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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGD4-CMC2 (FusionGDB2 ID:30161)

Fusion Gene Summary for FGD4-CMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: FGD4-CMC2
Fusion gene ID: 30161
HgeneTgene
Gene symbol

FGD4

CMC2

Gene ID

121512

56942

Gene nameFYVE, RhoGEF and PH domain containing 4C-X9-C motif containing 2
SynonymsCMT4H|FRABP|ZFYVE62310061C15Rik|C16orf61|DC13
Cytomap

12p11.21

16q23.2

Type of geneprotein-codingprotein-coding
DescriptionFYVE, RhoGEF and PH domain-containing protein 4FGD1 family, member 4FGD1-related F-actin-binding proteinactin-filament binding protein frabinzinc finger FYVE domain-containing protein 6COX assembly mitochondrial protein 2 homologC-x(9)-C motif containing 2
Modification date2020032820200313
UniProtAcc

Q96M96

Q9NRP2

Ensembl transtripts involved in fusion geneENST00000534526, ENST00000266482, 
ENST00000381025, ENST00000427716, 
ENST00000472289, ENST00000473513, 
ENST00000525053, ENST00000531134, 
ENST00000546442, 		ENST00000219400, 
ENST00000486645, ENST00000562713, 
ENST00000564174, ENST00000564249, 
ENST00000565108, ENST00000565914, 
ENST00000565925, ENST00000570195, 
ENST00000566231, 
Fusion gene scores* DoF score19 X 13 X 13=32118 X 7 X 3=168
# samples 228
** MAII scorelog2(22/3211*10)=-3.86744723620111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGD4 [Title/Abstract] AND CMC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGD4(32552893)-CMC2(81031034), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FGD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CMC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8534-01AFGD4chr12

32552893

+CMC2chr16

81031034

-


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Fusion Gene ORF analysis for FGD4-CMC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000534526ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-5UTRENST00000534526ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
5CDS-intronENST00000534526ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000266482ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000381025ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000427716ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000472289ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000473513ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000525053ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000531134ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000219400FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000486645FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000562713FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000564174FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000564249FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000565108FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000565914FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000565925FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-5UTRENST00000546442ENST00000570195FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000266482ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000381025ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000427716ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000472289ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000473513ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000525053ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000531134ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-
intron-intronENST00000546442ENST00000566231FGD4chr12

32552893

+CMC2chr16

81031034

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FGD4-CMC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FGD4-CMC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32552893/:81031034)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGD4

Q96M96

CMC2

Q9NRP2

FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}.FUNCTION: May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FGD4-CMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FGD4-CMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGD4-CMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGD4-CMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource