FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FCHSD2-ZNF564 (FusionGDB2 ID:30022)

Fusion Gene Summary for FCHSD2-ZNF564

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2-ZNF564
Fusion gene ID: 30022
HgeneTgene
Gene symbol

FCHSD2

ZNF564

Gene ID

9873

163050

Gene nameFCH and double SH3 domains 2zinc finger protein 564
SynonymsNWK|NWK1|SH3MD3-
Cytomap

11q13.4

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1zinc finger protein 564
Modification date2020031320200313
UniProtAcc

O94868

.
Ensembl transtripts involved in fusion geneENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000409853, 
ENST00000458644, ENST00000409263, 
ENST00000416136, ENST00000339282, 
Fusion gene scores* DoF score43 X 26 X 16=178884 X 1 X 4=16
# samples 594
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FCHSD2 [Title/Abstract] AND ZNF564 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD2(72578910)-ZNF564(12639510), # samples:2
Anticipated loss of major functional domain due to fusion event.FCHSD2-ZNF564 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FCHSD2-ZNF564 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF564 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1319-01AFCHSD2chr11

72578910

-ZNF564chr19

12639510

-


Top

Fusion Gene ORF analysis for FCHSD2-ZNF564

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311172ENST00000416136FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
5CDS-intronENST00000409314ENST00000416136FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
5CDS-intronENST00000409418ENST00000416136FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
5CDS-intronENST00000409853ENST00000416136FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
5CDS-intronENST00000458644ENST00000416136FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
Frame-shiftENST00000409853ENST00000339282FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
In-frameENST00000311172ENST00000339282FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
In-frameENST00000409314ENST00000339282FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
In-frameENST00000409418ENST00000339282FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
In-frameENST00000458644ENST00000339282FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
intron-3CDSENST00000409263ENST00000339282FCHSD2chr11

72578910

-ZNF564chr19

12639510

-
intron-intronENST00000409263ENST00000416136FCHSD2chr11

72578910

-ZNF564chr19

12639510

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311172FCHSD2chr1172578910-ENST00000339282ZNF564chr1912639510-411413791253037970
ENST00000409314FCHSD2chr1172578910-ENST00000339282ZNF564chr1912639510-4284154916932071012
ENST00000409418FCHSD2chr1172578910-ENST00000339282ZNF564chr1912639510-442716923843350988
ENST00000458644FCHSD2chr1172578910-ENST00000339282ZNF564chr1912639510-400612712902929879

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311172ENST00000339282FCHSD2chr1172578910-ZNF564chr1912639510-0.0001261750.99987376
ENST00000409314ENST00000339282FCHSD2chr1172578910-ZNF564chr1912639510-0.0002675430.99973243
ENST00000409418ENST00000339282FCHSD2chr1172578910-ZNF564chr1912639510-0.0001807060.99981934
ENST00000458644ENST00000339282FCHSD2chr1172578910-ZNF564chr1912639510-0.00044140.9995586

Top

Fusion Genomic Features for FCHSD2-ZNF564


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FCHSD2-ZNF564


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72578910/chr19:12639510)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD2

O94868

.
FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409418-1320356_397436741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000311172-12198_282380685.0DomainF-BAR
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409418-13208_282436741.0DomainF-BAR
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409853-13168_282380516.0DomainF-BAR
TgeneZNF564chr11:72578910chr19:12639510ENST00000339282044_831554.0DomainKRAB
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204103_1251554.0Zinc fingerC2H2-type 1
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204141_1631554.0Zinc fingerC2H2-type 2
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204169_1911554.0Zinc fingerC2H2-type 3
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204197_2191554.0Zinc fingerC2H2-type 4
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204225_2471554.0Zinc fingerC2H2-type 5
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204253_2751554.0Zinc fingerC2H2-type 6
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204281_3031554.0Zinc fingerC2H2-type 7
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204309_3311554.0Zinc fingerC2H2-type 8
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204337_3591554.0Zinc fingerC2H2-type 9
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204365_3871554.0Zinc fingerC2H2-type 10
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204393_4151554.0Zinc fingerC2H2-type 11
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204421_4431554.0Zinc fingerC2H2-type 12
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204449_4711554.0Zinc fingerC2H2-type 13
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204477_4991554.0Zinc fingerC2H2-type 14
TgeneZNF564chr11:72578910chr19:12639510ENST0000033928204505_5271554.0Zinc fingerC2H2-type 15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000311172-1219356_397380685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409853-1316356_397380516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000311172-1219718_721380685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409418-1320718_721436741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409853-1316718_721380516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000311172-1219469_530380685.0DomainSH3 1
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409418-1320469_530436741.0DomainSH3 1
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409853-1316469_530380516.0DomainSH3 1
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000311172-1219567_629380685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409418-1320567_629436741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72578910chr19:12639510ENST00000409853-1316567_629380516.0RegionRequired and sufficient for location at clathrin-coated pits


Top

Fusion Gene Sequence for FCHSD2-ZNF564


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30022_30022_1_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000311172_ZNF564_chr19_12639510_ENST00000339282_length(transcript)=4114nt_BP=1379nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGA
GAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGG
TAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAAC
TAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTAGCCGACAGTTAGAATCAGAAACTGGGACCACAGAGGAGCACAGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCAC
GTGAGCATAAAAACATTGTTCACCAACAACGGGTTCTAAATGATCTGGAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGC
TAGAACAGAAAATAGATGAAGCTAGAGAAAATATTCGTAAAGCAGAGATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGC
AGATTGGTGTTTCTGTGGACACATGGCTAAAGAGTGCCATGAACCAAGTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTG
CAGTGACCAGTAATGGCACTTTACACTCGGACTCAGTGGCCTCTGAGGATGTGGCTGTGAACTTCACACTTGAGGAGTGGGCTTTGCTGG
ATCCTTCCCAGAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCTGTGTAGGAAAAAAATGGGAAGACCAGAGCA
TTGAAGATTGGTACAAAAATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCAGTGAAAGTAAAGAATATGATCAATGTGGAG
AAGCCTTCAGTCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGACCATGTGAATGTAGTTTGTGTGGGAAAGTCT
TCATGCATCATTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATGACTATCAGGAATATGGAGAGAAACCATATA
AATGTAAGCAGTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAACTCACACTGGTGAGAAACCCTATGCATGTC
CGGAATGTGGGAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACACTGGAGATGGACCATATAAATGTCAGGAAT
GTGGGAAAGCCTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGAATGTGCAA
AAGCTTTCATTTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGACCTTATAAATGTCAGGAATGTGGAAAAGCCT
TTGACCGCCCCAGTTTATTTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATGAATGTAAACAGTGTGGGAAGGCCTTCATTT
CTTTCACAAATTTTCAAAGTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTAAAGTATGTGGGAGAGCCTTTATTTTTCCCA
GTTATGTTCGAAAGCATGAAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAATGTGGTAAAACCTTCAGTTCTTCCAGTAATG
TTCGAACACATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGAAAGCCTTCATTTCTCTCCCAAGTGTCCGAA
GACACATGATAAAGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCTTTGACTGTCCCAGTTCATTTCAAATACACG
AAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTTCTCTTAAAAGGATTAGAAAACATATGATAC
TGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTAGTTCTGTCCGAACACATGAAAGAACTCATA
CTGGAGAAAAACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCATTAGAATACATGAAAGAACTCATACCGGAG
AAAAACCCTATGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAAGACATGAAAGAGCTCATAATGGAGATAAAC
CTTACGTAAAGAATGTGGGAAAGCTTTCATTTATCACACAACCTTCGAATACCTGTGAAAATGAATAGTGGAGGACAGGTCTACAAGTAT
CTACATATCTAAAGAATATGGAAAGTCTTCAGTTTGCTTTCTGGGTTTCAGACTTGTTTGGGAGCTCACCCCTTTCTCCTGTTTCTCACT
TTTGGAATAGGAATCTCTATCCTGTGCCTGTCTCATATTTTGGAAATACATGACTAGTTTGGTTTTCACCGGTTCGGAGCTGAAGAAGAA
TTTTGCCTCAGCATGAATTGAGTCTCATCCATATCTGAGTGATGTGATATTGAGATGACACTTTGGAGTTTGAGTTTAAACATTAGGCTT
CATGCTGGAATTAACTGAGACTTTTGAGGCCTTTGGGATGAGATGAATATATTTTACATGTGATGACATGGATTTTGGGGGCCAGAGGTG
TAATGTTTTGGCTGAGTGTATGCCACCTCAGATTCATATGTTGAAACCTTACCCCCGTGCCCCCCCTCTCCCCCACAATGTGATGGTATT
TGGAGGCCCTGTCTCTGGTGGTTTTTAGGATTGGAGGACATCATGAAGATGGAGGCCTTGTAATTGGGATTAGTTTCCTGATAGGAATCC
CTAGAGAGCTAGCTTTGCCCTTCACCATGAGAGGGTGCAGTGAGAAGATAGCTATCTTTGAACCGGGAAGCAGGCCCTTACCAGACATGG
ACTATGCCAGTGCCTTGATATTGGACTTCCCAGCCTCCCAAACCATGAGAAATAAATGTTTGTTGATTAATTAAGCTTTCCAATTTATGG
TATTTTGTTTTAGCAACCCAAGCTAAGACACAATCCAATTTTAAAATGGAGGAAAGGACTTGAATAGACATTTCTCCAAAGAAGATACCC
AGATGGCCAATAAGCACGTAACAATGCTCGACATCTTTAGTCATTAGGGAAATACAAATCAAACTCAAGACATACATAGCATCTCATTAG
GATTAGTAGTATCAAAGATGGAAAACAAGAAATACTGTCAAGGATGTGGAATGTTGGAGAACATTGTGCACTATCACTGGGAATGTACAG

>30022_30022_1_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000311172_ZNF564_chr19_12639510_ENST00000339282_length(amino acids)=970AA_BP=553
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENI
RKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSDSVASEDVAVNFTLEEWALLDPSQKKLYRDVM
RETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSRHIR
SHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQ
IHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHMIRH
TGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHMIKHTGDGPY
KCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECKECG

--------------------------------------------------------------
>30022_30022_2_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000409314_ZNF564_chr19_12639510_ENST00000339282_length(transcript)=4284nt_BP=1549nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATA
CCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAAC
AATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGA
ACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAA
ATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAAT
CAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTAC
CCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCA
TCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTC
CAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTG
TGACAGTGATACTAGTTTAAAAGCCGCCCAACTGGTGGATATTGAGCTCTCCCCTGTCAGTGCTCTGAGAATGACCATAGCTGAGAGCCG
ACAGTTAGAATCAGAAACTGGGACCACAGAGGAGCACAGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCACGTGAGCATAA
AAACATTGTTCACCAACAACGGGTTCTAAATGATCTGGAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGCTAGAACAGAA
AATAGATGAAGCTAGAGAAAATATTCGTAAAGCAGAGATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGCAGATTGGTGT
TTCTGTGGACACATGGCTAAAGAGTGCCATGAACCAAGTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTGCAGTGACCAG
TAATGGCACTTTACACTCGGACTCAGTGGCCTCTGAGGATGTGGCTGTGAACTTCACACTTGAGGAGTGGGCTTTGCTGGATCCTTCCCA
GAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCTGTGTAGGAAAAAAATGGGAAGACCAGAGCATTGAAGATTG
GTACAAAAATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCAGTGAAAGTAAAGAATATGATCAATGTGGAGAAGCCTTCAG
TCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGACCATGTGAATGTAGTTTGTGTGGGAAAGTCTTCATGCATCA
TTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATGACTATCAGGAATATGGAGAGAAACCATATAAATGTAAGCA
GTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAACTCACACTGGTGAGAAACCCTATGCATGTCCGGAATGTGG
GAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACACTGGAGATGGACCATATAAATGTCAGGAATGTGGGAAAGC
CTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGAATGTGCAAAAGCTTTCAT
TTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGACCTTATAAATGTCAGGAATGTGGAAAAGCCTTTGACCGCCC
CAGTTTATTTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATGAATGTAAACAGTGTGGGAAGGCCTTCATTTCTTTCACAAA
TTTTCAAAGTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTAAAGTATGTGGGAGAGCCTTTATTTTTCCCAGTTATGTTCG
AAAGCATGAAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAATGTGGTAAAACCTTCAGTTCTTCCAGTAATGTTCGAACACA
TGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGAAAGCCTTCATTTCTCTCCCAAGTGTCCGAAGACACATGAT
AAAGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCTTTGACTGTCCCAGTTCATTTCAAATACACGAAAGAACTCA
CACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTTCTCTTAAAAGGATTAGAAAACATATGATACTGCACACTGG
AGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTAGTTCTGTCCGAACACATGAAAGAACTCATACTGGAGAAAA
ACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCATTAGAATACATGAAAGAACTCATACCGGAGAAAAACCCTA
TGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAAGACATGAAAGAGCTCATAATGGAGATAAACCTTACGTAAA
GAATGTGGGAAAGCTTTCATTTATCACACAACCTTCGAATACCTGTGAAAATGAATAGTGGAGGACAGGTCTACAAGTATCTACATATCT
AAAGAATATGGAAAGTCTTCAGTTTGCTTTCTGGGTTTCAGACTTGTTTGGGAGCTCACCCCTTTCTCCTGTTTCTCACTTTTGGAATAG
GAATCTCTATCCTGTGCCTGTCTCATATTTTGGAAATACATGACTAGTTTGGTTTTCACCGGTTCGGAGCTGAAGAAGAATTTTGCCTCA
GCATGAATTGAGTCTCATCCATATCTGAGTGATGTGATATTGAGATGACACTTTGGAGTTTGAGTTTAAACATTAGGCTTCATGCTGGAA
TTAACTGAGACTTTTGAGGCCTTTGGGATGAGATGAATATATTTTACATGTGATGACATGGATTTTGGGGGCCAGAGGTGTAATGTTTTG
GCTGAGTGTATGCCACCTCAGATTCATATGTTGAAACCTTACCCCCGTGCCCCCCCTCTCCCCCACAATGTGATGGTATTTGGAGGCCCT
GTCTCTGGTGGTTTTTAGGATTGGAGGACATCATGAAGATGGAGGCCTTGTAATTGGGATTAGTTTCCTGATAGGAATCCCTAGAGAGCT
AGCTTTGCCCTTCACCATGAGAGGGTGCAGTGAGAAGATAGCTATCTTTGAACCGGGAAGCAGGCCCTTACCAGACATGGACTATGCCAG
TGCCTTGATATTGGACTTCCCAGCCTCCCAAACCATGAGAAATAAATGTTTGTTGATTAATTAAGCTTTCCAATTTATGGTATTTTGTTT
TAGCAACCCAAGCTAAGACACAATCCAATTTTAAAATGGAGGAAAGGACTTGAATAGACATTTCTCCAAAGAAGATACCCAGATGGCCAA
TAAGCACGTAACAATGCTCGACATCTTTAGTCATTAGGGAAATACAAATCAAACTCAAGACATACATAGCATCTCATTAGGATTAGTAGT
ATCAAAGATGGAAAACAAGAAATACTGTCAAGGATGTGGAATGTTGGAGAACATTGTGCACTATCACTGGGAATGTACAGTGGTATAAGC

>30022_30022_2_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000409314_ZNF564_chr19_12639510_ENST00000339282_length(amino acids)=1012AA_BP=595
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVA
REHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPP
AVTSNGTLHSDSVASEDVAVNFTLEEWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCG
EAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYAC
PECGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKA
FDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSN
VRTHERTHTGEKPYECKECGKAFISLPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMI
LHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECKECGKAFNYASSIRIHERTHTGEKPYECKQCGKTFSYSSSFQRHERAHNGDK

--------------------------------------------------------------
>30022_30022_3_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000409418_ZNF564_chr19_12639510_ENST00000339282_length(transcript)=4427nt_BP=1692nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGC
ATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATT
TCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAA
GAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAG
GCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCC
AAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAAC
ATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCT
GTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTA
TTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTGATACTAGCCGACAGTTAGAATCAGAAACTGGGACCACAGAGGAGCAC
AGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCACGTGAGCATAAAAACATTGTTCACCAACAACGGGTTCTAAATGATCTG
GAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGCTAGAACAGAAAATAGATGAAGCTAGAGAAAATATTCGTAAAGCAGAG
ATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGCAGATTGGTGTTTCTGTGGACACATGGCTAAAGAGTGCCATGAACCAA
GTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTGCAGTGACCAGTAATGGCACTTTACACTCGGACTCAGTGGCCTCTGAG
GATGTGGCTGTGAACTTCACACTTGAGGAGTGGGCTTTGCTGGATCCTTCCCAGAAGAAACTCTACAGAGATGTGATGCGGGAAACCTTT
AGAAACCTGGCCTGTGTAGGAAAAAAATGGGAAGACCAGAGCATTGAAGATTGGTACAAAAATCAGGGGAGAATTTTAAGAAATCATATG
GAAGAGGGACTCAGTGAAAGTAAAGAATATGATCAATGTGGAGAAGCCTTCAGTCAGATTCTCAATCTTAATCTGAACAAGAAAATTCCT
ACTATAGTAAGACCATGTGAATGTAGTTTGTGTGGGAAAGTCTTCATGCATCATTCATCCCTTAGTAGGCACATCAGATCTCACCTTGGA
CACAAACCATATGACTATCAGGAATATGGAGAGAAACCATATAAATGTAAGCAGTGTGGGAAAGCCTTCAGTTCTTGTCAATCCTTTCGA
AGACATGAAAGAACTCACACTGGTGAGAAACCCTATGCATGTCCGGAATGTGGGAAAGCCTTCATTTCTCTCCCAAGTGTTCGAAGACAC
ATGATTAAGCACACTGGAGATGGACCATATAAATGTCAGGAATGTGGGAAAGCCTTTGATCGCCCAAGTTTATTTCAGATACATGAAAGA
ACTCACACTGGAGAGAAACCCTATGAATGTCAGGAATGTGCAAAAGCTTTCATTTCTCTTCCAAGTTTTCAAAGACACATGATTAGGCAC
ACTGGAGATGGACCTTATAAATGTCAGGAATGTGGAAAAGCCTTTGACCGCCCCAGTTTATTTCGAATACATGAAAGAACTCATACTGGA
GAGAAACCCCATGAATGTAAACAGTGTGGGAAGGCCTTCATTTCTTTCACAAATTTTCAAAGTCATATGATTAGGCACACTGGGGATGGA
CCTTATAAATGTAAAGTATGTGGGAGAGCCTTTATTTTTCCCAGTTATGTTCGAAAGCATGAAAGAACTCATACTGGGGAGAAACCCTAT
GAATGTAATAAATGTGGTAAAACCTTCAGTTCTTCCAGTAATGTTCGAACACATGAAAGGACTCACACTGGAGAGAAGCCCTATGAATGT
AAGGAATGCGGGAAAGCCTTCATTTCTCTCCCAAGTGTCCGAAGACACATGATAAAGCACACTGGAGATGGACCTTATAAATGTCAGGTA
TGTGGTAGAGCCTTTGACTGTCCCAGTTCATTTCAAATACACGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGTATGTGGG
AAAGCCTTCATTTCTCTTAAAAGGATTAGAAAACATATGATACTGCACACTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAAAGCC
TTTGACTGTCCTAGTTCTGTCCGAACACATGAAAGAACTCATACTGGAGAAAAACCCTATGAATGTAAAGAATGTGGGAAAGCATTCAAT
TATGCCAGTTCCATTAGAATACATGAAAGAACTCATACCGGAGAAAAACCCTATGAATGTAAGCAATGTGGAAAAACGTTCAGTTATTCC
AGTTCCTTTCAAAGACATGAAAGAGCTCATAATGGAGATAAACCTTACGTAAAGAATGTGGGAAAGCTTTCATTTATCACACAACCTTCG
AATACCTGTGAAAATGAATAGTGGAGGACAGGTCTACAAGTATCTACATATCTAAAGAATATGGAAAGTCTTCAGTTTGCTTTCTGGGTT
TCAGACTTGTTTGGGAGCTCACCCCTTTCTCCTGTTTCTCACTTTTGGAATAGGAATCTCTATCCTGTGCCTGTCTCATATTTTGGAAAT
ACATGACTAGTTTGGTTTTCACCGGTTCGGAGCTGAAGAAGAATTTTGCCTCAGCATGAATTGAGTCTCATCCATATCTGAGTGATGTGA
TATTGAGATGACACTTTGGAGTTTGAGTTTAAACATTAGGCTTCATGCTGGAATTAACTGAGACTTTTGAGGCCTTTGGGATGAGATGAA
TATATTTTACATGTGATGACATGGATTTTGGGGGCCAGAGGTGTAATGTTTTGGCTGAGTGTATGCCACCTCAGATTCATATGTTGAAAC
CTTACCCCCGTGCCCCCCCTCTCCCCCACAATGTGATGGTATTTGGAGGCCCTGTCTCTGGTGGTTTTTAGGATTGGAGGACATCATGAA
GATGGAGGCCTTGTAATTGGGATTAGTTTCCTGATAGGAATCCCTAGAGAGCTAGCTTTGCCCTTCACCATGAGAGGGTGCAGTGAGAAG
ATAGCTATCTTTGAACCGGGAAGCAGGCCCTTACCAGACATGGACTATGCCAGTGCCTTGATATTGGACTTCCCAGCCTCCCAAACCATG
AGAAATAAATGTTTGTTGATTAATTAAGCTTTCCAATTTATGGTATTTTGTTTTAGCAACCCAAGCTAAGACACAATCCAATTTTAAAAT
GGAGGAAAGGACTTGAATAGACATTTCTCCAAAGAAGATACCCAGATGGCCAATAAGCACGTAACAATGCTCGACATCTTTAGTCATTAG
GGAAATACAAATCAAACTCAAGACATACATAGCATCTCATTAGGATTAGTAGTATCAAAGATGGAAAACAAGAAATACTGTCAAGGATGT
GGAATGTTGGAGAACATTGTGCACTATCACTGGGAATGTACAGTGGTATAAGCCTGCTGAAAACAGTATGGCAGATCCCCAGATTAAAAT

>30022_30022_3_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000409418_ZNF564_chr19_12639510_ENST00000339282_length(amino acids)=988AA_BP=571
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS
EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSDSVASEDVAVNFTL
EEWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCEC
SLCGKVFMHHSSLSRHIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDG
PYKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQ
CGKAFISFTNFQSHMIRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFI
SLPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVR

--------------------------------------------------------------
>30022_30022_4_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000458644_ZNF564_chr19_12639510_ENST00000339282_length(transcript)=4006nt_BP=1271nt
GCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAA
GTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCT
ATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAAT
GATTACAGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTAGTTTAAAAGCCGCCCAACTGGTGGATATTGAGCTCTCCCCTGTCAGTGCTCTGAGAATGACCATAGCTGAGAGCCGACAGTTAG
AATCAGAAACTGGGACCACAGAGGAGCACAGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCACGTGAGCATAAAAACATTG
TTCACCAACAACGGGTTCTAAATGATCTGGAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGCTAGAACAGAAAATAGATG
AAGCTAGAGAAAATATTCGTAAAGCAGAGATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGCAGATTGGTGTTTCTGTGG
ACACATGGCTAAAGAGTGCCATGAACCAAGTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTGCAGTGACCAGTAATGGCA
CTTTACACTCGGACTCAGTGGCCTCTGAGGATGTGGCTGTGAACTTCACACTTGAGGAGTGGGCTTTGCTGGATCCTTCCCAGAAGAAAC
TCTACAGAGATGTGATGCGGGAAACCTTTAGAAACCTGGCCTGTGTAGGAAAAAAATGGGAAGACCAGAGCATTGAAGATTGGTACAAAA
ATCAGGGGAGAATTTTAAGAAATCATATGGAAGAGGGACTCAGTGAAAGTAAAGAATATGATCAATGTGGAGAAGCCTTCAGTCAGATTC
TCAATCTTAATCTGAACAAGAAAATTCCTACTATAGTAAGACCATGTGAATGTAGTTTGTGTGGGAAAGTCTTCATGCATCATTCATCCC
TTAGTAGGCACATCAGATCTCACCTTGGACACAAACCATATGACTATCAGGAATATGGAGAGAAACCATATAAATGTAAGCAGTGTGGGA
AAGCCTTCAGTTCTTGTCAATCCTTTCGAAGACATGAAAGAACTCACACTGGTGAGAAACCCTATGCATGTCCGGAATGTGGGAAAGCCT
TCATTTCTCTCCCAAGTGTTCGAAGACACATGATTAAGCACACTGGAGATGGACCATATAAATGTCAGGAATGTGGGAAAGCCTTTGATC
GCCCAAGTTTATTTCAGATACATGAAAGAACTCACACTGGAGAGAAACCCTATGAATGTCAGGAATGTGCAAAAGCTTTCATTTCTCTTC
CAAGTTTTCAAAGACACATGATTAGGCACACTGGAGATGGACCTTATAAATGTCAGGAATGTGGAAAAGCCTTTGACCGCCCCAGTTTAT
TTCGAATACATGAAAGAACTCATACTGGAGAGAAACCCCATGAATGTAAACAGTGTGGGAAGGCCTTCATTTCTTTCACAAATTTTCAAA
GTCATATGATTAGGCACACTGGGGATGGACCTTATAAATGTAAAGTATGTGGGAGAGCCTTTATTTTTCCCAGTTATGTTCGAAAGCATG
AAAGAACTCATACTGGGGAGAAACCCTATGAATGTAATAAATGTGGTAAAACCTTCAGTTCTTCCAGTAATGTTCGAACACATGAAAGGA
CTCACACTGGAGAGAAGCCCTATGAATGTAAGGAATGCGGGAAAGCCTTCATTTCTCTCCCAAGTGTCCGAAGACACATGATAAAGCACA
CTGGAGATGGACCTTATAAATGTCAGGTATGTGGTAGAGCCTTTGACTGTCCCAGTTCATTTCAAATACACGAAAGAACTCACACTGGAG
AGAAACCCTATGAATGTCAGGTATGTGGGAAAGCCTTCATTTCTCTTAAAAGGATTAGAAAACATATGATACTGCACACTGGAGATGGAC
CTTATAAATGTCAGGTATGTGGTAAAGCCTTTGACTGTCCTAGTTCTGTCCGAACACATGAAAGAACTCATACTGGAGAAAAACCCTATG
AATGTAAAGAATGTGGGAAAGCATTCAATTATGCCAGTTCCATTAGAATACATGAAAGAACTCATACCGGAGAAAAACCCTATGAATGTA
AGCAATGTGGAAAAACGTTCAGTTATTCCAGTTCCTTTCAAAGACATGAAAGAGCTCATAATGGAGATAAACCTTACGTAAAGAATGTGG
GAAAGCTTTCATTTATCACACAACCTTCGAATACCTGTGAAAATGAATAGTGGAGGACAGGTCTACAAGTATCTACATATCTAAAGAATA
TGGAAAGTCTTCAGTTTGCTTTCTGGGTTTCAGACTTGTTTGGGAGCTCACCCCTTTCTCCTGTTTCTCACTTTTGGAATAGGAATCTCT
ATCCTGTGCCTGTCTCATATTTTGGAAATACATGACTAGTTTGGTTTTCACCGGTTCGGAGCTGAAGAAGAATTTTGCCTCAGCATGAAT
TGAGTCTCATCCATATCTGAGTGATGTGATATTGAGATGACACTTTGGAGTTTGAGTTTAAACATTAGGCTTCATGCTGGAATTAACTGA
GACTTTTGAGGCCTTTGGGATGAGATGAATATATTTTACATGTGATGACATGGATTTTGGGGGCCAGAGGTGTAATGTTTTGGCTGAGTG
TATGCCACCTCAGATTCATATGTTGAAACCTTACCCCCGTGCCCCCCCTCTCCCCCACAATGTGATGGTATTTGGAGGCCCTGTCTCTGG
TGGTTTTTAGGATTGGAGGACATCATGAAGATGGAGGCCTTGTAATTGGGATTAGTTTCCTGATAGGAATCCCTAGAGAGCTAGCTTTGC
CCTTCACCATGAGAGGGTGCAGTGAGAAGATAGCTATCTTTGAACCGGGAAGCAGGCCCTTACCAGACATGGACTATGCCAGTGCCTTGA
TATTGGACTTCCCAGCCTCCCAAACCATGAGAAATAAATGTTTGTTGATTAATTAAGCTTTCCAATTTATGGTATTTTGTTTTAGCAACC
CAAGCTAAGACACAATCCAATTTTAAAATGGAGGAAAGGACTTGAATAGACATTTCTCCAAAGAAGATACCCAGATGGCCAATAAGCACG
TAACAATGCTCGACATCTTTAGTCATTAGGGAAATACAAATCAAACTCAAGACATACATAGCATCTCATTAGGATTAGTAGTATCAAAGA
TGGAAAACAAGAAATACTGTCAAGGATGTGGAATGTTGGAGAACATTGTGCACTATCACTGGGAATGTACAGTGGTATAAGCCTGCTGAA

>30022_30022_4_FCHSD2-ZNF564_FCHSD2_chr11_72578910_ENST00000458644_ZNF564_chr19_12639510_ENST00000339282_length(amino acids)=879AA_BP=462
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAA
QLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIR
KAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSDSVASEDVAVNFTLEEWALLDPSQKKLYRDVMR
ETFRNLACVGKKWEDQSIEDWYKNQGRILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSRHIRS
HLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFISLPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQI
HERTHTGEKPYECQECAKAFISLPSFQRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHMIRHT
GDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHTGEKPYECKECGKAFISLPSVRRHMIKHTGDGPYK
CQVCGRAFDCPSSFQIHERTHTGEKPYECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECKECGK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FCHSD2-ZNF564


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FCHSD2-ZNF564


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FCHSD2-ZNF564


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource