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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FCHSD2-SHANK2 (FusionGDB2 ID:30016)

Fusion Gene Summary for FCHSD2-SHANK2

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2-SHANK2
Fusion gene ID: 30016
HgeneTgene
Gene symbol

FCHSD2

SHANK2

Gene ID

9873

22941

Gene nameFCH and double SH3 domains 2SH3 and multiple ankyrin repeat domains 2
SynonymsNWK|NWK1|SH3MD3AUTS17|CORTBP1|CTTNBP1|ProSAP1|SHANK|SPANK-3
Cytomap

11q13.4

11q13.3-q13.4

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1SH3 and multiple ankyrin repeat domains protein 2GKAP/SAPAP interacting proteincortactin SH3 domain-binding proteincortactin-binding protein 1proline-rich synapse associated protein 1
Modification date2020031320200326
UniProtAcc

O94868

.
Ensembl transtripts involved in fusion geneENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000409853, 
ENST00000458644, ENST00000409263, 
ENST00000357171, ENST00000409530, 
ENST00000449116, ENST00000468619, 
ENST00000338508, ENST00000409161, 
ENST00000423696, ENST00000449833, 
Fusion gene scores* DoF score43 X 26 X 16=1788836 X 29 X 10=10440
# samples 5947
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(47/10440*10)=-4.47331714489225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FCHSD2 [Title/Abstract] AND SHANK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD2(72851076)-SHANK2(70338570), # samples:2
FCHSD2(72632873)-SHANK2(70319544), # samples:2
Anticipated loss of major functional domain due to fusion event.FCHSD2-SHANK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FCHSD2-SHANK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SHANK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0RL-01AFCHSD2chr11

72851076

-SHANK2chr11

70338570

-
ChimerDB4BRCATCGA-B6-A0RLFCHSD2chr11

72851075

-SHANK2chr11

70338570

-
ChimerDB4BRCATCGA-EW-A6SC-01AFCHSD2chr11

72632873

-SHANK2chr11

70319544

-
ChimerDB4BRCATCGA-EW-A6SCFCHSD2chr11

72632872

-SHANK2chr11

70319544

-


Top

Fusion Gene ORF analysis for FCHSD2-SHANK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311172ENST00000357171FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000357171FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000409530FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000409530FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000449116FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000449116FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000468619FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000311172ENST00000468619FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000357171FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000357171FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000409530FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000409530FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000449116FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000449116FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000468619FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5CDS-intronENST00000409314ENST00000468619FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5CDS-intronENST00000409314ENST00000468619FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409314ENST00000468619FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000357171FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000357171FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000409530FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000409530FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000449116FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000449116FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000468619FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5CDS-intronENST00000409418ENST00000468619FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5CDS-intronENST00000409418ENST00000468619FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409418ENST00000468619FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000357171FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000357171FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000409530FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000409530FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000449116FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000449116FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000468619FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000409853ENST00000468619FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000357171FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000357171FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000409530FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000409530FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000449116FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000449116FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000468619FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
5CDS-intronENST00000458644ENST00000468619FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
5UTR-3CDSENST00000409853ENST00000338508FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000338508FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000357171FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000357171FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000409161FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000409161FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000409530FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000409530FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000423696FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000423696FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000449116FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000449116FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000449833FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000409853ENST00000449833FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000338508FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000338508FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000357171FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000357171FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000409161FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000409161FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000409530FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000409530FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000423696FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000423696FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000449116FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000449116FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000449833FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-3CDSENST00000458644ENST00000449833FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-intronENST00000409853ENST00000468619FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-intronENST00000409853ENST00000468619FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
5UTR-intronENST00000458644ENST00000468619FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
5UTR-intronENST00000458644ENST00000468619FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000311172ENST00000338508FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000338508FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000409161FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000409161FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000423696FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000423696FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000449833FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000311172ENST00000449833FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000338508FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000338508FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000338508FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000338508FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000357171FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000357171FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000409161FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000409161FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000409161FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000409161FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000409530FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000409530FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000423696FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000423696FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000423696FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000423696FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000449116FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000449116FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000449833FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000449833FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409314ENST00000449833FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409314ENST00000449833FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000338508FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000338508FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000338508FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000338508FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000357171FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000357171FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000409161FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000409161FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000409161FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000409161FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000409530FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000409530FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000423696FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000423696FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000423696FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000423696FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000449116FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000449116FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000449833FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000449833FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
Frame-shiftENST00000409418ENST00000449833FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409418ENST00000449833FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409853ENST00000409161FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409853ENST00000409161FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000409853ENST00000449833FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000409853ENST00000449833FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000338508FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000338508FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000409161FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000409161FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000423696FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000423696FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000449833FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
Frame-shiftENST00000458644ENST00000449833FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
In-frameENST00000409853ENST00000338508FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
In-frameENST00000409853ENST00000338508FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
In-frameENST00000409853ENST00000423696FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
In-frameENST00000409853ENST00000423696FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-3CDSENST00000311172ENST00000338508FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000338508FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000357171FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000357171FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000409161FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000409161FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000409530FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000409530FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000423696FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000423696FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000449116FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000449116FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000449833FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000311172ENST00000449833FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000338508FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000338508FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000338508FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000338508FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000357171FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000357171FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000409161FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000409161FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000409161FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000409161FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000409530FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000409530FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000423696FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000423696FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000423696FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000423696FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000449116FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000449116FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000449833FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000449833FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-3CDSENST00000409263ENST00000449833FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-3CDSENST00000409263ENST00000449833FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-intronENST00000311172ENST00000468619FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-intronENST00000311172ENST00000468619FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-intronENST00000409263ENST00000357171FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000357171FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000409530FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000409530FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000449116FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000449116FCHSD2chr11

72632872

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000468619FCHSD2chr11

72851076

-SHANK2chr11

70338570

-
intron-intronENST00000409263ENST00000468619FCHSD2chr11

72851075

-SHANK2chr11

70338570

-
intron-intronENST00000409263ENST00000468619FCHSD2chr11

72632873

-SHANK2chr11

70319544

-
intron-intronENST00000409263ENST00000468619FCHSD2chr11

72632872

-SHANK2chr11

70319544

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409853FCHSD2chr1172632872-ENST00000423696SHANK2chr1170319544-479879388906272
ENST00000409853FCHSD2chr1172632872-ENST00000338508SHANK2chr1170319544-479879388906272
ENST00000409853FCHSD2chr1172632873-ENST00000423696SHANK2chr1170319544-479879388906272
ENST00000409853FCHSD2chr1172632873-ENST00000338508SHANK2chr1170319544-479879388906272

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409853ENST00000423696FCHSD2chr1172632872-SHANK2chr1170319544-0.0021517670.9978483
ENST00000409853ENST00000338508FCHSD2chr1172632872-SHANK2chr1170319544-0.0021517670.9978483
ENST00000409853ENST00000423696FCHSD2chr1172632873-SHANK2chr1170319544-0.0021517670.9978483
ENST00000409853ENST00000338508FCHSD2chr1172632873-SHANK2chr1170319544-0.0021517670.9978483

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Fusion Genomic Features for FCHSD2-SHANK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FCHSD2-SHANK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72851076/chr11:70338570)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD2

O94868

.
FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSHANK2chr11:72632872chr11:70319544ENST0000042369614161407_147012801471.0DomainSAM
TgeneSHANK2chr11:72632872chr11:70319544ENST000004498338101407_147010641255.0DomainSAM
TgeneSHANK2chr11:72632873chr11:70319544ENST0000042369614161407_147012801471.0DomainSAM
TgeneSHANK2chr11:72632873chr11:70319544ENST000004498338101407_147010641255.0DomainSAM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000311172-819356_397220685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409418-920356_397276741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409853-916356_397220516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000311172-819356_397220685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409418-920356_397276741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409853-916356_397220516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000311172-819718_721220685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409418-920718_721276741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409853-916718_721220516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000311172-819718_721220685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409418-920718_721276741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409853-916718_721220516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000311172-819469_530220685.0DomainSH3 1
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000311172-8198_282220685.0DomainF-BAR
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409418-920469_530276741.0DomainSH3 1
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409418-9208_282276741.0DomainF-BAR
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409853-916469_530220516.0DomainSH3 1
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409853-9168_282220516.0DomainF-BAR
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000311172-819469_530220685.0DomainSH3 1
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000311172-8198_282220685.0DomainF-BAR
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409418-920469_530276741.0DomainSH3 1
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409418-9208_282276741.0DomainF-BAR
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409853-916469_530220516.0DomainSH3 1
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409853-9168_282220516.0DomainF-BAR
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000311172-819567_629220685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409418-920567_629276741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72632872chr11:70319544ENST00000409853-916567_629220516.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000311172-819567_629220685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409418-920567_629276741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72632873chr11:70319544ENST00000409853-916567_629220516.0RegionRequired and sufficient for location at clathrin-coated pits
TgeneSHANK2chr11:72632872chr11:70319544ENST000004236961416509_53512801471.0Compositional biasNote=Pro-rich
TgeneSHANK2chr11:72632872chr11:70319544ENST00000449833810509_53510641255.0Compositional biasNote=Pro-rich
TgeneSHANK2chr11:72632873chr11:70319544ENST000004236961416509_53512801471.0Compositional biasNote=Pro-rich
TgeneSHANK2chr11:72632873chr11:70319544ENST00000449833810509_53510641255.0Compositional biasNote=Pro-rich
TgeneSHANK2chr11:72632872chr11:70319544ENST000004236961416147_20612801471.0DomainSH3
TgeneSHANK2chr11:72632872chr11:70319544ENST000004236961416247_34112801471.0DomainPDZ
TgeneSHANK2chr11:72632872chr11:70319544ENST00000449833810147_20610641255.0DomainSH3
TgeneSHANK2chr11:72632872chr11:70319544ENST00000449833810247_34110641255.0DomainPDZ
TgeneSHANK2chr11:72632873chr11:70319544ENST000004236961416147_20612801471.0DomainSH3
TgeneSHANK2chr11:72632873chr11:70319544ENST000004236961416247_34112801471.0DomainPDZ
TgeneSHANK2chr11:72632873chr11:70319544ENST00000449833810147_20610641255.0DomainSH3
TgeneSHANK2chr11:72632873chr11:70319544ENST00000449833810247_34110641255.0DomainPDZ
TgeneSHANK2chr11:72632872chr11:70319544ENST000004236961416948_95412801471.0MotifSH3-binding
TgeneSHANK2chr11:72632872chr11:70319544ENST00000449833810948_95410641255.0MotifSH3-binding
TgeneSHANK2chr11:72632873chr11:70319544ENST000004236961416948_95412801471.0MotifSH3-binding
TgeneSHANK2chr11:72632873chr11:70319544ENST00000449833810948_95410641255.0MotifSH3-binding


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Fusion Gene Sequence for FCHSD2-SHANK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30016_30016_1_FCHSD2-SHANK2_FCHSD2_chr11_72632872_ENST00000409853_SHANK2_chr11_70319544_ENST00000338508_length(transcript)=4798nt_BP=793nt
AAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGTATTCCATTGTAT
GGATATACCACAGTTTATCCATTTTCCTGTTGATGGACATGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGT
AAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGAT
GAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGA
CCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGC
TCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAA
GTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCA
GGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTT
CAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGAAGCCCGGAGATCATGA
GCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCCG
ACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCC
TGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGA
ACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGT
GGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTC
ACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGC
TGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTTATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCA
AGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAATACTGAGTTGTGTCCACAACATGGCTGGGTC
TTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAGTTTTTCTAACATGGAAAAAGA
TTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGCACGGGATCCTAGCTCTTGT
AGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAGG
CCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCA
GATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTT
GCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCT
GCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGA
GACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCTCCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAG
GATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGATGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCA
CTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTGAGACAGCGTCTCCTCTGGGAGCTGGGCGGGC
ACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGAGGCCAGGGAAGATGGTACTTA
GAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTTTGAGGACCCAGTGGGTATG
GAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGGT
CTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATAC
CTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATAC
TCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCC
TTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGT
TGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGTCTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTT
AAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAATTATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATG
CATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAAGGACAATTTCTTCAAAGTGGTTACAATTCAT
AATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACACCCCTGATGTTGGAACCAAGTT
TTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAGTCAATTGAATATTAAGGCG
CTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCCT
GCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGA
GTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGA
GTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGT
TATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATT
TTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACTGACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCT
CTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAAATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGA
CGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAAAGATCATGTTGATATTATTCCAGGTTTTAAG
ATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGTATACAAAACCCAAATCTCTCA
AAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACATAATATAAAAATTACTCAA
TGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGTT
ATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTT
GTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTAT
TCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTTGTATGGCAACCAAAATTAC

>30016_30016_1_FCHSD2-SHANK2_FCHSD2_chr11_72632872_ENST00000409853_SHANK2_chr11_70319544_ENST00000338508_length(amino acids)=272AA_BP=235
MDIPQFIHFPVDGHGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCV
DQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAH
QDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKKPGDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAP

--------------------------------------------------------------
>30016_30016_2_FCHSD2-SHANK2_FCHSD2_chr11_72632872_ENST00000409853_SHANK2_chr11_70319544_ENST00000423696_length(transcript)=4798nt_BP=793nt
AAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGTATTCCATTGTAT
GGATATACCACAGTTTATCCATTTTCCTGTTGATGGACATGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGT
AAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGAT
GAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGA
CCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGC
TCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAA
GTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCA
GGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTT
CAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGAAGCCCGGAGATCATGA
GCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCCG
ACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCC
TGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGA
ACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGT
GGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTC
ACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGC
TGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTTATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCA
AGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAATACTGAGTTGTGTCCACAACATGGCTGGGTC
TTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAGTTTTTCTAACATGGAAAAAGA
TTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGCACGGGATCCTAGCTCTTGT
AGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAGG
CCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCA
GATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTT
GCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCT
GCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGA
GACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCTCCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAG
GATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGATGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCA
CTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTGAGACAGCGTCTCCTCTGGGAGCTGGGCGGGC
ACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGAGGCCAGGGAAGATGGTACTTA
GAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTTTGAGGACCCAGTGGGTATG
GAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGGT
CTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATAC
CTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATAC
TCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCC
TTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGT
TGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGTCTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTT
AAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAATTATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATG
CATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAAGGACAATTTCTTCAAAGTGGTTACAATTCAT
AATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACACCCCTGATGTTGGAACCAAGTT
TTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAGTCAATTGAATATTAAGGCG
CTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCCT
GCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGA
GTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGA
GTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGT
TATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATT
TTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACTGACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCT
CTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAAATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGA
CGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAAAGATCATGTTGATATTATTCCAGGTTTTAAG
ATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGTATACAAAACCCAAATCTCTCA
AAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACATAATATAAAAATTACTCAA
TGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGTT
ATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTT
GTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTAT
TCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTTGTATGGCAACCAAAATTAC

>30016_30016_2_FCHSD2-SHANK2_FCHSD2_chr11_72632872_ENST00000409853_SHANK2_chr11_70319544_ENST00000423696_length(amino acids)=272AA_BP=235
MDIPQFIHFPVDGHGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCV
DQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAH
QDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKKPGDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAP

--------------------------------------------------------------
>30016_30016_3_FCHSD2-SHANK2_FCHSD2_chr11_72632873_ENST00000409853_SHANK2_chr11_70319544_ENST00000338508_length(transcript)=4798nt_BP=793nt
AAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGTATTCCATTGTAT
GGATATACCACAGTTTATCCATTTTCCTGTTGATGGACATGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGT
AAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGAT
GAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGA
CCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGC
TCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAA
GTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCA
GGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTT
CAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGAAGCCCGGAGATCATGA
GCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCCG
ACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCC
TGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGA
ACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGT
GGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTC
ACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGC
TGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTTATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCA
AGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAATACTGAGTTGTGTCCACAACATGGCTGGGTC
TTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAGTTTTTCTAACATGGAAAAAGA
TTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGCACGGGATCCTAGCTCTTGT
AGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAGG
CCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCA
GATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTT
GCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCT
GCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGA
GACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCTCCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAG
GATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGATGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCA
CTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTGAGACAGCGTCTCCTCTGGGAGCTGGGCGGGC
ACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGAGGCCAGGGAAGATGGTACTTA
GAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTTTGAGGACCCAGTGGGTATG
GAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGGT
CTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATAC
CTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATAC
TCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCC
TTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGT
TGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGTCTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTT
AAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAATTATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATG
CATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAAGGACAATTTCTTCAAAGTGGTTACAATTCAT
AATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACACCCCTGATGTTGGAACCAAGTT
TTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAGTCAATTGAATATTAAGGCG
CTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCCT
GCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGA
GTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGA
GTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGT
TATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATT
TTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACTGACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCT
CTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAAATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGA
CGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAAAGATCATGTTGATATTATTCCAGGTTTTAAG
ATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGTATACAAAACCCAAATCTCTCA
AAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACATAATATAAAAATTACTCAA
TGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGTT
ATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTT
GTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTAT
TCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTTGTATGGCAACCAAAATTAC

>30016_30016_3_FCHSD2-SHANK2_FCHSD2_chr11_72632873_ENST00000409853_SHANK2_chr11_70319544_ENST00000338508_length(amino acids)=272AA_BP=235
MDIPQFIHFPVDGHGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCV
DQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAH
QDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKKPGDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAP

--------------------------------------------------------------
>30016_30016_4_FCHSD2-SHANK2_FCHSD2_chr11_72632873_ENST00000409853_SHANK2_chr11_70319544_ENST00000423696_length(transcript)=4798nt_BP=793nt
AAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGTATTCCATTGTAT
GGATATACCACAGTTTATCCATTTTCCTGTTGATGGACATGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGT
AAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGAT
GAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGA
CCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGC
TCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAA
GTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCA
GGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTT
CAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGAAGCCCGGAGATCATGA
GCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCCG
ACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCC
TGTCTGCTGCCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGA
ACCCAGCGGGACGCAGTAGGTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGT
GGACTAAACCAGATGTGGCCGATTGGCTGGAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTC
ACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTGGGGTAACTCGAGTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGC
TGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGTTATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCA
AGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAATACTGAGTTGTGTCCACAACATGGCTGGGTC
TTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAGTTTTTCTAACATGGAAAAAGA
TTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGCACGGGATCCTAGCTCTTGT
AGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAGG
CCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCA
GATGCATTTGTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTT
GCATCCATGGCTCTTTGGCCATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCT
GCAAATCTGTTAGCATAATTCCAAGGTGGCCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGA
GACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAAGCTCCAGGTCTCCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAG
GATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAGATGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCA
CTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTGAGACAGCGTCTCCTCTGGGAGCTGGGCGGGC
ACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGAGGCCAGGGAAGATGGTACTTA
GAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTTTGAGGACCCAGTGGGTATG
GAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGGT
CTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATAC
CTCGAATTTCCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATAC
TCGAATGTCAGGTTTTTGGTTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCC
TTTTTTTCTTGATTAGGTCTGGAACAGCTCTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGT
TGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAAAAGTGGCTGGTCTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTT
AAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAATTATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATG
CATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAAGGACAATTTCTTCAAAGTGGTTACAATTCAT
AATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACACCCCTGATGTTGGAACCAAGTT
TTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAGTCAATTGAATATTAAGGCG
CTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCCT
GCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGA
GTCCATTCCTTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGA
GTCAAGGAAACCGCTGGCAGACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGT
TATTCCCTTTCTTAAAGATACTCCAAGCCACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATT
TTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCAGAACCTGCACTGACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCT
CTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCAAATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGA
CGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAAAGATCATGTTGATATTATTCCAGGTTTTAAG
ATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGTATACAAAACCCAAATCTCTCA
AAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACATAATATAAAAATTACTCAA
TGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGTT
ATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTT
GTTTTTTAAATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTAT
TCTTTTTAGACTTTATAAAAAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTTGTATGGCAACCAAAATTAC

>30016_30016_4_FCHSD2-SHANK2_FCHSD2_chr11_72632873_ENST00000409853_SHANK2_chr11_70319544_ENST00000423696_length(amino acids)=272AA_BP=235
MDIPQFIHFPVDGHGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCV
DQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAH
QDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKKPGDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FCHSD2-SHANK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FCHSD2-SHANK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FCHSD2-SHANK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource