCTACTGCAGAGTAGCAGCAAAGGAGCCCCTCTTTTCCTTTGTGGGGCTCTTCGAGGGGTCATTGGGTCTCTTCCTTTGCCCCCAGCTTG
ACTGCGTTTCCTACTGGGGCAAGGAGGAAGTGCCCTTCAGAGATGTTCACTGCCCACCTACTCTACTACATTGTTTGTTACAAGTTCTCT
CTTGCTTTAACCCCTCCTGCTTTGATATCTCCACAACCCAGAGCAGAGGGTCAGTTAGTCTCCGTCAATTCTAGGTTACATGACAACTGA
TTGGCCCAGACTTAGGTGGGTTTTCCCTCCTGTACCATTTGGGGGTACTCTGCCTTTTATTGGGAGGGACTAATTTAACCCCAAATCCTT
TTGTCAGCCTGGGTATAGCTGTTGCTCCAGGAAGGGATTTCTCTTCTGGATCTTAAATTTCACAGACCTCATTAGGTTGTATGGCCCTGA
GAGTGGGTATCCTTGAGGGAGTACAAGCTGTTTCAACTTAGCCCTTTTCTGCGCTAATTAGAATTTCAAGCGTCACAGAGCCTGGGGGCT
TTCAAGATAGCACTAAACTAGGTTTACTTAACTCCTTGGCAGGAAATAGTGGCCCCCATGCATCACTTCTGTGAATCCACTGCCAGGGAG
AAGTGGAGAAACAGATCATATATGTCACAGGTCTAGAGTGGTTGGAATTGACAAATATAATTAGCTAGTTGGTTAATTAGGGTCATGTCC

>29977_29977_2_FCHSD1-NCKAP1L_FCHSD1_chr5_141029926_ENST00000519800_NCKAP1L_chr12_54936359_ENST00000293373_length(amino acids)=91AA_BP=54
MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQVVEESSFLTLDMLESCFPYVLLRNAYREVSRAFHL

--------------------------------------------------------------
>29977_29977_3_FCHSD1-NCKAP1L_FCHSD1_chr5_141029926_ENST00000522783_NCKAP1L_chr12_54936359_ENST00000293373_length(transcript)=1541nt_BP=173nt
GAGCGGAGATGCAGCCGCCGCCCCGAAAAGTGAAGCCGGCCCAGGAGGTGAAGCTTCGCTTCCTGGAACAGCTGAGCATCCTTCAGACCT
GGCAGCAGAGGGAGGCGGATCTGCTGGAGGACATCAGATCCTACAGCAAGCAGAGGGCAGCCATTGAACGGGAGTATGGGCAGGTGGTGG
AGGAGTCATCCTTCCTGACCCTGGACATGCTGGAGTCCTGTTTCCCTTATGTCCTGCTTCGAAATGCCTATCGGGAGGTGTCTCGGGCCT
TCCACCTAAACTGAATGCCTGCCAGTACCCACTGAAGAGCCCTTTGGACCTTCCTAAACCCTTGCCATAGTGGAAGCTGTGGTCACTTTC
GCAGGGGGTGGGAATGGGGTGGGGTCACTAAGGAGAGAGGGTCAGGAGCCAGAGTTGATGAGCAGATCTGTGGAAGAACAATCCAGGGCT
GAGAAATCGTAGAGCAGTGAGGCAGGCTGGGAGCATGGAGGACAGCTTATGGAAAAAGTTAGGGCGTGGGGCCACATGTGTGAATTTTAC
AATGAAAAAAGGAGTAACGTACAAGTATATTTTCTATCTTCTGGTGACTTGAGCTTGAGCTCTGACAGGCATGGGCCTCTCCGACCTTCA
TCACTATTCTTAGGATAATGCTGGCGGGCAGAGATGATCAATCATCATATTAAATCATAATGAGCTTATAATCCTCCCACTGGAGCTGCT
ATTGTCTCCTGCACATTCATTAGGACCATTATCTTCTCTCTTCCTTTTTCAAATGTGTTCAGCAAACATTCAACCTGCTCCTACTGCAGA
GTAGCAGCAAAGGAGCCCCTCTTTTCCTTTGTGGGGCTCTTCGAGGGGTCATTGGGTCTCTTCCTTTGCCCCCAGCTTGACTGCGTTTCC
TACTGGGGCAAGGAGGAAGTGCCCTTCAGAGATGTTCACTGCCCACCTACTCTACTACATTGTTTGTTACAAGTTCTCTCTTGCTTTAAC
CCCTCCTGCTTTGATATCTCCACAACCCAGAGCAGAGGGTCAGTTAGTCTCCGTCAATTCTAGGTTACATGACAACTGATTGGCCCAGAC
TTAGGTGGGTTTTCCCTCCTGTACCATTTGGGGGTACTCTGCCTTTTATTGGGAGGGACTAATTTAACCCCAAATCCTTTTGTCAGCCTG
GGTATAGCTGTTGCTCCAGGAAGGGATTTCTCTTCTGGATCTTAAATTTCACAGACCTCATTAGGTTGTATGGCCCTGAGAGTGGGTATC
CTTGAGGGAGTACAAGCTGTTTCAACTTAGCCCTTTTCTGCGCTAATTAGAATTTCAAGCGTCACAGAGCCTGGGGGCTTTCAAGATAGC
ACTAAACTAGGTTTACTTAACTCCTTGGCAGGAAATAGTGGCCCCCATGCATCACTTCTGTGAATCCACTGCCAGGGAGAAGTGGAGAAA
CAGATCATATATGTCACAGGTCTAGAGTGGTTGGAATTGACAAATATAATTAGCTAGTTGGTTAATTAGGGTCATGTCCATACTTTCATG

>29977_29977_3_FCHSD1-NCKAP1L_FCHSD1_chr5_141029926_ENST00000522783_NCKAP1L_chr12_54936359_ENST00000293373_length(amino acids)=91AA_BP=54
MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQVVEESSFLTLDMLESCFPYVLLRNAYREVSRAFHL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FCHSD1-NCKAP1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FCHSD1-NCKAP1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FCHSD1-NCKAP1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource