Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:A2M-SERPINA1 (FusionGDB2 ID:30)

Fusion Gene Summary for A2M-SERPINA1

Fusion gene summary

Fusion gene information	Fusion gene name: A2M-SERPINA1
	Fusion gene ID: 30
		Hgene	Tgene
	Gene symbol	A2M	SERPINA1
	Gene ID	2	5265
	Gene name	alpha-2-macroglobulin	serpin family A member 1
	Synonyms	A2MD\|CPAMD5\|FWP007\|S863-7	A1A\|A1AT\|AAT\|PI\|PI1\|PRO2275\|alpha1AT\|nNIF
	Cytomap	12p13.31	14q32.13
	Type of gene	protein-coding	protein-coding
	Description	alpha-2-macroglobulinC3 and PZP-like alpha-2-macroglobulin domain-containing protein 5alpha-2-M	alpha-1-antitrypsinalpha-1 antitrypsinalpha-1 protease inhibitoralpha-1-antiproteinasealpha-1-antitrypsin nullalpha-1-antitrypsin short transcript variant 1C4alpha-1-antitrypsin short transcript variant 1C5epididymis secretory sperm binding protein
	Modification date	20200328	20200327
	UniProtAcc	P01023	.
	Ensembl transtripts involved in fusion gene	ENST00000318602, ENST00000542567,	ENST00000402629, ENST00000555289, ENST00000355814, ENST00000393087, ENST00000393088, ENST00000404814, ENST00000437397, ENST00000440909, ENST00000448921, ENST00000449399,
Fusion gene scores	* DoF score	15 X 18 X 6=1620	16 X 17 X 6=1632
	# samples	20	18
	** MAII score	log2(20/1620*10)=-3.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1632*10)=-3.18057224564182 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: A2M [Title/Abstract] AND SERPINA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	A2M(9232690)-SERPINA1(94844977), # samples:2
Anticipated loss of major functional domain due to fusion event.	A2M-SERPINA1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	A2M	GO:0001869	negative regulation of complement activation, lectin pathway	12538697

Fusion gene breakpoints across A2M (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SERPINA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A3A3-01A	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-

Top

Fusion Gene ORF analysis for A2M-SERPINA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000318602	ENST00000402629	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5CDS-intron	ENST00000318602	ENST00000555289	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000355814	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000393087	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000393088	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000404814	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000437397	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000440909	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000448921	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-3CDS	ENST00000542567	ENST00000449399	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-intron	ENST00000542567	ENST00000402629	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
5UTR-intron	ENST00000542567	ENST00000555289	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000355814	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000393087	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000404814	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000437397	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000440909	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000448921	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
Frame-shift	ENST00000318602	ENST00000449399	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-
In-frame	ENST00000318602	ENST00000393088	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000318602

A2M

chr12

9232690

ENST00000393088

SERPINA1

chr14

94844977

3427

3162

308

3172

954

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000318602	ENST00000393088	A2M	chr12	9232690	-	SERPINA1	chr14	94844977	-	0.000222554	0.9997775

Top

Fusion Genomic Features for A2M-SERPINA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for A2M-SERPINA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:9232690/chr14:94844977)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
A2M P01023	.
FUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

A2M

chr12:9232690

chr14:94844977

ENST00000318602

690_728

951

1475.0

Region

Note=Bait region

Hgene

A2M

chr12:9232690

chr14:94844977

ENST00000318602

704_709

951

1475.0

Region

Note=Inhibitory

Hgene

A2M

chr12:9232690

chr14:94844977

ENST00000318602

719_723

951

1475.0

Region

Note=Inhibitory

Hgene

A2M

chr12:9232690

chr14:94844977

ENST00000318602

730_735

951

1475.0

Region

Note=Inhibitory

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000355814

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000393087

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000393088

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000402629

368_392

360.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000404814

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000437397

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000440909

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000448921

368_392

355

419.0

Region

Note=RCL

Tgene

SERPINA1

chr12:9232690

chr14:94844977

ENST00000449399

368_392

355

419.0

Region

Note=RCL

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for A2M-SERPINA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>30_30_1_A2M-SERPINA1_A2M_chr12_9232690_ENST00000318602_SERPINA1_chr14_94844977_ENST00000393088_length(transcript)=3427nt_BP=3162nt
GAAAAGCTTATTAGCTGCTGTACGGTAAAAGTGAGCTCTTACGGGAATGGGAATGTAGTTTTAGCCCTCCAGGGATTCTATTTAGCCCGC
CAGGAATTAACCTTGACTATAAATAGGCCATCAATGACCTTTCCAGAGAATGTTCAGAGACCTCAACTTTGTTTAGAGATCTTGTGTGGG
TGGAACTTCCTGTTTGCACACAGAGCAGCATAAAGCCCAGTTGCTTTGGGAAGTGTTTGGGACCAGATGGATTGTAGGGAGTAGGGTACA
ATACAGTCTGTTCTCCTCCAGCTCCTTCTTTCTGCAACATGGGGAAGAACAAACTCCTTCATCCAAGTCTGGTTCTTCTCCTCTTGGTCC
TCCTGCCCACAGACGCCTCAGTCTCTGGAAAACCGCAGTATATGGTTCTGGTCCCCTCCCTGCTCCACACTGAGACCACTGAGAAGGGCT
GTGTCCTTCTGAGCTACCTGAATGAGACAGTGACTGTAAGTGCTTCCTTGGAGTCTGTCAGGGGAAACAGGAGCCTCTTCACTGACCTGG
AGGCGGAGAATGACGTACTCCACTGTGTCGCCTTCGCTGTCCCAAAGTCTTCATCCAATGAGGAGGTAATGTTCCTCACTGTCCAAGTGA
AAGGACCAACCCAAGAATTTAAGAAGCGGACCACAGTGATGGTTAAGAACGAGGACAGTCTGGTCTTTGTCCAGACAGACAAATCAATCT
ACAAACCAGGGCAGACAGTGAAATTTCGTGTTGTCTCCATGGATGAAAACTTTCACCCCCTGAATGAGTTGATTCCACTAGTATACATTC
AGGATCCCAAAGGAAATCGCATCGCACAATGGCAGAGTTTCCAGTTAGAGGGTGGCCTCAAGCAATTTTCTTTTCCCCTCTCATCAGAGC
CCTTCCAGGGCTCCTACAAGGTGGTGGTACAGAAGAAATCAGGTGGAAGGACAGAGCACCCTTTCACCGTGGAGGAATTTGTTCTTCCCA
AGTTTGAAGTACAAGTAACAGTGCCAAAGATAATCACCATCTTGGAAGAAGAGATGAATGTATCAGTGTGTGGCCTATACACATATGGGA
AGCCTGTCCCTGGACATGTGACTGTGAGCATTTGCAGAAAGTATAGTGACGCTTCCGACTGCCACGGTGAAGATTCACAGGCTTTCTGTG
AGAAATTCAGTGGACAGCTAAACAGCCATGGCTGCTTCTATCAGCAAGTAAAAACCAAGGTCTTCCAGCTGAAGAGGAAGGAGTATGAAA
TGAAACTTCACACTGAGGCCCAGATCCAAGAAGAAGGAACAGTGGTGGAATTGACTGGAAGGCAGTCCAGTGAAATCACAAGAACCATAA
CCAAACTCTCATTTGTGAAAGTGGACTCACACTTTCGACAGGGAATTCCCTTCTTTGGGCAGGTGCGCCTAGTAGATGGGAAAGGCGTCC
CTATACCAAATAAAGTCATATTCATCAGAGGAAATGAAGCAAACTATTACTCCAATGCTACCACGGATGAGCATGGCCTTGTACAGTTCT
CTATCAACACCACCAATGTTATGGGTACCTCTCTTACTGTTAGGGTCAATTACAAGGATCGTAGTCCCTGTTACGGCTACCAGTGGGTGT
CAGAAGAACACGAAGAGGCACATCACACTGCTTATCTTGTGTTCTCCCCAAGCAAGAGCTTTGTCCACCTTGAGCCCATGTCTCATGAAC
TACCCTGTGGCCATACTCAGACAGTCCAGGCACATTATATTCTGAATGGAGGCACCCTGCTGGGGCTGAAGAAGCTCTCCTTCTATTATC
TGATAATGGCAAAGGGAGGCATTGTCCGAACTGGGACTCATGGACTGCTTGTGAAGCAGGAAGACATGAAGGGCCATTTTTCCATCTCAA
TCCCTGTGAAGTCAGACATTGCTCCTGTCGCTCGGTTGCTCATCTATGCTGTTTTACCTACCGGGGACGTGATTGGGGATTCTGCAAAAT
ATGATGTTGAAAATTGTCTGGCCAACAAGGTGGATTTGAGCTTCAGCCCATCACAAAGTCTCCCAGCCTCACACGCCCACCTGCGAGTCA
CAGCGGCTCCTCAGTCCGTCTGCGCCCTCCGTGCTGTGGACCAAAGCGTGCTGCTCATGAAGCCTGATGCTGAGCTCTCGGCGTCCTCGG
TTTACAACCTGCTACCAGAAAAGGACCTCACTGGCTTCCCTGGGCCTTTGAATGACCAGGACAATGAAGACTGCATCAATCGTCATAATG
TCTATATTAATGGAATCACATATACTCCAGTATCAAGTACAAATGAAAAGGATATGTACAGCTTCCTAGAGGACATGGGCTTAAAGGCAT
TCACCAACTCAAAGATTCGTAAACCCAAAATGTGTCCACAGCTTCAACAGTATGAAATGCATGGACCTGAAGGTCTACGTGTAGGTTTTT
ATGAGTCAGATGTAATGGGAAGAGGCCATGCACGCCTGGTGCATGTTGAAGAGCCTCACACGGAGACCGTACGAAAGTACTTCCCTGAGA
CATGGATCTGGGATTTGGTGGTGGTAAACTCAGCAGGTGTGGCTGAGGTAGGAGTAACAGTCCCTGACACCATCACCGAGTGGAAGGCAG
GGGCCTTCTGCCTGTCTGAAGATGCTGGACTTGGTATCTCTTCCACTGCCTCTCTCCGAGCCTTCCAGCCCTTCTTTGTGGAGCTCACAA
TGCCTTACTCTGTGATTCGTGGAGAGGCCTTCACACTCAAGGCCACGGTCCTAAACTACCTTCCCAAATGCATCCGGGTCAGTGTGCAGC
TGGAAGCCTCTCCCGCCTTCCTAGCTGTCCCAGTGGAGAAGGAACAAGCGCCTCACTGCATCTGTGCAAACGGGCGGCAAACTGTGTCCT
GGGCAGTAACCCCAAAGTCATTAGGAAATGTGAATTTCACTGTGAGCGCAGAGGCACTAGAGTCTCAAGAGCTGTGTGGGACTGAGGTGC
CTTCAGTTCCTGAACACGGAAGGAAAGACACAGTCATCAAGCCTCTGTTGGTTGAACCTGAAGGACTAGAGAAGGAAACAACATTCAACT
CCCTACTTTGTCCATCAGGTGGTGAGGTTTCTGAAGAATTATCCCTGAAACTGCCACCAAATGTGGTAGAAGAATCTGCCCGAGCTTCTG
TCTCAGTTTTGGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCC
ATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTCATGGGAAAA
GTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACATTAAAGAAGG

>30_30_1_A2M-SERPINA1_A2M_chr12_9232690_ENST00000318602_SERPINA1_chr14_94844977_ENST00000393088_length(amino acids)=954AA_BP=
MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFA
VPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQS
FQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICR
KYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFR
QGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYL
VFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARL
LIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGF
PGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARL
VHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTL
KATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for A2M-SERPINA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for A2M-SERPINA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for A2M-SERPINA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source