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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FDXR-TMSB15B (FusionGDB2 ID:30070)

Fusion Gene Summary for FDXR-TMSB15B

check button Fusion gene summary
Fusion gene informationFusion gene name: FDXR-TMSB15B
Fusion gene ID: 30070
HgeneTgene
Gene symbol

FDXR

TMSB15B

Gene ID

2232

286527

Gene nameferredoxin reductasethymosin beta 15B
SynonymsADR|ADXR|ANOATMSB15A|TMSL8|TMSNB|Tbeta15b
Cytomap

17q25.1

Xq22.2

Type of geneprotein-codingprotein-coding
DescriptionNADPH:adrenodoxin oxidoreductase, mitochondrialARadrenodoxin reductaseadrenodoxin-NADP(+) reductaseepididymis secretory sperm binding proteinferredoxin--NADP(+) reductasethymosin beta-15BNB thymosin betaThymosin beta-15AThymosin-like protein 8
Modification date2020031320200313
UniProtAcc

P22570

.
Ensembl transtripts involved in fusion geneENST00000293195, ENST00000413947, 
ENST00000420580, ENST00000442102, 
ENST00000581530, ENST00000582944, 
ENST00000583917, ENST00000455107, 
ENST00000544854, ENST00000581969, 
ENST00000419165, ENST00000436583, 
ENST00000540220, ENST00000563257, 
ENST00000567181, ENST00000569577, 
ENST00000455723, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: FDXR [Title/Abstract] AND TMSB15B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFDXR(72868160)-TMSB15B(103219078), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FDXR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMSB15B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8604FDXRchr17

72868160

-TMSB15BchrX

103219078

+


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Fusion Gene ORF analysis for FDXR-TMSB15B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000293195ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000293195ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000293195ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000293195ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000293195ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000293195ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000413947ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000413947ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000413947ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000413947ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000413947ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000413947ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000420580ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000420580ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000420580ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000420580ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000420580ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000420580ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000442102ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000442102ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000442102ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000442102ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000442102ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000442102ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000581530ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000581530ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000581530ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000581530ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000581530ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000581530ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000582944ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000582944ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000582944ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000582944ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000582944ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000582944ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000583917ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000583917ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000583917ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000583917ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000583917ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-5UTRENST00000583917ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000293195ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000413947ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000420580ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000442102ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000581530ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000582944ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5CDS-intronENST00000583917ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-5UTRENST00000455107ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-5UTRENST00000455107ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-5UTRENST00000455107ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-5UTRENST00000455107ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-5UTRENST00000455107ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-5UTRENST00000455107ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
5UTR-intronENST00000455107ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000544854ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000544854ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000544854ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000544854ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000544854ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000544854ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000581969ENST00000419165FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000581969ENST00000436583FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000581969ENST00000540220FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000581969ENST00000563257FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000581969ENST00000567181FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-5UTRENST00000581969ENST00000569577FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-intronENST00000544854ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+
intron-intronENST00000581969ENST00000455723FDXRchr17

72868160

-TMSB15BchrX

103219078

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FDXR-TMSB15B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FDXRchr1772868160-TMSB15BchrX103219078+0.045063310.9549367
FDXRchr1772868160-TMSB15BchrX103219078+0.045063310.9549367

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FDXR-TMSB15B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:72868160/:103219078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FDXR

P22570

.
FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. {ECO:0000250|UniProtKB:P08165}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FDXR-TMSB15B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FDXR-TMSB15B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FDXR-TMSB15B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FDXR-TMSB15B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource