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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FERMT1-MCM8 (FusionGDB2 ID:30108)

Fusion Gene Summary for FERMT1-MCM8

check button Fusion gene summary
Fusion gene informationFusion gene name: FERMT1-MCM8
Fusion gene ID: 30108
HgeneTgene
Gene symbol

FERMT1

MCM8

Gene ID

55612

84515

Gene namefermitin family member 1minichromosome maintenance 8 homologous recombination repair factor
SynonymsC20orf42|DTGCU2|KIND1|UNC112A|URP1C20orf154|POF10|dJ967N21.5
Cytomap

20p12.3

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionfermitin family homolog 1UNC112 related protein 1kindlerinkindlin 1kindlin syndrome proteinunc-112-related protein 1DNA helicase MCM8DNA replication licensing factor MCM8MCM8 minichromosome maintenance deficient 8REC homologminichromosome maintenance complex component 8
Modification date2020031320200315
UniProtAcc

Q9BQL6

Q9UJA3

Ensembl transtripts involved in fusion geneENST00000478194, ENST00000536936, 
ENST00000217289, 		ENST00000265187, 
ENST00000378883, ENST00000378886, 
ENST00000378896, 
Fusion gene scores* DoF score8 X 8 X 3=1925 X 4 X 4=80
# samples 85
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FERMT1 [Title/Abstract] AND MCM8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFERMT1(6060083)-MCM8(5937772), # samples:1
Anticipated loss of major functional domain due to fusion event.FERMT1-MCM8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FERMT1-MCM8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFERMT1

GO:0007155

cell adhesion

17012746

HgeneFERMT1

GO:0043616

keratinocyte proliferation

17012746

HgeneFERMT1

GO:0051546

keratinocyte migration

17012746

HgeneFERMT1

GO:0090162

establishment of epithelial cell polarity

17012746

TgeneMCM8

GO:0006974

cellular response to DNA damage stimulus

22771115


check buttonFusion gene breakpoints across FERMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MCM8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CM-01AFERMT1chr20

6060083

-MCM8chr20

5937772

+


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Fusion Gene ORF analysis for FERMT1-MCM8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000478194ENST00000265187FERMT1chr20

6060083

-MCM8chr20

5937772

+
5UTR-3CDSENST00000478194ENST00000378883FERMT1chr20

6060083

-MCM8chr20

5937772

+
5UTR-3CDSENST00000478194ENST00000378886FERMT1chr20

6060083

-MCM8chr20

5937772

+
5UTR-3CDSENST00000478194ENST00000378896FERMT1chr20

6060083

-MCM8chr20

5937772

+
Frame-shiftENST00000536936ENST00000265187FERMT1chr20

6060083

-MCM8chr20

5937772

+
Frame-shiftENST00000536936ENST00000378883FERMT1chr20

6060083

-MCM8chr20

5937772

+
Frame-shiftENST00000536936ENST00000378886FERMT1chr20

6060083

-MCM8chr20

5937772

+
Frame-shiftENST00000536936ENST00000378896FERMT1chr20

6060083

-MCM8chr20

5937772

+
In-frameENST00000217289ENST00000265187FERMT1chr20

6060083

-MCM8chr20

5937772

+
In-frameENST00000217289ENST00000378883FERMT1chr20

6060083

-MCM8chr20

5937772

+
In-frameENST00000217289ENST00000378886FERMT1chr20

6060083

-MCM8chr20

5937772

+
In-frameENST00000217289ENST00000378896FERMT1chr20

6060083

-MCM8chr20

5937772

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000217289FERMT1chr206060083-ENST00000378883MCM8chr205937772+5335264973545441269
ENST00000217289FERMT1chr206060083-ENST00000378896MCM8chr205937772+5501264973546851316
ENST00000217289FERMT1chr206060083-ENST00000378886MCM8chr205937772+4844264973548051356
ENST00000217289FERMT1chr206060083-ENST00000265187MCM8chr205937772+5453264973546371300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000217289ENST00000378883FERMT1chr206060083-MCM8chr205937772+0.0006096740.99939036
ENST00000217289ENST00000378896FERMT1chr206060083-MCM8chr205937772+0.0011405150.9988595
ENST00000217289ENST00000378886FERMT1chr206060083-MCM8chr205937772+0.0019866770.99801326
ENST00000217289ENST00000265187FERMT1chr206060083-MCM8chr205937772+0.0006680770.9993319

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Fusion Genomic Features for FERMT1-MCM8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FERMT1chr206060082-MCM8chr205937771+0.88255410.117445886
FERMT1chr206060082-MCM8chr205937771+0.88255410.117445886

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FERMT1-MCM8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:6060083/chr20:5937772)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FERMT1

Q9BQL6

MCM8

Q9UJA3

FUNCTION: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}.FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093). {ECO:0000250|UniProtKB:Q9CWV1, ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFERMT1chr20:6060083chr20:5937772ENST00000217289-1415147_154620678.0Compositional biasNote=Poly-Lys
HgeneFERMT1chr20:6060083chr20:5937772ENST00000217289-1415377_473620678.0DomainPH
TgeneMCM8chr20:6060083chr20:5937772ENST00000265187419481_490162825.0Compositional biasNote=Thr-rich
TgeneMCM8chr20:6060083chr20:5937772ENST00000378883418481_490162794.0Compositional biasNote=Thr-rich
TgeneMCM8chr20:6060083chr20:5937772ENST00000378886419481_490162881.0Compositional biasNote=Thr-rich
TgeneMCM8chr20:6060083chr20:5937772ENST00000378896419481_490162841.0Compositional biasNote=Thr-rich
TgeneMCM8chr20:6060083chr20:5937772ENST00000265187419402_609162825.0DomainNote=MCM
TgeneMCM8chr20:6060083chr20:5937772ENST00000378883418402_609162794.0DomainNote=MCM
TgeneMCM8chr20:6060083chr20:5937772ENST00000378886419402_609162881.0DomainNote=MCM
TgeneMCM8chr20:6060083chr20:5937772ENST00000378896419402_609162841.0DomainNote=MCM
TgeneMCM8chr20:6060083chr20:5937772ENST00000265187419454_461162825.0Nucleotide bindingATP
TgeneMCM8chr20:6060083chr20:5937772ENST00000378883418454_461162794.0Nucleotide bindingATP
TgeneMCM8chr20:6060083chr20:5937772ENST00000378886419454_461162881.0Nucleotide bindingATP
TgeneMCM8chr20:6060083chr20:5937772ENST00000378896419454_461162841.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFERMT1chr20:6060083chr20:5937772ENST00000217289-141596_653620678.0DomainNote=FERM


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Fusion Gene Sequence for FERMT1-MCM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30108_30108_1_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000265187_length(transcript)=5453nt_BP=2649nt
CTGGAGTCTCCCCTGGTCGGGAGCCTCAGCCTTCTGGAGACTGACACCACCCTCTTACTCAGAGACGAATCGTTTTGTCGTTGCCTTCAC
CTCCCTGACCACAAGTGCTCCGGGGCTCTTTCTGAGGGAGGCAGCTGTTCTAGGCGGGAGGCTGGAGTCTCCTGGGCCTGGACGCACCCC
GGGGTGTGAGTGATGGGTATGCCTGAAAGGAGGGGAAGTGGCGCGGCTTTAATCATCTGGGCTAGTCCCCGGCGGGCCTGGGGGAACAGG
GAAACTGGAGGCGGCCTTAAAGCGTCAGGATGAGACATCGCAAGAGGAGCTGCAGATACTGAGCGTGCGCCCCGGGTTCTCGCCGCCTTC
TCTCCGCCGAGCAGCCCTTCGGCCACCCTTTGCCCTTAAAAATCTGCAGACTGCGCCTCCTCTCCGCGGGAGCGAGACCTAGCAGGCCCG
GGGCTGGGCGTGCCCTCGCCTGCCACGCTGCGCGCTGCCCTCAGCCGGGCCGCTGGGGCCGTGCAGTGCACCGGGCACGCCGCGCCAGGC
TGGGGGCAGGCACCGAGCCTCCGTGGGAGGTCCCGAGGCAGCTTCGCCTGCTCGCCCTGGCTCCAGCCCTCACCTGCCGCAGCCTTAGCT
GAGCAGCCGCCGCCACTGGGCGCCCCCCGCTCCCCACTTCGCCAGCGCCCGCTCCTCGGCTCGGCCCGGGGTAGTTTGTAGGGACGCAGC
TCTCCACGTGCGCGACTGCGAGGCTGGACGCTACGGGCTCCTGGAAAGGAGACACCAGCATTTGCCACAATGCTGTCATCCACTGACTTT
ACATTTGCTTCCTGGGAGCTTGTGGTCCGCGTTGACCATCCCAATGAAGAGCAGCAGAAAGACGTCACACTGAGAGTATCTGGAGACCTT
CATGTTGGAGGAGTGATGCTCAAGTTAGTAGAACAGATCAATATATCCCAAGACTGGTCAGACTTTGCTCTTTGGTGGGAACAGAAGCAT
TGCTGGCTTCTGAAAACCCACTGGACCCTGGACAAATATGGGGTCCAGGCAGATGCAAAGCTTCTCTTCACCCCTCAGCATAAAATGCTG
CGCCTTCGTCTGCCGAATTTGAAGATGGTGAGGTTGCGAGTCAGCTTCTCAGCTGTGGTTTTTAAAGCTGTCAGTGATATCTGCAAAATC
CTGAATATTAGAAGATCAGAAGAGCTTTCCTTGTTAAAGCCGTCTGGTGACTATTTTAAGAAGAAGAAGAAAAAAGACAAAAATAATAAG
GAACCCATAATTGAAGATATTCTAAACCTGGAGAGTTCTCCAACAGCTTCAGGTTCATCAGTAAGTCCTGGTTTATACAGTAAAACCATG
ACCCCTATATATGACCCCATCAATGGAACACCAGCATCATCCACCATGACTTGGTTCAGTGACAGCCCTTTGACGGAACAAAACTGCAGC
ATCCTCGCATTCAGCCAACCCCCCCAGTCCCCAGAAGCACTTGCGGATATGTACCAGCCTCGGTCTCTGGTTGATAAAGCCAAGCTCAAT
GCAGGTTGGCTAGACTCCTCACGCTCCCTTATGGAACAAGGCATCCAAGAGGATGAGCAGCTGCTCTTACGATTTAAATATTATTCTTTC
TTCGACTTGAATCCTAAATATGATGCTGTCCGAATAAACCAACTCTATGAGCAAGCCAGGTGGGCCATTCTCTTAGAAGAAATTGATTGC
ACAGAGGAAGAAATGTTGATCTTTGCAGCTCTACAGTACCACATTAGCAAACTGTCGTTGTCTGCTGAAACACAGGATTTTGCAGGCGAG
TCCGAGGTTGATGAAATAGAAGCGGCGCTTTCTAATTTGGAAGTAACCCTAGAAGGTGGAAAAGCGGACAGCCTTTTGGAGGACATTACT
GATATCCCTAAACTTGCAGATAATCTCAAATTATTTAGGCCCAAGAAGTTACTACCAAAAGCTTTCAAACAATATTGGTTTATCTTTAAA
GACACATCCATAGCATACTTTAAAAATAAGGAACTTGAACAAGGAGAACCACTAGAAAAACTAAATCTTAGAGGCTGCGAAGTTGTGCCC
GATGTAAATGTAGCAGGAAGAAAATTTGGAATCAAGTTACTAATCCCTGTTGCCGATGGTATGAATGAAATGTATTTGAGATGTGACCAT
GAGAATCAATACGCCCAATGGATGGCTGCCTGCATGTTGGCATCGAAGGGCAAAACCATGGCAGACAGCTCCTACCAGCCAGAGGTCCTC
AACATCCTTTCATTTCTGAGGATGAAAAACAGGAACTCTGCATCTCAGGTGGCTTCCAGTCTCGAAAACATGGATATGAACCCAGAATGT
TTTGTGTCACCACGGTGTGCAAAAAGACACAAATCCAAACAGCTGGCCGCCCGGATCCTGGAGGCGCACCAGAACGTGGCCCAGATGCCC
CTGGTCGAAGCCAAGCTGCGGTTCATCCAGGCGTGGCAGTCACTGCCTGAGTTTGGCCTCACCTACTACCTTGTCAGATTTAAAGGAAGC
AAAAAAGATGACATTCTGGGAGTTTCATATAACAGGTTGATTAAAATTGATGCAGCCACCGGGATTCCAGTGACAACATGGAGATTCACA
AATATCAAACAGTGGAATGTAAACTGGGAAACCCGGCAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAA
GGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAAT
GTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCT
TTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGT
CGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGAT
GATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTG
ACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGCAAATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGAT
GGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGACCTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTC
ATTGTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATAC
GCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAG
GCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGT
TCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAAT
CAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCC
ATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCC
AGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGA
AAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCA
TTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAG
TATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGC
TCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAA
GACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAG
CATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTT
CAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGT
TACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGAT
TAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACACACACACACACACACACACACACACACACACACA
GTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATA
AAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAA
CCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTC
AGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAATCACTGCACTCCA
GCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGG
GCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATAGTTTTGCATATCAGA
TGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAA

>30108_30108_1_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000265187_length(amino acids)=1300AA_BP=638
MRGWTLRAPGKETPAFATMLSSTDFTFASWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLK
THWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSLLKPSGDYFKKKKKKDKNNKEPIIE
DILNLESSPTASGSSVSPGLYSKTMTPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLNAGWLD
SSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVDE
IEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVA
GRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEVLNILSFLRMKNRNSASQVASSLENMDMNPECFVSPR
CAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQW
NVNWETRQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAA
CGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGI
VKVSNAEEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKN
RIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQAL
LEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTI
SSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITT
RQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQL

--------------------------------------------------------------
>30108_30108_2_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000378883_length(transcript)=5335nt_BP=2649nt
CTGGAGTCTCCCCTGGTCGGGAGCCTCAGCCTTCTGGAGACTGACACCACCCTCTTACTCAGAGACGAATCGTTTTGTCGTTGCCTTCAC
CTCCCTGACCACAAGTGCTCCGGGGCTCTTTCTGAGGGAGGCAGCTGTTCTAGGCGGGAGGCTGGAGTCTCCTGGGCCTGGACGCACCCC
GGGGTGTGAGTGATGGGTATGCCTGAAAGGAGGGGAAGTGGCGCGGCTTTAATCATCTGGGCTAGTCCCCGGCGGGCCTGGGGGAACAGG
GAAACTGGAGGCGGCCTTAAAGCGTCAGGATGAGACATCGCAAGAGGAGCTGCAGATACTGAGCGTGCGCCCCGGGTTCTCGCCGCCTTC
TCTCCGCCGAGCAGCCCTTCGGCCACCCTTTGCCCTTAAAAATCTGCAGACTGCGCCTCCTCTCCGCGGGAGCGAGACCTAGCAGGCCCG
GGGCTGGGCGTGCCCTCGCCTGCCACGCTGCGCGCTGCCCTCAGCCGGGCCGCTGGGGCCGTGCAGTGCACCGGGCACGCCGCGCCAGGC
TGGGGGCAGGCACCGAGCCTCCGTGGGAGGTCCCGAGGCAGCTTCGCCTGCTCGCCCTGGCTCCAGCCCTCACCTGCCGCAGCCTTAGCT
GAGCAGCCGCCGCCACTGGGCGCCCCCCGCTCCCCACTTCGCCAGCGCCCGCTCCTCGGCTCGGCCCGGGGTAGTTTGTAGGGACGCAGC
TCTCCACGTGCGCGACTGCGAGGCTGGACGCTACGGGCTCCTGGAAAGGAGACACCAGCATTTGCCACAATGCTGTCATCCACTGACTTT
ACATTTGCTTCCTGGGAGCTTGTGGTCCGCGTTGACCATCCCAATGAAGAGCAGCAGAAAGACGTCACACTGAGAGTATCTGGAGACCTT
CATGTTGGAGGAGTGATGCTCAAGTTAGTAGAACAGATCAATATATCCCAAGACTGGTCAGACTTTGCTCTTTGGTGGGAACAGAAGCAT
TGCTGGCTTCTGAAAACCCACTGGACCCTGGACAAATATGGGGTCCAGGCAGATGCAAAGCTTCTCTTCACCCCTCAGCATAAAATGCTG
CGCCTTCGTCTGCCGAATTTGAAGATGGTGAGGTTGCGAGTCAGCTTCTCAGCTGTGGTTTTTAAAGCTGTCAGTGATATCTGCAAAATC
CTGAATATTAGAAGATCAGAAGAGCTTTCCTTGTTAAAGCCGTCTGGTGACTATTTTAAGAAGAAGAAGAAAAAAGACAAAAATAATAAG
GAACCCATAATTGAAGATATTCTAAACCTGGAGAGTTCTCCAACAGCTTCAGGTTCATCAGTAAGTCCTGGTTTATACAGTAAAACCATG
ACCCCTATATATGACCCCATCAATGGAACACCAGCATCATCCACCATGACTTGGTTCAGTGACAGCCCTTTGACGGAACAAAACTGCAGC
ATCCTCGCATTCAGCCAACCCCCCCAGTCCCCAGAAGCACTTGCGGATATGTACCAGCCTCGGTCTCTGGTTGATAAAGCCAAGCTCAAT
GCAGGTTGGCTAGACTCCTCACGCTCCCTTATGGAACAAGGCATCCAAGAGGATGAGCAGCTGCTCTTACGATTTAAATATTATTCTTTC
TTCGACTTGAATCCTAAATATGATGCTGTCCGAATAAACCAACTCTATGAGCAAGCCAGGTGGGCCATTCTCTTAGAAGAAATTGATTGC
ACAGAGGAAGAAATGTTGATCTTTGCAGCTCTACAGTACCACATTAGCAAACTGTCGTTGTCTGCTGAAACACAGGATTTTGCAGGCGAG
TCCGAGGTTGATGAAATAGAAGCGGCGCTTTCTAATTTGGAAGTAACCCTAGAAGGTGGAAAAGCGGACAGCCTTTTGGAGGACATTACT
GATATCCCTAAACTTGCAGATAATCTCAAATTATTTAGGCCCAAGAAGTTACTACCAAAAGCTTTCAAACAATATTGGTTTATCTTTAAA
GACACATCCATAGCATACTTTAAAAATAAGGAACTTGAACAAGGAGAACCACTAGAAAAACTAAATCTTAGAGGCTGCGAAGTTGTGCCC
GATGTAAATGTAGCAGGAAGAAAATTTGGAATCAAGTTACTAATCCCTGTTGCCGATGGTATGAATGAAATGTATTTGAGATGTGACCAT
GAGAATCAATACGCCCAATGGATGGCTGCCTGCATGTTGGCATCGAAGGGCAAAACCATGGCAGACAGCTCCTACCAGCCAGAGGTCCTC
AACATCCTTTCATTTCTGAGGATGAAAAACAGGAACTCTGCATCTCAGGTGGCTTCCAGTCTCGAAAACATGGATATGAACCCAGAATGT
TTTGTGTCACCACGGTGTGCAAAAAGACACAAATCCAAACAGCTGGCCGCCCGGATCCTGGAGGCGCACCAGAACGTGGCCCAGATGCCC
CTGGTCGAAGCCAAGCTGCGGTTCATCCAGGCGTGGCAGTCACTGCCTGAGTTTGGCCTCACCTACTACCTTGTCAGATTTAAAGGAAGC
AAAAAAGATGACATTCTGGGAGTTTCATATAACAGGTTGATTAAAATTGATGCAGCCACCGGGATTCCAGTGACAACATGGAGATTCACA
AATATCAAACAGTGGAATGTAAACTGGGAAACCCGGCAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAA
GGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAAT
GTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCT
TTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGT
CGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGAT
GATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTG
ACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAAGAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCA
AATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGAC
CTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAAGCA
GCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCC
TCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAA
CATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATT
ATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGA
TTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAG
CAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTA
TCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTAT
GTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCA
CCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGAC
GCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCAT
GGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAA
TTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTAC
CTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACTATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAA
AGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGACAGACACACACACACACACACACACACACACACACACACACACACACAGTC
AAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAG
TCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCT
TGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGC
TACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCC
TGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCT
AAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATATGTATGAATATTTCATAGTTTTGCATATCAGATGT
AGGCATACAGACAAATACATAAACCAATGAATATATTACATATTCTGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTT

>30108_30108_2_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000378883_length(amino acids)=1269AA_BP=638
MRGWTLRAPGKETPAFATMLSSTDFTFASWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLK
THWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSLLKPSGDYFKKKKKKDKNNKEPIIE
DILNLESSPTASGSSVSPGLYSKTMTPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLNAGWLD
SSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVDE
IEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVA
GRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEVLNILSFLRMKNRNSASQVASSLENMDMNPECFVSPR
CAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQW
NVNWETRQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAA
CGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGI
VKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHEAACNVA
PRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAAN
PVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLK
VVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIV
EIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKG

--------------------------------------------------------------
>30108_30108_3_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000378886_length(transcript)=4844nt_BP=2649nt
CTGGAGTCTCCCCTGGTCGGGAGCCTCAGCCTTCTGGAGACTGACACCACCCTCTTACTCAGAGACGAATCGTTTTGTCGTTGCCTTCAC
CTCCCTGACCACAAGTGCTCCGGGGCTCTTTCTGAGGGAGGCAGCTGTTCTAGGCGGGAGGCTGGAGTCTCCTGGGCCTGGACGCACCCC
GGGGTGTGAGTGATGGGTATGCCTGAAAGGAGGGGAAGTGGCGCGGCTTTAATCATCTGGGCTAGTCCCCGGCGGGCCTGGGGGAACAGG
GAAACTGGAGGCGGCCTTAAAGCGTCAGGATGAGACATCGCAAGAGGAGCTGCAGATACTGAGCGTGCGCCCCGGGTTCTCGCCGCCTTC
TCTCCGCCGAGCAGCCCTTCGGCCACCCTTTGCCCTTAAAAATCTGCAGACTGCGCCTCCTCTCCGCGGGAGCGAGACCTAGCAGGCCCG
GGGCTGGGCGTGCCCTCGCCTGCCACGCTGCGCGCTGCCCTCAGCCGGGCCGCTGGGGCCGTGCAGTGCACCGGGCACGCCGCGCCAGGC
TGGGGGCAGGCACCGAGCCTCCGTGGGAGGTCCCGAGGCAGCTTCGCCTGCTCGCCCTGGCTCCAGCCCTCACCTGCCGCAGCCTTAGCT
GAGCAGCCGCCGCCACTGGGCGCCCCCCGCTCCCCACTTCGCCAGCGCCCGCTCCTCGGCTCGGCCCGGGGTAGTTTGTAGGGACGCAGC
TCTCCACGTGCGCGACTGCGAGGCTGGACGCTACGGGCTCCTGGAAAGGAGACACCAGCATTTGCCACAATGCTGTCATCCACTGACTTT
ACATTTGCTTCCTGGGAGCTTGTGGTCCGCGTTGACCATCCCAATGAAGAGCAGCAGAAAGACGTCACACTGAGAGTATCTGGAGACCTT
CATGTTGGAGGAGTGATGCTCAAGTTAGTAGAACAGATCAATATATCCCAAGACTGGTCAGACTTTGCTCTTTGGTGGGAACAGAAGCAT
TGCTGGCTTCTGAAAACCCACTGGACCCTGGACAAATATGGGGTCCAGGCAGATGCAAAGCTTCTCTTCACCCCTCAGCATAAAATGCTG
CGCCTTCGTCTGCCGAATTTGAAGATGGTGAGGTTGCGAGTCAGCTTCTCAGCTGTGGTTTTTAAAGCTGTCAGTGATATCTGCAAAATC
CTGAATATTAGAAGATCAGAAGAGCTTTCCTTGTTAAAGCCGTCTGGTGACTATTTTAAGAAGAAGAAGAAAAAAGACAAAAATAATAAG
GAACCCATAATTGAAGATATTCTAAACCTGGAGAGTTCTCCAACAGCTTCAGGTTCATCAGTAAGTCCTGGTTTATACAGTAAAACCATG
ACCCCTATATATGACCCCATCAATGGAACACCAGCATCATCCACCATGACTTGGTTCAGTGACAGCCCTTTGACGGAACAAAACTGCAGC
ATCCTCGCATTCAGCCAACCCCCCCAGTCCCCAGAAGCACTTGCGGATATGTACCAGCCTCGGTCTCTGGTTGATAAAGCCAAGCTCAAT
GCAGGTTGGCTAGACTCCTCACGCTCCCTTATGGAACAAGGCATCCAAGAGGATGAGCAGCTGCTCTTACGATTTAAATATTATTCTTTC
TTCGACTTGAATCCTAAATATGATGCTGTCCGAATAAACCAACTCTATGAGCAAGCCAGGTGGGCCATTCTCTTAGAAGAAATTGATTGC
ACAGAGGAAGAAATGTTGATCTTTGCAGCTCTACAGTACCACATTAGCAAACTGTCGTTGTCTGCTGAAACACAGGATTTTGCAGGCGAG
TCCGAGGTTGATGAAATAGAAGCGGCGCTTTCTAATTTGGAAGTAACCCTAGAAGGTGGAAAAGCGGACAGCCTTTTGGAGGACATTACT
GATATCCCTAAACTTGCAGATAATCTCAAATTATTTAGGCCCAAGAAGTTACTACCAAAAGCTTTCAAACAATATTGGTTTATCTTTAAA
GACACATCCATAGCATACTTTAAAAATAAGGAACTTGAACAAGGAGAACCACTAGAAAAACTAAATCTTAGAGGCTGCGAAGTTGTGCCC
GATGTAAATGTAGCAGGAAGAAAATTTGGAATCAAGTTACTAATCCCTGTTGCCGATGGTATGAATGAAATGTATTTGAGATGTGACCAT
GAGAATCAATACGCCCAATGGATGGCTGCCTGCATGTTGGCATCGAAGGGCAAAACCATGGCAGACAGCTCCTACCAGCCAGAGGTCCTC
AACATCCTTTCATTTCTGAGGATGAAAAACAGGAACTCTGCATCTCAGGTGGCTTCCAGTCTCGAAAACATGGATATGAACCCAGAATGT
TTTGTGTCACCACGGTGTGCAAAAAGACACAAATCCAAACAGCTGGCCGCCCGGATCCTGGAGGCGCACCAGAACGTGGCCCAGATGCCC
CTGGTCGAAGCCAAGCTGCGGTTCATCCAGGCGTGGCAGTCACTGCCTGAGTTTGGCCTCACCTACTACCTTGTCAGATTTAAAGGAAGC
AAAAAAGATGACATTCTGGGAGTTTCATATAACAGGTTGATTAAAATTGATGCAGCCACCGGGATTCCAGTGACAACATGGAGATTCACA
AATATCAAACAGTGGAATGTAAACTGGGAAACCCGGCAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAA
GGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAAT
GTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCT
TTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGT
CGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGAT
GATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTG
ACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAAGAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCA
AATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGAC
CTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAAATGGAGTCTTGCTCTGTCGCCCAGGCTAGAGTAC
AGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCCCAAGTTCAAACAGTTCTCCCACCTCAGCCTGCCGAGTAGCTGGGACTACAGGC
ATGCGCCACCAGACCCAGCTACTTTTGCTTGTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAA
AACAGAATTCCAATTCGGGGAGACCCCCACATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAAT
GTTGCCCCACGTGGCGTGTATGTTTGTGGTAACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGAT
TTTGCTTTGGAAGCTGGTGCCCTGGTACTTGGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCC
TTGTTGGAAGCCATGGAGCAGCAAAGTATTAGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCT
GCAAATCCAGTTGGAGGACATTACAATAAAGCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTG
GTCTTTATCCTGTTAGATACTCCAAATGAGCATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACC
ATTAGCAGTGCCACAGTAGCTCGTATGAATAGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGA
CTAAAGGTGGTTCCTGGAGAAACAATAGATCCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCA
AGGCTATCCACAGAAGCTGCTCGAGTTCTTCAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACT
ACCAGGCAGCTGGAATCTTTGATTCGTCTGACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGAT
ATAGTGGAAATTATGAAATATAGCATGCTAGGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGA
ATGAGCAACAGGTCAACAGCGAAAAGATTTATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAA
CTTCGGCAGATTGCCAAAGAACTAAACATTCAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAA

>30108_30108_3_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000378886_length(amino acids)=1356AA_BP=1
MRGWTLRAPGKETPAFATMLSSTDFTFASWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLK
THWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSLLKPSGDYFKKKKKKDKNNKEPIIE
DILNLESSPTASGSSVSPGLYSKTMTPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLNAGWLD
SSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVDE
IEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVA
GRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEVLNILSFLRMKNRNSASQVASSLENMDMNPECFVSPR
CAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQW
NVNWETRQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAA
CGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGI
VKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVKWSLALSPRLEYSGAIS
AHCNLHLPSSNSSPTSACRVAGTTGMRHQTQLLLLVKAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRG
VYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVG
GHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVP
GETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIM
KYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKV

--------------------------------------------------------------
>30108_30108_4_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000378896_length(transcript)=5501nt_BP=2649nt
CTGGAGTCTCCCCTGGTCGGGAGCCTCAGCCTTCTGGAGACTGACACCACCCTCTTACTCAGAGACGAATCGTTTTGTCGTTGCCTTCAC
CTCCCTGACCACAAGTGCTCCGGGGCTCTTTCTGAGGGAGGCAGCTGTTCTAGGCGGGAGGCTGGAGTCTCCTGGGCCTGGACGCACCCC
GGGGTGTGAGTGATGGGTATGCCTGAAAGGAGGGGAAGTGGCGCGGCTTTAATCATCTGGGCTAGTCCCCGGCGGGCCTGGGGGAACAGG
GAAACTGGAGGCGGCCTTAAAGCGTCAGGATGAGACATCGCAAGAGGAGCTGCAGATACTGAGCGTGCGCCCCGGGTTCTCGCCGCCTTC
TCTCCGCCGAGCAGCCCTTCGGCCACCCTTTGCCCTTAAAAATCTGCAGACTGCGCCTCCTCTCCGCGGGAGCGAGACCTAGCAGGCCCG
GGGCTGGGCGTGCCCTCGCCTGCCACGCTGCGCGCTGCCCTCAGCCGGGCCGCTGGGGCCGTGCAGTGCACCGGGCACGCCGCGCCAGGC
TGGGGGCAGGCACCGAGCCTCCGTGGGAGGTCCCGAGGCAGCTTCGCCTGCTCGCCCTGGCTCCAGCCCTCACCTGCCGCAGCCTTAGCT
GAGCAGCCGCCGCCACTGGGCGCCCCCCGCTCCCCACTTCGCCAGCGCCCGCTCCTCGGCTCGGCCCGGGGTAGTTTGTAGGGACGCAGC
TCTCCACGTGCGCGACTGCGAGGCTGGACGCTACGGGCTCCTGGAAAGGAGACACCAGCATTTGCCACAATGCTGTCATCCACTGACTTT
ACATTTGCTTCCTGGGAGCTTGTGGTCCGCGTTGACCATCCCAATGAAGAGCAGCAGAAAGACGTCACACTGAGAGTATCTGGAGACCTT
CATGTTGGAGGAGTGATGCTCAAGTTAGTAGAACAGATCAATATATCCCAAGACTGGTCAGACTTTGCTCTTTGGTGGGAACAGAAGCAT
TGCTGGCTTCTGAAAACCCACTGGACCCTGGACAAATATGGGGTCCAGGCAGATGCAAAGCTTCTCTTCACCCCTCAGCATAAAATGCTG
CGCCTTCGTCTGCCGAATTTGAAGATGGTGAGGTTGCGAGTCAGCTTCTCAGCTGTGGTTTTTAAAGCTGTCAGTGATATCTGCAAAATC
CTGAATATTAGAAGATCAGAAGAGCTTTCCTTGTTAAAGCCGTCTGGTGACTATTTTAAGAAGAAGAAGAAAAAAGACAAAAATAATAAG
GAACCCATAATTGAAGATATTCTAAACCTGGAGAGTTCTCCAACAGCTTCAGGTTCATCAGTAAGTCCTGGTTTATACAGTAAAACCATG
ACCCCTATATATGACCCCATCAATGGAACACCAGCATCATCCACCATGACTTGGTTCAGTGACAGCCCTTTGACGGAACAAAACTGCAGC
ATCCTCGCATTCAGCCAACCCCCCCAGTCCCCAGAAGCACTTGCGGATATGTACCAGCCTCGGTCTCTGGTTGATAAAGCCAAGCTCAAT
GCAGGTTGGCTAGACTCCTCACGCTCCCTTATGGAACAAGGCATCCAAGAGGATGAGCAGCTGCTCTTACGATTTAAATATTATTCTTTC
TTCGACTTGAATCCTAAATATGATGCTGTCCGAATAAACCAACTCTATGAGCAAGCCAGGTGGGCCATTCTCTTAGAAGAAATTGATTGC
ACAGAGGAAGAAATGTTGATCTTTGCAGCTCTACAGTACCACATTAGCAAACTGTCGTTGTCTGCTGAAACACAGGATTTTGCAGGCGAG
TCCGAGGTTGATGAAATAGAAGCGGCGCTTTCTAATTTGGAAGTAACCCTAGAAGGTGGAAAAGCGGACAGCCTTTTGGAGGACATTACT
GATATCCCTAAACTTGCAGATAATCTCAAATTATTTAGGCCCAAGAAGTTACTACCAAAAGCTTTCAAACAATATTGGTTTATCTTTAAA
GACACATCCATAGCATACTTTAAAAATAAGGAACTTGAACAAGGAGAACCACTAGAAAAACTAAATCTTAGAGGCTGCGAAGTTGTGCCC
GATGTAAATGTAGCAGGAAGAAAATTTGGAATCAAGTTACTAATCCCTGTTGCCGATGGTATGAATGAAATGTATTTGAGATGTGACCAT
GAGAATCAATACGCCCAATGGATGGCTGCCTGCATGTTGGCATCGAAGGGCAAAACCATGGCAGACAGCTCCTACCAGCCAGAGGTCCTC
AACATCCTTTCATTTCTGAGGATGAAAAACAGGAACTCTGCATCTCAGGTGGCTTCCAGTCTCGAAAACATGGATATGAACCCAGAATGT
TTTGTGTCACCACGGTGTGCAAAAAGACACAAATCCAAACAGCTGGCCGCCCGGATCCTGGAGGCGCACCAGAACGTGGCCCAGATGCCC
CTGGTCGAAGCCAAGCTGCGGTTCATCCAGGCGTGGCAGTCACTGCCTGAGTTTGGCCTCACCTACTACCTTGTCAGATTTAAAGGAAGC
AAAAAAGATGACATTCTGGGAGTTTCATATAACAGGTTGATTAAAATTGATGCAGCCACCGGGATTCCAGTGACAACATGGAGATTCACA
AATATCAAACAGTGGAATGTAAACTGGGAAACCCGGCAGGTGTTAACTAAGGACCTTGAAAGGCATGCAGCTGAGTTACAAGCCCAGGAA
GGATTGTCTAATGATGGAGAAACAATGGTAAATGTGCCACATATTCATGCAAGGGTGTACAACTATGAGCCTTTGACACAGCTCAAGAAT
GTCAGAGCAAATTACTATGGAAAATACATTGCTCTAAGAGGGACAGTGGTTCGTGTCAGTAATATAAAGCCTCTTTGCACCAAGATGGCT
TTTCTTTGTGCTGCATGTGGAGAAATTCAGAGCTTTCCTCTTCCAGATGGAAAATACAGTCTTCCCACAAAGTGTCCTGTGCCTGTGTGT
CGAGGCAGGTCATTTACTGCTCTCCGCAGCTCTCCTCTCACAGTTACGATGGACTGGCAGTCAATCAAAATCCAGGAATTGATGTCTGAT
GATCAGAGAGAAGCAGGTCGGATTCCACGAACAATAGAATGTGAGCTTGTTCATGATCTTGTGGATAGCTGTGTCCCGGGAGACACAGTG
ACTATTACTGGAATTGTCAAAGTCTCAAATGCGGAAGAAGGTTCTCGAAATAAGAATGACAAGTGTATGTTCCTTTTGTATATTGAAGCA
AATTCTATTAGTAATAGCAAAGGACAGAAAACAAAGAGTTCTGAGGATGGGTGTAAGCATGGAATGTTGATGGAGTTCTCACTTAAAGAC
CTTTATGCCATCCAAGAGATTCAAGCTGAAGAAAACCTGTTTAAACTCATTGTCAACTCGCTTTGCCCTGTCATTTTTGGTCATGAACTT
GTTAAAGCAGGTTTGGCATTAGCACTCTTTGGAGGAAGCCAGAAATACGCAGATGACAAAAACAGAATTCCAATTCGGGGAGACCCCCAC
ATCCTTGTTGTTGGAGATCCAGGCCTAGGAAAAAGTCAAATGCTACAGGCAGCGTGCAATGTTGCCCCACGTGGCGTGTATGTTTGTGGT
AACACCACGACCACCTCTGGTCTGACGGTAACTCTTTCAAAAGATAGTTCCTCTGGAGATTTTGCTTTGGAAGCTGGTGCCCTGGTACTT
GGTGATCAAGGTATTTGTGGAATCGATGAATTTGATAAGATGGGGAATCAACATCAAGCCTTGTTGGAAGCCATGGAGCAGCAAAGTATT
AGTCTTGCTAAGGCTGGTGTGGTTTGTAGCCTTCCTGCAAGAACTTCCATTATTGCTGCTGCAAATCCAGTTGGAGGACATTACAATAAA
GCCAAAACAGTTTCTGAGAATTTAAAAATGGGGAGTGCACTACTATCCAGATTTGATTTGGTCTTTATCCTGTTAGATACTCCAAATGAG
CATCATGATCACTTACTCTCTGAACATGTGATTGCAATAAGAGCTGGAAAGCAGAGAACCATTAGCAGTGCCACAGTAGCTCGTATGAAT
AGTCAAGATTCAAATACTTCCGTACTTGAAGTAGTTTCTGAGAAGCCATTATCAGAAAGACTAAAGGTGGTTCCTGGAGAAACAATAGAT
CCCATTCCCCACCAGCTATTGAGAAAGTACATTGGCTATGCTCGGCAGTATGTGTACCCAAGGCTATCCACAGAAGCTGCTCGAGTTCTT
CAAGATTTTTACCTTGAGCTCCGGAAACAGAGCCAGAGGTTAAATAGCTCACCAATCACTACCAGGCAGCTGGAATCTTTGATTCGTCTG
ACAGAGGCACGAGCAAGGTTGGAATTGAGAGAGGAAGCAACCAAAGAAGACGCTGAGGATATAGTGGAAATTATGAAATATAGCATGCTA
GGAACTTACTCTGATGAATTTGGGAACCTAGATTTTGAGCGATCCCAGCATGGTTCTGGAATGAGCAACAGGTCAACAGCGAAAAGATTT
ATTTCTGCTCTCAACAACGTTGCTGAAAGAACTTATAATAATATATTTCAATTTCATCAACTTCGGCAGATTGCCAAAGAACTAAACATT
CAGGTTGCTGATTTTGAAAATTTTATTGGATCACTAAATGACCAGGGTTACCTCTTGAAAAAAGGCCCAAAAGTTTACCAGCTTCAAACT
ATGTAAAAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGACAGA
CAGACACACACACACACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATGTCCCAAAAGTATTA
TAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTAGCTCACACTGTAATCACAGTGACT
CAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGCAACATAGCAAGACCCCATTTCTTAAAAAAAAAAA
AAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTCTCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAG
GAGTTTGAGGTTACAGTGAGCCACAATCACACCAATCACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAA
AATTGTAGTGGTAGCCATGTGTTAATTGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTT
TGACCTGCCTTTTATATGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTAC
ATATTCTGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTTCATAAAATTTTCCCATGTCAAGAATACAAAATACTTGAG

>30108_30108_4_FERMT1-MCM8_FERMT1_chr20_6060083_ENST00000217289_MCM8_chr20_5937772_ENST00000378896_length(amino acids)=1316AA_BP=638
MRGWTLRAPGKETPAFATMLSSTDFTFASWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWLLK
THWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNIRRSEELSLLKPSGDYFKKKKKKDKNNKEPIIE
DILNLESSPTASGSSVSPGLYSKTMTPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLNAGWLD
SSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTEEEMLIFAALQYHISKLSLSAETQDFAGESEVDE
IEAALSNLEVTLEGGKADSLLEDITDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVVPDVNVA
GRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEVLNILSFLRMKNRNSASQVASSLENMDMNPECFVSPR
CAKRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGIPVTTWRFTNIKQW
NVNWETRQVLTKDLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAA
CGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGI
VKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELVKAGL
ALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGI
CGIDEFDKMGNQHQALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHL
LSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYL
ELRKQSQRLNSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALN

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Fusion Gene PPI Analysis for FERMT1-MCM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FERMT1-MCM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FERMT1-MCM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource