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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FDFT1-DEFB135 (FusionGDB2 ID:30043)

Fusion Gene Summary for FDFT1-DEFB135

check button Fusion gene summary
Fusion gene informationFusion gene name: FDFT1-DEFB135
Fusion gene ID: 30043
HgeneTgene
Gene symbol

FDFT1

DEFB135

Gene ID

2222

613209

Gene namefarnesyl-diphosphate farnesyltransferase 1defensin beta 135
SynonymsDGPT|ERG9|SQS|SQSD|SSDEFB136
Cytomap

8p23.1

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionsqualene synthaseFPP:FPP farnesyltransferasepresqualene-di-diphosphate synthasesqualene synthetasebeta-defensin 135beta-defensin 136
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000446331, ENST00000220584, 
ENST00000525777, ENST00000525900, 
ENST00000528643, ENST00000538689, 
ENST00000443614, ENST00000528812, 
ENST00000530664, 		ENST00000382208, 
Fusion gene scores* DoF score16 X 12 X 9=17285 X 2 X 6=60
# samples 208
** MAII scorelog2(20/1728*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FDFT1 [Title/Abstract] AND DEFB135 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFDFT1(11696082)-DEFB135(11841930), # samples:2
Anticipated loss of major functional domain due to fusion event.FDFT1-DEFB135 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FDFT1-DEFB135 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FDFT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DEFB135 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-35-5375-01AFDFT1chr8

11679387

+DEFB135chr8

11841930

+
ChimerDB4OVTCGA-30-1860-01AFDFT1chr8

11696082

+DEFB135chr8

11841930

+
ChimerDB4UCECTCGA-DI-A1NO-01AFDFT1chr8

11667359

+DEFB135chr8

11841930

+


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Fusion Gene ORF analysis for FDFT1-DEFB135

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000446331ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
Frame-shiftENST00000220584ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
Frame-shiftENST00000525777ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
Frame-shiftENST00000525900ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
Frame-shiftENST00000528643ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
Frame-shiftENST00000538689ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
In-frameENST00000220584ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000220584ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000443614ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
In-frameENST00000443614ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000525777ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000525777ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000525900ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000525900ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000528643ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000528643ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000528812ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000528812ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
In-frameENST00000528812ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000530664ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000530664ENST00000382208FDFT1chr8

11696082

+DEFB135chr8

11841930

+
In-frameENST00000530664ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
In-frameENST00000538689ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
In-frameENST00000538689ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+
intron-3CDSENST00000443614ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
intron-3CDSENST00000446331ENST00000382208FDFT1chr8

11679387

+DEFB135chr8

11841930

+
intron-3CDSENST00000446331ENST00000382208FDFT1chr8

11667359

+DEFB135chr8

11841930

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538689FDFT1chr811679387+ENST00000382208DEFB135chr811841930+1020850376933185
ENST00000220584FDFT1chr811679387+ENST00000382208DEFB135chr811841930+902732222815197
ENST00000525900FDFT1chr811679387+ENST00000382208DEFB135chr811841930+72655667639190
ENST00000528812FDFT1chr811679387+ENST00000382208DEFB135chr811841930+10889185251001158
ENST00000530664FDFT1chr811679387+ENST00000382208DEFB135chr811841930+956786345869174
ENST00000528643FDFT1chr811679387+ENST00000382208DEFB135chr811841930+830660369743124
ENST00000525777FDFT1chr811679387+ENST00000382208DEFB135chr811841930+894724433807124
ENST00000443614FDFT1chr811696082+ENST00000382208DEFB135chr811841930+13771207941032312
ENST00000528812FDFT1chr811696082+ENST00000382208DEFB135chr811841930+199718275251475316
ENST00000530664FDFT1chr811696082+ENST00000382208DEFB135chr811841930+174515753451343332
ENST00000538689FDFT1chr811667359+ENST00000382208DEFB135chr811841930+891721376804142
ENST00000220584FDFT1chr811667359+ENST00000382208DEFB135chr811841930+773603222686154
ENST00000443614FDFT1chr811667359+ENST00000382208DEFB135chr811841930+64547594558154
ENST00000525900FDFT1chr811667359+ENST00000382208DEFB135chr811841930+59742767510147
ENST00000528812FDFT1chr811667359+ENST00000382208DEFB135chr811841930+959789525872115
ENST00000530664FDFT1chr811667359+ENST00000382208DEFB135chr811841930+827657345740131
ENST00000528643FDFT1chr811667359+ENST00000382208DEFB135chr811841930+70153136961481
ENST00000525777FDFT1chr811667359+ENST00000382208DEFB135chr811841930+76559543367881

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538689ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.0044408180.9955592
ENST00000220584ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.0047993190.99520063
ENST00000525900ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.0017390180.99826103
ENST00000528812ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.00536150.9946385
ENST00000530664ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.005012120.99498785
ENST00000528643ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.009969560.9900304
ENST00000525777ENST00000382208FDFT1chr811679387+DEFB135chr811841930+0.015959220.98404074
ENST00000443614ENST00000382208FDFT1chr811696082+DEFB135chr811841930+0.0012811440.99871886
ENST00000528812ENST00000382208FDFT1chr811696082+DEFB135chr811841930+0.0003234060.9996766
ENST00000530664ENST00000382208FDFT1chr811696082+DEFB135chr811841930+0.0003945960.9996055
ENST00000538689ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0206642340.9793357
ENST00000220584ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0103959940.989604
ENST00000443614ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0087354490.9912646
ENST00000525900ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0046221130.9953779
ENST00000528812ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0274769220.9725231
ENST00000530664ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0273972430.9726027
ENST00000528643ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.0700158550.9299842
ENST00000525777ENST00000382208FDFT1chr811667359+DEFB135chr811841930+0.272967460.7270326

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Fusion Genomic Features for FDFT1-DEFB135


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FDFT1chr811679387+DEFB135chr811841929+0.0884934140.9115066
FDFT1chr811667359+DEFB135chr811841929+2.15E-050.99997854
FDFT1chr811679387+DEFB135chr811841929+0.0884934140.9115066
FDFT1chr811667359+DEFB135chr811841929+2.15E-050.99997854

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FDFT1-DEFB135


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11696082/chr8:11841930)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFDFT1chr8:11667359chr8:11841930ENST00000220584+38284_304127418.0TransmembraneHelical
HgeneFDFT1chr8:11667359chr8:11841930ENST00000220584+38384_404127418.0TransmembraneHelical
HgeneFDFT1chr8:11679387chr8:11841930ENST00000220584+48284_304170418.0TransmembraneHelical
HgeneFDFT1chr8:11679387chr8:11841930ENST00000220584+48384_404170418.0TransmembraneHelical
HgeneFDFT1chr8:11696082chr8:11841930ENST00000220584+18284_3040418.0TransmembraneHelical
HgeneFDFT1chr8:11696082chr8:11841930ENST00000220584+18384_4040418.0TransmembraneHelical


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Fusion Gene Sequence for FDFT1-DEFB135


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30043_30043_1_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000220584_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=773nt_BP=603nt
AATCAGCGCCCGTCAGCCCACCCCACGAGGCCGCAGCTAGCCCCGCTGGCGGCCGAGGCCGGTTGAAGTGGGCGGAGCGGCGGGCGGGGC
GTCGCCGTACTAGGCCTGCCCCCTGTCCGGCCAGCCCCTCGAAGCACCTACTCCACAGGTCCAGCCGGCCGGTGAGCGCCTGGGGACCGC
AGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGCCAGGATGGAGTTCGTGAAATGCCTTGGCCACCCCGAAGAGTTCTACAACCTG
GTGCGCTTCCGGATCGGGGGCAAGCGGAAGGTGATGCCCAAGATGGACCAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTAT
CTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTC
CGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAA
CCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTGGACCCAATGTCTACATAC
AAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTA

>30043_30043_1_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000220584_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=154AA_BP=0
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV

--------------------------------------------------------------
>30043_30043_2_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000443614_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=645nt_BP=475nt
TCGAAGCACCTACTCCACAGGTCCAGCCGGCCGGTGAGCGCCTGGGGACCGCAGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGC
CAGGATGGAGTTCGTGAAATGCCTTGGCCACCCCGAAGAGTTCTACAACCTGGTGCGCTTCCGGATCGGGGGCAAGCGGAAGGTGATGCC
CAAGATGGACCAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCA
GGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAG
TGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCG
CCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACT
TGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTACCTATA

>30043_30043_2_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000443614_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=154AA_BP=0
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV

--------------------------------------------------------------
>30043_30043_3_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000525777_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=765nt_BP=595nt
GCACATTACACCCATGAACTTAGACCAGTTGCCTTTATGTATGATCGTATTTATACTGAGAAGTTACTGTGTTTTTTGACTTTCTTTTCT
ATTTGCTACATATTAGTTCGGTCTAAACGTTTGGTCTTCTGGTCTCCATAGTTCTACATTGGTTAAATGCAACTCACTTCTGGGAGTAGT
GGTGACATTCAACTAGTAGGCTTTTTAATAAACTACAGAAGTTCATTACTCTCATGTAAGGAAGGAAAACTAATGTAACTTTCGTTAAGT
ATGAAAAGCGTTGGATATCCTTATAGTTCTTTAGAGTTAAGGGTGAGATGGGTTTAGAAAGTGGCCAGGCACAAGTTATTTTAAAATAAA
AAATCTTTGGCTGTTTGTTCCAATATATTAATAGTTTTCCCTTTTTTACAGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCT
GGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTG
GCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTGGACCCAATGTCTACATACAAAAAATC
TTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTG

>30043_30043_3_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000525777_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=81AA_BP=1

--------------------------------------------------------------
>30043_30043_4_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000525900_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=597nt_BP=427nt
CGGCCGGTGAGCGCCTGGGGACCGCAGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGCCAGGATGGAGTTCGTGAAATGCCTTGG
CCACCCCGAAGAGTTCTACAACCTGGTGCGCTTCCGGATCGGGGGCAAGCGGAAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAA
GTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGT
TCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTA
CCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTGGACCCAATGTCTAC
ATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGAT

>30043_30043_4_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000525900_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=147AA_BP=0
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL

--------------------------------------------------------------
>30043_30043_5_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000528643_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=701nt_BP=531nt
CTTGGCAGCTGAACCTGCCTGTGAGCAGGTCGTGTATTTCTCGGCTTCCCTTATCCAACTTTGCATTTCTATTTCTAGCATATTGGGTTG
ATTCTTTTGAAGCTGCCTCTGTGCACATTACACCCATGAACTTAGACCAGTTGCCTTTATGTATGATCGTATTTATACTGAGAAGTTACT
GTGTTTTTTGACTTTCTTTTCTATTTGCTACATATTAGTTCGGTCTAAACGTTTGGTCTTCTGGTCTCCATAGTTCTACATTGGTTAAAT
GCAACTCACTTCTGGGAGTAGTGGTGACATTCAACTAGTAGGCTTTTTAATAAACTACAGAAGTTCATTACTCTCATCAACGCAGTGTGC
ATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTT
CACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTG
GACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATC

>30043_30043_5_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000528643_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=81AA_BP=1

--------------------------------------------------------------
>30043_30043_6_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000528812_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=959nt_BP=789nt
ATCTGGGGCAAGGGGCGCGGCGAGCAGGGCCGACGCCTGGGTGTTCCCGTCCCCCTTTCCTCGAGCCTTCCCCCTGTAGGGCCCGGGTGG
ACGCGGCCGTCCTGGCTGACCTGTCCCTGCCCCCGCAAGCCGCCCTGGGCATGAGCGACTTTTGCGTGGTTCCCGGTGGTTGCGCTCCCC
GTTTCGTCCCCTCCGTGAGCATCGGCGCTTACCGGTATTTTAACCCGAGGGTTACACATCTGAGGCAATGTGGGTGGGTTACGCGGGAGA
GGACGAGTGAGTTTTTTGGTAAGCGGAATGAACTATGCAGATAACATCACATGAAGGCCGTTTCTGGAATGAAGTCTGACTCCTCCAGTT
TCACCACCTCTTCCGGAGCTCTCCCCGCCTTGCTGCCTTCCATCGCTTCATCCTCGGTGCTTCCTGAGTTTTAAAATCGCCTATCTACGC
TTCCAAGTTCCAATGAGTTATCTAACGTCTATGGATTAGCTAGGTGGTTGGTGGAAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTAC
AAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTG
GTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTT
TACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTGGACCCAATGTCT
ACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTG

>30043_30043_6_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000528812_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=115AA_BP=1
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTVE

--------------------------------------------------------------
>30043_30043_7_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000530664_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=827nt_BP=657nt
AATTGATGGCGGGGGAGCCGGATGTCAGTGGATGGAAAATTATTACGAGGAAACACAGGGGTGTGCATTCTTGCTGAAGGCAGGCCAGAG
TTATCAGACATCACCTGAGGGATGGAGGGGGATGTGGAACCTAATCGGCTGTCTAGGGTGATCAGATACTGAAGTTGGGGGATTCTGGTC
AAATCAATTTAGCAGGATTCTTGGTAAAACTGGGCGATGCAAAGACAGATGCGTTGAGTACAAAGTCCAGGCCTTATTGGGAAGAGGATT
TCAGCGGAGCCCGAGTAGAGTTTGGTCTAGGGAGACTCTGTCACTGGGAGGACGAGCGAGCCGCTCGGAAGTGCGCTGGGTTCCCTTAGC
GGCCAGTGGGTTCTGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATC
CAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATC
AGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGAT
CGCCAGGTGCTGGAGGACTTCCCAACGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTA
CTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTACCTA

>30043_30043_7_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000530664_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=131AA_BP=1
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME

--------------------------------------------------------------
>30043_30043_8_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000538689_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=891nt_BP=721nt
AAAAACGGTGGCAACACGCTGGGTTTGCTTTACAACGCTTGGGAAGCTTTGTTGTTTGCAATAAATTTTAATACTTGTCTGTTTCGGTCT
GCACTGCCTTTATGAGCTGTAACACTCACAGGGTAGGTTTGCAGCTTCACTCCTGAAGCCAGTAAGACAACGAACCCACTGGGAGAAACA
AACAACTCCAGACGCGCCGACTTAAGAGCTGTAATACTCGCTGTGACGGTCTGCAGCTTCACTCCTGAGCCAGCGAGACCACGAACCCAC
CAGAAGGAAGAAACTCCGAACACATCTGAACATCAGAAGGAACAGACTCCGGACACGCCGCCTTTAAGAACTGTAACACTCACCGCGAGG
GTGGGCGGTTTCATTCCTGAAGTCAGTGAGACCAAGAACCAACCAATTCCGGACACACTTGGACTCGACAGACTCTAAGGACTCGCTCAG
CAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAA
CGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTT
ACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAAC
GGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAAC

>30043_30043_8_FDFT1-DEFB135_FDFT1_chr8_11667359_ENST00000538689_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=142AA_BP=1
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS

--------------------------------------------------------------
>30043_30043_9_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000220584_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=902nt_BP=732nt
AATCAGCGCCCGTCAGCCCACCCCACGAGGCCGCAGCTAGCCCCGCTGGCGGCCGAGGCCGGTTGAAGTGGGCGGAGCGGCGGGCGGGGC
GTCGCCGTACTAGGCCTGCCCCCTGTCCGGCCAGCCCCTCGAAGCACCTACTCCACAGGTCCAGCCGGCCGGTGAGCGCCTGGGGACCGC
AGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGCCAGGATGGAGTTCGTGAAATGCCTTGGCCACCCCGAAGAGTTCTACAACCTG
GTGCGCTTCCGGATCGGGGGCAAGCGGAAGGTGATGCCCAAGATGGACCAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTAT
CTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTC
CGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAA
CCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAATCTGGCT
GAGAAATACCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCTGAACAG
GAGTGGGACAAGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAAT
GTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTACCTATACTGACTGGGAAAT

>30043_30043_9_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000220584_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=197AA_BP=0
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKVEVDPMSTYK

--------------------------------------------------------------
>30043_30043_10_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000525777_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=894nt_BP=724nt
GCACATTACACCCATGAACTTAGACCAGTTGCCTTTATGTATGATCGTATTTATACTGAGAAGTTACTGTGTTTTTTGACTTTCTTTTCT
ATTTGCTACATATTAGTTCGGTCTAAACGTTTGGTCTTCTGGTCTCCATAGTTCTACATTGGTTAAATGCAACTCACTTCTGGGAGTAGT
GGTGACATTCAACTAGTAGGCTTTTTAATAAACTACAGAAGTTCATTACTCTCATGTAAGGAAGGAAAACTAATGTAACTTTCGTTAAGT
ATGAAAAGCGTTGGATATCCTTATAGTTCTTTAGAGTTAAGGGTGAGATGGGTTTAGAAAGTGGCCAGGCACAAGTTATTTTAAAATAAA
AAATCTTTGGCTGTTTGTTCCAATATATTAATAGTTTTCCCTTTTTTACAGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCT
GGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTG
GCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAATCTGGCTGAGAAATA
CCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCTGAACAGGAGTGGGA
CAAGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAA

>30043_30043_10_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000525777_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=124AA_BP=1
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT

--------------------------------------------------------------
>30043_30043_11_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000525900_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=726nt_BP=556nt
CGGCCGGTGAGCGCCTGGGGACCGCAGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGCCAGGATGGAGTTCGTGAAATGCCTTGG
CCACCCCGAAGAGTTCTACAACCTGGTGCGCTTCCGGATCGGGGGCAAGCGGAAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAA
GTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGT
TCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTA
CCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAATCT
GGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCTGA
ACAGGAGTGGGACAAGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCA
AAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTACCTATACTGACTGGG

>30043_30043_11_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000525900_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=190AA_BP=0
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKVEVDPMSTYKKSLLHVG

--------------------------------------------------------------
>30043_30043_12_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000528643_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=830nt_BP=660nt
CTTGGCAGCTGAACCTGCCTGTGAGCAGGTCGTGTATTTCTCGGCTTCCCTTATCCAACTTTGCATTTCTATTTCTAGCATATTGGGTTG
ATTCTTTTGAAGCTGCCTCTGTGCACATTACACCCATGAACTTAGACCAGTTGCCTTTATGTATGATCGTATTTATACTGAGAAGTTACT
GTGTTTTTTGACTTTCTTTTCTATTTGCTACATATTAGTTCGGTCTAAACGTTTGGTCTTCTGGTCTCCATAGTTCTACATTGGTTAAAT
GCAACTCACTTCTGGGAGTAGTGGTGACATTCAACTAGTAGGCTTTTTAATAAACTACAGAAGTTCATTACTCTCATCAACGCAGTGTGC
ATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTT
CACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTT
GAGTTTAGAAATCTGGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAG
CATGTGACCTCTGAACAGGAGTGGGACAAGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAG
GTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTAC

>30043_30043_12_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000528643_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=124AA_BP=1
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT

--------------------------------------------------------------
>30043_30043_13_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000528812_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=1088nt_BP=918nt
ATCTGGGGCAAGGGGCGCGGCGAGCAGGGCCGACGCCTGGGTGTTCCCGTCCCCCTTTCCTCGAGCCTTCCCCCTGTAGGGCCCGGGTGG
ACGCGGCCGTCCTGGCTGACCTGTCCCTGCCCCCGCAAGCCGCCCTGGGCATGAGCGACTTTTGCGTGGTTCCCGGTGGTTGCGCTCCCC
GTTTCGTCCCCTCCGTGAGCATCGGCGCTTACCGGTATTTTAACCCGAGGGTTACACATCTGAGGCAATGTGGGTGGGTTACGCGGGAGA
GGACGAGTGAGTTTTTTGGTAAGCGGAATGAACTATGCAGATAACATCACATGAAGGCCGTTTCTGGAATGAAGTCTGACTCCTCCAGTT
TCACCACCTCTTCCGGAGCTCTCCCCGCCTTGCTGCCTTCCATCGCTTCATCCTCGGTGCTTCCTGAGTTTTAAAATCGCCTATCTACGC
TTCCAAGTTCCAATGAGTTATCTAACGTCTATGGATTAGCTAGGTGGTTGGTGGAAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTAC
AAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTG
GTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTT
TACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAAT
CTGGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCT
GAACAGGAGTGGGACAAGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGC
CAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTACCTATACTGACTG

>30043_30043_13_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000528812_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=158AA_BP=1
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS

--------------------------------------------------------------
>30043_30043_14_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000530664_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=956nt_BP=786nt
AATTGATGGCGGGGGAGCCGGATGTCAGTGGATGGAAAATTATTACGAGGAAACACAGGGGTGTGCATTCTTGCTGAAGGCAGGCCAGAG
TTATCAGACATCACCTGAGGGATGGAGGGGGATGTGGAACCTAATCGGCTGTCTAGGGTGATCAGATACTGAAGTTGGGGGATTCTGGTC
AAATCAATTTAGCAGGATTCTTGGTAAAACTGGGCGATGCAAAGACAGATGCGTTGAGTACAAAGTCCAGGCCTTATTGGGAAGAGGATT
TCAGCGGAGCCCGAGTAGAGTTTGGTCTAGGGAGACTCTGTCACTGGGAGGACGAGCGAGCCGCTCGGAAGTGCGCTGGGTTCCCTTAGC
GGCCAGTGGGTTCTGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATC
CAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATC
AGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGAT
CGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAATCTGGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGG
AGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCTGAACAGGAGTGGGACAAGGTAGAAGTGGACCCAATGTCTACA
TACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATA

>30043_30043_14_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000530664_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=174AA_BP=1
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME

--------------------------------------------------------------
>30043_30043_15_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000538689_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=1020nt_BP=850nt
AAAAACGGTGGCAACACGCTGGGTTTGCTTTACAACGCTTGGGAAGCTTTGTTGTTTGCAATAAATTTTAATACTTGTCTGTTTCGGTCT
GCACTGCCTTTATGAGCTGTAACACTCACAGGGTAGGTTTGCAGCTTCACTCCTGAAGCCAGTAAGACAACGAACCCACTGGGAGAAACA
AACAACTCCAGACGCGCCGACTTAAGAGCTGTAATACTCGCTGTGACGGTCTGCAGCTTCACTCCTGAGCCAGCGAGACCACGAACCCAC
CAGAAGGAAGAAACTCCGAACACATCTGAACATCAGAAGGAACAGACTCCGGACACGCCGCCTTTAAGAACTGTAACACTCACCGCGAGG
GTGGGCGGTTTCATTCCTGAAGTCAGTGAGACCAAGAACCAACCAATTCCGGACACACTTGGACTCGACAGACTCTAAGGACTCGCTCAG
CAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAA
CGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTT
ACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAAC
GATCTCCCTTGAGTTTAGAAATCTGGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTT
TTTGGATAAGCATGTGACCTCTGAACAGGAGTGGGACAAGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGG
CGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCA

>30043_30043_15_FDFT1-DEFB135_FDFT1_chr8_11679387_ENST00000538689_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=185AA_BP=1
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKVEVDPMSTYKKSLLHVGDCKVL

--------------------------------------------------------------
>30043_30043_16_FDFT1-DEFB135_FDFT1_chr8_11696082_ENST00000443614_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=1377nt_BP=1207nt
TCGAAGCACCTACTCCACAGGTCCAGCCGGCCGGTGAGCGCCTGGGGACCGCAGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGC
CAGGATGGAGTTCGTGAAATGCCTTGGCCACCCCGAAGAGTTCTACAACCTGGTGCGCTTCCGGATCGGGGGCAAGCGGAAGGTGATGCC
CAAGATGGACCAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCA
GGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAG
TGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCG
CCAGGTGCTGGAGGACTTCCCAACGTACTGCCACTATGTTGCTGGGCTGGTCGGAATTGGCCTTTCCCGTCTTTTCTCAGCCTCAGAGTT
TGAAGACCCCTTAGTTGGTGAAGATACAGAACGTGCCAACTCTATGGGCCTGTTTTTGCAGAAAACAAACATCATCCGTGACTATCTGGA
AGACCAGCAAGGAGGAAGAGAGTTCTGGCCTCAAGAGGTTTGGAGCAGGTATGTTAAGAAGTTAGGGGATTTTGCTAAGCCGGAGAATAT
TGACTTGGCCGTGCAGTGCCTGAATGAACTTATAACCAATGCACTGCACCACATCCCAGATGTCATCACCTACCTTTCGAGACTCAGAAA
CCAGAGTGTGTTTAACTTCTGTGCTATTCCACAGGTGATGGCCATTGCCACTTTGGCTGCCTGTTATAATAACCAGCAGGTGTTCAAAGG
GGCAGTGAAGATTCGGAAAGGGCAAGCAGTGACCCTGATGATGGATGCCACCAATATGCCAGCTGTCAAAGCCATCATATATCAGTATAT
GGAAGAGGTAACAGAAGACTATGTTCAGACTGGAGAACACTGATCCCAAATTTGTCCATAGCTGAAGTCCACCATAAAGTGGATTTACTT
TTTTTCTTTAAGGATGGATGTTGTGTTCTCTTTATTTTTTTCCTACTACTTTAATCCCTAAAAGAACGCTGTGTGGCTGGGACCTTTAGG
AAAGTGAAATGCAGGTGAGAAGAACCTAAACATGAAAGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGA
CTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAA

>30043_30043_16_FDFT1-DEFB135_FDFT1_chr8_11696082_ENST00000443614_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=312AA_BP=
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGA

--------------------------------------------------------------
>30043_30043_17_FDFT1-DEFB135_FDFT1_chr8_11696082_ENST00000528812_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=1997nt_BP=1827nt
ATCTGGGGCAAGGGGCGCGGCGAGCAGGGCCGACGCCTGGGTGTTCCCGTCCCCCTTTCCTCGAGCCTTCCCCCTGTAGGGCCCGGGTGG
ACGCGGCCGTCCTGGCTGACCTGTCCCTGCCCCCGCAAGCCGCCCTGGGCATGAGCGACTTTTGCGTGGTTCCCGGTGGTTGCGCTCCCC
GTTTCGTCCCCTCCGTGAGCATCGGCGCTTACCGGTATTTTAACCCGAGGGTTACACATCTGAGGCAATGTGGGTGGGTTACGCGGGAGA
GGACGAGTGAGTTTTTTGGTAAGCGGAATGAACTATGCAGATAACATCACATGAAGGCCGTTTCTGGAATGAAGTCTGACTCCTCCAGTT
TCACCACCTCTTCCGGAGCTCTCCCCGCCTTGCTGCCTTCCATCGCTTCATCCTCGGTGCTTCCTGAGTTTTAAAATCGCCTATCTACGC
TTCCAAGTTCCAATGAGTTATCTAACGTCTATGGATTAGCTAGGTGGTTGGTGGAAGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTAC
AAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTG
GTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTT
TACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAAT
CTGGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCT
GAACAGGAGTGGGACAAGTACTGCCACTATGTTGCTGGGCTGGTCGGAATTGGCCTTTCCCGTCTTTTCTCAGCCTCAGAGTTTGAAGAC
CCCTTAGTTGGTGAAGATACAGAACGTGCCAACTCTATGGGCCTGTTTTTGCAGAAAACAAACATCATCCGTGACTATCTGGAAGACCAG
CAAGGAGGAAGAGAGTTCTGGCCTCAAGAGGTTTGGAGCAGGTATGTTAAGAAGTTAGGGGATTTTGCTAAGCCGGAGAATATTGACTTG
GCCGTGCAGTGCCTGAATGAACTTATAACCAATGCACTGCACCACATCCCAGATGTCATCACCTACCTTTCGAGACTCAGAAACCAGAGT
GTGTTTAACTTCTGTGCTATTCCACAGGTGATGGCCATTGCCACTTTGGCTGCCTGTTATAATAACCAGCAGGTGTTCAAAGGGGCAGTG
AAGATTCGGAAAGGGCAAGCAGTGACCCTGATGATGGATGCCACCAATATGCCAGCTGTCAAAGCCATCATATATCAGTATATGGAAGAG
GTAACAGAAGACTATGTTCAGACTGGAGAACACTGATCCCAAATTTGTCCATAGCTGAAGTCCACCATAAAGTGGATTTACTTTTTTTCT
TTAAGGATGGATGTTGTGTTCTCTTTATTTTTTTCCTACTACTTTAATCCCTAAAAGAACGCTGTGTGGCTGGGACCTTTAGGAAAGTGA
AATGCAGGTGAGAAGAACCTAAACATGAAAGGAAAGGGTGCCTCATCCCAGCAACCTGTCCTTGTGGGTGATGATCACTGTGCTGCTTGT
GGCTCATGGCAGAGCATTCAGTGCCACGGTTTAGGTGAAGTCGCTGCATATGTGACTGTCATGAGATCCTACTTAGTATGATCCTGGCTA
GAATGATAATTAAAAGTATTTAATTTGGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCATGTTGGCGACTGCAAGGTA
CTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAAACCCAAAATATTTACCTA

>30043_30043_17_FDFT1-DEFB135_FDFT1_chr8_11696082_ENST00000528812_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=316AA_BP=
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQV

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>30043_30043_18_FDFT1-DEFB135_FDFT1_chr8_11696082_ENST00000530664_DEFB135_chr8_11841930_ENST00000382208_length(transcript)=1745nt_BP=1575nt
AATTGATGGCGGGGGAGCCGGATGTCAGTGGATGGAAAATTATTACGAGGAAACACAGGGGTGTGCATTCTTGCTGAAGGCAGGCCAGAG
TTATCAGACATCACCTGAGGGATGGAGGGGGATGTGGAACCTAATCGGCTGTCTAGGGTGATCAGATACTGAAGTTGGGGGATTCTGGTC
AAATCAATTTAGCAGGATTCTTGGTAAAACTGGGCGATGCAAAGACAGATGCGTTGAGTACAAAGTCCAGGCCTTATTGGGAAGAGGATT
TCAGCGGAGCCCGAGTAGAGTTTGGTCTAGGGAGACTCTGTCACTGGGAGGACGAGCGAGCCGCTCGGAAGTGCGCTGGGTTCCCTTAGC
GGCCAGTGGGTTCTGGACTCGCTCAGCAGCAGCCTGAAAACTTGCTACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATC
CAGGCGCTGGATGGGGAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAAGATGACATGACCATC
AGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTCCTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGAT
CGCCAGGTGCTGGAGGACTTCCCAACGATCTCCCTTGAGTTTAGAAATCTGGCTGAGAAATACCAAACAGTGATTGCCGACATTTGCCGG
AGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACCTCTGAACAGGAGTGGGACAAGTACTGCCACTATGTTGCTGGGCTG
GTCGGAATTGGCCTTTCCCGTCTTTTCTCAGCCTCAGAGTTTGAAGACCCCTTAGTTGGTGAAGATACAGAACGTGCCAACTCTATGGGC
CTGTTTTTGCAGAAAACAAACATCATCCGTGACTATCTGGAAGACCAGCAAGGAGGAAGAGAGTTCTGGCCTCAAGAGGTTTGGAGCAGG
TATGTTAAGAAGTTAGGGGATTTTGCTAAGCCGGAGAATATTGACTTGGCCGTGCAGTGCCTGAATGAACTTATAACCAATGCACTGCAC
CACATCCCAGATGTCATCACCTACCTTTCGAGACTCAGAAACCAGAGTGTGTTTAACTTCTGTGCTATTCCACAGGTGATGGCCATTGCC
ACTTTGGCTGCCTGTTATAATAACCAGCAGGTGTTCAAAGGGGCAGTGAAGATTCGGAAAGGGCAAGCAGTGACCCTGATGATGGATGCC
ACCAATATGCCAGCTGTCAAAGCCATCATATATCAGTATATGGAAGAGGTAACAGAAGACTATGTTCAGACTGGAGAACACTGATCCCAA
ATTTGTCCATAGCTGAAGTCCACCATAAAGTGGATTTACTTTTTTTCTTTAAGGATGGATGTTGTGTTCTCTTTATTTTTTTCCTACTAC
TTTAATCCCTAAAAGAACGCTGTGTGGCTGGGACCTTTAGGAAAGTGAAATGCAGGTGAGAAGAACCTAAACATGAAAGGAAAGGGTGCC
TCATCCCAGCAACCTGTCCTTGTGGGTGATGATCACTGTGCTGCTGTAGAAGTGGACCCAATGTCTACATACAAAAAATCTTTGCTTCAT
GTTGGCGACTGCAAGGTACTTGCCGGCCAAAATGTCTAAAAAACGAACAATATCGTATTTTGTGTGATACTATACATTTGTGCTGTGTAA

>30043_30043_18_FDFT1-DEFB135_FDFT1_chr8_11696082_ENST00000530664_DEFB135_chr8_11841930_ENST00000382208_length(amino acids)=332AA_BP=
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQ

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Fusion Gene PPI Analysis for FDFT1-DEFB135


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FDFT1-DEFB135


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FDFT1-DEFB135


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource