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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FDPS-KHSRP (FusionGDB2 ID:30059)

Fusion Gene Summary for FDPS-KHSRP

check button Fusion gene summary
Fusion gene informationFusion gene name: FDPS-KHSRP
Fusion gene ID: 30059
HgeneTgene
Gene symbol

FDPS

KHSRP

Gene ID

2224

8570

Gene namefarnesyl diphosphate synthaseKH-type splicing regulatory protein
SynonymsFPPS|FPS|POROK9FBP2|FUBP2|KSRP|p75
Cytomap

1q22

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionfarnesyl pyrophosphate synthase(2E,6E)-farnesyl diphosphate synthaseFPP synthaseFPP synthetasefarnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferasefar upstream element-binding protein 2FUSE-binding protein 2epididymis secretory sperm binding protein
Modification date2020032920200329
UniProtAcc

P14324

Q92945

Ensembl transtripts involved in fusion geneENST00000487002, ENST00000356657, 
ENST00000368356, ENST00000447866, 
ENST00000398148, 
Fusion gene scores* DoF score6 X 2 X 6=724 X 4 X 3=48
# samples 74
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FDPS [Title/Abstract] AND KHSRP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFDPS(155282186)-KHSRP(6422447), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKHSRP

GO:0043488

regulation of mRNA stability

16126846

TgeneKHSRP

GO:0045019

negative regulation of nitric oxide biosynthetic process

16126846

TgeneKHSRP

GO:0061014

positive regulation of mRNA catabolic process

16126846

TgeneKHSRP

GO:0061158

3'-UTR-mediated mRNA destabilization

16126846


check buttonFusion gene breakpoints across FDPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KHSRP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4IZFDPSchr1

155282186

+KHSRPchr19

6422447

-


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Fusion Gene ORF analysis for FDPS-KHSRP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487002ENST00000398148FDPSchr1

155282186

+KHSRPchr19

6422447

-
In-frameENST00000356657ENST00000398148FDPSchr1

155282186

+KHSRPchr19

6422447

-
In-frameENST00000368356ENST00000398148FDPSchr1

155282186

+KHSRPchr19

6422447

-
In-frameENST00000447866ENST00000398148FDPSchr1

155282186

+KHSRPchr19

6422447

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000447866FDPSchr1155282186+ENST00000398148KHSRPchr196422447-31525012192387722
ENST00000368356FDPSchr1155282186+ENST00000398148KHSRPchr196422447-32465951152481788
ENST00000356657FDPSchr1155282186+ENST00000398148KHSRPchr196422447-32936421622528788

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000447866ENST00000398148FDPSchr1155282186+KHSRPchr196422447-0.0058057290.9941943
ENST00000368356ENST00000398148FDPSchr1155282186+KHSRPchr196422447-0.0028642840.99713576
ENST00000356657ENST00000398148FDPSchr1155282186+KHSRPchr196422447-0.0023365270.9976635

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Fusion Genomic Features for FDPS-KHSRP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FDPS-KHSRP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:155282186/chr19:6422447)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FDPS

P14324

KHSRP

Q92945

FUNCTION: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.FUNCTION: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020498_61283712.0Compositional biasNote=Ala/Gly/Pro-rich
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020144_20883712.0DomainKH 1
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020233_29983712.0DomainKH 2
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020322_38683712.0DomainKH 3
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020424_49183712.0DomainKH 4
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020571_68483712.0RegionNote=4 X 12 AA imperfect repeats
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020571_58283712.0RepeatNote=1
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020617_62883712.0RepeatNote=2
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020643_65483712.0RepeatNote=3
TgeneKHSRPchr1:155282186chr19:6422447ENST00000398148020673_68483712.0RepeatNote=4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKHSRPchr1:155282186chr19:6422447ENST0000039814802068_49683712.0Compositional biasNote=Gly-rich
TgeneKHSRPchr1:155282186chr19:6422447ENST000003981480207_6783712.0Compositional biasNote=Gly/Pro-rich


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Fusion Gene Sequence for FDPS-KHSRP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30059_30059_1_FDPS-KHSRP_FDPS_chr1_155282186_ENST00000356657_KHSRP_chr19_6422447_ENST00000398148_length(transcript)=3293nt_BP=642nt
GAGTACCCGCCAACAAGCGGGACCGAGCAGGAATCCGTATCTGGGAACAGGTGAGAGAGGATGTGTGCTGGGCCTTGGAGGAAGGGGGCC
GAGACCGGGCCTTACTTCTGTAACGATACTGTGAGGCATCGGAAGGCCAGCCTGTTGTGTCCGTTTTGAAGGATGCCCCTGTCCCGCTGG
TTGAGATCTGTGGGGGTCTTCCTGCTGCCAGCCCCCTACTGGGCACCCCGGGAGAGGTGGCTGGGTTCCCTACGGCGGCCCTCCCTGGTG
CACGGGTACCCAGTCCTGGCCTGGCACAGTGCCCGCTGCTGGTGCCAAGCGTGGACAGAGGAACCTCGAGCCCTTTGCTCCTCCCTCAGA
ATGAACGGAGACCAGAATTCAGATGTTTATGCCCAAGAAAAGCAGGATTTCGTTCAGCACTTCTCCCAGATCGTTAGGGTGCTGACTGAG
GATGAGATGGGGCACCCAGAGATAGGAGATGCTATTGCCCGGCTCAAGGAGGTCCTGGAGTACAATGCCATTGGAGGCAAGTATAACCGG
GGTTTGACGGTGGTAGTAGCATTCCGGGAGCTGGTGGAGCCAAGGAAACAGGATGCTGATAGTCTCCAGCGGGCCTGGACTGTGGGCTGG
TGTGTGGAACTGATTGCAGCCAAAATTGGAGGCGATGCTGCCACGACAGTGAATAACAGCACTCCTGATTTTGGTTTTGGGGGCCAAAAG
AGACAGTTGGAAGATGGAGATCAACCGGAGAGCAAGAAGCTGGCTTCCCAGGGAGACTCAATCAGTTCTCAACTTGGACCCATCCATCCT
CCCCCAAGGACTTCAATGACAGAAGAGTACAGGGTCCCAGACGGCATGGTGGGCCTGATCATTGGCAGAGGAGGTGAACAAATTAACAAA
ATCCAACAGGATTCAGGCTGCAAAGTACAGATTTCTCCAGACAGCGGTGGCCTACCCGAGCGCAGTGTGTCCTTGACAGGAGCCCCAGAA
TCTGTCCAGAAAGCCAAGATGATGCTGGATGACATTGTGTCTCGGGGTCGTGGGGGCCCCCCAGGACAGTTCCACGACAACGCCAACGGG
GGCCAGAACGGCACCGTGCAGGAGATCATGATCCCCGCGGGCAAGGCCGGCCTGGTCATTGGCAAGGGCGGGGAGACCATTAAGCAGCTG
CAGGAACGCGCTGGAGTGAAGATGATCTTAATTCAGGACGGATCTCAGAATACGAATGTGGACAAACCTCTCCGCATCATTGGGGATCCT
TACAAAGTGCAGCAAGCCTGTGAGATGGTGATGGACATCCTCCGGGAACGTGACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCT
CGGATTGGCGGAGGCATCGATGTGCCAGTGCCCAGGCATTCTGTTGGCGTGGTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAG
AATGATGCTGGCGTGCGGATACAGTTCAAGCAAGATGACGGGACAGGGCCCGAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGC
GAGCACGCAGCCCGGATCATCAACGACCTCCTCCAGAGCCTCAGGAGTGGTCCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGG
GGCCGAGGCCGAGGAAGAGGCCAAGGCAATTGGGGTCCCCCTGGCGGGGAGATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTC
ATCGGCCGAGGTGGCGAGAATGTGAAAGCCATAAACCAGCAGACGGGAGCCTTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGAC
CCCAACTTCAAGTTGTTCATCATCCGGGGTTCACCCCAGCAGATTGACCACGCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTC
TGCCCAGTTGGACCAGGCCCAGGTGGCCCAGGCCCTGCTGGCCCAATGGGGCCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGG
GCTCCCCCACATGCCGGGGGGCCCCCTCCTCACCAGTACCCACCCCAGGGCTGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCT
CATGACCCAAGCAAAGCAGCTGCAGCGGCCGCGGACCCCAACGCCGCGTGGGCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGC
CCCGTCCCCGGCCCCGCACCGGCCCCTGCGGCCCCACCGGCTCAGGGTGAGCCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACT
AAGGCCTGGGAAGAGTATTACAAAAAGATCGGCCAGCAGCCCCAGCAGCCCGGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAG
GAGTACTACAAGAAGCAAGCGCAAGTGGCCACCGGAGGGGGTCCAGGAGCTCCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCG
GAATATTACAGACAGCAGGCCGCTTACTACGGACAGACCCCAGGTCCTGGCGGCCCCCAGCCGCCGCCCACGCAGCAGGGACAGCAGCAG
GCTCAATGAATCGAATGAATGTGAACTTCTTCATCTGTGAAAAATCTTTTTTTTTTCCATTTTGTTCTGTTTGGGGGCTTCTGTTTTGTT
TGGCGAGAGAGCGATGGCTGCCGTGGGGAGTACTGGGGAGCCCTCGCGGCAAGCAGGGTGGGGGGGACTTGGGGGCATGCCGGGCCCTCA
CTCTCTCGCCTGTTCTGTGTCTCACATGCTTTTTCTTTCAAAATTGGGATCCTTCCATGTTGAGCCAGCCAGAGAAGATAGCGAGATCTA
AATCTCTGCCAAAAAAAAAAAAAAACTTAAAAATTAAAAACACAAAGAGCAAAGCAGAACTTATAAAATTATATATATATATATTAAAAA
GTCTCTATTCTTCACCCCCCAGCCTTCCTGAACCTGCCTCTCTGAGGATAAAGCAATTCATTTTCTCCCACCCTCGGCCCTCTTGTTTTT
AAAATAAACTTTTAAAAAGGAAAAAAAAAAGTCACTCTTGCTATTTCTTTTTTTTAGTTAGAGGTGGAACATTCCTTGGACCAGGTGTTG
TATTGCAGGACCCCTTCCCCCAGCAGCCAAGCCCCCTCTTCTCTCCCTCCCGCCCTGGCTCAGCTCCCGCGGCCCCGCCCGTCCCCCCTC
CCAGGACTGGTCTGTTGTCTTTTCATCTGTTCAAGAGGAGATTGAAACTGAAAACAAAATGAGAACAACAAAAAAAATTGTATGGCAGTT

>30059_30059_1_FDPS-KHSRP_FDPS_chr1_155282186_ENST00000356657_KHSRP_chr19_6422447_ENST00000398148_length(amino acids)=788AA_BP=160
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQI
VRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELIAAKIGGDAATTVNNSTPDF
GFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVS
LTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPL
RIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIM
GPPDRCEHAARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQ
LPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQ
WQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQD

--------------------------------------------------------------
>30059_30059_2_FDPS-KHSRP_FDPS_chr1_155282186_ENST00000368356_KHSRP_chr19_6422447_ENST00000398148_length(transcript)=3246nt_BP=595nt
AGTGTGGGGAGAGCGGGAACTACTCGACCCACAGAGCCGATCGCGGAGCGGATTCTGCTTTTAGGAGTACCCGCCAACAAGCGGGACCGA
GCAGGAATCCGTATCTGGGAACAGGATGCCCCTGTCCCGCTGGTTGAGATCTGTGGGGGTCTTCCTGCTGCCAGCCCCCTACTGGGCACC
CCGGGAGAGGTGGCTGGGTTCCCTACGGCGGCCCTCCCTGGTGCACGGGTACCCAGTCCTGGCCTGGCACAGTGCCCGCTGCTGGTGCCA
AGCGTGGACAGAGGAACCTCGAGCCCTTTGCTCCTCCCTCAGAATGAACGGAGACCAGAATTCAGATGTTTATGCCCAAGAAAAGCAGGA
TTTCGTTCAGCACTTCTCCCAGATCGTTAGGGTGCTGACTGAGGATGAGATGGGGCACCCAGAGATAGGAGATGCTATTGCCCGGCTCAA
GGAGGTCCTGGAGTACAATGCCATTGGAGGCAAGTATAACCGGGGTTTGACGGTGGTAGTAGCATTCCGGGAGCTGGTGGAGCCAAGGAA
ACAGGATGCTGATAGTCTCCAGCGGGCCTGGACTGTGGGCTGGTGTGTGGAACTGATTGCAGCCAAAATTGGAGGCGATGCTGCCACGAC
AGTGAATAACAGCACTCCTGATTTTGGTTTTGGGGGCCAAAAGAGACAGTTGGAAGATGGAGATCAACCGGAGAGCAAGAAGCTGGCTTC
CCAGGGAGACTCAATCAGTTCTCAACTTGGACCCATCCATCCTCCCCCAAGGACTTCAATGACAGAAGAGTACAGGGTCCCAGACGGCAT
GGTGGGCCTGATCATTGGCAGAGGAGGTGAACAAATTAACAAAATCCAACAGGATTCAGGCTGCAAAGTACAGATTTCTCCAGACAGCGG
TGGCCTACCCGAGCGCAGTGTGTCCTTGACAGGAGCCCCAGAATCTGTCCAGAAAGCCAAGATGATGCTGGATGACATTGTGTCTCGGGG
TCGTGGGGGCCCCCCAGGACAGTTCCACGACAACGCCAACGGGGGCCAGAACGGCACCGTGCAGGAGATCATGATCCCCGCGGGCAAGGC
CGGCCTGGTCATTGGCAAGGGCGGGGAGACCATTAAGCAGCTGCAGGAACGCGCTGGAGTGAAGATGATCTTAATTCAGGACGGATCTCA
GAATACGAATGTGGACAAACCTCTCCGCATCATTGGGGATCCTTACAAAGTGCAGCAAGCCTGTGAGATGGTGATGGACATCCTCCGGGA
ACGTGACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCTCGGATTGGCGGAGGCATCGATGTGCCAGTGCCCAGGCATTCTGTTGG
CGTGGTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAGAATGATGCTGGCGTGCGGATACAGTTCAAGCAAGATGACGGGACAGG
GCCCGAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGCGAGCACGCAGCCCGGATCATCAACGACCTCCTCCAGAGCCTCAGGAG
TGGTCCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGGGGCCGAGGCCGAGGAAGAGGCCAAGGCAATTGGGGTCCCCCTGGCGG
GGAGATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTCATCGGCCGAGGTGGCGAGAATGTGAAAGCCATAAACCAGCAGACGGG
AGCCTTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGACCCCAACTTCAAGTTGTTCATCATCCGGGGTTCACCCCAGCAGATTGA
CCACGCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTCTGCCCAGTTGGACCAGGCCCAGGTGGCCCAGGCCCTGCTGGCCCAAT
GGGGCCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGGGCTCCCCCACATGCCGGGGGGCCCCCTCCTCACCAGTACCCACCCCA
GGGCTGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCTCATGACCCAAGCAAAGCAGCTGCAGCGGCCGCGGACCCCAACGCCGC
GTGGGCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGCCCCGTCCCCGGCCCCGCACCGGCCCCTGCGGCCCCACCGGCTCAGGG
TGAGCCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACTAAGGCCTGGGAAGAGTATTACAAAAAGATCGGCCAGCAGCCCCAGCA
GCCCGGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAGGAGTACTACAAGAAGCAAGCGCAAGTGGCCACCGGAGGGGGTCCAGG
AGCTCCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCGGAATATTACAGACAGCAGGCCGCTTACTACGGACAGACCCCAGGTCC
TGGCGGCCCCCAGCCGCCGCCCACGCAGCAGGGACAGCAGCAGGCTCAATGAATCGAATGAATGTGAACTTCTTCATCTGTGAAAAATCT
TTTTTTTTTCCATTTTGTTCTGTTTGGGGGCTTCTGTTTTGTTTGGCGAGAGAGCGATGGCTGCCGTGGGGAGTACTGGGGAGCCCTCGC
GGCAAGCAGGGTGGGGGGGACTTGGGGGCATGCCGGGCCCTCACTCTCTCGCCTGTTCTGTGTCTCACATGCTTTTTCTTTCAAAATTGG
GATCCTTCCATGTTGAGCCAGCCAGAGAAGATAGCGAGATCTAAATCTCTGCCAAAAAAAAAAAAAAACTTAAAAATTAAAAACACAAAG
AGCAAAGCAGAACTTATAAAATTATATATATATATATTAAAAAGTCTCTATTCTTCACCCCCCAGCCTTCCTGAACCTGCCTCTCTGAGG
ATAAAGCAATTCATTTTCTCCCACCCTCGGCCCTCTTGTTTTTAAAATAAACTTTTAAAAAGGAAAAAAAAAAGTCACTCTTGCTATTTC
TTTTTTTTAGTTAGAGGTGGAACATTCCTTGGACCAGGTGTTGTATTGCAGGACCCCTTCCCCCAGCAGCCAAGCCCCCTCTTCTCTCCC
TCCCGCCCTGGCTCAGCTCCCGCGGCCCCGCCCGTCCCCCCTCCCAGGACTGGTCTGTTGTCTTTTCATCTGTTCAAGAGGAGATTGAAA
CTGAAAACAAAATGAGAACAACAAAAAAAATTGTATGGCAGTTTTTACTTTTTATCGCTCGTTTTTAACTTCACAAATAAATGATAACAA

>30059_30059_2_FDPS-KHSRP_FDPS_chr1_155282186_ENST00000368356_KHSRP_chr19_6422447_ENST00000398148_length(amino acids)=788AA_BP=160
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQI
VRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELIAAKIGGDAATTVNNSTPDF
GFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVS
LTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPL
RIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIM
GPPDRCEHAARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQ
LPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQ
WQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQD

--------------------------------------------------------------
>30059_30059_3_FDPS-KHSRP_FDPS_chr1_155282186_ENST00000447866_KHSRP_chr19_6422447_ENST00000398148_length(transcript)=3152nt_BP=501nt
TCAGCGCGGCTCATCTTCGCCCAGCCAGGACACGCAGGATCGCGTTATCTGTCCCTCCCGCGGGCACATTGGGAGTTGTAGTCTAATTAT
ATATTTCCGCCCTTAGTGTGGGGAGAGCGGGAACTACTCGACCCACAGAGCCGATCGCGGAGCGGATTCTGCTTTTAGGAGTACCCGCCA
ACAAGCGGGACCGAGCAGGAATCCGTATCTGGGAACAGAATGAACGGAGACCAGAATTCAGATGTTTATGCCCAAGAAAAGCAGGATTTC
GTTCAGCACTTCTCCCAGATCGTTAGGGTGCTGACTGAGGATGAGATGGGGCACCCAGAGATAGGAGATGCTATTGCCCGGCTCAAGGAG
GTCCTGGAGTACAATGCCATTGGAGGCAAGTATAACCGGGGTTTGACGGTGGTAGTAGCATTCCGGGAGCTGGTGGAGCCAAGGAAACAG
GATGCTGATAGTCTCCAGCGGGCCTGGACTGTGGGCTGGTGTGTGGAACTGATTGCAGCCAAAATTGGAGGCGATGCTGCCACGACAGTG
AATAACAGCACTCCTGATTTTGGTTTTGGGGGCCAAAAGAGACAGTTGGAAGATGGAGATCAACCGGAGAGCAAGAAGCTGGCTTCCCAG
GGAGACTCAATCAGTTCTCAACTTGGACCCATCCATCCTCCCCCAAGGACTTCAATGACAGAAGAGTACAGGGTCCCAGACGGCATGGTG
GGCCTGATCATTGGCAGAGGAGGTGAACAAATTAACAAAATCCAACAGGATTCAGGCTGCAAAGTACAGATTTCTCCAGACAGCGGTGGC
CTACCCGAGCGCAGTGTGTCCTTGACAGGAGCCCCAGAATCTGTCCAGAAAGCCAAGATGATGCTGGATGACATTGTGTCTCGGGGTCGT
GGGGGCCCCCCAGGACAGTTCCACGACAACGCCAACGGGGGCCAGAACGGCACCGTGCAGGAGATCATGATCCCCGCGGGCAAGGCCGGC
CTGGTCATTGGCAAGGGCGGGGAGACCATTAAGCAGCTGCAGGAACGCGCTGGAGTGAAGATGATCTTAATTCAGGACGGATCTCAGAAT
ACGAATGTGGACAAACCTCTCCGCATCATTGGGGATCCTTACAAAGTGCAGCAAGCCTGTGAGATGGTGATGGACATCCTCCGGGAACGT
GACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCTCGGATTGGCGGAGGCATCGATGTGCCAGTGCCCAGGCATTCTGTTGGCGTG
GTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAGAATGATGCTGGCGTGCGGATACAGTTCAAGCAAGATGACGGGACAGGGCCC
GAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGCGAGCACGCAGCCCGGATCATCAACGACCTCCTCCAGAGCCTCAGGAGTGGT
CCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGGGGCCGAGGCCGAGGAAGAGGCCAAGGCAATTGGGGTCCCCCTGGCGGGGAG
ATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTCATCGGCCGAGGTGGCGAGAATGTGAAAGCCATAAACCAGCAGACGGGAGCC
TTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGACCCCAACTTCAAGTTGTTCATCATCCGGGGTTCACCCCAGCAGATTGACCAC
GCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTCTGCCCAGTTGGACCAGGCCCAGGTGGCCCAGGCCCTGCTGGCCCAATGGGG
CCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGGGCTCCCCCACATGCCGGGGGGCCCCCTCCTCACCAGTACCCACCCCAGGGC
TGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCTCATGACCCAAGCAAAGCAGCTGCAGCGGCCGCGGACCCCAACGCCGCGTGG
GCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGCCCCGTCCCCGGCCCCGCACCGGCCCCTGCGGCCCCACCGGCTCAGGGTGAG
CCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACTAAGGCCTGGGAAGAGTATTACAAAAAGATCGGCCAGCAGCCCCAGCAGCCC
GGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAGGAGTACTACAAGAAGCAAGCGCAAGTGGCCACCGGAGGGGGTCCAGGAGCT
CCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCGGAATATTACAGACAGCAGGCCGCTTACTACGGACAGACCCCAGGTCCTGGC
GGCCCCCAGCCGCCGCCCACGCAGCAGGGACAGCAGCAGGCTCAATGAATCGAATGAATGTGAACTTCTTCATCTGTGAAAAATCTTTTT
TTTTTCCATTTTGTTCTGTTTGGGGGCTTCTGTTTTGTTTGGCGAGAGAGCGATGGCTGCCGTGGGGAGTACTGGGGAGCCCTCGCGGCA
AGCAGGGTGGGGGGGACTTGGGGGCATGCCGGGCCCTCACTCTCTCGCCTGTTCTGTGTCTCACATGCTTTTTCTTTCAAAATTGGGATC
CTTCCATGTTGAGCCAGCCAGAGAAGATAGCGAGATCTAAATCTCTGCCAAAAAAAAAAAAAAACTTAAAAATTAAAAACACAAAGAGCA
AAGCAGAACTTATAAAATTATATATATATATATTAAAAAGTCTCTATTCTTCACCCCCCAGCCTTCCTGAACCTGCCTCTCTGAGGATAA
AGCAATTCATTTTCTCCCACCCTCGGCCCTCTTGTTTTTAAAATAAACTTTTAAAAAGGAAAAAAAAAAGTCACTCTTGCTATTTCTTTT
TTTTAGTTAGAGGTGGAACATTCCTTGGACCAGGTGTTGTATTGCAGGACCCCTTCCCCCAGCAGCCAAGCCCCCTCTTCTCTCCCTCCC
GCCCTGGCTCAGCTCCCGCGGCCCCGCCCGTCCCCCCTCCCAGGACTGGTCTGTTGTCTTTTCATCTGTTCAAGAGGAGATTGAAACTGA
AAACAAAATGAGAACAACAAAAAAAATTGTATGGCAGTTTTTACTTTTTATCGCTCGTTTTTAACTTCACAAATAAATGATAACAAAACC

>30059_30059_3_FDPS-KHSRP_FDPS_chr1_155282186_ENST00000447866_KHSRP_chr19_6422447_ENST00000398148_length(amino acids)=722AA_BP=94
MNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW
CVELIAAKIGGDAATTVNNSTPDFGFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINK
IQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQL
QERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQ
NDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLV
IGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPG
APPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYT
KAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPPTQQGQQQ

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Fusion Gene PPI Analysis for FDPS-KHSRP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FDPS-KHSRP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FDPS-KHSRP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource