|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FGD3-SYK (FusionGDB2 ID:30153) |
Fusion Gene Summary for FGD3-SYK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGD3-SYK | Fusion gene ID: 30153 | Hgene | Tgene | Gene symbol | FGD3 | SYK | Gene ID | 89846 | 6850 |
| Gene name | FYVE, RhoGEF and PH domain containing 3 | spleen associated tyrosine kinase | |
| Synonyms | ZFYVE5 | p72-Syk | |
| Cytomap | 9q22.31 | 9q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FYVE, RhoGEF and PH domain-containing protein 3FGD1 family, member 3faciogenital dysplasia 3zinc finger FYVE domain-containing protein 5 | tyrosine-protein kinase SYKspleen tyrosine kinase | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q5JSP0 | P43405 | |
| Ensembl transtripts involved in fusion gene | ENST00000375482, ENST00000337352, ENST00000416701, ENST00000468206, ENST00000538555, | ENST00000476708, ENST00000375746, ENST00000375747, ENST00000375751, ENST00000375754, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 9 X 6=486 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FGD3 [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FGD3(95710011)-SYK(93606140), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SYK | GO:0006468 | protein phosphorylation | 17681949 |
| Tgene | SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
| Tgene | SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
| Fusion gene breakpoints across FGD3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SYK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-DK-A2I1-01A | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
Top |
Fusion Gene ORF analysis for FGD3-SYK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3UTR | ENST00000375482 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| 5UTR-5UTR | ENST00000375482 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| 5UTR-5UTR | ENST00000375482 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| 5UTR-5UTR | ENST00000375482 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| 5UTR-5UTR | ENST00000375482 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-3UTR | ENST00000337352 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-3UTR | ENST00000416701 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-3UTR | ENST00000468206 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-3UTR | ENST00000538555 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000337352 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000337352 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000337352 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000337352 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000416701 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000416701 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000416701 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000416701 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000468206 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000468206 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000468206 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000468206 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000538555 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000538555 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000538555 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| intron-5UTR | ENST00000538555 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for FGD3-SYK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606139 | + | 1.83E-07 | 0.99999976 |
| FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606139 | + | 1.83E-07 | 0.99999976 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for FGD3-SYK |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:95710011/:93606140) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGD3 | SYK |
| FUNCTION: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. | FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for FGD3-SYK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for FGD3-SYK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FGD3-SYK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FGD3-SYK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies