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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FCRL1-ILF2 (FusionGDB2 ID:30030)

Fusion Gene Summary for FCRL1-ILF2

Fusion gene summary

Fusion gene information	Fusion gene name: FCRL1-ILF2
	Fusion gene ID: 30030
		Hgene	Tgene
	Gene symbol	FCRL1	ILF2
	Gene ID	115350	3608
	Gene name	Fc receptor like 1	interleukin enhancer binding factor 2
	Synonyms	CD307a\|FCRH1\|IFGP1\|IRTA5	NF45\|PRO3063
	Cytomap	1q23.1	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	Fc receptor-like protein 1IFGP family protein 1fc receptor homolog 1fcR-like protein 1hIFGP1immune receptor translocation-associated protein 5immunoglobulin superfamily Fc receptor, gp42	interleukin enhancer-binding factor 2interleukin enhancer binding factor 2, 45kDinterleukin enhancer binding factor 2, 45kDanuclear factor of activated T-cells, 45-kDa
	Modification date	20200320	20200313
	UniProtAcc	Q96LA6	Q12905
	Ensembl transtripts involved in fusion gene	ENST00000358292, ENST00000368176, ENST00000491942, ENST00000489998,	ENST00000368681, ENST00000480213, ENST00000361891,
Fusion gene scores	* DoF score	3 X 3 X 1=9	8 X 8 X 3=192
	# samples	3	8
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FCRL1 [Title/Abstract] AND ILF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FCRL1(157773635)-ILF2(153637812), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FCRL1	GO:0042113	B cell activation	15479727
Tgene	ILF2	GO:0006351	transcription, DNA-templated	11739746
Tgene	ILF2	GO:0045893	positive regulation of transcription, DNA-templated	11739746

Fusion gene breakpoints across FCRL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ILF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CD703668	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-

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Fusion Gene ORF analysis for FCRL1-ILF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000358292	ENST00000368681	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5CDS-intron	ENST00000358292	ENST00000480213	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5CDS-intron	ENST00000368176	ENST00000368681	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5CDS-intron	ENST00000368176	ENST00000480213	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5CDS-intron	ENST00000491942	ENST00000368681	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5CDS-intron	ENST00000491942	ENST00000480213	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5UTR-3CDS	ENST00000489998	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5UTR-intron	ENST00000489998	ENST00000368681	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
5UTR-intron	ENST00000489998	ENST00000480213	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
In-frame	ENST00000358292	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
In-frame	ENST00000368176	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-
In-frame	ENST00000491942	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358292	FCRL1	chr1	157773635	-	ENST00000361891	ILF2	chr1	153637812	-	1444	371	43	1083	346
ENST00000368176	FCRL1	chr1	157773635	-	ENST00000361891	ILF2	chr1	153637812	-	1460	387	59	1099	346
ENST00000491942	FCRL1	chr1	157773635	-	ENST00000361891	ILF2	chr1	153637812	-	1415	342	14	1054	346

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358292	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-	0.008763007	0.99123704
ENST00000368176	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-	0.00915744	0.9908426
ENST00000491942	ENST00000361891	FCRL1	chr1	157773635	-	ILF2	chr1	153637812	-	0.008247463	0.99175256

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Fusion Genomic Features for FCRL1-ILF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FCRL1-ILF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:157773635/chr1:153637812)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FCRL1 Q96LA6	ILF2 Q12905
FUNCTION: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269\|PubMed:15479727}.	FUNCTION: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. {ECO:0000269\|PubMed:10574923, ECO:0000269\|PubMed:11739746, ECO:0000269\|PubMed:21123651, ECO:0000269\|PubMed:9442054}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

17_104

106

367.0

Domain

Note=Ig-like C2-type 1

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

17_104

106

430.0

Domain

Note=Ig-like C2-type 1

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

17_104

106

429.0

Domain

Note=Ig-like C2-type 1

Tgene

ILF2

chr1:157773635

chr1:153637812

ENST00000361891

366_372

153

391.0

Compositional bias

Note=Poly-Glu

Tgene

ILF2

chr1:157773635

chr1:153637812

ENST00000361891

381_384

153

391.0

Compositional bias

Note=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

109_200

106

367.0

Domain

Note=Ig-like C2-type 2

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

208_291

106

367.0

Domain

Note=Ig-like C2-type 3

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

109_200

106

430.0

Domain

Note=Ig-like C2-type 2

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

208_291

106

430.0

Domain

Note=Ig-like C2-type 3

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

109_200

106

429.0

Domain

Note=Ig-like C2-type 2

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

208_291

106

429.0

Domain

Note=Ig-like C2-type 3

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

354_359

106

367.0

Motif

Note=ITIM motif 1

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

367_372

106

367.0

Motif

Note=ITIM motif 2

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

379_384

106

367.0

Motif

Note=ITIM motif 3

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

410_415

106

367.0

Motif

Note=ITIM motif 4

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

423_428

106

367.0

Motif

Note=ITIM motif 5

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

354_359

106

430.0

Motif

Note=ITIM motif 1

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

367_372

106

430.0

Motif

Note=ITIM motif 2

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

379_384

106

430.0

Motif

Note=ITIM motif 3

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

410_415

106

430.0

Motif

Note=ITIM motif 4

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

423_428

106

430.0

Motif

Note=ITIM motif 5

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

354_359

106

429.0

Motif

Note=ITIM motif 1

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

367_372

106

429.0

Motif

Note=ITIM motif 2

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

379_384

106

429.0

Motif

Note=ITIM motif 3

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

410_415

106

429.0

Motif

Note=ITIM motif 4

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

423_428

106

429.0

Motif

Note=ITIM motif 5

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

17_307

106

367.0

Topological domain

Extracellular

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

329_429

106

367.0

Topological domain

Cytoplasmic

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

17_307

106

430.0

Topological domain

Extracellular

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

329_429

106

430.0

Topological domain

Cytoplasmic

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

17_307

106

429.0

Topological domain

Extracellular

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

329_429

106

429.0

Topological domain

Cytoplasmic

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000358292

308_328

106

367.0

Transmembrane

Helical

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000368176

308_328

106

430.0

Transmembrane

Helical

Hgene

FCRL1

chr1:157773635

chr1:153637812

ENST00000491942

308_328

106

429.0

Transmembrane

Helical

Tgene

ILF2

chr1:157773635

chr1:153637812

ENST00000361891

24_371

153

391.0

Domain

DZF

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Fusion Gene Sequence for FCRL1-ILF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>30030_30030_1_FCRL1-ILF2_FCRL1_chr1_157773635_ENST00000358292_ILF2_chr1_153637812_ENST00000361891_length(transcript)=1444nt_BP=371nt
ATTCTTTTTTTGATGAGAGGCATCTCTAGGTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGTTGATCTGTGCTCCACT
CTGTGAACCTGCCGAGCTGTTTTTGATAGCCAGCCCCTCCCATCCCACAGAGGGGAGCCCAGTGACCCTGACGTGTAAGATGCCCTTTCT
ACAGAGTTCAGATGCCCAGTTCCAGTTCTGCTTTTTCAGAGACACCCGGGCCTTGGGCCCAGGCTGGAGCAGCTCCCCCAAGCTCCAGAT
CGCTGCCATGTGGAAAGAAGACACAGGGTCATACTGGTGCGAGGCACAGACAATGGCGTCCAAAGTCTTGAGGAGCAGGAGATCCCAGAT
AAATGTGCACATTTTAACCATGCTGACCAACGAAACTGGCTTTGAAATCAGTTCTTCTGATGCTACAGTGAAGATTCTCATTACAACAGT
GCCACCCAATCTTCGAAAACTGGATCCAGAACTCCATTTGGATATCAAAGTATTGCAGAGTGCCTTAGCAGCCATCCGACATGCCCGCTG
GTTCGAGGAAAATGCTTCTCAGTCCACAGTTAAAGTTCTCATCAGACTACTGAAGGACTTGAGGATTCGTTTTCCTGGCTTTGAGCCCCT
CACACCCTGGATCCTTGACCTACTAGGCCATTATGCTGTGATGAACAACCCCACCAGACAGCCTTTGGCCCTAAACGTTGCATACAGGCG
CTGCTTGCAGATTCTGGCTGCAGGACTGTTCCTGCCAGGTTCAGTGGGTATCACTGACCCCTGTGAGAGTGGCAACTTTAGAGTACACAC
AGTCATGACCCTAGAACAGCAGGACATGGTCTGCTATACAGCTCAGACTCTCGTCCGAATCCTCTCACATGGTGGCTTTAGGAAGATCCT
TGGCCAGGAGGGTGATGCCAGCTATCTTGCTTCTGAAATATCTACCTGGGATGGAGTGATAGTAACACCTTCAGAAAAGGCTTATGAGAA
GCCACCAGAGAAGAAGGAAGGAGAGGAAGAAGAGGAGAATACAGAAGAACCACCTCAAGGAGAGGAAGAAGAAAGCATGGAAACTCAGGA
GTGACATTCCCTTCACTCCTTTTCCTACCCAAGGGGGAAGACTGGAGCCTAAGCTGCCTGCTACTGGGCTTTACATGGTGACAGACATTT
CCGTGGGATAGGGAAGATAGCAGGAAGAAAAGTAAACTCCATAGAAGTGTCATTCCACTGGGTTTTGATATTGGCTTAGCTGCCAGTCTC
CCATTTGTGACCTATGCCATCCATCTATAATGGAGGATACCAACATTTCTTCCTAATATTCTATAATCTCCAACTCCTGAAAACCCCTCT
CTCAACTAATACTTTGCTGTTGAAATGTTGTGAAATGTTAAGTGTCTGGAAATTTTTTTTTCTAAGAAAAACTATTAAAGTACTTCCTAG

>30030_30030_1_FCRL1-ILF2_FCRL1_chr1_157773635_ENST00000358292_ILF2_chr1_153637812_ENST00000361891_length(amino acids)=346AA_BP=110
MVLMLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCE
AQTMASKVLRSRRSQINVHILTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLI
RLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTA

--------------------------------------------------------------
>30030_30030_2_FCRL1-ILF2_FCRL1_chr1_157773635_ENST00000368176_ILF2_chr1_153637812_ENST00000361891_length(transcript)=1460nt_BP=387nt
CTCGACTCTGAGGTGCATTCTTTTTTTGATGAGAGGCATCTCTAGGTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGT
TGATCTGTGCTCCACTCTGTGAACCTGCCGAGCTGTTTTTGATAGCCAGCCCCTCCCATCCCACAGAGGGGAGCCCAGTGACCCTGACGT
GTAAGATGCCCTTTCTACAGAGTTCAGATGCCCAGTTCCAGTTCTGCTTTTTCAGAGACACCCGGGCCTTGGGCCCAGGCTGGAGCAGCT
CCCCCAAGCTCCAGATCGCTGCCATGTGGAAAGAAGACACAGGGTCATACTGGTGCGAGGCACAGACAATGGCGTCCAAAGTCTTGAGGA
GCAGGAGATCCCAGATAAATGTGCACATTTTAACCATGCTGACCAACGAAACTGGCTTTGAAATCAGTTCTTCTGATGCTACAGTGAAGA
TTCTCATTACAACAGTGCCACCCAATCTTCGAAAACTGGATCCAGAACTCCATTTGGATATCAAAGTATTGCAGAGTGCCTTAGCAGCCA
TCCGACATGCCCGCTGGTTCGAGGAAAATGCTTCTCAGTCCACAGTTAAAGTTCTCATCAGACTACTGAAGGACTTGAGGATTCGTTTTC
CTGGCTTTGAGCCCCTCACACCCTGGATCCTTGACCTACTAGGCCATTATGCTGTGATGAACAACCCCACCAGACAGCCTTTGGCCCTAA
ACGTTGCATACAGGCGCTGCTTGCAGATTCTGGCTGCAGGACTGTTCCTGCCAGGTTCAGTGGGTATCACTGACCCCTGTGAGAGTGGCA
ACTTTAGAGTACACACAGTCATGACCCTAGAACAGCAGGACATGGTCTGCTATACAGCTCAGACTCTCGTCCGAATCCTCTCACATGGTG
GCTTTAGGAAGATCCTTGGCCAGGAGGGTGATGCCAGCTATCTTGCTTCTGAAATATCTACCTGGGATGGAGTGATAGTAACACCTTCAG
AAAAGGCTTATGAGAAGCCACCAGAGAAGAAGGAAGGAGAGGAAGAAGAGGAGAATACAGAAGAACCACCTCAAGGAGAGGAAGAAGAAA
GCATGGAAACTCAGGAGTGACATTCCCTTCACTCCTTTTCCTACCCAAGGGGGAAGACTGGAGCCTAAGCTGCCTGCTACTGGGCTTTAC
ATGGTGACAGACATTTCCGTGGGATAGGGAAGATAGCAGGAAGAAAAGTAAACTCCATAGAAGTGTCATTCCACTGGGTTTTGATATTGG
CTTAGCTGCCAGTCTCCCATTTGTGACCTATGCCATCCATCTATAATGGAGGATACCAACATTTCTTCCTAATATTCTATAATCTCCAAC
TCCTGAAAACCCCTCTCTCAACTAATACTTTGCTGTTGAAATGTTGTGAAATGTTAAGTGTCTGGAAATTTTTTTTTCTAAGAAAAACTA

>30030_30030_2_FCRL1-ILF2_FCRL1_chr1_157773635_ENST00000368176_ILF2_chr1_153637812_ENST00000361891_length(amino acids)=346AA_BP=110
MVLMLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCE
AQTMASKVLRSRRSQINVHILTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLI
RLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTA

--------------------------------------------------------------
>30030_30030_3_FCRL1-ILF2_FCRL1_chr1_157773635_ENST00000491942_ILF2_chr1_153637812_ENST00000361891_length(transcript)=1415nt_BP=342nt
GTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGTTGATCTGTGCTCCACTCTGTGAACCTGCCGAGCTGTTTTTGATAG
CCAGCCCCTCCCATCCCACAGAGGGGAGCCCAGTGACCCTGACGTGTAAGATGCCCTTTCTACAGAGTTCAGATGCCCAGTTCCAGTTCT
GCTTTTTCAGAGACACCCGGGCCTTGGGCCCAGGCTGGAGCAGCTCCCCCAAGCTCCAGATCGCTGCCATGTGGAAAGAAGACACAGGGT
CATACTGGTGCGAGGCACAGACAATGGCGTCCAAAGTCTTGAGGAGCAGGAGATCCCAGATAAATGTGCACATTTTAACCATGCTGACCA
ACGAAACTGGCTTTGAAATCAGTTCTTCTGATGCTACAGTGAAGATTCTCATTACAACAGTGCCACCCAATCTTCGAAAACTGGATCCAG
AACTCCATTTGGATATCAAAGTATTGCAGAGTGCCTTAGCAGCCATCCGACATGCCCGCTGGTTCGAGGAAAATGCTTCTCAGTCCACAG
TTAAAGTTCTCATCAGACTACTGAAGGACTTGAGGATTCGTTTTCCTGGCTTTGAGCCCCTCACACCCTGGATCCTTGACCTACTAGGCC
ATTATGCTGTGATGAACAACCCCACCAGACAGCCTTTGGCCCTAAACGTTGCATACAGGCGCTGCTTGCAGATTCTGGCTGCAGGACTGT
TCCTGCCAGGTTCAGTGGGTATCACTGACCCCTGTGAGAGTGGCAACTTTAGAGTACACACAGTCATGACCCTAGAACAGCAGGACATGG
TCTGCTATACAGCTCAGACTCTCGTCCGAATCCTCTCACATGGTGGCTTTAGGAAGATCCTTGGCCAGGAGGGTGATGCCAGCTATCTTG
CTTCTGAAATATCTACCTGGGATGGAGTGATAGTAACACCTTCAGAAAAGGCTTATGAGAAGCCACCAGAGAAGAAGGAAGGAGAGGAAG
AAGAGGAGAATACAGAAGAACCACCTCAAGGAGAGGAAGAAGAAAGCATGGAAACTCAGGAGTGACATTCCCTTCACTCCTTTTCCTACC
CAAGGGGGAAGACTGGAGCCTAAGCTGCCTGCTACTGGGCTTTACATGGTGACAGACATTTCCGTGGGATAGGGAAGATAGCAGGAAGAA
AAGTAAACTCCATAGAAGTGTCATTCCACTGGGTTTTGATATTGGCTTAGCTGCCAGTCTCCCATTTGTGACCTATGCCATCCATCTATA
ATGGAGGATACCAACATTTCTTCCTAATATTCTATAATCTCCAACTCCTGAAAACCCCTCTCTCAACTAATACTTTGCTGTTGAAATGTT

>30030_30030_3_FCRL1-ILF2_FCRL1_chr1_157773635_ENST00000491942_ILF2_chr1_153637812_ENST00000361891_length(amino acids)=346AA_BP=110
MVLMLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCE
AQTMASKVLRSRRSQINVHILTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLI
RLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTA

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Fusion Gene PPI Analysis for FCRL1-ILF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FCRL1-ILF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FCRL1-ILF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source